127 research outputs found
Using matrix assisted laser desorption ionisation mass spectrometry (MALDI-MS) profiling in order to predict clinical outcomes of patients with heart failure
- Author
- A Bizzini
- AA Voors
- AA Voors
- Adriaan A. Voors
- Aeilko H. Zwinderman
- BA Howard
- Chim C. Lang
- Daniel Chu Siong Chan
- Dirk J. Van Veldhuisen
- Donald J. L. Jones
- Faiez Zannad
- Gerasimos Filippatos
- H Mischak
- Hans L. Hillege
- Helen M. Parry
- Jatinderpal K. Sandhu
- John G. Cleland
- JP Ferreira
- K Dickstein
- Kenneth Dickstein
- Leong L. Ng
- M Welker
- MA Karpova
- Marco Metra
- ML Merchant
- ML Merchant
- Mohapradeep Mohan
- Narayan Hafid
- Nilesh J. Samani
- Paulene A. Quinn
- Piotr Ponikowski
- Q Niu
- RS Vasan
- S Ranganathan
- SA Varghese
- SF Hansson
- Stefan D. Anker
- T Ahmad
- T Ahmad
- Thong Huy Cao
- W Kolch
- W Ouwerkerk
- W Ouwerkerk
- Y Dai
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Background
Current risk prediction models in heart failure (HF) including clinical characteristics and biomarkers only have moderate predictive value. The aim of this study was to use matrix assisted laser desorption ionisation mass spectrometry (MALDI-MS) profiling to determine if a combination of peptides identified with MALDI-MS will better predict clinical outcomes of patients with HF.
Methods
A cohort of 100 patients with HF were recruited in the biomarker discovery phase (50 patients who died or had a HF hospital admission vs. 50 patients who did not have an event). The peptide extraction from plasma samples was performed using reversed phase C18. Then samples were analysed using MALDI-MS. A multiple peptide biomarker model was discovered that was able to predict clinical outcomes for patients with HF. Finally, this model was validated in an independent cohort with 100 patients with HF.
Results
After normalisation and alignment of all the processed spectra, a total of 11,389 peptides (m/z) were detected using MALDI-MS. A multiple biomarker model was developed from 14 plasma peptides that was able to predict clinical outcomes in HF patients with an area under the receiver operating characteristic curve (AUC) of 1.000 (pâ=â0.0005). This model was validated in an independent cohort with 100 HF patients that yielded an AUC of 0.817 (pâ=â0.0005) in the biomarker validation phase. Addition of this model to the BIOSTAT risk prediction model increased the predictive probability for clinical outcomes of HF from an AUC value of 0.643 to an AUC of 0.823 (pâ=â0.0021). Moreover, using the prediction model of fourteen peptides and the composite model of the multiple biomarker of fourteen peptides with the BIOSTAT risk prediction model achieved a better predictive probability of time-to-event in prediction of clinical events in patients with HF (pâ=â0.0005).
Conclusions
The results obtained in this study suggest that a cluster of plasma peptides using MALDI-MS can reliably predict clinical outcomes in HF that may help enable precision medicine in HF
Reducing Binge Drinking? The Effect of a Ban on Late-Night Off-Premise Alcohol Sales on Alcohol-Related Hospital Stays in Germany
- Author
- A Figure
- Aaron M White
- Alastair Newton
- Alexander C Wagenaar
- Anna Grundel
- B Panel
- Benjamin Crost
- Binge Dhs
- Bisakha Sen
- Bzga
- Christopher J Ruhm
- Christopher S Carpenter
- Colin Cameron
- Dafna Kanny
- Douglas J Young
- Elaine Kelly
- Emily Conover
- Evelyn
- Frank J Chaloupka
- Garnett P Mcmillan
- Gary S Becker
- Gharad Bryan
- Grossman
- H O&apos
- Ian W H Parry
- J Birckmayer
- J Williams
- Jan Marcus
- Jason Y Kim
- Jennifer Middleton
- Jens Hainmueller
- John Mullahy
- Kevin Hoffmann
- Krankenhausdiagnosestatistik Fdz
- Landtag Von Baden-Wïżœrttemberg
- M M Maldonado-Molina
- Marit Hinnosaar
- Mark F Stehr
- Martin Stolle
- Mary-Anne Enoch
- Matthias Wicki
- Michael F Lovenheim
- Michael Lechner
- Mirko Draca
- Oliver Hoischen
- P Speer
- Paul Heaton
- Philip J Cook
- R Scribner
- Scott E Carrell
- Selma H Bouthoorn
- Stephen G Donald
- Stephen W Hwang
- Svetlana Popova
- Tanya Chikritzhs
- Thomas S Dee
- Thomas Siedler
- Thor Norstrïżœm
- Traci L Toomey
- Willard G Manning
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2015
- Field of study
Excessive alcohol consumption among young people is a major public health concern. On March 1, 2010, the German state of Baden-WĂŒrttemberg banned the sale of alcoholic beverages between 10pm and 5am at off-premise outlets (e.g., gas stations, kiosks, supermarkets). We use rich monthly administrative data from a 70 percent random sample of all hospitalizations during the years 2007-2011 in Germany in order to evaluate the short-term impact of this policy on alcohol-related hospitalizations. Applying difference-in-differences methods, we find that the policy change reduces alcohol-related hospitalizations among adolescents and young adults by about seven percent. There is also evidence of a decrease in the number of hospitalizations due to violent assault as a result of the ban
Developing a predictive modelling capacity for a climate change-vulnerable blanket bog habitat: Assessing 1961-1990 baseline relationships
- Author
- Accadia C.
- Agresti A.
- Austin M.P.
- Baker R.H.A.
- Bakkenes M.
