85 research outputs found
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
- Abdelmonem SA
- Abdo WF
- Abellan AN
- AbellĂĄn AN
- AbellĂĄn AN
- AbellĂĄn AN
- Abrams ST
- Ackerley C
- Acuña M
- Adda M
- Adhikari NK
- Adriano G
- Adrie C
- Affatato R
- Affatato R
- Afonso-Rivero D
- Agarossi A
- Agarwal LK
- Ageeva T
- Agrawal R
- Aguayo-DeHoyos E
- Aguilar AL
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguirregabyria M
- Ahmadnia E
- Ahn C
- Ahn JY
- Ahn JY
- Ahn MY
- Ahn MY
- Aitken LM
- Akalaev R
- Akbarzadeh A
- Akcan-Arikan A
- Akhlagh SH
- Akhtar N
- AKI Research Group
- Akiduki N
- Akin S
- Akizuki N
- Akkoc T
- Ala-Kokko T
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- Albaiceta GM
- Albaladejo P
- Alberto F
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- ARIAM registry of adult cardiac surgery
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- Khaliq W
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- Kim DJ
- Kim HJ
- Kim JM
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- Kim JW
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- Komuro T
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- Kongpolprom N
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- Kosuk ME
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- Kumari BK
- Kumbamu A
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- Kwon WY
- Kwon WY
- Kwon WY
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- Kyle UG
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- Labra C
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- Lafuente E
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- Lagos R
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- Lukaszewicz AC
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- Merino-Vega D
- Messenger D
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- Midwinter MJ
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- Okayama Research Investigation Organizing Network (ORION)investigators
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- Olavarria E
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- Pickkers P
- Picoita F
- PICS- HCPA: Programa Intrahospitalar de Combate Ă Sepse do Hospital de ClĂnicas de Porto Alegre
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- Plug Working Group
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- Pozzi M
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- Pugliese F
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- Rapid Diagnosis of Infections in the Critically Ill Team
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- ReVA Research Network and the PROVE Network Investigators
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- RodrĂguez FG
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- Rosario LE
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- Runge I
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- Salgado DR
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- Sandiumenge A
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- Santacruz C
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- Santana JD
- Santana MC
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- Santana PS
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- Santiago AI
- Santiago AI
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- Scales DC
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- Shimony JS
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- Shin WJ
- Shinotsuka CR
- Shlyk I
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- Shuinotsuka C
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- Spronk PE
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- St Georgeâs University of London
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- Stubbs C
- Student Research Committee - Shiraz University of Medical Sciences
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- SĂĄnchez MJ
- SĂĄnchez MJ
- SĂĄnchez MJ
- SĂĄnchez MJ
- SĂĄnchez PC
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- Tabei SH
- Taccone F
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- Thomas B
- Thompson E
- Thévenin D
- Tiainen M
- Timsit JF
- Tirkkonen J
- Tirumala S
- Tjepkema-Cloostermans MC
- Tobar M
- Tofiño AL
- Toh CH
- Tokyo Womens Medical University
- Tomas E
- Tomas E
- Tomic I
- Tominaga N
- TomĂĄs MA
- Tonelotto BF
- Tonetti T
- Tonetti T
- Topcu L
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- Torner MM
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- Vallverdu M
- Vallverdu M
- VallverdĂș I
- Vallés J
- van den Boogaard M
- van der Heiden ES
- van der Hoeven JG
- van der Hoeven JG
- van der Voort PH
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- Villarreal E
