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    9408 research outputs found

    The impact of innovation failure: Entrepreneurship adversity or opportunity?

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    Innovation is key to the economic performance of firms. However, several types of risks and uncertainties often lead to high failure rates in innovation projects, to the extent that failure is now considered a typical step in an innovation process. If innovation failure was provoking stress in the past, the current socio-economic contexts makes if it something to regularly deal with and learning from. However, there still is a dilemma on whether innovation failure should be considered as an opportunity or a trauma for the firm. Exploring the three steps of an innovation failure, that is identifying, analyzing and experimenting, the present research offers new insights on the nature of innovation failure at an individual and team levels. In particular, via an inductive approach this study provides fours key approaches to understanding innovation failure. First, we have uncovered a wide range of approaches to organizational management and ‘Spaghetti’ organizational models of innovation that perceive failure as an opportunity for the innovation process. Secondly, our study identified what seems to be a widespread perception of innovation failure as a trauma, which encourages the culture of openness to failure and to share knowledge of failing innovations. Such views apply not only at organizational but also at individual and team levels. Third, our results serve to encourage individuals, teams and organizations to find new ways to learn from failures in innovation projects, and to have a less centralized management and control over innovation. Fourth, in our perception of the domain, failure could become the ‘new normal’ and a mean to generate new knowledge. This stimulates new directions in the decision-making process, towards novel pathways to innovation

    Comparative study of steam, organic Rankine cycle and supercritical CO2 power plants integrated with residual municipal solid waste gasification for district heating and cooling

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    Among the different waste-to-energy solutions, gasification is considered a promising option and an alternative to landfilling of residual municipal solid waste (RMSW). Therefore, the potential of RMSW air gasification in combination with three different power cycles for district cooling and heating applications is investigated. The model of a fluidized bed air gasifier developed in Aspen Plus is integrated with the models of steam turbine (ST), organic Rankine cycle (ORC), and supercritical CO2 (sCO2) Brayton cycle power plants for the combined cooling, heating, and power production in district networks. The results of the numerical study show that the ST power plant provides higher electrical power compared to the other systems, while sCO2 exhibits better thermal power and the maxima combined energy conversion efficiency. In between, ORCs prove to be a reliable and flexible solution for varying RMSW compositions and temperature levels of the district network. The size of the district network strongly varies with scenarios and in the best case, more than 1,400 residential buildings can be connected to the trigeneration plant considering 20 ktons/year of RMSW input to the gasifier

    Sustainable development and human capital

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    Recently, the academic literature has investigated the existence of a direct link between sustainable development and human capital. In following this growing body of literature, the present paper aims to formalise, and then verify, the role of human capital on environmental quality. Precisely, from a theoretical point of view, the work introduces the ecological identity into a basic growth model that is based on human capital. By increasing sensitivity and concern for environmental issues, human capital can reduce the impact of economic activity on the environment, as well as adding its positive effect on economic growth. This key assumption of the theoretical model is empirically tested through a panel analysis on 81 national economies (62 low-and middle-income economies and 19 high-income economies) over a period of more than 20 years. The paper finds a direct and positive link between sustainable development and an advanced stage of tertiary education (namely, a Master’s degree or a PhD). This result could potentially be a good indicator for the future of the environment and for humankind

    The Chaperone System in Tumors of the Vocal Cords: Quantity and Distribution Changes of Hsp10, Hsp27, Hsp60, and Hsp90 during Carcinogenesis

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    Laryngeal squamous cell carcinoma (LSCC) constitutes a noteworthy subset of head and neck cancers, contributing to about 4.5% of all malignancies. Its clinical behavior and characteristics exhibit variations contingent upon the specific anatomical site affected, with the glottis, supraglottis, and subglottis emerging as the most prevalent locations. Notably, squamous cell carcinoma represents a predominant histological type, accounting for 85% to 95% of all laryngeal cancers. The gender disparity is evident, with a higher incidence among males, exhibiting a ratio of 3.9:1. Moreover, disparities among racial groups are observed, as African American patients tend to manifest the condition at a younger age, coupled with lower overall survival rates compared to their Caucasian, Hispanic, and Asian counterparts. The primary etiological factors implicated in the onset of laryngeal cancer are tobacco and alcohol consumption, with a direct correlation to the intensity and duration of usage. Importantly, the risk diminishes gradually following cessation, necessitating a substantial period of at least 15 years for a return to baseline rates. Given the diverse nature of laryngeal SCC, treatment modalities are tailored based on the specific site and stage of the disease. Therapeutic interventions, such as radiotherapy, transoral laser microsurgery, open horizontal partial laryngectomy, or total laryngectomy, are employed with the overarching goal of preserving organ function. This study delves into the intricate realm of laryngeal SCC, specifically exploring the involvement of heat shock proteins (HSPs) in disease progression. This research meticulously examines the expression levels of Hsp10, Hsp27, Hsp60, and Hsp90 in dysplastic and benign tissue samples extracted from the right vocal cord, utilizing immunohistochemistry analysis. The focal point of the investigation revolves around unraveling the intricate role of these molecular chaperones in tissue differentiation mechanisms and cellular homeostasis, particularly within the inflammatory milieu characteristic of the tumor phenotype. The findings from this study serve as a robust histopathological foundation, paving the way for more in-depth analyses of the underlying mechanisms governing the contribution of the four chaperones to the development of squamous cell carcinoma in the larynx. Additionally, the data gleaned from this research hint at the potential of these four chaperones as valuable biomarkers, not only for diagnostic purposes but also for prognostication and ongoing patient monitoring. As our understanding of the molecular intricacies deepens, the prospect of targeted therapeutic interventions and personalized treatment strategies for laryngeal SCC becomes increasingly promising