- Bambar D.
- Beale C.M.
- Beaumont L.J.
- Box E.O.
- Box E.O.
- Boylan N.
- Brauner N.
- Brereton R.
- Bruun H.H.
- Byrne C.
- BĂ€ssler C.
- Carter T.M.
- Cawsey E.M.
- Charman D.
- Coll J.
- Cowley M.J.R.
- Crawley M.J.
- Crisp D.T.
- Crumpacker D.W.
- Crushell P.
- Czado C.
- David Bourke
- Donald P.F.
- Donnelly A.
- Douglas C.
- Elith J.
- Elmore K.L.
- Evans D.
- Fealy R.
- Finley J.P.
- Fitzmaurice G.M.
- Foden W.
- Foss P.J.
- Gates S.
- Guisan A.
- Guisan A.
- Hammond R.F.
- Hammond R.F.
- Hanley J.A.
- Hauck W.W.
- Heikkinen R.K.
- Hensher D.
- Hill J.K.
- Hill J.K.
- Hopkins J.J.
- Hosmer D.W.
- Huntley B.
- Huntley B.
- Iverson L.R.
- John Coll
- John Sweeney
- Jones M.B.
- Kleyer M.
- Kurbatova J.
- Lavergne S.
- Lawler J.J.
- Leathwick J.R.
- Lindsay R.A.
- Liu C.
- Luoto M.
- Luoto M.
- Luoto M.
- MacNally R.
- Menzel A.
- Metz C.E.
- Meynecke J.O.
- Michael Gormally
- Micheline Sheehy Skeffington
- Mitchell R.J.
- Moore J.J.
- Nichols A.O.
- Ostermann O.P.
- Parmesan C.
- Parry M.
- Pauli H.
- Pausas J.G.
- Pearson R.G.
- Prasad A.M.
- Price J.
- Rangel T.F.L.V.B.
- Real R.
- Saseendran S.A.
- Schouten M.G.C.
- Sheehy Skeffington M.J.
- Sokal R.R.
- Sottocornola M.
- Suarez-Seoane S.
- Swart R.
- Sweeney J.
- Sweeney J.
- Sweeney K.
- Sykes M.T.
- Thuiller W.
- Thuiller W.
- Tomlinson R.W.
- Visser M.E.
- Walther G.R.
- Walther G.R.
- Wright D.H.
- Zavaleta E.S.
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2011
- Field of study
Aim: Understanding the spatial distribution of high priority habitats and
developing predictive models using climate and environmental variables to
replicate these distributions are desirable conservation goals. The aim of this
study was to model and elucidate the contributions of climate and topography to
the distribution of a priority blanket bog habitat in Ireland, and to examine how
this might inform the development of a climate change predictive capacity for
peat-lands in Ireland.
Methods: Ten climatic and two topographic variables were recorded for grid
cells with a spatial resolution of 1010 km, covering 87% of the mainland
land surface of Ireland. Presence-absence data were matched to these variables
and generalised linear models (GLMs) fitted to identify the main climatic and
terrain predictor variables for occurrence of the habitat. Candidate predictor
variables were screened for collinearity, and the accuracy of the final fitted GLM
was evaluated using fourfold cross-validation based on the area under the curve
(AUC) derived from a receiver operating characteristic (ROC) plot. The GLM
predicted habitat occurrence probability maps were mapped against the actual
distributions using GIS techniques.
Results: Despite the apparent parsimony of the initial GLM using only climatic
variables, further testing indicated collinearity among temperature and precipitation
variables for example. Subsequent elimination of the collinear variables and
inclusion of elevation data produced an excellent performance based on the AUC
scores of the final GLM. Mean annual temperature and total mean annual
precipitation in combination with elevation range were the most powerful
explanatory variable group among those explored for the presence of blanket
bog habitat.
Main conclusions: The results confirm that this habitat distribution in general
can be modelled well using the non-collinear climatic and terrain variables tested
at the grid resolution used. Mapping the GLM-predicted distribution to the
observed distribution produced useful results in replicating the projected
occurrence of the habitat distribution over an extensive area. The methods
developed will usefully inform future climate change predictive modelling for
Irelan
Enter Mercury, Sleeping: Delivering Prayers on the Early Modern Stage
- Author
- 257Donne
- Adams
- Ainsworth
- Anderson
- Andrewes
- Andrewes
- Andrewes
- Andrewes
- Andrewes
- Arminius
- Augustine
- Augustine
- Augustine
- Austin
- Barrett
- Batman
- Beadle
- Beaumont
- Benoit
- Benson
- Bethell
- Bloom
- Bongard
- Booty
- Bossy
- Botonaki
- Bourcier
- Bray
- Brecht
- Brightman
- Brodie
- Budick
- Bunny
- Burnet
- Bury
- Butler
- Butler
- Byrd
- Calhoun
- Calvin
- Calvin
- Calvin
- Calvin
- Cambers
- Carlson
- Caussin
- Chamberlain
- Chernaik
- Christopherson
- Clark
- Colclough
- Collinson
- Collinson
- Colman
- Comber
- Comber
- Corns
- Cosin
- Cox
- Craigie
- Cuming
- Cummings
- Cust
- Daems
- Darbishire
- Davies
- Dawes
- Dawson
- Dekkers
- Delany
- Delaval
- Derrida