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- Vincent JL
- Vincent JL
- Vinje LJ
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- Wang H
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- Welters I
- Wetz A
- Weyer CM
- White C
- Wiesner O
- Wijayatilake DS
- Wildenberg L
- Wilks M
- Wilson ME
- WIND study group
- WIND study group
- WIND study group
- Winder-Rhodes S
- Witter T
- Wolf M
- Wolff M
- Wong Y
- Wood B
- Wood CA
- Wood D
- Wood M
- Wray J
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- Yaguchi A
- Yaguchi A
- Yamaguchi O
- Yamaguchi O
- Yamaguchi Y
- Yamaguchi Y
- Yamamoto H
- Yamamoto N
- Yaman G
- Yamashita K
- Yamazaki A
- Yan WW
- Yan WW
- Yang JH
- Yang JS
- Yang YL
- Yasuda H
- Yatabe T
- Yebenes JC
- Yeh YC
- Yemets H
- Yergaliyeva A
- Yılmaz G
- Yilmazer F
- Yodice P
- Yokoyama M
- Yonis H
- Yonis H
- Yonis H
- Yoon SZ
- Yoruk F
- Yoshida K
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshihiro S
- Yoshitake E
- You KM
- Youn AM
- Young A
- Yu KM
- Yumoto T
- Yuzawa J
- Yuzawa J
- Zabaletta WJ
- Zabini D
- Zahorec M
- Zaien I
- Zakynthinos S
- Zanello M
- Zani D
- Zarantonello F
- Zayas B
- Zepeda EM
- Zeroual N
- Zerva L
- Zhang J
- Zhou JC
- Zhou JC
- Zhou JX
- Zhovnir V
- Zibandah N
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- Zimmerman J
- Zogheib E
- Zogheib E
- Zogheib E
- Zullino V
- Zwaag J
- ZĂœkovĂĄ I
- Ălvarez JT
- Ălvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Spontaneous Breathing in Early Acute Respiratory Distress Syndrome: Insights From the Large Observational Study to UNderstand the Global Impact of Severe Acute Respiratory FailurE Study
- Author
- Abad RD
- Abe T
- Abroug F
- Adams JC
- Adamsson RO
- Adolfsson A
- Aguilar RZ
- Aguirre JS
- Aguirre-Bermeo H
- Aisa TM
- Aisiku I
- Ajetunmobi OO
- Aker M
- Akyol OO
- Al Dorzi HM
- Al Jabbary AS
- Albaiceta GM
- Albarrak MM
- Albiero D
- Alda RS
- Alejandro RV
- Alexander P
- Algaba Ă
- Aliaga FA
- Alisasis AU
- Allan RM
- Allue RM
- Almekhlaf G
- Alonso JG
- Altaf W
- Alvarez AM
- Alvarez J
- Amin P
- Amir F
- Amor M
- An Y
- Andersen FH
- Andoh K
- Andruszkiewicz P
- Aneman A
- Antonelli MM
- AntĂŽnio ACP
- Aoki N
- Appelberg H
- Arabi Y
- Arabi YM
- Araujo AM
- Arizmendi A
- Arnal JM
- Artiga MJD
- Artigas A
- Ascoli A
- Au SM
- Avila LE
- Azad R
- Azevedo LC
- Baboi L
- Badie JC
- Bailey IM
- Bailey MB
- Bajwa E
- Balkhi H
- Baltus T
- Banner-Goodspeed VM
- Barberet G
- Baron RM
- Baronia AK
- Barratt-Due A
- Barros FM
- Barros NC
- Batra H
- Battle CE
- Bauer PR
- Beck E
- Beck O
- Bedreag OH
- Beegle SH
- Beitler JR
- Bellani G
- Bellani G.
- Beloncle F
- Ben Souissi A
- Benslama A
- Beraldo DO
- Berghe C
- Berkelmans F
- Besset SL
- Bettini LR
- Beuret P
- Bezzi MG
- Bhardwaj VK
- Bhowmick K
- Biehler J
- Bigot C
- Bihari S
- Biondi RS
- Biscione RR
- Bisso MC
- Black CS
- Blakeman TC
- Blanco J
- Bolon S
- Borello SA
- Borotto EE
- Botteri M
- Bouchoucha S
- Boukhazna M
- Bouw MJ
- Boyd O
- Bramall J
- Braschi A
- Brazzi L
- Breen DM
- Briquet A
- Brito VA
- Brizuela M
- Brochard L
- Brochard L.
- Broman LM
- Brown SM
- Browne TS
- Bruhn AR
- Brunettini B
- Bruns MM
- Buensuseso JA
- Bugedo G
- Buise MP
- Bulpa PA
- Bumbasierevic V
- Bumbasirevic V
- Burtenshaw AJ
- Burtin P
- Buzancais G
- BĂ©duneau G
- Camsooksai J
- Canestrini S
- Cani A
- Carbayo-Gorriz C
- Cardonnet LP
- Careless JP
- Carpentier D
- Carreño NG
- Carteaux G
- Casalena P
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- Castro AG
- Castro S
- Catorze NT
- Cazorla-Barranquero FG
- Ceniceros-Barros A
- Cereijo E
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- Cerrato VI
- Cesar PS
- Ceunen H
- Ceylan I
- Chabanne R
- Chapman R
- Chau SK
- Chelly J
- Chen K
- Chena A
- Cheng MP
- Chiche JD
- Chouchene I
- Choudry S
- Christiansen A
- Cimic N
- Cinnella G
- Cirone R
- CitalĂĄn JE
- Claraco-Vega LM
- Clarkson K
- Clarkson KP
- Claverias L
- Cohen JE
- Cole JM
- Collins DV
- Collyer T
- Colombo R
- Combaux DM
- Combes A
- Cooper R
- Coppadoro A
- Corneci DE
- Cortegiani A
- Cortez CA
- Coxo CM
- Cracchiolo AN
- Cranshaw JH
- Crapelli G
- Crouch DR
- Crova PJ
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- Curto EG
- Daldin J
- Dangers L
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- Daviaud F
- Davies KG
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- De Cima-Iglesias S
- De Gordoa LO
- De Haro C
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- Dean MN
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- Dellera C
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- Elisabet GM
- Elkhayari M
- Ellis HE
- Elmasri M
- Erbabacan E
- Eriksson KE
- Esteban A
- Estenssoro E
- Esteve F
- Estilita JM
- Estrella CR
- Eugenio Luis PS
- Ezzouine H
- Fan E
- Fan E.
