1,744 research outputs found
Entropy production in phase field theories
Allen-Cahn (Ginzburg-Landau) dynamics for scalar fields with heat conduction
is treated in rigid bodies using a non-equilibrium thermodynamic framework with
weakly nonlocal internal variables. The entropy production and entropy flux is
calculated with the classical method of irreversible thermodynamics by
separating full divergences.Comment: 5 pages, no figure
Health related quality of life in patients with multiple myeloma undergoing a double transplantation
Pilot outcomes research: effects and costs of bortezomib in relapsed or refractory multiple myeloma
Pilot outcomes research: effects and costs of bortezomib in relapsed or refractory multiple myeloma
Association of polymorphisms in the beta-2 adrenergic receptor gene with fracture risk and bone mineral density
Pain-preventing strategies in mammography: an observational study of simultaneously recorded pain and breast mechanics throughout the entire breast compression cycle
Leg blood flow measurements using venous occlusion plethysmography during head-up tilt
We tested whether venous occlusion plethysmography (VOP) is an appropriate method to measure calf blood flow (CBF) during head-up tilt (HUT). CBF measured with VOP was compared with superficial femoral artery blood flow as measured by Doppler ultrasound during incremental tilt angles. Measurements of both methods correlated well (r = 0.86). Reproducibility of VOP was fair in supine position and 30° HUT (CV: 11%â15%). This indicates that VOP is an applicable tool to measure leg blood flow during HUT, especially up to 30° HUT
The nuclear receptors of Biomphalaria glabrata and Lottia gigantea: Implications for developing new model organisms
© 2015 Kaur et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedNuclear receptors (NRs) are transcription regulators involved in an array of diverse physiological functions including key roles in endocrine and metabolic function. The aim of this study was to identify nuclear receptors in the fully sequenced genome of the gastropod snail, Biomphalaria glabrata, intermediate host for Schistosoma mansoni and compare these to known vertebrate NRs, with a view to assessing the snail's potential as a invertebrate model organism for endocrine function, both as a prospective new test organism and to elucidate the fundamental genetic and mechanistic causes of disease. For comparative purposes, the genome of a second gastropod, the owl limpet, Lottia gigantea was also investigated for nuclear receptors. Thirty-nine and thirty-three putative NRs were identified from the B. glabrata and L. gigantea genomes respectively, based on the presence of a conserved DNA-binding domain and/or ligand-binding domain. Nuclear receptor transcript expression was confirmed and sequences were subjected to a comparative phylogenetic analysis, which demonstrated that these molluscs have representatives of all the major NR subfamilies (1-6). Many of the identified NRs are conserved between vertebrates and invertebrates, however differences exist, most notably, the absence of receptors of Group 3C, which includes some of the vertebrate endocrine hormone targets. The mollusc genomes also contain NR homologues that are present in insects and nematodes but not in vertebrates, such as Group 1J (HR48/DAF12/HR96). The identification of many shared receptors between humans and molluscs indicates the potential for molluscs as model organisms; however the absence of several steroid hormone receptors indicates snail endocrine systems are fundamentally different.The National Centre for the Replacement, Refinement and Reduction of Animals in Research, Grant Ref:G0900802 to CSJ, LRN, SJ & EJR [www.nc3rs.org.uk]
Search for time-dependent B0s - B0s-bar oscillations using a vertex charge dipole technique
We report a search for B0s - B0s-bar oscillations using a sample of 400,000
hadronic Z0 decays collected by the SLD experiment. The analysis takes
advantage of the electron beam polarization as well as information from the
hemisphere opposite that of the reconstructed B decay to tag the B production
flavor. The excellent resolution provided by the pixel CCD vertex detector is
exploited to cleanly reconstruct both B and cascade D decay vertices, and tag
the B decay flavor from the charge difference between them. We exclude the
following values of the B0s - B0s-bar oscillation frequency: Delta m_s < 4.9
ps-1 and 7.9 < Delta m_s < 10.3 ps-1 at the 95% confidence level.Comment: 18 pages, 3 figures, replaced by version accepted for publication in
Phys.Rev.D; results differ slightly from first versio
Local is not always better: the impact of climate information on values, behavior and policy support
In the current research, we experimentally examined the effect of providing local or global information about the impacts of climate change on individualsâ perceived importance of climate change and on their willingness to take action to address it, including policy support. We examined these relationships in the context of individualsâ general value orientations. Our findings, from 99 US residents, suggest that different kinds of climate information (local, global, or none) interact with values vis-Ă -vis our dependent variables. Specifically, while self-transcendent values predict perceived importance and pro-environmental behavior across all three information conditions, the effect on policy support is less clear. Furthermore, we detected a âreactance effectâ where individuals with self-enhancing values who read local information thought that climate change was less important and were less willing to engage in pro-environmental behavior and support policy than self-enhancing individuals in the other information conditions. These results suggest that policy makers and public communicators may want to be cognizant of their audienceâs general value orientation. Local information may not only be ineffective but may also prove counterproductive with individuals whose value orientations are more self-enhancing than self-transcendent
- âŠ