From the Committee of 100 to the Committee to Re-Elect the President: The Political Campaigns of Richard M. Nixon

From the Committee of 100 to the Committee to Re-elect the President: The Political Campaigns of Richard M. Nixon offers the reader a comprehensive biography of Richard M. Nixon through the lens of his political campaigns. This thesis illustrates how Richard Nixon became one of the fiercest campaigners in 20th century American political history. This thesis, furthermore, examines the key staff and strategy of each campaign Nixon waged. This thesis, additionally, presents to the reader insight on how Nixon often fought his campaigns independently from the Republican Party and how he relied on the help of a few dedicated men

Controlling the charge transfer flow at the graphene/pyrene-nitrilotriacetic acid interface

The fabrication of highly efficient bio-organic nanoelectronic devices is still a challenge due to the difficulty in interfacing the biomolecular component to the organic counterparts. One of the ways to overcome this bottleneck is to add a self-assembled monolayer (SAM) in between the electrode and the biological material. The addition of a pyrene-nitrilotriacetic acid layer to a graphene metal electrode enhances the charge transfer within the device. Our theoretical calculations and electrochemical results show that the formation of a pyrene-nitrilotriacetic acid SAM enforces a direct electron transfer from graphene to the SAM, while the addition of the Ni2+ cation and imidazole reverses the charge transfer direction, allowing an atomic control of the electron flow, which is essential for a true working device. © 2018 The Royal Society of Chemistry

Face and emotion recognition on commercial property under EU data protection law

This paper integrates and cuts through domains of privacy law and biometrics. Specifically, this paper presents a legal analysis on the use of Automated Facial Recognition Systems (the AFRS) in commercial (retail store) settings within the European Union data protection framework. The AFRS is a typical instance of biometric technologies, where a distributed system of dozens of low-cost cameras uses psychological states, sociodemographic characteristics, and identity recognition algorithms on thousands of passers-by and customers. Current use cases and theoretical possibilities are discussed due to the technology’s potential of becoming a substantial privacy issue. First, this paper introduces the AFRS and EU data protection law. This is followed by an analysis of European Data protection law and its application in relation to the use of the AFRS, including requirements concerning data quality and legitimate processing of personal data, which, finally, leads to an overview of measures that traders can take to comply with data protection law, including by means of information, consent, and anonymization

Genetically Encoded Photo-cross-linkers Map the Binding Site of an Allosteric Drug on a G Protein-Coupled Receptor

G protein-coupled receptors (GPCRs) are dynamic membrane proteins that bind extracellular molecules to transduce signals. Although GPCRs represent the largest class of therapeutic targets, only a small percentage of their ligand-binding sites are precisely defined. Here we describe the novel application of targeted photo-cross-linking using unnatural amino acids to obtain structural information about the allosteric binding site of a small molecule drug, the CCR5-targeted HIV-1 co-receptor blocker maraviroc

Consumer Protection and Premium Rate Services In Denmark

The regulation of the telecommunication industry in Denmark is quite liberal. There are no requirements to register with national authorities when providing telecommunication services or Premium Rate Services. Only Network Operators, who want to make use of the scarce frequency resources, must register with the National IT and Telecom Agency. This liberal approach may be a contributory factor to the fact that there are no official statistics on Premium Rate Services available from public authorities. This article is structured into five parts concerning 1) Premium Rate Services in Denmark, 2) relevant actors, 3) regulation concerning Network Operators, 4) regulation concerning Content Providers, and 5) telecommunication services that are not Premium Rate Services. The proposed structure has been departed to reflect the general division of regulation concerning the Network Operator and the Content Provider, respectively. The areas covered, reflects the regulation that is relevant to those Premium Rate Services provided in Denmark. The emphasis of the article is laid on the regulation safeguarding consumers in the context of Premium Rate Services. This regulation may be grouped into regulation that: sets requirements for carrying out business as Network Operator or Content Provider, concerns which Premium Rate Service may be provided, and under which number-series or applications codes, imposes certain information requirements, ensures fair and truthful marketing of the Premium Rate Services, or allows the User to monitor his bill, limit his usage, or limits the liability in connection to unauthorised usage. Infringement of the legislation in question is mainly sanctioned by administrative or civil sanctions. The overall impression is that the Danish telecommunication industry is quite active in securing compliance with the law