- Derrida
- Dickson
- Dix
- Donald
- Donaldson
- Donaldson
- Donne
- Donne
- Donne
- Donne
- Dowd
- Duffy
- Duffy
- Duffy
- Eckerle
- Engle
- Erasmus
- Erasmus
- Erikson
- Eucherii
- Fallon
- Featley
- Fenner
- Findlay
- Foxe
- Frere
- Frontain
- Gadamer
- Gadamer
- Ganoczy
- Gibbons
- Gibson
- Gill
- Goldberg
- Granada
- Green
- Greenblatt
- Greenham
- Greer
- Grondin
- Guibbory
- Hall
- Harcourt
- Harley
- Heiler
- Herbert
- Herbert
- Herbert
- Herbert
- Herbert
- Heywood
- Hieron
- Hoby
- Hooker
- Hooker
- Howard
- Howell
- Hunt
- Jackson
- Jackson
- Jewel
- Johnson
- Johnson
- Jones
- Jonson
- Jonson
- Josselin
- Julian de
- Kaufman
- Kerrigan
- Kyd
- Lacey
- Lake
- Lander
- Larkin
- Legg
- Leo
- Leonard
- Lieb
- Loewenstein
- Loftis
- Luther
- Luther
- MacCulloch
- Madan
- Major
- Maltby
- Marilla
- Marlowe
- Marlowe
- Marlowe
- Marno
- Marsh
- Martindale
- Martz
- Marvell
- Maus
- Mauss
- McCarthy
- McCarthy
- McColley
- McCullough
- McCullough
- Migne
- Milton
- Milton
- Milton
- Milton
- Montrose
- Mordaunt
- Morley
- Newcome
- Nicolson
- Niesel
- Nuttall
- Oram
- Osmond
- Packman
- Parish
- Parr
- Parry
- Parsons
- Paster
- Patrides
- Peel
- Peel
- Peele
- Perrinchief
- Phillips
- Phillips
- Pinkard
- Plutarch
- Porter
- Powicke
- Prideaux
- Prideaux
- Procter
- Rebhorn
- Rhatigan
- Rich
- Ricks
- Rogers
- Ryrie
- RĂžstvig
- Savage
- Schwartz
- Scott
- Sellars
- Shakespeare
- Shami
- Sharon-Zisser
- Sharpe
- Sherlock
- Shuger
- Sidney
- Skerpan
- Smith
- Smith
- Smyth
- Some
- Spenser
- Spenser
- Spenser
- Starr
- Stegner
- Stephens
- Stevenson
- Targoff
- Taylor
- Taylor
- Taylor
- Temperley
- Thiel
- Thompson
- Trapp
- Tuke
- Tylor
- van der Myle
- Vaughan
- Vaughan
- Veevers
- Virgil
- W.
- Walker
- Walker
- Wall
- Waller
- Wallington
- Walsham
- Walton
- Warwick
- Watt
- Webster
- Welsby
- Wendel
- Wettenhall
- Whitaker
- Whittingham (?)
- Wilcher
- Wilcher
- Williams
- Williamson
- Willis
- Wilson
- Wilson
- Wolf
- Wordsworth
- Yates
- Publication venue
- 'Cambridge University Press (CUP)'
- Publication date
- 01/01/2018
- Field of study
This is the author accepted manuscript. The final version is available from CUP via the DOI in this recor
The Physics of the B Factories
- Author
- A Abashian
- A. A. Botov
- A. A. Grillo
- A. A. Korol
- A. A. Salnikov
- A. Abashian
- A. Adametz
- A. Agarwal
- A. Anjomshoaa
- A. B. Breon
- A. Bala
- A. Bay
- A. Bondar
- A. Bozek
- A. Buzzo
- A. C. Forti
- A. C. Wren
- A. Calcaterra
- A. Cecchi
- A. Cervelli
- A. Ceseracciu
- A. Chen
- A. Chuvikov
- A. Cotta Ramusino
- A. Crescente
- A. Cunha
- A. D. Bukin
- A. Das
- A. de Lesquen
- A. De Silva
- A. Dorigo
- A. Drutskoy
- A. Dvoretskii
- A. DâOrazio
- A. E. Rubin
- A. Farbin
- A. Fella
- A. Filippi
- A. Frey
- A. G. Denig
- A. Gaidot
- A. Garmash
- A. Gaz
- A. Go
- A. Gordon
- A. GoriĆĄek
- A. Hafner
- A. Hanushevsky
- A. Hasan
- A. Hauke
- A. Hicheur
- A. Höcker
- A. I. Panova
- A. I. Robertson
- A. Igarashi
- A. Ishikawa
- A. J. Bevan
- A. J. Edwards
- A. J. Hart
- A. J. Lankford
- A. J. Lyon
- A. J. Martinez
- A. J. R. Weinstein
- A. J. S. Smith
- A. J. Schwartz
- A. Jawahery
- A. K. McKemey
- A. K. Michael
- A. K. Mohapatra
- A. K. Yarritu
- A. Khan
- A. Khodjamirian
- A. Kibayashi
- A. Kirk
- A. Krasnykh
- A. Kreisel
- A. Kronfeld
- A. Kulikov
- A. Kurup
- A. Kusaka
- A. Kuzmin
- A. Lazzaro
- A. Limosani
- A. Lu
- A. Lusiani
- A. M. Bakich
- A. M. Boyarski
- A. M. Eichenbaum
- A. M. Eisner
- A. M. Gabareen
- A. M. Lutz
- A. M. Merchant
- A. M. Rahimi
- A. M. Ruland
- A. Manabe
- A. Mass
- A. Mathieu
- A. Matyja
- A. Mihalyi
- A. Mohapatra
- A. Moll
- A. Muir
- A. Murakami
- A. N. Yushkov
- A. Novokhatski
- A. Ogawa
- A. Olivas
- A. Oyanguren
- A. P. Onuchin
- A. P. Wagner
- A. Palano
- A. Penzkofer
- A. Perazzo
- A. Perez
- A. Petrella
- A. Petzold
- A. Pich
- A. Pilloni
- A. Poluektov
- A. Pompili
- A. R. Buzykaev
- A. R. Clark
- A. Randle-Conde
- A. Romosan
- A. Roodman
- A. Rossi
- A. Rostomyan
- A. Ryd
- A. Samuel
- A. Santroni
- A. Sarti
- A. Satpathy
- A. Seiden
- A. Sibidanov
- A. Sidorov
- A. Smol
- A. Snyder
- A. Soffer
- A. Soha
- A. Sokolov
- A. Somov
- A. Stocchi
- A. Sugi
- A. Sugiyama
- A. Suzuki
- A. T. Watson
- A. Trunov
- A. Tumanov
- A. V. Gritsan
- A. V. Telnov
- A. Valassi
- A. Vallereau
- A. Vinokurova
- A. Volk
- A. Vossen
- A. W. Borgland
- A. W. Weidemann
- A. Woch
- A. Y. Rakitin
- A. Yamaguchi
- A. Zallo
- A. Zghiche
- A. Zupanc
- A.I. Sekiya
- A.S. Fisher
- Aleksan