- Fartoukh M
- FarĂas PA
- Fawkes DA
- Ferguson A
- Ferguson ND
- Fernandes ADV
- Fernandez AM
- Fernandez RO
- Fierro JM
- Floris L
- Follin A
- Fontenele DC
- Formenti P
- Forteza C
- Fossali T
- Foti G
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- Frati E
- Frendl G
- Frigyik AD
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- Futami S
- Gally J
- Ganesan D
- Gao Y
- Gao YN
- Garcia PH
- Gattinoni L
- Gazenkampf AA
- Gelée B
- George FG
- Ghazi M
- Gianinetto H
- Giarratano A
- Gillis S
- Girgin NK
- Gjedsted J
- Glietsch R
- Goldgran-Toledano D
- Goligher E. C.
- Goligher EC
- Gomaa D
- Gomaa D
- Gomes RM
- Gomez PE
- Gomez-Flores SS
- Gonzalez DR
- Gonzalez M
- GonzĂĄlez RM
- GonzĂĄlez Rojas MA
- GonzĂĄlez-Salamanca Ă
- Gonçalves CH
- Goodson JC
- Gordo F
- Gosselin RJ
- Goubaux B
- Graziani R
- Grelon F
- Griffin RO
- Grigoriev E
- Grijalba CQ
- Grissom CK
- Gritsan AI
- Grubissich N
- Gueret RM
- Gurjar M
- Guttormsen AB
- Guérin C
- GĂłmez PRA
- Hacking DJ
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- Hadfield D
- Hagan SJ
- Han H
- Han Y
- Hang AY
- Hanlon GC
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- Hashemian SM
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- Heunks LM
- Heunks LM
- Higashijima U
- Hirata A
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- Honda H
- Honrubia T
- Hopf HF
- Hopkins P
- Hormis AP
- Hou PC
- Hou SK
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- Hua MX
- Huang QQ
- Huang XB
- Huerta FP
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- Hurtado J
- Hurtado J
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- Hutton PJ
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- Ilaria Pattarino PT
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- Imma VP
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- Ismail D
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- Izawa M
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- Jarquin-Badiola YD
- Jassal M
- Javeed A
- Jha RR
- Jiang L
- Jibaja M
- Jimenez AG
- Jochmans S
- Jog SA
- Jovanovic B
- Judy C
- Jurado MT
- Kadaba V
- Kajtor I
- Kakar V
- Kalaitzis E
- Kalkoff M
- Kamel G
- Kameyama Y
- Kamoun S
- Kander T
- Kannan SG
- Kashiwa Y
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- Kennedy B
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- Kheir FM
- Kimura H
- Kiourtzieva EV
- Kitch BT
- Knapman KM
- Knoll J
- Knowles S
- Kol MR
- Kong J
- Koyama K
- KraĂler J
- Krstevski A
- Kulkarni S
- Kumar A
- Kurahashi K
- Kusumoto K
- Laake JH
- Laake JH
- Labarca EF
- Laffey J
- Laffey J.
- Laffey JG
- Lamb KD
- Lanspa MJ
- Larsson A
- Larsson A
- Larsson N
- Le Moal C
- Lebbinck H
- Lee J
- Leemann-Refondini C
- Lemiale V
- Lemus JS
- Leon Yoshido HH
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- Lynch J.
- Lynch JM
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- Macfadyen R
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- Mohammadreza Hashemian S
- Mohr NM
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- Oetting TW
- Ogino Y
- Oikonomou MA
- Okuda N
- Oldroyd MG
- Olga MF
- Oliveira BS
- Ortiz CA
- Osman EM
- Oss P
- Ouanes I
- Ourailogloy V
- Owens RL
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- Palaniswamy V
- Palma DM
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- Palo JE
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- Tabhan EE
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- Tibblin AO
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- Tomescu DR
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- Uchiyama A
- Ueda T
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- Unnikrishnan R
- Uppalapati A
- van Haren F
- van Haren F.
- Van Wezel HM
- Vargas MP
- Vascotto ER
- Vasquez DN
- Vega LD
- Veljovic M.
- Venti A
- Vercueil A
- Vermassen J
- Verstraete R
- Villagomez A
- Villagomez AJ
- Villamagua BG
- Villar V
- Vinzio M
- Virgilio CG
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- Woods PW
- Wrathall DW
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- Wrigge H
- Wrigge H.
