An assessment of prospective memory retrieval in women with chronic fatigue syndrome using a virtual-reality environment: an initial study

People with chronic fatigue syndrome (CFS) have increased rates of depression, anxiety, and illness intrusiveness; they may also suffer from cognitive problems such as retrospective memory (RM) deficits and concentration difficulties that can stem from diminished information-processing capability. We predicted that this diminished capacity may also lead to deficits in other cognitive functions, such as prospective memory (ProM). Event-, time-, and activity-based ProM was assessed in 11 women with CFS and 12 healthy women using a computer-generated virtual environment (VE). RM was assessed using a free-recall test, and subjective assessment of both ProM and RM was assessed by questionnaire. Groups were equivalent in age and measures of IQ. People with CFS performed slightly worse than healthy controls on both the event- and time-based ProM measures, although these were not statistically significant. However, the CFS group performed significantly worse than the healthy controls on both the free recall-task and on subjective assessment of both RM and ProM. Women with CFS do have some subtle decrements in memory, particularly RM. However, it is possible that the decrements found in the present sample would be greater in real life. Further studies utilizing both healthy controls and illness controls are now needed to ascertain how sensitive the VE measure is and to inform the development of tasks in the VE that place progressively increasing demands on working memory capacity

Flooding Fragility Model Development Using Bayesian Regression

Traditional component pass/fail design analysis and testing protocol drives excessively conservative operating limits and setpoints as well as unnecessarily large margins of safety. Component performance testing coupled with failure probability model development can support selection of more flexible operating limits and setpoints as well as softening defense-in-depth elements. This chapter discuses the process of Bayesian regression fragility model development using Markov Chain Monte Carlo methods and model checking protocol using three types of Bayesian p-values. The chapter also discusses application of the model development and testing techniques through component flooding performance experiments associated with industrial steel doors being subjected to a rising water scenario. These component tests yield the necessary data for fragility model development while providing insight into development of testing protocol that will yield meaningful data for fragility model development. Finally, the chapter discusses development and selection of a fragility model for industrial steel door performance when subjected to a water-rising scenario

The dust-to-gas mass ratio of luminous galaxies as a function of their metallicity at cosmic noon

We aim to quantify the relation between the dust-to-gas (DTG) mass ratio and gas-phase metallicity of $z=$2.1-2.5 luminous galaxies and contrast this high-redshift relation against analogous constraints at $z=$0. We present a sample of 10 star-forming main-sequence galaxies in the redshift range $2.1<z<2.5$ with rest-optical emission-line information available from the MOSDEF survey and with ALMA 1.2 millimeter and CO J$=$3--2 follow-up observations. The galaxies have stellar masses ranging from $10^{10.3}$ to $10^{10.6}\,\rm{M}_\odot$ and cover a range in star-formation rate from 35 to 145 $\rm{M}_\odot\,\rm{yr}^{-1}$. We calculate the gas-phase oxygen abundance of these galaxies from rest-optical nebular emission lines (8.4 < $12 + \log{(\rm{O/H})} < 8.8$, corresponding to 0.5-1.25 Z$_\odot$). We estimate the dust and H2 masses (using a metallicity dependent CO-to-H2 conversion factor) of the galaxies from the 1.2 mm and CO J$=$3-2 observations, respectively, from which we estimate a DTG. We find that the galaxies in this sample follow the earlier observed trends between CO line luminosity and dust-continuum luminosity from $z=0$ to $z=3$, extending such trends to fainter galaxies at $2.1<z<2.5$ than observed to date. We find no second-order metallicity dependence in the CO - dust-continuum luminosity relation for the galaxies presented in this work. The DTG of main-sequence galaxies at $2.1<z<2.5$ are consistent with an increase in DTG with gas-phase metallicity. Galaxies at $z=$2.1-2.5 are furthermore consistent with the DTG-metallicity relation found at $z=$0, providing relevant constraints for galaxy formation models. These results furthermore imply that the metallicity of galaxies should be taken into account when estimating cold-gas masses from dust-continuum emission, especially relevant when studying metal-poor low-mass or high-redshift galaxies. [abridged]Comment: Submitted to A&A, 7 pages. Figure 4 is the key figur

