Optimizing decomposition of software architecture for local recovery

Cataloged from PDF version of article.The increasing size and complexity of software systems has led to an amplified number of potential failures and as such makes it harder to ensure software reliability. Since it is usually hard to prevent all the failures, fault tolerance techniques have become more important. An essential element of fault tolerance is the recovery from failures. Local recovery is an effective approach whereby only the erroneous parts of the system are recovered while the other parts remain available. For achieving local recovery, the architecture needs to be decomposed into separate units that can be recovered in isolation. Usually, there are many different alternative ways to decompose the system into recoverable units. It appears that each of these decomposition alternatives performs differently with respect to availability and performance metrics. We propose a systematic approach dedicated to optimizing the decomposition of software architecture for local recovery. The approach provides systematic guidelines to depict the design space of the possible decomposition alternatives, to reduce the design space with respect to domain and stakeholder constraints and to balance the feasible alternatives with respect to availability and performance. The approach is supported by an integrated set of tools and illustrated for the open-source MPlayer software

Community Outpatient Psychotherapy Engagement Service for Self-harm (COPESS): a feasibility trial protocol.

BACKGROUND: People who self-harm are at high risk for future suicide and often suffer considerable emotional distress. Depression is common among people who self-harm and may be an underlying driver of self-harm behaviour. Self-harm is often repeated, and risk of repetition is highest immediately after an act of self-harm. Readily accessible brief talking therapies show promise in helping people who self-harm, but further evaluation of these approaches is needed. A brief talking therapy intervention for depression and self-harm has been designed for use in a community setting. This mixed methods feasibility study with repeated measures will examine the feasibility and acceptability of the Community Outpatient Psychological Engagement Service for Self-Harm (COPESS) for people with self-harm and depression in the community, compared to routine care. METHODS: Sixty participants with a history of self-harm within the last six months, who are also currently depressed, will be recruited to take part in a feasibility single-blind randomised controlled trial (RCT). Participants will be randomised 1:1 to receive COPESS plus treatment as usual (TAU) or TAU alone. Recruitment will be via General Practitioners (GP) and self-referral. Assessment of feasibility and acceptability will be assessed via quantitative and qualitative methods including measures of recruitment and retention to the feasibility trial, participants' experience of therapy, completion/completeness of outcome measures at relevant time-points and completion of a service use questionnaire. DISCUSSION: The results will indicate whether it is feasible to conduct a definitive full trial to determine whether COPESS is a clinically and cost effective intervention for people who self-harm in the community. Qualitative and quantitative data will in addition help identify potential strengths and/or challenges of implementing brief community-based interventions for people who self-harm. TRIAL REGISTRATION: NCT04191122 registered 9th December 2019

Acceptability and feasibility of a Community Outpatient Psychotherapy Engagement Service for Self-harm: COPESS a mixed methods study

Background: Self-harm refers to any intentional self-injury or self-poisoning, with or without the intention to end one’s life. People who self-harm are at high risk of suicide, and often experience a range of social and mental health issues as well as considerable emotional distress. Around 70% of people who self-harm also experience symptoms of depression. There is very little help available from health and mental health services designed specifically for people who self-harm, and many receive no help at all. Most self-harm happens in the community but there have been very few attempts to develop self-harm specific services in community settings, such as GP practices. Readily accessible brief talking therapies show promise in helping people who self-harm, but further evaluation of these approaches is needed. The Community Outpatient Psychological Engagement Service for Self-Harm (COPESS) is a brief talking therapy intervention for depression and self-harm. Objectives: The objectives were to assess the feasibility of conducting a trial of the COPESS intervention in a community setting in relation to participant recruitment, data collection, the acceptability of the intervention and retention in treatment and study. Design: A mixed-method study, using a single-blind randomised controlled trial (RCT), assessing the acceptability and feasibility of the COPESS intervention for people with depression who self-harm, and purposefully collected qualitative data. Setting: GP practices in Northwest England. Participants: Individuals aged >16 years who had depression and self-harmed in previous six months. Interventions: The COPESS intervention is a psychological ‘talking’ therapy designed to help people who self-harm. It is made up of a short course of sessions with a therapist, that are available quickly after self-harm has been identified by that person’s GP. People were randomised 1:1 to receive either COPESS plus treatment-as-usual (TAU) or TAU alone. Main outcome measures: The primary outcome was the feasibility and acceptability of COPESS for people in the community with self-harm and co-existing depression. Secondary outcome measures were assessed at baseline, with follow-up assessments occurring at 1- month, 2-months and 3-months. Results: Findings indicated that COPESS was both acceptable and feasible, with all progression criteria being met. Fifty-seven people were recruited into the trial. Fifty-five were then randomly allocated to receive either the COPESS therapy (28 people) or treatment as usual only (27 people). Primary care staff and COPESS therapists based in a 3 mental health trust reported the intervention fitted and complemented existing services, and patients reported that they favoured the rapid, self-harm focused, person-centred approach of the intervention. The response to the therapy was very positive, with most participants attending all sessions. There were early indications that receiving COPESS may lower levels of depression, general distress and urges to self-harm compared to treatment as usual. Qualitative interviews were completed with participants, therapists, and primary care staff and feedback was positive about the COPESS intervention. Limitations: Due to the COVID-19 pandemic the COPESS intervention was delivered remotely only, therefore the experiences of the patients in the feasibility trial may not be representative of therapy delivered in person. Furthermore, the pandemic and associated disease control measures (i.e., lockdowns) may have had a general impact on outcomes, including recruitment into the study (both GP surgeries and participants), and experiences of participants and therapists. Conclusions: All progression criteria were met supporting further evaluation of the intervention in a full-scale clinical effectiveness trial. COPESS has potential as a brief primary-care based intervention for those struggling with self-harm. Future work: Further work involving stakeholder engagement is needed to refine the delivery of the intervention across multiple sites and conduct a full-scale efficacy trial. Trial registration: NCT04191122. Funding details: This project was funded by the National Institute for Health and Care Research (NIHR200543) Research for Patient Benefit Programme

