REVISIÓN BIBLIOGRAFICA SOBRE EL DETERIORO COGNITIVO EN PACIENTES CON TRASTORNO BIPOLAR

Los últimos estudios realizados demuestran que tanto el trastorno bipolar como el deterioro cognitivo tienen una gran repercusión en la calidad de vida y en las discapacidades que experimentan las personas que se ven afectadas por cualquiera de ambos. El presente trabajo fin de grado tiene como objetivo principal contrastar a través de la bibliografía existente la relación entre el trastorno bipolar y el deterioro cognitivo en pacientes que padecen esta patología. Para ello, se ha seguido una metodología que consiste en analizar estudios publicados en bases de datos médicas de reconocido prestigio, en idioma inglés o español, y con una antigüedad máxima de diez años. (Salvo excepciones muy relevantes para el estudio). En general, la literatura muestra que en efecto, el trastorno bipolar ejerce un efecto negativo en el deterioro cognitivo de los pacientes, incluso en las fases de remisión de la enfermedad. Igualmente, hay evidencias de que factores ambientales como los hábitos de vida poco saludables influyen negativamente en el deterioro cognitivo de los pacientes. De la misma manera lo puede hacer el propio transcurso de la enfermedad y los propios efectos de la medicación administrada. Todo ello sin perder de vista la fuerte influencia que tiene la base genética en la enfermedad

Gene Silencing of \u3ci\u3eArgonaute5\u3c/i\u3e Negatively Affects the Establishment of the Legume-Rhizobia Symbiosis

The establishment of the symbiosis between legumes and nitrogen-fixing rhizobia is finely regulated at the transcriptional, posttranscriptional and posttranslational levels. Argonaute5 (AGO5), a protein involved in RNA silencing, can bind both viral RNAs and microRNAs to control plant-microbe interactions and plant physiology. For instance, AGO5 regulates the systemic resistance of Arabidopsis against Potato Virus X as well as the pigmentation of soybean (Glycine max) seeds. Here, we show that AGO5 is also playing a central role in legume nodulation based on its preferential expression in common bean (Phaseolus vulgaris) and soybean roots and nodules. We also report that the expression of AGO5 is induced after 1 h of inoculation with rhizobia. Down-regulation of AGO5 gene in P. vulgaris and G. max causes diminished root hair curling, reduces nodule formation and interferes with the induction of three critical symbiotic genes: Nuclear Factor Y-B (NF-YB), Nodule Inception (NIN) and Flotillin2 (FLOT2). Our findings provide evidence that the common bean and soybean AGO5 genes play an essential role in the establishment of the symbiosis with rhizobia

Planificación estratégica y mejora en la estructura organizacional para fomentar la orientación y la gestión del cambio, eficiencia y eficacia en Food Carnes S.A.S en el 2022.

El presente Trabajo de Investigación tiene como finalidad, analizar las necesidades que, en materia de Gestión Humana presenta la compañía FOOD CARNES S.A.S. ya que se evidencia ciertos vacíos en esta área, a partir de lo cual se pretende establecer una mejor estructura y planificación, al tiempo que permita desarrollar un nuevo concepto de contratación dentro de la compañía. Algunas de las variables a tener en cuenta en el estudio, son los procesos que se están llevando a cabo al día de hoy, tales como la variedad de productos que no alcanzan su meta de producción, el servicio al cliente, la relación con los proveedores, entre otros, hacen necesario tomar algunas decisiones, respecto en el futuro inmediato. La metodología empleada en esta investigación se enfoca tanto en lo cuantitativo como en lo cualitativo del estudio explicativo, para la cual se establecerá un tiempo determinado para la recolección de datos, análisis de variables y estadísticas arrojadas, las cuales se podrán determinar las posibles deficiencias, más precisas y puntuales en cada uno de los procesos que actualmente se realizan en la empresa. Así las cosas, el propósito, es hacer una medición del problema e identificar un diagnóstico real, específicamente en la Gestión del Talento Humano, en donde se conozcan los aspectos más relevantes de carácter formal e informal que se presenta esta área de la empresa. Dicho lo anterior y una vez se cuente con los resultados de la investigación, el objetivo será cambiar el espectro de la compañía en lo concerniente al Talento Humano, de donde se deriva la situación planteada.The present research work consists of analyzing the needs of the company FOOD CARNES S.A.S and, establishing a better structured planning since it is being affected by not having an area of human talent that guarantees a projection in the processes, to give agility and guarantee quality of service to its customers. Some of the variables to take into account in the study are the processes that are taking place today, where different gaps are evident; Likewise, the variety of products that do not reach their production goal, customer service, the relationship with suppliers, among others, make it necessary to make some decisions regarding the future of the company. The methodology used in this research focuses on both the quantitative and qualitative aspects of the explanatory study, for which a certain time will be established for data collection, analysis of the variables and statistics obtained, with which it will be possible to determine the possible more precise and punctual deficiencies in the processes that are currently carried out in the company. Thus, the objective is to measure the problem and identify the diagnosis, specifically in Human Talent Management, where the most relevant aspects of a formal and informal nature that are described in this area of the company are known. Having said the above and once the results of the investigation are available, the objective will be to change the spectrum of the company in relation to Human Talent, from which the proposed situation derives