Exile Anthology: A Special Sesquicentennial Issue

Horses by Deborah S. Appleton 1 Man and His World by Clark Baise 2-11 South Dakota, Route 34 by Bonnie Bishop 12 Heads and Tails by Tim Cockey 13-17 When The Bough Breaks by Alison Orleans Conte 17 Poem by Christine Cooper (Oosterbaan) 18 Flood on the Jemez by Doug Cox 19 San Antonia Canyon by Doug Cox 19 Canyon Poems by Doug Cox 19 Busy Being Born by Lindrith Davies 20-26 The Queen is Dead, Long Life The Queen by James Funaro 27 The Gates of Hell by James Funaro 28 What The Chorus Said by James Funaro 28 Coronado by James Gallant 29-35 The End Of Art by Dianne L. Goss 35 Visiting Relatives by Cynthia Hohn 36-38 Swinging by Kathy Kerchner 39 The Big House by Kim McMullen 40-47 Seasons by Dan Pancake 48 Basho\u27s Road by D. Patnode 49 Back Home by D. Patnode 49 Basket Charm by Angela Peckenpaugh 50 There Is something by Deborah Pope 51 Twilight Loneliness by Robert Smyth 52 Molting by Robert Smyth 52 Parkman by Mary S. Treco 53 The Guest by Dennis Trudell 54 The Wormwood Review by Dennis Trudell 55 Milkweed by Bonnie L. Verburg 56 Orion Falling by Lawrence Weber 57 Third by Lawrence Weber 58 Cover Drawing: Kim Fleishma

Making sense of evidence in management decisions: the role of research-based knowledge on innovation adoption and implementation in healthcare. study protocol

<p>Abstract</p> <p>Background</p> <p>We know that patient care can be improved by implementing evidence-based innovations and applying research findings linked to good practice. Successfully implementing innovations in complex organisations, such as the UK's National Health Service (NHS), is often challenging as multiple contextual dynamics mediate the process. Research studies have explored the challenges of introducing innovations into healthcare settings and have contributed to a better understanding of why potentially useful innovations are not always implemented in practice, even if backed by strong evidence. Mediating factors include health policy and health system influences, organisational factors, and individual and professional attitudes, including decision makers' perceptions of innovation evidence. There has been limited research on how different forms of evidence are accessed and utilised by organisational decision makers during innovation adoption. We also know little about how diverse healthcare professionals (clinicians, administrators) make sense of evidence and how this collective sensemaking mediates the uptake of innovations.</p> <p>Methods</p> <p>The study will involve nine comparative case study sites of acute care organisations grouped into three regional clusters across England. Each of the purposefully selected sites represents a variety of trust types and organisational contexts. We will use qualitative methods, in-depth interviews, observation of key meetings, and systematic analysis of relevant secondary data to understand the rationale and challenges involved in sourcing and utilising innovation evidence in the empirical setting of infection prevention and control. We will use theories of innovation adoption and sensemaking in organisations to interpret the data. The research will provide lessons for the uptake and continuous use of innovations in the English and international health systems.</p> <p>Discussion</p> <p>Unlike most innovation studies, which involve single-level analysis, our study will explore the innovation-adoption process at multiple embedded levels: micro (individual), meso (organisational), and macro (interorganisational). By comparing and contrasting across the nine sites, each with different organisational contexts, local networks, leadership styles, and different innovations considered for adoption, the findings of the study will have wide relevance. The research will produce actionable findings responding to the political and economic need for healthcare organisations to be innovation-ready.</p

The physical scale of the far-infrared emission in the most luminous submillimetre galaxies II: evidence for merger-driven star formation

We present high-resolution 345 GHz interferometric observations of two extreme luminous (L_{IR}>10^{13} L_sun), submillimetre-selected galaxies (SMGs) in the COSMOS field with the Submillimeter Array (SMA). Both targets were previously detected as unresolved point-sources by the SMA in its compact configuration, also at 345 GHz. These new data, which provide a factor of ~3 improvement in resolution, allow us to measure the physical scale of the far-infrared in the submillimetre directly. The visibility functions of both targets show significant evidence for structure on 0.5-1 arcsec scales, which at z=1.5 translates into a physical scale of 5-8 kpc. Our results are consistent with the angular and physical scales of two comparably luminous objects with high-resolution SMA followup, as well as radio continuum and CO sizes. These relatively compact sizes (<5-10 kpc) argue strongly for merger-driven starbursts, rather than extended gas-rich disks, as the preferred channel for forming SMGs. For the most luminous objects, the derived sizes may also have important physical consequences; under a series of simplifying assumptions, we find that these two objects in particular are forming stars close to or at the Eddington limit for a starburst.Comment: 9 pages, 3 Figures, submitted to MNRA