- ALEPH CDF, D0, DELPHI, L3, OPAL, SLD and the LEP, Tevatron and SLD Electroweak and Heavy Flavour Working Groups
- B. A. Petersen
- B. A. Schumm
- B. Aubert
- B. Bhuyan
- B. Brau
- B. Broomer
- B. C. K. Casey
- B. C. Shen
- B. C. Wray
- B. Camanzi
- B. Cheng
- B. Claxton
- B. D. Yabsley
- B. Dahmes
- B. Dey
- B. Di Girolamo
- B. Echenard
- B. Foster
- B. Franek
- B. G. Cheon
- B. G. Fulsom
- B. G. Zaslavsky
- B. Golob
- B. H. Kim
- B. Hamilton
- B. Harrop
- B. Hooberman
- B. J. Wogsland
- B. Kronenbitter
- B. L. Hartfiel
- B. Lewandowski
- B. Lindquist
- B. Malaescu
- B. Mayer
- B. Mellado
- B. N. Ratcliff
- B. Oberhof
- B. Pan
- B. R. Ko
- B. Reisert
- B. S. Ahn
- B. Serfass
- B. Shwartz
- B. Spaan
- B. Stugu
- B. T. Meadows
- B. Viaud
- B. W. Drummond
- B. Y. Han
- B. Zhang
- B.V. Grinyov
- Ball Ali
- Bartelt Aleksan
- Bernlochner and Schonherr
- Bigi Benson
- Blok Bigi
- Braaten Bodwin
- Braun Ball
- Buchalla Beneke
- Buchalla Beneke
- Buchalla Beneke
- Buchalla Beneke
- C. A. Chavez
- C. A. Heusch
- C. A. West
- C. Angelini
- C. B. Locke
- C. Beigbeder
- C. Borean
- C. Bozzi
- C. Brew
- C. Buchanan
- C. BĂŒnger
- C. C. Chiang
- C. C. Kuo
- C. C. Peng
- C. C. Wang
- C. C. Young
- C. C. Zhang
- C. Campagnari
- C. Cartaro
- C. Chen
- C. Condurache
- C. Dallapiccola
- C. Davies
- C. De la VaissiĂšre
- C. E. Marker
- C. Fabby
- C. Fanin
- C. Fukunaga
- C. G. West
- C. Gatto
- C. H. Cheng
- C. H. Kim
- C. H. Wang
- C. H. Wu
- C. Hagner
- C. Hast
- C. Hearty
- C. Hee
- C. J. Flacco
- C. J. Schilling
- C. Jacoby
- C. K. Clarke
- C. K. Lae
- C. Kiesling
- C. L. Brown
- C. L. Davis
- C. L. Edgar
- C. L. Hsu
- C. L. Lee
- C. L. Lim
- C. LeClerc
- C. Leonidopoulos
- C. Lindsay
- C. Liu
- C. Lu
- C. M. Brown
- C. M. Cormack
- C. M. Hawkes
- C. M. Jen
- C. Mackay
- C. Mindas
- C. Ng
- C. Niebuhr
- C. O. Vuosalo
- C. Oswald
- C. P. Jessop
- C. P. OâGrady
- C. P. Shen
- C. Padoan
- C. Patrignani
- C. Renard
- C. Rivetta
- C. Roat
- C. S. Lin
- C. S. Park
- C. Schwanda
- C. Sciacca
- C. T. Boeheim
- C. T. Day
- C. T. Hoi
- C. T. Potter
- C. Touramanis
- C. Van Hulse
- C. Voci
- C. Voena
- C. VoĂ
- C. W. Everton
- C. W. Park
- C. X. Yu
- C. Z. Yuan
- Ch. de la VaissiĂšre
- Ch. Thiebaux
- Ch. YĂ©che
- Chapovsky Beneke
- Cheung Braaten
- Contino Agashe
- Corazza Bernardini
- Cronin Christenson
- Czyz Rodrigo
- D. A. Bowerman
- D. A. Doll
- D. A. Hopkins
- D. A. Milanes
- D. A. Roberts
- D. A. Sanders
- D. Altenburg
- D. Andreotti
- D. Anipko
- D. Aston
- D. B. MacFarlane
- D. Beiline
- D. Bernard
- D. Bettoni
- D. Boutigny
- D. Breton
- D. C. Williams
- D. Cinabro
- D. Cote
- D. del Re
- D. Derkach
- D. Dujmic
- D. Dutta
- D. E. Azzopardi
- D. E. Hutchcroft
- D. E. Wagoner
- D. Epifanov
- D. Fortin
- D. G. Hitlin
- D. Gamba
- D. H. Kah
- D. H. Wright
- D. Heffernan
- D. Hufnagel
- D. I. Britton
- D. J. Asgeirsson
- D. J. Bard
- D. J. J. Mangeol
- D. J. Jackson
- D. J. Knowles
- D. J. Lange
- D. J. Payne
- D. J. Sherwood
- D. J. Summers
- D. Judd
- D. Kharakh
- D. Kirkby
- D. Kovalskyi
- D. L. Wagner
- D. Lindemann
- D. Liventsev
- D. Lopes Pegna
- D. M. Asner
- D. M. Rodriguez
- D. M. Wright
- D. Marlow
- D. Matvienko
- D. Mohapatra
- D. Monorchio
- D. N. Brown
- D. Nelson
- D. Newman-Coburn
- D. P. Coupal
- D. P. Stoker
- D. Piccolo
- D. R. Johnson
- D. R. Lavin
- D. R. Muller
- D. R. Peimer
- D. S. Bailey
- D. S. Best
- D. S. Chao
- D. S. Smith
- D. S. Yan
- D. Santel
- D. Semmler
- D. Smith
- D. Strom
- D. Su
- D. Teytelman
- D. Thiessen
- D. Troost
- D. van Winkle
- D. W. G. S. Leith
- D. W. Kim
- D. Walker
- D. Wallom
- D. Z. Shen
- D. Zander
- D. Zanin
- D. ZĂŒrcher
- D. Ćœontar
- Datta Browder
- De Rujula
- Degrassi Ciuchini
- Degrassi Ciuchini
- Dokshitzer Azimov
- Dunietz Aleksan
- DW Sivers
- DâAlesio Bacchetta
- E. A. Antillon
- E. A. Eckhart
- E. A. Kravchenko
- E. Antonioli
- E. Banas
- E. Baracchini
- E. Barberio
- E. Behn
- E. Ben-Haim
- E. Bloom
- E. Borsato
- E. C. Martin
- E. Campagna
- E. Charles
- E. Chen
- E. D. Frank
- E. Di Marco
- E. Erdos
- E. Feltresi
- E. Fioravanti
- E. Gabathuler
- E. Grauges
- E. Guido
- E. I. Rosenberg
- E. J. Hill
- E. Kato
- E. Kikutani
- E. Kou
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- Z. C. Clifton
- Z. DoleĆŸal
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
This work is on the Physics of the B Factories. Part A of this book contains a brief description of the SLAC and KEK B Factories as well as their detectors, BaBar and Belle, and data taking related issues. Part B discusses tools and methods used by the experiments in order to obtain results. The results themselves can be found in Part C