- Wu YQ
- Xin-Hua Q
- Xu Y
- Yamaguchi O
- Yamaji Y
- Yao Q
- Ye ZL
- Yeatts DJ
- Yu R
- Yu T
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- Yumha JS
- Yuste LJ
- Zacharas GA
- Zacharowsk KD
- Zani G
- Zantua KS
- Zazu A
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- Zein SO
- Zender HO
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- Zhao XY
- Zheng R
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- Zhu BH
- Zhu WH
- Zogheib EH
- Ăamendys-Silva SA
- Ănal N
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2019
- Field of study
OBJECTIVES: To describe the characteristics and outcomes of patients with acute respiratory distress syndrome with or without spontaneous breathing and to investigate whether the effects of spontaneous breathing on outcome depend on acute respiratory distress syndrome severity. DESIGN: Planned secondary analysis of a prospective, observational, multicentre cohort study. SETTING: International sample of 459 ICUs from 50 countries. PATIENTS: Patients with acute respiratory distress syndrome and at least 2 days of invasive mechanical ventilation and available data for the mode of mechanical ventilation and respiratory rate for the 2 first days. INTERVENTIONS: Analysis of patients with and without spontaneous breathing, defined by the mode of mechanical ventilation and by actual respiratory rate compared with set respiratory rate during the first 48 hours of mechanical ventilation. MEASUREMENTS AND MAIN RESULTS: Spontaneous breathing was present in 67% of patients with mild acute respiratory distress syndrome, 58% of patients with moderate acute respiratory distress syndrome, and 46% of patients with severe acute respiratory distress syndrome. Patients with spontaneous breathing were older and had lower acute respiratory distress syndrome severity, Sequential Organ Failure Assessment scores, ICU and hospital mortality, and were less likely to be diagnosed with acute respiratory distress syndrome by clinicians. In adjusted analysis, spontaneous breathing during the first 2 days was not associated with an effect on ICU or hospital mortality (33% vs 37%; odds ratio, 1.18 [0.92-1.51]; p = 0.19 and 37% vs 41%; odds ratio, 1.18 [0.93-1.50]; p = 0.196, respectively ). Spontaneous breathing was associated with increased ventilator-free days (13 [0-22] vs 8 [0-20]; p = 0.014) and shorter duration of ICU stay (11 [6-20] vs 12 [7-22]; p = 0.04). CONCLUSIONS: Spontaneous breathing is common in patients with acute respiratory distress syndrome during the first 48 hours of mechanical ventilation. Spontaneous breathing is not associated with worse outcomes and may hasten liberation from the ventilator and from ICU. Although these results support the use of spontaneous breathing in patients with acute respiratory distress syndrome independent of acute respiratory distress syndrome severity, the use of controlled ventilation indicates a bias toward use in patients with higher disease severity. In addition, because the lack of reliable data on inspiratory effort in our study, prospective studies incorporating the magnitude of inspiratory effort and adjusting for all potential severity confounders are required
Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis of the LUNG SAFE database
- Author
- Abad Rd
- Abe T
- Abroug F
- Adams Jc
- Adamsson Ro
- Adolfsson A
- Aguilar Rz
- Aguirre Js
- Aguirre-Bermeo H
- Aisa Tm
- Aisiku I
- Ajetunmobi Oo
- Aker M
- Akyol Oo
- Al Dorzi Hm
- Al Jabbary As
- Albaiceta Gm
- Albarrak Mm
- Albiero D
- Alda Rs
- Alejandro Rv
- Alexander P
- Algaba Ă
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- Alisasis Au
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- Almekhlafi G
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- Andruszkiewicz P
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- Appelberg H
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- Venti A
- Vercueil A
- Vermassen J
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- Zogheib Eh
- Ăamendys-Silva Sa
- Ănal N
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Background: Diabetes mellitus is a common co-existing disease in the critically ill. Diabetes mellitus may reduce the risk of acute respiratory distress syndrome (ARDS), but data from previous studies are conflicting. The objective of this study was to evaluate associations between pre-existing diabetes mellitus and ARDS in critically ill patients with acute hypoxemic respiratory failure (AHRF). Methods: An ancillary analysis of a global, multi-centre prospective observational study (LUNG SAFE) was undertaken. LUNG SAFE evaluated all patients admitted to an intensive care unit (ICU) over a 4-week period, that required mechanical ventilation and met AHRF criteria. Patients who had their AHRF fully explained by cardiac failure were excluded. Important clinical characteristics were included in a stepwise selection approach (forward and backward selection combined with a significance level of 0.05) to identify a set of independent variables associated with having ARDS at any time, developing ARDS (defined as ARDS occurring after day 2 from meeting AHRF criteria) and with hospital mortality. Furthermore, propensity score analysis was undertaken to account for the differences in baseline characteristics between patients with and without diabetes mellitus, and the association between diabetes mellitus and outcomes of interest was assessed on matched samples. Results: Of the 4107 patients with AHRF included in this study, 3022 (73.6%) patients fulfilled ARDS criteria at admission or developed ARDS during their ICU stay. Diabetes mellitus was a pre-existing co-morbidity in 913 patients (22.2% of patients with AHRF). In multivariable analysis, there was no association between diabetes mellitus and having ARDS (OR 0.93 (0.78-1.11); p = 0.39), developing ARDS late (OR 0.79 (0.54-1.15); p = 0.22), or hospital mortality in patients with ARDS (1.15 (0.93-1.42); p = 0.19). In a matched sample of patients, there was no association between diabetes mellitus and outcomes of interest. Conclusions: In a large, global observational study of patients with AHRF, no association was found between diabetes mellitus and having ARDS, developing ARDS, or outcomes from ARDS. Trial registration: NCT02010073. Registered on 12 December 2013