Evaluating the cost implications of integrating SARS-CoV-2 genome sequencing for infection prevention and control investigation of nosocomial transmission within hospitals

OBJECTIVES: The COG-UK hospital-onset COVID-19 infection (HOCI) trial evaluated the impact of SARS-CoV-2 whole genome sequencing (WGS) on acute infection, prevention, and control (IPC) investigation of nosocomial transmission within hospitals. We estimated the cost implications of using the information from the sequencing reporting tool (SRT), used to determine likelihood of nosocomial infection in IPC practice. METHODS: We conducted a micro-costing approach for SARS-CoV-2 WGS. Data on IPC management resource use and costs were collected from interviews with IPC teams from 14 participating sites and used to assign cost estimates for IPC activities as collected in the trial. Activities included IPC specific actions following a suspicion of healthcare-associated infection (HAI) or outbreak, as well as changes to practice following the return of data via SRT. RESULTS: The mean per sample costs of SARS-CoV-2 sequencing was estimated at £77.10 for rapid and £66.94 for longer turnaround phases. Over the 3 months interventional phases, the total management cost of IPC-defined HAIs and outbreak events across the sites was estimated at £225,070 and £416,447, respectively. Main cost drivers were bed-day lost due to wards closures because of outbreaks followed by outbreak meetings and bed-day lost due to cohorting contacts. Actioning SRTs, the cost of HAIs increased by £5,178 due to unidentified cases and the cost of outbreaks lowered by £11,246 as SRTs excluded hospital outbreaks. CONCLUSIONS: Although, SARS-CoV-2 WGS adds to the total IPC management cost, additional information provided could balance out the additional cost, depending on identified design improvements and effective deployment

Search for squarks and gluinos in events with isolated leptons, jets and missing transverse momentum at s√=8 TeV with the ATLAS detector

The results of a search for supersymmetry in final states containing at least one isolated lepton (electron or muon), jets and large missing transverse momentum with the ATLAS detector at the Large Hadron Collider are reported. The search is based on proton-proton collision data at a centre-of-mass energy s√=8 TeV collected in 2012, corresponding to an integrated luminosity of 20 fb−1. No significant excess above the Standard Model expectation is observed. Limits are set on supersymmetric particle masses for various supersymmetric models. Depending on the model, the search excludes gluino masses up to 1.32 TeV and squark masses up to 840 GeV. Limits are also set on the parameters of a minimal universal extra dimension model, excluding a compactification radius of 1/R c = 950 GeV for a cut-off scale times radius (ΛR c) of approximately 30

Measurements of fiducial and differential cross sections for Higgs boson production in the diphoton decay channel at s√=8 TeV with ATLAS

Measurements of fiducial and differential cross sections are presented for Higgs boson production in proton-proton collisions at a centre-of-mass energy of s√=8 TeV. The analysis is performed in the H → γγ decay channel using 20.3 fb−1 of data recorded by the ATLAS experiment at the CERN Large Hadron Collider. The signal is extracted using a fit to the diphoton invariant mass spectrum assuming that the width of the resonance is much smaller than the experimental resolution. The signal yields are corrected for the effects of detector inefficiency and resolution. The pp → H → γγ fiducial cross section is measured to be 43.2 ±9.4(stat.) − 2.9 + 3.2 (syst.) ±1.2(lumi)fb for a Higgs boson of mass 125.4GeV decaying to two isolated photons that have transverse momentum greater than 35% and 25% of the diphoton invariant mass and each with absolute pseudorapidity less than 2.37. Four additional fiducial cross sections and two cross-section limits are presented in phase space regions that test the theoretical modelling of different Higgs boson production mechanisms, or are sensitive to physics beyond the Standard Model. Differential cross sections are also presented, as a function of variables related to the diphoton kinematics and the jet activity produced in the Higgs boson events. The observed spectra are statistically limited but broadly in line with the theoretical expectations