Risks to human and animal health related to the presence of moniliformin in food and feed

The CONTAM Panel wishes to acknowledge all European competent authorities and other stakeholders that provided occurrence data on moniliformin in food and feed, and supported the consumption data collection for the Comprehensive European Food Consumption Database. Adopted: 21 November 2017Peer reviewedPublisher PD

Free Radicals, Salicylic Acid and Mycotoxins in Asparagus After Inoculation with Fusarium proliferatum and F. oxysporum

Electron paramagnetic resonance was used to monitor free radicals and paramagnetic species like Fe, Mn, Cu generation, stability and status in Asparagus officinalis infected by common pathogens Fusarium proliferatum and F. oxysporum. Occurrence of F. proliferatum and F. oxysporum, level of free radicals and other paramagnetic species, as well as salicylic acid and mycotoxins content in roots and stems of seedlings were estimated on the second and fourth week after inoculation. In the first term free and total salicylic acid contents were related to free radicals level in stem (P = 0.010 and P = 0.033, respectively). Concentration of Fe3+ ions in porphyrin complexes (g = 2.3, g = 2.9) was related to the species of pathogen. There was no significant difference between Mn2+ concentrations in stem samples; however, the level of free radicals in samples inoculated with F. proliferatum was significantly higher when compared to F. oxysporum

Measurement of the cross-section and charge asymmetry of WW bosons produced in proton-proton collisions at s=8\sqrt{s}=8 TeV with the ATLAS detector

This paper presents measurements of the $W^+ \rightarrow \mu^+\nu$ and $W^- \rightarrow \mu^-\nu$ cross-sections and the associated charge asymmetry as a function of the absolute pseudorapidity of the decay muon. The data were collected in proton--proton collisions at a centre-of-mass energy of 8 TeV with the ATLAS experiment at the LHC and correspond to a total integrated luminosity of 20.2~\mbox{fb^{-1}}. The precision of the cross-section measurements varies between 0.8% to 1.5% as a function of the pseudorapidity, excluding the 1.9% uncertainty on the integrated luminosity. The charge asymmetry is measured with an uncertainty between 0.002 and 0.003. The results are compared with predictions based on next-to-next-to-leading-order calculations with various parton distribution functions and have the sensitivity to discriminate between them.Comment: 38 pages in total, author list starting page 22, 5 figures, 4 tables, submitted to EPJC. All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2017-13

Different states of integrin LFA-1 aggregation are controlled through its association with tetraspanin CD9

This is the author’s version of a work that was accepted for publication in Biochimica et Biophysica Acta - Mollecular Cell Research. A definitive version was subsequently published in Biochimica et Biophysica Acta - Mollecular Cell Research, 1853.10 (2015): 2464-2480 DOI: 10.1016/j.bbamcr.2015.05.018The tetraspanin CD9 has been shown to interact with different members of the β1 and β3 subfamilies of integrins, regulating through these interactions cell adhesion, migration and signaling. Based on confocal microscopy co-localization and on coimmunoprecipitation results, we report here that CD9 associates with the β2 integrin LFA-1 in different types of leukocytes including T, B and monocytic cells. This association is resistant to stringent solubilisation conditions which, together with data from chemical crosslinking, in situ Proximity Ligation Assays and pull-down experiments, suggests a primary/direct type of interaction mediated by the Large Extracellular Loop of the tetraspanin. CD9 exerts inhibitory effects on the adhesive function of LFA-1 and on LFA-1-dependent leukocyte cytotoxic activity. The mechanism responsible for this negative regulation exerted by CD9 on LFA-1 adhesion does not involve changes in the affinity state of this integrin but seems to be related to alterations in its state of aggregationThis work was supported by grant SAF2012-34561 from the Spanish «Ministerio de Economía y Competitividad-MINECO», (to C.C.). R.R.M. salary is supported by a «Profesor Ayudante» position from Departamento de Biología, Facutad de Ciencias, Universidad Autónoma de Madri