Multi-messenger observations of a binary neutron star merger
- Author
- Aab A
- Aartsen MG
- Abbott BP
- Abbott R
- Abbott TD
- Abbott TMC
- Abdalla H
- Abe F
- Abeysekara AU
- Abramo LR
- Abramowski A
- Abreu P
- Acernese F
- Acero F
- Ackermann M
- Ackley K
- Ackley K
- Adams C
- Adams J
- Adams SM
- Adams T
- Addesso P
- Adhikari RX
- Adya VB
- Affeldt C
- Afrough M
- Agarwal B
- Agathos M
- Agatsuma K
- Aggarwal N
- Aglietta M
- Agliozzo C
- Agudo I
- Aguiar OD
- Aguilar JA
- Aharonian F
- Ahlers M
- Ahrens M
- Aiello L
- Ain A
- Ajith P
- Akras S
- Al Samarai I
- Albert A
- Albert A
- Albuquerque IFM
- Albury JM
- Alcaniz JS
- Alexander KD
- Alfaro R
- Alighieri S Di Serego
- Allam S
- Allekotte I
- Allen B
- Allen G
- Allison J
- Allison JR
- Allocca A
- Almela A
- Altin PA
- Altmann D
- Alvarez C
- Alvarez JD
- Alvarez M Dovale
- Alvarez-Muiz J
- Amati L
- Amato A
- An T
- Ananyeva A
- Anastasi GA
- Anchordoqui L
- Andeen K
- Anderson JP
- Anderson SB
- Anderson T
- Anderson WG
- Andrada B
- Andre M
- Andreoni I
- Andreoni I
- Andringa S
- Angelova SV
- Anghinolfi M
- Angner EO
- Angus CR
- Annis J
- Ansseau I
- Antier S
- Anton G
- Antonelli LA
- Antonelli LA
- Anupama GC
- Aoki K
- Aoki W
- Appert S
- Aptekar RL
- Arai K
- Arakawa M
- Aramo C
- Araya MC
- Arcavi I
- Arceo R
- Ardid M
- Areeda JS
- Aresu G
- Argan A
- Argelles C
- Arnaud N
- Array LWA Long Wavelength
- Array MWA Murchison Widefield
- Arrieta M
- Arsene N
- Arteaga-Velzquez JC
- Artola R
- Arun KG
- Asakura Y
- Asaoka Y
- Ascenzi S
- Ashall C
- Ashley MCB
- Ashton G
- Asorey H
- Assis P
- Ast M
- Aston SM
- Astone P
- Atallah DV
- ATLAS
- Atwood WB
- Aubert J-J
- Aubert P
- Aublin J
- Auffenberg J
- Aufmuth P
- Aulbert C
- AultONeal K
- Austin C
- Avgitas T
- Avila G
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- Awad A Kuotb
- Axani S
- Baar S
- Babak S
- Bachetti M
- Backes M
- Bacon P
- Bader MKM
- Badescu AM
- Bae S
- Bagherpour H
- Bai X
- Bailes M
- Baker PT
- Balaceanu A
- Balanutsa PV
- Balasubramanian A
- Balbinot E
- Baldaccini F
- Baldini L
- Ballardin G
- Ballmer SW
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- Bannister KW
- Barayoga JC
- Barbarino C
- Barbato F
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- Barsuglia M
- Barta D
- Barthelmy SD
- Bartlett J
- Bartos I
- Barway S
- Barway S
- Barwick SW
- Basa S
- Bassiri R
- Basti A
- Bastieri D
- Batch JC
- Bauer FE
- Bauer FE
- Baum V
- Bawaj M
- Bay R
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- Bazzan M
- Bazzano A
- Bchele M
- Beardmore AP
- Beardsley A
- Beatty JJ
- Becerril A
- Becherini Y
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- Bernardini MG
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- Bertin E
- Bertin V
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- Borner M
- Borodai N
- Bos F
- Boschi V
- Bose D
- Bose S
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- Botner O
- Bottacini E
- Bottcher M
- Botti AM
- Botticella MT
- Bouffanais Y
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- Bourbeau J
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- Bozzi A
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- Cano Z
- Cao H
- Cao J
- Cao XL
- Capaccioli M
- Capano CD
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- Caramete L
- Caraveo P
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- Carbognani F
- Carboni G
- Cardenas B Vargas
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- Chatterjee D
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- Coughlin M
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- Coutu S
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- Coward DM
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- Cowart MJ
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- Creusot A
- Cripe J
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- Drouhin D
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- El Bojaddaini I
- El Khayati N
- El Moursli R Cherkaoui
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- Elipe G Torralba
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- Fenu F
- Fermi GBM
- Fernandes MV
- Fernandez D
- Fernandez E
- Fernandez G Rodriguez
- Fernandez-Galiana A
- Feroci M
- Ferrante I
- Ferrari A
- Ferreira EC
- Ferrigno C
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- Fiori I
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- Frail DA
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- Fulda P
- Funk S
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- Furusawa H
- Fuschino F
- Fusco LA
- Fusco P
- Fuster A
- Fyffe M
- Fynbo JPU
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- Gadre BU
- Gaebel SM
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- Gaior R
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- Gal-Yam A
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- Ghia PL
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- Ghosh Abhirup
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- Goldstein A
- Goldstein DA
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- Golup G
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- Zimmerman AB
- Zimmermann B
- Zimnukhov DS
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- Zucker ME
- Zuniga J
- Zweizig J
- Zywucka N
- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transientâs position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
Epidemiology and patterns of tracheostomy practice in patients with acute respiratory distress syndrome in ICUs across 50 countries
- Author
- Abad RD
- Abe T
- Abe T.