Probing the Nuclear and Circumnuclear Activity of NGC1365 in the Infrared

We present new far-infrared (70-500micron) Herschel PACS and SPIRE imaging observations as well as new mid-IR Gemini/T-ReCS imaging (8.7 and 18.3micron) and spectroscopy of the inner Lindblad resonance (ILR) region (R<2.5kpc) of the spiral galaxy NGC1365. We complemented these observations with archival Spitzer imaging and spectral mapping observations. The ILR region of NGC1365 contains a Seyfert 1.5 nucleus and a ring of star formation with an approximate diameter of 2kpc. The strong star formation activity in the ring is resolved by the Herschel/PACS imaging data, as well as by the Spitzer 24micron continuum emission, [NeII]12.81micron line emission, and 6.2 and 11.3micron PAH emission. The AGN is the brightest source in the central regions up to lambda~24micron, but it becomes increasingly fainter in the far-infrared when compared to the emission originating in the infrared clusters (or groups of them) located in the ring. We modeled the AGN unresolved infrared emission with the CLUMPY torus models and estimated that the AGN contributes only to a small fraction (~5%) of the infrared emission produced in the inner ~5kpc. We fitted the non-AGN 24-500micron spectral energy distribution of the ILR region and found that the dust temperatures and mass are similar to those of other nuclear and circumnuclear starburst regions. Finally we showed that within the ILR region of NGC1365 most of the on-going star formation activity is taking place in dusty regions as probed by the 24micron emission.Comment: Accepted for publication in MNRA

The role of HLA-G in human pregnancy

Pregnancy in mammals featuring hemochorial placentation introduces a major conflict with the mother's immune system, which is dedicated to repelling invaders bearing foreign DNA and RNA. Numerous and highly sophisticated strategies for preventing mothers from rejecting their genetically different fetus(es) have now been identified. These involve production of novel soluble and membrane-bound molecules by uterine and placental cells. In humans, the placenta-derived molecules include glycoproteins derived from the HLA class Ib gene, HLA-G. Isoforms of HLA-G saturate the maternal-fetal interface and circulate in mothers throughout pregnancy. Uteroplacental immune privilege for the fetus and its associated tissues is believed to result when immune cells encounter HLA-G. Unequivocally demonstration of this concept requires experiments in animal models. Both the monkey and the baboon express molecules that are similar but not identical to HLA-G, and may comprise suitable animal models for establishing a central role for these proteins in pregnancy

Planck 2013 results. XXII. Constraints on inflation

We analyse the implications of the Planck data for cosmic inflation. The Planck nominal mission temperature anisotropy measurements, combined with the WMAP large-angle polarization, constrain the scalar spectral index to be ns = 0:9603 _ 0:0073, ruling out exact scale invariance at over 5_: Planck establishes an upper bound on the tensor-to-scalar ratio of r < 0:11 (95% CL). The Planck data thus shrink the space of allowed standard inflationary models, preferring potentials with V00 < 0. Exponential potential models, the simplest hybrid inflationary models, and monomial potential models of degree n _ 2 do not provide a good fit to the data. Planck does not find statistically significant running of the scalar spectral index, obtaining dns=dln k = 0:0134 _ 0:0090. We verify these conclusions through a numerical analysis, which makes no slowroll approximation, and carry out a Bayesian parameter estimation and model-selection analysis for a number of inflationary models including monomial, natural, and hilltop potentials. For each model, we present the Planck constraints on the parameters of the potential and explore several possibilities for the post-inflationary entropy generation epoch, thus obtaining nontrivial data-driven constraints. We also present a direct reconstruction of the observable range of the inflaton potential. Unless a quartic term is allowed in the potential, we find results consistent with second-order slow-roll predictions. We also investigate whether the primordial power spectrum contains any features. We find that models with a parameterized oscillatory feature improve the fit by __2 e_ _ 10; however, Bayesian evidence does not prefer these models. We constrain several single-field inflation models with generalized Lagrangians by combining power spectrum data with Planck bounds on fNL. Planck constrains with unprecedented accuracy the amplitude and possible correlation (with the adiabatic mode) of non-decaying isocurvature fluctuations. The fractional primordial contributions of cold dark matter (CDM) isocurvature modes of the types expected in the curvaton and axion scenarios have upper bounds of 0.25% and 3.9% (95% CL), respectively. In models with arbitrarily correlated CDM or neutrino isocurvature modes, an anticorrelated isocurvature component can improve the _2 e_ by approximately 4 as a result of slightly lowering the theoretical prediction for the ` <_ 40 multipoles relative to the higher multipoles. Nonetheless, the data are consistent with adiabatic initial conditions