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
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- De Backer A
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- De Cassai A
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- De La Fuente-Martos C
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- ENVIN-HELICS Study Group
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- FINNRESUSCI Study Group
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- IPREA Study Group
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- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
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- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
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- Rapid Diagnosis of Infections in the Critically Ill Team
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- Rudiger A
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- Ruiz BL
- Ruiz FC
- Ruiz J
- Ruiz-Ramos J
- Ruiz-Rodriguez JC
- Ruiz-RodrĂguez JC
- Ruiz-Ruano RDEL
- Runge I
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- Rutherford WB
- Rutten AM
- Rydingsward JE
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- Sabetian G
- SabeÄŒĆikovs O
- Sabirov D
- Sadamoto Y
- Sadamoto Y
- Sadamoto Y
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- Saha T
- Saigal S
- Saito M
- Saito N
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- Sakieva FI
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- Sampath S
- Sampath S
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- Sampson D
- Samuels T
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- Sanchez-Orézzoli MG
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- Sandiumenge A
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- Santana JD
- Santana JD
- Santana MC
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- Santana PS
- Santana PS
- Santana SR
- Santana SR
- Santiago AI
- Santiago AI
- Santos F
- Sanui M
- Sanz ER
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- Savin I
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- Sawamura A
- Sawamura A
- Sawamura A
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- Scales DC
- Scanziani E
- Scanziani E
- Schaller SJ
- Schlaepfer P
- Schleifer J
- Schmid RM
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- Schneider AG
- Schoenenberger JA
- Schortgen F
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- Sciurti R
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- Sellés MD
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- Shekerdemian LS
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- Shuinotsuka C
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- Siddiqui SS
- Sidhu P
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- Sigurta A
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- St Georgeâs University of London
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- Stretti F
- Struijs A
- Stubbs C
- Stubbs C
- Student Research Committee - Shiraz University of Medical Sciences
- StĂŒmpfle R
- StĂŒmpfle R
- Su F
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- Suchomel P
- Suh GJ
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- Sung D
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- SĂĄez VC
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- SĂĄnchez MJ
- SĂĄnchez MJ
- SĂĄnchez MJ
- SĂĄnchez MJ
- SĂĄnchez MJ
- SĂĄnchez PC
- SĂĄnchez PC
- SĂĄnchez-Elvira LA
- Tabatabaei HR
- Tabei SH
- Taccone F
- Taccone FS
- Taccone FS
- Taccone FS
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- Taccone FS
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- Tokyo Womens Medical University
- Tomas E
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- Tonetti T
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- Torner MM
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- Torrance HD
- Torrent RL
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- Tsukahara K
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- Tsunoda M
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- Tucci MR
- Tudor BA
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- Uriona S
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- Vallverdu M
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- VallverdĂș I
- Vallés J
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- van der Heiden ES
