The Ursinus Weekly, January 20, 1941

Dr. Dahlberg gives marriage essentials • Vice-president confirms his promise to visit Ursinus • Three strong foes defeat bear quintet • Scott leads man-hunt as Lorelei dance chief • Pakenham resigns YWCA presidency • Richards named head of soph hop committee • Besse Howard returns to address next forum • Men\u27s Debate Club goes over plans for second semester • Fred Wrigley and orchestra entertain at inter-frat. ball • Book collecting to be subject of talk by Rev. James Niblo • Interfraternity council fixes new dates for rushing parties • Fraternity rushing rules • Albright, F. and M., and Muhlenberg take hashmen during week; Mule game in extra period here • Basketeers topple Albright foe, 69-9 • Pete urges wrestlers to whip into condition • Cubs beat Albright fall to F-M, Mules • Amazons top men in sports summary • Men\u27s debating season opens on Wednesday with F. and M. • McClure to attend meeting of college prexies at Harrisburg • I.R.C. members report on hemisphere defense meetings • Y group tours social service points in Philadelphiahttps://digitalcommons.ursinus.edu/weekly/1805/thumbnail.jp

The Ursinus Weekly, October 28, 1940

Senator J. A. Ellender holds Willkie temperamentally unfit for president • Importance of \u27but\u27 told by vespers talk • Connor calls news staff to plan for Jr. paper • Republican rally to hear Davis tomorrow evening • Rev. Mr. Faye \u2724, to speak on problems of college students • Prof. Mauchly gives lecture at conference of physicists • Hoosier prophet ventures vote prognostication • Get a mask for Friday! • Results of Berlin-Tokyo axis discussed in IRC panel talks • Meistersingers to sing at Collegeville-Trappe assembly • Minutes before, Huey and I were talking... • Campaigning with Yehudi! • Mules\u27 offensive attack swamps bears by 15-6 • Allison leads \u27Fords against bakermen, 3-0 • Rootin\u27 tootin\u27 bout slated, Nov. 5, Sam\u27s arena • Ursinus hockeyites blank Rosemont • Baker is optimistic on soccer future • English Club admits seven; discusses books for review • Joyce Ward reports plans of women\u27s archery practice • \u27Big sisters\u27 treat freshmen and co-ed transfers at movie • Pre-legals fingerprinted; hear of scientific detectionhttps://digitalcommons.ursinus.edu/weekly/1796/thumbnail.jp

The Ursinus Weekly, October 14, 1940

Fighting bears eleven smothered by strong Bucknell squad, 33-7 • Louisiana senator to address Democratic rally next week; Republican senator Davis to follow, October 29 • Singers will appear in recital at Ursinus • Bowen will chairman senior ball on Dec.6 • McClure assails defeatism at local high school dedication • Mediation services arranged by religious organizations • Beardwood society presents film Water power tonight • Perpetuation of democracy is theme of vespers speaker • Regional secretary addresses Y\u27s first Wednesday program • Lesher and co. redecorate Highland • IRC suspends publication of quarterly; expense prohibitive • Johnson hearing orchestras for Old Timers\u27 Day choice • Campus artists display talent in first musical • Bone-breakers of gridiron are jaw-breakers for fans • Viennese frosh finds Paris wonderful, but America profuse with drug stores, vendors • New student writers sought for first issue of Lantern • Lafayette booters defeat bears, 1-0 • Hockeyites tie opening game at West Chester • Eleanor Frost Snell • Kellett eleven will travel to Newark for game with Hens • Women\u27s tournament in tennis opens October 10 • Republicans select college publicity head from Ursinus • Many; varied relationships to present and past Ursinus students found among freshmen • French Club bans English! • Snyder enters MIT as U.S. Army meteorological traineehttps://digitalcommons.ursinus.edu/weekly/1794/thumbnail.jp

Fitness impact and stability of a transgene conferring resistance to dengue-2 virus following introgression into a genetically diverse Aedes aegypti strain.

In 2006, we reported a mariner (Mos1)-transformed Aedes aegypti line, Carb77, which was highly resistant to dengue-2 virus (DENV2). Carb77 mosquitoes expressed a DENV2-specific inverted-repeat (IR) RNA in midgut epithelial cells after ingesting an infectious bloodmeal. The IR-RNA formed double-stranded DENV2-derived RNA, initiating an intracellular antiviral RNA interference (RNAi) response. However, Carb77 mosquitoes stopped expressing the IR-RNA after 17 generations in culture and lost their DENV2-refractory phenotype. In the current study, we generated new transgenic lines having the identical transgene as Carb77. One of these lines, Carb109M, has been genetically stable and refractory to DENV2 for >33 generations. Southern blot analysis identified two transgene integration sites in Carb109M. Northern blot analysis detected abundant, transient expression of the IR-RNA 24 h after a bloodmeal. Carb109M mosquitoes were refractory to different DENV2 genotypes but not to other DENV serotypes. To further test fitness and stability, we introgressed the Carb109M transgene into a genetically diverse laboratory strain (GDLS) by backcrossing for five generations and selecting individuals expressing the transgene's EGFP marker in each generation. Comparison of transgene stability in replicate backcross 5 (BC5) lines versus BC1 control lines demonstrated that backcrossing dramatically increased transgene stability. We subjected six BC5 lines to five generations of selection based on EGFP marker expression to increase the frequency of the transgene prior to final family selection. Comparison of the observed transgene frequencies in the six replicate lines relative to expectations from Fisher's selection model demonstrated lingering fitness costs associated with either the transgene or linked deleterious genes. Although minimal fitness loss (relative to GDLS) was manifest in the final family selection stage, we were able to select homozygotes for the transgene in one family, Carb109M/GDLS.BC5.HZ. This family has been genetically stable and DENV2 refractory for multiple generations. Carb109M/GDLS.BC5.HZ represents an important line for testing proof-of-principle vector population replacement

Self-discovery from Byron to Raban: The long afterlife of romantic travel

Despite the heterogeneity of Romantic-era travel writing, the idea of Romantic travel has become all but identified with a’subjective turn’ in the late eighteenth century, and with narratives of self-realisation or self-discovery, illustrated here chiefly with reference to the work of Byron, Goethe, and de Staël. Despite the adoption in much modern travel writing of a rhetoric of belatedness and self-mocking irony, such narratives can be shown to inhere in travel works by authors as different as V. S. Naipaul, Edward Marriott, Jenny Diski, Bruce Chatwin, and Roland Barthes. A rich instance of the enduring legacy of Romantic travel is provided by the innovative work of Jonathan Raban, the most recent of whose series of American travel books, Passage to Juneau (1999), sustains a complex and healthy dialogue with the literature and culture of the Romantic period. Despite the anti-Romantic cast of its intertextual relations with George Vancouver’s 1794 survey of the Inside Passage, which provides the model for Raban’s own expedition, in many respects—not least in its exploration of the maritime culture of the Northwest Coast Indians—Raban’s book gives vigorous new life to the exemplary Romantic trope of self-discovery. © 2005 The White Horse Press