    Modelling approaches of micro and small-scale organic Rankine cycle systems: A critical review

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    Organic Rankine cycle (ORC) systems are a technology capable of producing electricity and heat from a wide range of energy sources and are particularly well-suited for medium and low-temperature sources. However, an almost infinite number of technical solutions (cycle configurations, working fluids, components, etc.) can be adopted making the full experimental characterisation of ORC operations for each application unfeasible. To overcome the limitations of extensive experimental investigations, numerical tools are often adopted, thereby supporting the design and operation of these plants. Therefore, over the last two decades, many researchers have put their efforts into developing models to elucidate the design and off-design performances of ORC systems. In this paper, the different modelling approaches for the analysis of ORC systems are discussed and a conclusive review is performed concerning the micro and small-scale ORCs. In total, more than 150 works are reviewed with many of them related to models of volumetric machines and assumption-based system modelling. Semi-empirical models of expanders show good capabilities and accuracy (with errors below 5%) while spatial resolution methods for heat exchangers are used to better capture the dynamics of the system. However, only a limited number of papers (10) deal with assumption-free models of the systems to predict their performance considering the actual boundary conditions. In summary, the present review paper provides a clear overview of the advantages and disadvantages of each modelling approach at both component and system levels to provide insights for interested readers in the advanced simulation of micro and small-scale ORC systems

    Mitridate VI re del Ponto

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    La vicenda del re pontico Mirtidate VI Eupatore viene sviscerata in modo approfondit

    Effects of Board Composition of Family Firms Within Inter-Firm Networks

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    Postural adjustments and perceptual responses of Nordic running: concurrent effects of poles and irregular terrain

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    Purpose: In the natural environment, humans must continuously negotiate irregular and unpredictable terrain. Recently, the poles have been extensively used during trial running events. However, we know little about how humans adjust posture and bilateral coordination to use poles in irregular terrain. Here, we compared kinematics, bilateral coordination and perceptual responses between regular (compact dust) and irregular terrain (medium-length grass) during running at preferred speed with and without poles. Methods: In this transversal observational study, thirteen young healthy adults (8 men; mean ± SD; age 29.1 ± 8.0 years, body mass 76.8 ± 11.4 kg; height 1.75 ± 0.08 m) were evaluated during running at a self-selected comfortable speed with and without poles on regular and irregular terrains. Results: Our results show that, despite more flexed pattern on lower-limb joints at irregular terrain, the usage of poles was not enough to re-stabilize the bilateral coordination. Also, the perceived exertion was impaired adding poles to running, probably due to more complex movement pattern using poles in comparison to free running, and the invariance in the bilateral coordination. Conclusion: Besides the invariability of usage poles on bilateral coordination and lower-limb kinematics, the runners seem to prioritize postural stability over lower limb stiffness when running in medium-length grass given the larger range of ankle and knee motion observed in irregular terrain. Further investigations at rougher/hilly terrains will likely provide additional insights into the neuromotor control strategies used to maintain the stability and on perceptual responses using poles during running

    Is Education the Best Tool to Fight Disinformation?

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    Education positively affects human development, while disinformation hinders human activities. However, in previous economic studies on disinformation, the role of education is, at the best, implicit. This theoretical and empirical paper, therefore, aims to put education at the centre of the disinformation problem. Precisely, a theoretic model of information search is used to show the negative effect of disinformation on market outcomes, while a survey study on graduates in Italian universities is used to highlight the role of education in reducing the negative impact of disinformation. Two are the main results of this analysis. First, in the presence of disinformation, the auditing of the sources of information is a necessary activity. Second, education is the most effective tool for reducing the auditing cost. It follows that the investment in education is the best economic and social policy to fight disinformation

    The metaverse: digital innovation in the fashion industry. A systematic literature review

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    he growing interest in the metaverse is continuously increasing in recent years and involves many economic sectors. Primarily the fashion sector has long understood the potential of digital platforms and the advantages of being present in the main online gaming ones. Many fashion brands have entered meaningful partnerships with video game companies in recent years, "dressing" the avatars with their clothing. Regarding the metaverse, the fashion sector has taken up the challenge by creating the first Metaverse Fashion Week. After New York, Milan, and Paris, the fashion houses have landed on the Decentraland platform for a week of all-digital fashion shows and events. This work aims to do a systematic literature review to explore state-of-the-art relating to the digital innovation of fashion in the metaverse, in both business and social relations dimensions, on virtual gaming platforms and not strictly to find future research fields

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