- van der Hoeven JG
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- van der Voort PH
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- van Ieperen SN
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- van Wijk A
- Vandijck D
- Vaneker I
- Vanhuyse F
- Vaporidi K
- Vaquerizo C
- Varas GM
- Varas JL
- Varea MM
- Vargiolu A
- Varma A
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- Vatsik MV
- Vazquez D
- Vedage D
- Vega LM
- Veigas P
- Vela JL
- Velasquez T
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- Venrdramin A
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- Vergani G
- Verginella F
- Verhaeghe R
- Verhage R
- Vermeir P
- Veronesi M
- Vezzani A
- Vezzani A
- Vianna G
- Viciana R
- Vidal A
- Vidal MV
- Vidal MV
- Viegas E
- Vieillard-Baron A
- Vieira JE
- Viera MA
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- Vigne C
- Villa G
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- Villalba D
- Villamizar PR
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- Villanova M
- Villard I
- Villarreal E
- Villarreal E
- Vincent B
- Vincent JL
- Vincent JL
- Vincent JL
- Vincent JL
- Vincent JL
- Vincent JL
- Vincent JL
- Vinje LJ
- Vinsonneau C
- Vitaller S
- Vittone F
- Vogelaers D
- Voiriot G
- Volker T
- Volta CA
- Volta CA
- Vondrakova D
- Vondrakova D
- Vondrakova D
- Vong LV
- Vourli S
- Vrettou C
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- VĂĄzquez CF
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- Wada T
- Wada T
- Wada T
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- Waldauf P
- Wand S
- Wang CH
- Wang H
- Wann SR
- Wann SR
- Wann SR
- Wann SR
- Wathanawatthu T
- Wee S
- Welte T
- Welters I
- Wetz A
- Weyer CM
- White C
- Wiesner O
- Wijayatilake DS
- Wildenberg L
- Wilks M
- Wilson ME
- WIND study group
- WIND study group
- WIND study group
- Winder-Rhodes S
- Witter T
- Wolf M
- Wolff M
- Wong Y
- Wood B
- Wood CA
- Wood D
- Wood M
- Wray J
- Xie Z
- Xini A
- Xini A
- Xiol EA
- Xu M
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- Yaguchi A
- Yaguchi A
- Yamaguchi O
- Yamaguchi O
- Yamaguchi Y
- Yamaguchi Y
- Yamamoto H
- Yamamoto N
- Yaman G
- Yamashita K
- Yamazaki A
- Yan WW
- Yan WW
- Yang JH
- Yang JS
- Yang YL
- Yasuda H
- Yatabe T
- Yebenes JC
- Yeh YC
- Yemets H
- Yergaliyeva A
- Yılmaz G
- Yilmazer F
- Yodice P
- Yokoyama M
- Yonis H
- Yonis H
- Yonis H
- Yoon SZ
- Yoruk F
- Yoshida K
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshihiro S
- Yoshitake E
- You KM
- Youn AM
- Young A
- Yu KM
- Yumoto T
- Yuzawa J
- Yuzawa J
- Zabaletta WJ
- Zabini D
- Zahorec M
- Zaien I
- Zakynthinos S
- Zanello M
- Zani D
- Zarantonello F
- Zayas B
- Zepeda EM
- Zeroual N
- Zerva L
- Zhang J
- Zhou JC
- Zhou JC
- Zhou JX
- Zhovnir V
- Zibandah N
- Zijlstra F
- Zimmerman J
- Zogheib E
- Zogheib E
- Zogheib E
- Zullino V
- Zwaag J
- ZĂœkovĂĄ I
- Ălvarez JT
- Ălvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990â2016: a systematic analysis for the Global Burden of Disease Study 2016
- Author
- Abajobir Amanuel Alemu
- Abate Kalkidan Hassen
- Abbafati Cristiana
- Abbas Kaja M.
- Abd-Allah Foad
- Abdulkader Rizwan Suliankatchi
- Abdulle Abdishakur M.
- Abebo Teshome Abuka
- Abera Semaw Ferede
- Aboyans Victor
- Abu-Raddad Laith J.
- Ackerman Ilana N.
- Adedeji Isaac A.
- Adedji
- Adetokunboh Olatunji
- Afshin Ashkan
- Aggarwal Rakesh
- Agrawal Anurag
- Agrawal Sutapa
- Ahmed Muktar Beshir
- Aichour Amani Nidhal
- Aichour Ibtihel
- Aichour Miloud Taki Eddine
- Aiyar Sneha
- Akinyemiju Tomi F.
- Akseer Nadia
- Al Lami Faris Hasan
- Al-Aly Ziyad
- Al-Maskari Fatma
- Al-Raddadi Rajaa
- Alahdab Fares
- Alam Khurshid
- Alam Noore
- Alam Tahiya
- Alasfoor Deena
- Alene Kefyalew Addis
- Ali Raghib
- Alizadeh-Navaei Reza
- Alkaabi Juma M.
- Alkerwi Ala'a
- Alla François
- Allebeck Peter
- Allen Christine
- Almazroa Mohammad Abdulaziz
- Alsharif Ubai
- Alsowaidi Shirina
- Althouse Benjamin M.
- Altirkawi Khalid A.
- Alvis-Guzman Nelson
- Amare Azmeraw T.
- Amini Erfan
- Ammar Walid
- Amoako Yaw Ampem
- Ansha Mustafa Geleto
- Antonio Carl Abelardo T.
- Anwari Palwasha
- Arora Megha
- Artaman Al
- Arthur Avokpaho Euripide Frinel G.
- Aryal Krishna Kumar
- Asgedom Solomon W.
- Atey Tesfay Mehari
- Atnafu Niguse Tadele
- Avila-Burgos Leticia
- Awasthi Ashish
- Awasthi Shally
- Azarpazhooh Mahmoud Reza
- Azzopardi Peter
- Babalola Tesleem Kayode
- Bacha Umar
- Badawi Alaa
- Balakrishnan Kalpana
- Bannick Marlena S.
- Barac Aleksandra
- Barker-Collo Suzanne L.