- Abroug F
- Adams JC
- Adamsson RO
- Adolfsson A
- Aguilar RZ
- Aguirre JS
- Aguirre-Bermeo H
- Aisa TM
- Aisiku I
- Ajetunmobi OO
- Aker M
- Akyol OO
- Al Dorzi HM
- Al Jabbary AS
- Albaiceta GM
- Albarrak MM
- Albiero D
- Alda RS
- Alejandro RV
- Alexander P
- Algaba Ă
- Aliaga FA
- Alisasis AU
- Allan RM
- Allue RM
- Almekhlafi G
- Alonso JG
- Altaf W
- Alvarez AM
- Alvarez J
- Amin P
- Amir F
- Amor M
- An Y
- Andersen FH
- Andoh K
- Andruszkiewicz P
- Aneman A
- Antonelli MM
- AntĂŽnio ACP
- Aoki N
- Appelberg H
- Arabi Y
- Arabi YM
- Arabim YM
- Araujo AM
- Arizmendi A
- Arnal JM
- Artiga MJD
- Artigas A
- Ascoli A
- Au SM
- Avila LE
- Azad R
- Azevedo LC
- Baboi L
- Badie JC
- Bailey IM
- Bailey MB
- Bajwa E
- Balkhi H
- Baltus T
- Banner-Goodspeed VM
- Barberet G
- Baron RM
- Baronia AK
- Barratt-Due A
- Barros FM
- Barros NC
- Batra H
- Battle CE
- Bauer PR
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- Beck O
- Bedreag OH
- Beegle SH
- Beitler JR
- Bellani G
- Bellani G.
- Beloncle F
- Benslama A
- Beraldo DO
- Berghe C
- Berkelmans F
- Besset SL
- Bettini LR
- Beuret P
- Bezzi MG
- Bhardwaj VK
- Bhowmick K
- Biehler J
- Bigot C
- Bihari S
- Biondi RS
- Biscione RR
- Bisso MC
- Black CS
- Blakeman TC
- Blanco J
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Background: To better understand the epidemiology and patterns of tracheostomy practice for patients with acute respiratory distress syndrome (ARDS), we investigated the current usage of tracheostomy in patients with ARDS recruited into the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG-SAFE) study. Methods: This is a secondary analysis of LUNG-SAFE, an international, multicenter, prospective cohort study of patients receiving invasive or noninvasive ventilation in 50 countries spanning 5 continents. The study was carried out over 4 weeks consecutively in the winter of 2014, and 459 ICUs participated. We evaluated the clinical characteristics, management and outcomes of patients that received tracheostomy, in the cohort of patients that developed ARDS on day 1-2 of acute hypoxemic respiratory failure, and in a subsequent propensity-matched cohort. Results: Of the 2377 patients with ARDS that fulfilled the inclusion criteria, 309 (13.0%) underwent tracheostomy during their ICU stay. Patients from high-income European countries (n = 198/1263) more frequently underwent tracheostomy compared to patients from non-European high-income countries (n = 63/649) or patients from middle-income countries (n = 48/465). Only 86/309 (27.8%) underwent tracheostomy on or before day 7, while the median timing of tracheostomy was 14 (Q1-Q3, 7-21) days after onset of ARDS. In the subsample matched by propensity score, ICU and hospital stay were longer in patients with tracheostomy. While patients with tracheostomy had the highest survival probability, there was no difference in 60-day or 90-day mortality in either the patient subgroup that survived for at least 5 days in ICU, or in the propensity-matched subsample. Conclusions: Most patients that receive tracheostomy do so after the first week of critical illness. Tracheostomy may prolong patient survival but does not reduce 60-day or 90-day mortality. Trial registration: ClinicalTrials.gov, NCT02010073. Registered on 12 December 2013
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- Abdel-Aziz AK
- Abdelfatah S
- Abdellatif M
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- Yang P-M
- Yang Q
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- Yang S-F
- Yang W
- Yang WY
- Yang X
- Yang X
- Yang Y
- Yang Y
- Yao H
- Yao S
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- Yao Y-G
- Yao Y-M
- Yasui T
- Yazdankhah M
- Yen PM
- Yi C
- Yi-Ren Hong C-WH
- Yin X-M
- Yin Y
- Yin Z
- Yin Z
- Ying M
- Ying Z
- Yip CK
- Yiu SPT
- Yoo YH
- Yoshida K
- Yoshii SR
- Yoshimori T
- Yousefi B
- Yu B
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- Yu M-L
- Yu S-W
- Yu VC
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- Yue J
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- Yun J
- Yung RL
- Zacks DN
- Zaffagnini G
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- Zang QS
- Zanivan S
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- Zarrouk A
- Zeitlin SO
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- Zhang H-L
- Zhang J
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- Zhang J-P
- Zhang KYB
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- Zhang LW
- Zhang M
- Zhang P
- Zhang S
- Zhang W
- Zhang X
- Zhang X
- Zhang X
- Zhang X
- Zhang X
- Zhang X-W
- Zhang XD
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Y-D
- Zhang Y-Y
- Zhang Z
- Zhang Z
- Zhang Z
- Zhang Z
- Zhang Z
- Zhang Z
- Zhao H
- Zhao L
- Zhao S
- Zhao T
- Zhao X-F
- Zhao Y
- Zhao Y
- Zhao Y
- Zhao Y
- Zheng G
- Zheng K
- Zheng L
- Zheng S
- Zheng X-L
- Zheng Y
- Zheng Z-G
- Zhivotovsky B
- Zhong Q
- Zhou A
- Zhou B
- Zhou C
- Zhou G
- Zhou H
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- Zhou H
- Zhou J
- Zhou J
- Zhou J
- Zhou J
- Zhou K
- Zhou R
- Zhou X-J
- Zhou Y
- Zhou Y
- Zhou Y
- Zhou Z
- Zhou Z-Y
- Zhu B
- Zhu C
- Zhu G-Q
- Zhu H
- Zhu H
- Zhu H
- Zhu W-G
- Zhu Y
- Zhu Y
- Zhuang H
- Zhuang X
- Zientara-Rytter K
- Zimmermann CM
- Ziviani E
- Zoladek T
- Zong W-X
- Zorov DB
- Zorzano A
- Zou W
- Zou Z
- Zou Z
- Zuryn S
- Zwerschke W
- Ălvarez ĂMC
- Ăvalos Y
- Ănal G
- ĂstĂŒn S
- ÄoliÄ M
- ÄokiÄ J
- Ćœerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Toward greener supply chains: is there a role for the new ISO 50001 approach to energy and carbon management?