Antennal sensilla of two female anopheline sibling species with differing host ranges

BACKGROUND: Volatile odors are important sensory inputs that shape the behaviour of insects, including agricultural pests and disease vectors. Anopheles gambiae s.s. is a highly anthropophilic mosquito and is the major vector for human malaria in sub-Sahara Africa, while Anopheles quadriannulatus, largely due to its zoophilic behaviour, is considered a non-vector species in the same region. Careful studies of olfaction in these sibling species may lead to insights about the mechanisms that drive host preference behaviour. In the present study, the external anatomy of the antenna, the principle olfactory organ in the female mosquito of both species, was examined as an initial step toward more detailed comparisons. METHODS: Scanning electron and light microscopy were used to examine the antennae ultrastructures of adult female An. gambiae s.s. and An. quadriannulatus. Sensory structures, called sensilla, were categorized and counted; their distributions are reported here as well as densities calculated for each species. RESULTS: Both An. gambiae s.s. and An. quadriannulatus bear five classes of sensilla on their antennae: chaetica (bristles), trichodea (hairs), basiconica (pegs), coeloconica (pitted pegs), and ampullacea (pegs in tubes). Female An. quadriannulatus antennae have approximately one-third more sensilla, and a proportionally larger surface area, than female An. gambiae s.s. antennae. CONCLUSION: The same types of sensilla are found on the antennae of both species. While An. quadriannulatus has greater numbers of each sensilla type, sensilla densities are very similar for each species, suggesting that other factors may be more important to such olfactory-driven behaviours as host preference

Small group interventions for children aged 5-9 years old with mathematical learning difficulties

The research related to educational interventions for children with mathematical learning difficulties has been increasing steadily. In this chapter I focus on small group interventions for children aged 5–9 years old with learning difficulties in mathematics. First, I describe the important issues: (1) who are the children having problems in mathematics, (2) what do we mean with (special) education intervention, (3) what does Responsiveness to Intervention mean, and (4) what intervention features have been found effective for children aged 5–9 years with learning difficulties in mathematics. Then, I describe the research and developmental work that has been done in Finland on designing web services which provide evidence-based information and materials for educators. The two web services are LukiMat and ThinkMath. Together, these two web services include the knowledge base, assessment batteries and intervention tools to be used in relation to mathematical learning difficulties in the age group 5–9 years.Peer reviewe

Adaptation to Aridity in the Malaria Mosquito Anopheles gambiae: Chromosomal Inversion Polymorphism and Body Size Influence Resistance to Desiccation

Chromosomal inversions are thought to confer a selective advantage in alternative habitats by protecting co-adapted alleles from recombination. The frequencies of two inversions (2La and 2Rb) of the afro-tropical malaria mosquito Anopheles gambiae change gradually along geographical clines, increasing in frequency with degree of aridity. Such clines can result from gene flow and local selection acting upon alternative karyotypes along the cline, suggesting that these inversions may be associated with tolerance to xeric conditions. Since water loss represents a major challenge in xeric habitats, it can be supposed that genes inside these inversions are involved in water homeostasis. To test this hypothesis, we compared the desiccation resistance of alternative karyotypes from a colonised 2Rb/2La polymorphic population of A. gambiae from Cameroon. The strain included only the molecular form S, one of the genetic units marking incipient speciation in this taxon. Day-old mosquitoes of both sexes were assayed individually for time to death in a dry environment and the karyotype of each was determined post-mortem using molecular diagnostic assays for each inversion. In agreement with expectations based on their eco-geographical distribution, we found that 2La homokaryotypes survived significantly longer (1.3 hours) than the other karyotypes. However, there was weak support for the effect of 2Rb on desiccation resistance. Larger mosquitoes survived longer than smaller ones. Median survival of females was greater than males, but the effect of sex on desiccation resistance was weakly supported, indicating that differential survival was correlated to differences between sexes in average size. We found weak evidence for a heterotic effect of 2La karyotype on size in females. These results support the notion that genes located inside the 2La inversion are involved in water balance, contributing towards local adaptation of A. gambiae to xeric habitats, beyond the adaptive value conferred by a larger body size