- Barquera Simon
- Barrero Lope H.
- Basu Sanjay
- Battista Robert
- Battle Katherine E.
- Baune Bernhard T.
- Bazargan-Hejazi Shahrzad
- Beardsley Justin
- Bedi Neeraj
- Bekele Bayu Begashaw
- Bell Michelle L.
- Bennett Derrick A.
- Bennett James R.
- Bensenor Isabela M.
- Benson Jennifer
- Berhane Adugnaw
- Berhe Derbew Fikadu
- Bernabé Eduardo
- Betsu Balem Demtsu
- Beuran Mircea
- Beyene Addisu Shunu
- Bhansali Anil
- Bhatt Samir
- Bhutta Zulfqar A.
- Biadgilign Sibhatu
- Bicer Burcu Kucuk
- Bienhof Kelly
- Bikbov Boris
- Birungi Charles
- Biryukov Stan
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- Williams Hywel C.
- Wiysonge Charles Shey
- Woldeyes Belete Getahun
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- Woodbrook Rachel
- Woolf Anthony D.
- Workicho Abdulhalik
- Xavier Denis
- Xu Gelin
- Yadgir Simon
- Yaghoubi Mohsen
- Yakob Bereket
- Yan Lijing L.
- Yano Yuichiro
- Ye Pengpeng
- Yihdego Mahari Gidey
- Yimam Hassen Hamid
- Yip Paul
- Yonemoto Naohiro
- Yoon Seok-Jun
- Yotebieng Marcel
- Younis Mustafa Z.
- Yu Chuanhua
- Zaidi Zoubida
- Zaki Maysaa El Sayed
- Zegeye Elias Asfaw
- Zenebe Zerihun Menlkalew
- Zhang Xueying
- Zheng Yingfeng
- Zhou Maigeng
- Zipkin Ben
- Zodpey Sanjay
- Zoeckler Leo
- Zuhlke Liesl Joanna
- Ărnlöv Johan
- Publication venue
- Publication date
- 01/01/2017
- Field of study
BACKGROUND: Measurement of changes in health across locations is useful to compare and contrast changing epidemiological patterns against health system performance and identify specific needs for resource allocation in research, policy development, and programme decision making. Using the Global Burden of Diseases, Injuries, and Risk Factors Study 2016, we drew from two widely used summary measures to monitor such changes in population health: disability-adjusted life-years (DALYs) and healthy life expectancy (HALE). We used these measures to track trends and benchmark progress compared with expected trends on the basis of the Socio-demographic Index (SDI).
METHODS: We used results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 for all-cause mortality, cause-specific mortality, and non-fatal disease burden to derive HALE and DALYs by sex for 195 countries and territories from 1990 to 2016. We calculated DALYs by summing years of life lost and years of life lived with disability for each location, age group, sex, and year. We estimated HALE using age-specific death rates and years of life lived with disability per capita. We explored how DALYs and HALE differed from expected trends when compared with the SDI: the geometric mean of income per person, educational attainment in the population older than age 15 years, and total fertility rate.
FINDINGS: The highest globally observed HALE at birth for both women and men was in Singapore, at 75·2 years (95% uncertainty interval 71·9-78·6) for females and 72·0 years (68·8-75·1) for males. The lowest for females was in the Central African Republic (45·6 years [42·0-49·5]) and for males was in Lesotho (41·5 years [39·0-44·0]). From 1990 to 2016, global HALE increased by an average of 6·24 years (5·97-6·48) for both sexes combined. Global HALE increased by 6·04 years (5·74-6·27) for males and 6·49 years (6·08-6·77) for females, whereas HALE at age 65 years increased by 1·78 years (1·61-1·93) for males and 1·96 years (1·69-2·13) for females. Total global DALYs remained largely unchanged from 1990 to 2016 (-2·3% [-5·9 to 0·9]), with decreases in communicable, maternal, neonatal, and nutritional (CMNN) disease DALYs offset by increased DALYs due to non-communicable diseases (NCDs). The exemplars, calculated as the five lowest ratios of observed to expected age-standardised DALY rates in 2016, were Nicaragua, Costa Rica, the Maldives, Peru, and Israel. The leading three causes of DALYs globally were ischaemic heart disease, cerebrovascular disease, and lower respiratory infections, comprising 16·1% of all DALYs. Total DALYs and age-standardised DALY rates due to most CMNN causes decreased from 1990 to 2016. Conversely, the total DALY burden rose for most NCDs; however, age-standardised DALY rates due to NCDs declined globally.
INTERPRETATION: At a global level, DALYs and HALE continue to show improvements. At the same time, we observe that many populations are facing growing functional health loss. Rising SDI was associated with increases in cumulative years of life lived with disability and decreases in CMNN DALYs offset by increased NCD DALYs. Relative compression of morbidity highlights the importance of continued health interventions, which has changed in most locations in pace with the gross domestic product per person, education, and family planning. The analysis of DALYs and HALE and their relationship to SDI represents a robust framework with which to benchmark location-specific health performance. Country-specific drivers of disease burden, particularly for causes with higher-than-expected DALYs, should inform health policies, health system improvement initiatives, targeted prevention efforts, and development assistance for health, including financial and research investments for all countries, regardless of their level of sociodemographic development. The presence of countries that substantially outperform others suggests the need for increased scrutiny for proven examples of best practices, which can help to extend gains, whereas the presence of underperforming countries suggests the need for devotion of extra attention to health systems that need more robust support.