- Author
- A Ahsen
- A HalldĂłrsson
- A Tognetti
- AB Jabbour
- AC Faruk
- Ana Beatriz Lopes de Sousa Jabbour
- B Shen
- B Sundarakani
- Charbel José Chiappetta Jabbour
- CJC Jabbour
- CM Harland
- D Nawrocka
- D Nawrocka
- D Nawrocka
- D Ărge-Vorsatz
- EWT Ngai
- G Siciliano
- H Min
- J Sarkis
- J Sarkis
- K Bruton
- K Bunse
- K Lee
- K Nishitani
- KH Lee
- Lucila S. Campos
- MT Johansson
- N Darnall
- O Michelsen
- P Karcher
- Q Zhu
- Q Zhu
- Q Zhu
- R Dubey
- R Kannan
- R Sada
- Rosani De Castro
- RR Lummus
- S Rahbauer
- SA Ates
- SK Srivastava
- SL Golicic
- SL Hart
- SĂlvio Aparecido VerdĂ©rio JĂșnior
- TH Arimura
- TY Chan
- V Oikonomou
- Walter Leal Filho
- Y Hongjuan
- Y Oshita
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
© 2016, The Author(s). Considering the increased interest of stakeholders in climate change and a low-carbon economy, this article has investigated and identified several contributions of the ISO 50001 in support of the adoption of green supply chain management (GSCM). In this context, energy efficiency and reduced CO 2 emissions are critical. Therefore, the proposal for and the requirements of ISO 50001 can generate useful insights on how to structure green and low-carbon supply chains, hence helping to address the challenges posed by climate change
A next-generation liquid xenon observatory for dark matter and neutrino physics
- Author
- Aalbers J
- AbdusSalam SS
- Abe K
- Aerne V
- Agostini F
- Ahmed Maouloud S
- Akerib DS
- Akimov DY
- Akshat J
- Al Musalhi AK
- Alder F
- Alsum SK
- Althueser L
- Amarasinghe CS
- Amaro FD
- Ames A
- Anderson TJ
- Andrieu B
- Angelides N
- Angelino E
- Angevaare J
- Antochi VC
- Antunovic B
- AntĂłn Martin D
- Aprile E
- AraĂșjo HM
- Armstrong JE
- Arneodo F
- Arthurs M
- Asadi P
- Baek S
- Bai X
- Bajpai D
- Baker A
- Balajthy J
- Balashov S
- Balzer M
- Bandyopadhyay A
- Bang J
- Barberio E
- Bargemann JW
- Baudis L
- Bauer D
- Baur D
- Baxter A
- Baxter AL
- Bazyk M
- Beattie K
- Behrens J
- Bell NF
- Bellagamba L
- Beltrame P
- Benabderrahmane M
- Bernard EP
- Bertone GF
- Bhattacharjee P
- Bhatti A
- Biekert A
- Biesiadzinski TP
- Binau AR
- Biondi R
- Biondi Y
- Birch HJ
- Bishara F
- Bismark A
- Blanco C
- Blockinger GM
- Bodnia E
- Boehm C
- Bolozdynya AI
- Bolton PD
- Bottaro S
- Bourgeois C
- Boxer B
- Breskin A
- Breur PA
- Brew CAJ
- Brod J
- Brookes E
- Brown A
- Brown E
- Bruenner S
- Bruno G
- BrĂĄs P
- Budnik R
- Bui TK
- Burdin S
- Buse S
- Busenitz JK
- Buttazzo D
- Buuck M
- Buzulutskov A
- Cabrita R
- Cai C
- Cai D
- Capelli C
- Cardoso JMR
- Carmona-Benitez MC
- Cascella M
- Catena R
- Chakraborty S
- Chan C
- Chang S
- Chauvin A
- Chawla A
- Chen H
- Chepel V
- Chott NI
- Cichon D
- Cimental Chavez A
- Cimmino B
- Clark M
- Co RT
- Colijn AP
- Conrad J
- Converse MV
- Costa M
- Cottle A
- Cox G
- Creaner O
- Cuenca Garcia JJ
- Cussonneau JP
- Cutter JE
- Dahl CE
- David A
- de GouvĂȘa A
- de Viveiros L
- Decowski MP
- Dent JB
- Deppisch FF
- Di Gangi P
- Di Giovanni A
- Di Pede S
- Dierle J
- Diglio S
- Dobson JEY
- Doerenkamp M
- dos Santos JMF
- Douillet D
- Drexlin G
- Druszkiewicz E
- Dunsky D
- DâAndrea V
- Eitel K
- Elykov A
- Emken T
- Engel R
- Eriksen SR
- Fairbairn M
- Fan A
- Fan JJ
- Farrell SJ
- Fayer S
- Fearon NM
- Ferella A
- Ferrari C
- Fieguth A
- Fieguth A
- Fiorucci S
- Fischer H
- Flaecher H