Wartościowanie tekstów literackich z perspektywy ontologicznej

Anhand ausgewählter Texte und Deutungsschemata wurden unter Berücksichtigung der kategorialen, idiographischen und anthropologischen Aspekte der Bewertung eines literarischen Werkes dessen Kriterien aus ontologischer Perspektive dargestellt. Die Deskription meritorischer, sozialgeschichtlicher, ästhetischer, moralischer und metaphysischer Bedingungen bestimmt den Verlauf der Überlegungen zur axiologischen Literaturrezeption.On the basis of selected texts and interpretation schemes, taking into account the issues of category, idiographics and anthropology as pertaining to evaluation of literary works, its criteria are presented from the ontological perspective. The description of content-related, socio-historical, aesthetic, moral and metaphysical conditions sets the ground for reflection on the axiological view of literature.Na podstawie wybranych tekstów i schematów interpretacyjnych, uwzględniając kategorialne, idiograficzne i antropologiczne aspekty wartościowania utworu literackiego, przedstawione zostały z perspektywy ontologicznej jego kryteria. Deskrypcja uwarunkowań merytorycznych, społeczno-historycznych, estetycznych, moralnych i metafizycznych wyznacza tok rozważań o aksjologicznym odbiorze literatury

Tworzenie wspólnej wartości jako nowe podejście do konkurencyjności firmy

Koncepcja tworzenia wspólnej wartości (Creating Shared Value, CSV), przedstawiona przez M. Portera i M. Kramera w 2011 r., ma prowadzić do uzyskania przewagi konkurencyjnej dzięki zaspokajaniu potrzeb społecznych oraz ekonomicznych w otoczeniu przedsiębiorstwa. Jej twórcy zidentyfikowali trzy sposoby tworzenia wspólnej wartości: nowe podejście do oferowanych produktów i usług, redefinicję produktywności w łańcuchu wartości, oraz budowę wspierających klastrów przemysłu w pobliżu przedsiębiorstwa. W artykule zostały zaprezentowane przypadki różnych firm, które stosują CSV. Autor podkreśla, że bez stworzenia efektywnego systemu pomiaru wartości ekonomicznej i społecznej, CSV stanie się niszową koncepcją, pozostającą bez większego wpływu na zarządzanie przedsiębiorstw

3D Structure Prediction of TAS2R38 Bitter Receptors Bound to Agonists Phenylthiocarbamide (PTC) and 6-n-Propylthiouracil (PROP)

The G protein-coupled receptor (GPCR) TAS2R38 is a bitter taste receptor that can respond to bitter compounds such as phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP). This receptor was chosen because its four haplotypes (based on three residue site polymorphism) hTAS2R38_PAV, hTAS2R38_AVI, hTAS2R38_AAI, and hTAS2R38_PVV are known to have dramatically different responses to PTC and PROP. We aimed to identify the protein–ligand interaction features that determine whether the bitter taste signal from this receptor is sent to the cortex. To do this we predicted the 3D structures of the TAS2R38 bitter taste receptor using our new BiHelix and SuperBiHelix Monte Carlo methods (No experimental determinations of the 3D structure have been reported for any taste receptors.). We find that residue 262 (2nd position in the polymorphism) is involved in the interhelical hydrogen bond network stabilizing the GPCR structure in tasters (hTAS2R38_PAV, hTAS2R38_AAI, and hTAS2R38_PVV), while it is not in the nontaster (hTAS2R38_AVI). This suggests that the hydrogen bond interactions between TM3 and TM6 or between TM5 and TM6 may play a role in activating this GPCR. To further validate these structures, we used the DarwinDock method to predict the binding sites and 3D structures for PTC and PROP bound to hTAS2R38_PAV, hTAS2R38_AVI, hTAS2R38_AAI, and hTAS2R38_PVV, respectively. Our results show that PTC and PROP can form H-bonds with the backbone of residue 262 in the tasters (hTAS2R38_PAV, hTAS2R38_AAI, and hTAS2R38_PVV) but not in the nontaster (hTAS2R38_AVI). Thus it appears that the hydrogen bond interaction between TM3 and TM6 may activate the receptor to pass the ligand binding signal to intracellular processes and that the H-bond between agonists and residue 262 in tasters is involved in the bitter tasting. This is in agreement with experimental observations, providing validation of the predicted ligand-protein complexes and also a potential activation mechanism for the TAS2R38 receptor

Skuteczne strategie nauczania uczniów uzdolnionych – wskazówki dla nauczycieli

Artykuł z numeru 1/2011 internetowego czasopisma edukacyjnego ORE "Trendy