FUNDING: Bill & Melinda Gates Foundation
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard VĂ©ronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
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- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
- Attwood John
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- Basu Suba
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- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers âŒ99% of the euchromatic genome and is accurate to an error rate of âŒ1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
A core outcome set for preâeclampsia research: an international consensus development study
- Author
- Abalos EJ
- Adamson CCD
- Akadri AA
- Akturk Z
- Allegaert K
- Angel Munoz M
- AngelâMĂŒller E
- Antretter J
- Audibert F
- Auger N
- Aygun C
- Babic I
- Bagga R
- Baker JM
- Bhandari V
- Bhattacharya S
- Blanker MH
- Bloomfield FH
- Bof A
- Brennan SM
- Broekhuijsen K
- Brown M
- Browne JL
- Browning RM
- Bull JW
- Butt A
- Button D
- Cairns AE
- Campbell DM
- Campbell JP
- Carbillon L
- Carthy S
- Casely E
- Cave JA
- Cecatti JG
- Chamillard ME
- Chappell LC
- Chassard D
- Checheir NC
- Chulkov VS
- Cluver CA
- Crawford CF
- Daly MC
- DarmochwalâKolarz DA
- Davies MW
- Davies RE
- Dawson JS
- Dobson N
- Dodd CN
- Donald F
- Duffy JMN
- Duley L
- EpsteinâMares J
- Erez O
- Evans E
- Farlie RN
- Ferris AV
- Fiona Broughton Pipkin E
- Fitzpatrick R
- Frankland EM
- Freeman DJ
- Gainder S
- Gale C
- Ganzevoort W
- Gbinigie OA
- Ghosh SK
- Glogowska M
- Goodlife A
- Gough KL
- Green JR
- Grobman WA
- Gul F
- Haggerty L
- Hall DR
- Hallman M
- Hammond SJ
- Harlow SD
- Hays KE
- Hickey SC
- Higgins M
- Hinton L
- Hobson SR
- Hogg MJ
- Hollands HJ
- Homer CSE
- Hoodbhoy Z
- Howell P
- Huppertz B
- Husain S
- Jacoby SD
- JacqzâAigrain E
- Jenkins G
- Jewel D
- Johnson MJ
- Johnston CL
- Jones PM
- KantrowitzâGordon I
- Karumanchi SA
- Khalil A
- Khan R
- Kirby LJ
- Kirk C
- Knight M
- Korey MT
- Lee GJ
- Lee VW
- Levene LS
- Londero AP
- Lucas DN
- Lust KM
- MacKenzie V
- Magee LA
- Malha L
- Mattone M
- McCartney DE
- McFadden A
- McKinstry BH
- McManus RJ
- Middleton PF
- Mistry HD
- Mitchell CA
- Mockler JC
- Mol BW
- Molsher S
- Monast ES
- Moodley J
- Mooij R
- Moore EL
- Morgan L
- Moulson A
- Mughal F
- Mundle SR
- Murray E
- Nagata C
- Nair AS
- Nakimuli A
- Nath G
- Newport RS
- Oakeshott P
- OchoaâFerraro MR
- Odendaal H
- Ohkuchi A
- Oliveira L
- OrtizâPanozo E
- Oudijk MA
- Oygucu SE
- Paech MJ
- Painter RC
- Parry CL
- Payne BA
- Pearson EL
- Phupong V
- Pickett N
- Pickles KA
- Plumb LK
- Prefumo F
- Preston R
- Ray JG
- Rayment J
- Regan LV
- Rey E
- RichardsâDoran D
- Robson EJ
- Rubin AN
- RubioâRomero JA
- Rull K
- Sass N
- Sauvé N
- Savory NA
- Scott JR
- Seaton SE
- Seed PT
- Shakespeare JM
- Shand AW
- Sharma S
- Shaw TY
- Smedley KL
- Smith Conk A
- Smith D
- Soward D
- Stark M
- Stepan H
- Stroumpoulis K
- Surendran A
- Takeda S
- Tan L
- Thangaratinam S
- Theriot BS
- Thomas HF
- Thompson K
- Thompson MJ
- Thompson PI
- Torney KLHT
- Treadwell JS
- Tucker KL
- Turrentine MA
- van 't Hooft J
- Van Hecke O
- Van Oostwaard MF
- Vasquez DN
- Vaughan DJA
- VInturache A
- von Dadelszen P
- Walker J
- Wardle SP
- Wasim T
- Waters JH
- Whitehead CL
- Williamson PR
- Wilson MJ
- Wolfson A
- Yeo S
- Zermansky AG
- Ziebland S
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
Objective
To develop a core outcome set for preâeclampsia.
Design
Consensus development study.
Setting
International.
Population
Two hundred and eightâone healthcare professionals, 41 researchers and 110 patients, representing 56 countries, participated.
Methods
Modified Delphi method and Modified Nominal Group Technique.
Results
A longâlist of 116 potential core outcomes was developed by combining the outcomes reported in 79 preâeclampsia trials with those derived from thematic analysis of 30 inâdepth interviews of women with lived experience of preâeclampsia. Fortyâseven consensus outcomes were identified from the Delphi process following which 14 maternal and eight offspring core outcomes were agreed at the consensus development meeting. Maternal core outcomes: death, eclampsia, stroke, cortical blindness, retinal detachment, pulmonary oedema, acute kidney injury, liver haematoma or rupture, abruption, postpartum haemorrhage, raised liver enzymes, low platelets, admission to intensive care required, and intubation and ventilation. Offspring core outcomes: stillbirth, gestational age at delivery, birthweight, smallâforâgestationalâage, neonatal mortality, seizures, admission to neonatal unit required and respiratory support.
Conclusions
The core outcome set for preâeclampsia should underpin future randomised trials and systematic reviews. Such implementation should ensure that future research holds the necessary reach and relevance to inform clinical practice, enhance women's care and improve the outcomes of pregnant women and their babies
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