- Flierman M
- Florek T
- Foot R
- Fox PJ
- Franceschini R
- Fraser ED
- Frenk CS
- Frohlich S
- Fruth T
- Fulgione W
- Fuselli C
- Gaemers P
- Gaior R
- Gaitskell RJ
- Galloway M
- Gao F
- Garcia Garcia I
- Genovesi J
- Ghag C
- Ghosh S
- Gibson E
- Gil W
- Giovagnoli D
- Girard F
- Glade-Beucke R
- GlĂŒck F
- Gokhale S
- Grandi L
- Grigat J
- Grinstein B
- GrĂĄf L
- Grössle R
- Guan H
- Guida M
- Gumbsheimer R
- Gwilliam CB
- Hall CR
- Hall LJ
- Hammann R
- Han K
- Hannen V
- Hansmann-Menzemer S
- Harata R
- Hardin SP
- Hardy CA
- Hardy E
- Harigaya K
- Harnik R
- Haselschwardt SJ
- Hernandez M
- Hertel SA
- Higuera A
- Hils C
- Hochrein S
- Hoetzsch L
- Hoferichter M
- Hood N
- Hooper D
- Horn M
- Howlett J
- Huang DQ
- Huang Y
- Hunt D
- Iacovacci M
- Iaquaniello G
- Ide R
- Ignarra CM
- Iloglu G
- Itow Y
- Jacquet E
- Jahangir O
- Jakob J
- James RS
- Jansen A
- Ji W
- Ji X
- Joerg F
- Johnson J
- Joy A
- Kaboth AC
- Kalhor L
- Kamaha AC
- Kanezaki K
- Kar K
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- Kazama S
- Keaveney AW
- Kellerer J
- Khaitan D
- Khazov A
- Khundzakishvili G
- Khurana I
- Kilminster B
- Kleifges M
- Ko P
- Kobayashi M
- Kodroff D
- Koltmann G
- Kopec A
- Kopmann A
- Kopp J
- Korley L
- Kornoukhov VN
- Korolkova EV
- Kraus H
- Krauss LM
- Kravitz S
- Kreczko L
- Kudryavtsev VA
- Kuger F
- Kumar J
- LaCascio L
- Laha R
- Laine Q
- Landsman H
- Lang RF
- Leason EA
- Lee J
- Leonard DS
- Lesko KT
- Levinson L
- Levy C
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- Liang S
- Liebenthal CS
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- Lindemann S
- Lindner M
- Lindote A
- Linehan R
- Lippincott WH
- Liu J
- Liu K
- Liu X
- Loizeau J
- Lombardi F
- Long J
- Lopes MI
- Lopez Asamar E
- Lorenzon W
- Lu C
- Luitz S
- LĂłpez Paredes B
- Ma Y
- Machado PAN
- Macolino C
- Maeda T
- Mahlstedt J
- Majewski PA
- Manalaysay A
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- Manfredini A
- Mannino RL
- Marangou N
- March-Russell J
- Marignetti F
- MarrodĂĄn Undagoitia T
- Martens K
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- Martinez-Soler I
- Masbou J
- Masson D
- Masson E
- Mastroianni S
- Mastronardi M
- Matias-Lopes JA
- McCarthy ME
- McFadden N
- McGinness E
- McKinsey DN
- McLaughlin J
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- Meinhardt P
- Meng Y
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- Midha R
- Milisavljevic D
- Miller EH
- Milosevic B
- Milutinovic S
- Mitra SA
- Miuchi K
- Mizrachi E
- Mizukoshi K
- Molinario A
- Monte A
- Monteiro CMB
- Monzani ME
- Moore JS
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- Morteau E
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- Naylor A
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- Nelson HN
- Neves F
- Newstead JL
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- Obradovic M
- Odgers K
- Oikonomou P
- Olcina I
- Oliver-Mallory K
- Oranday A
- Orpwood J
- Ostrovskiy I
- Ozaki K
- OâHare CAJ
- Paetsch B
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- Palacio J
- Palladino KJ
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- Parlati A
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- Patton SJ
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- Penning B
- Pereira G
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- Perry E
- Pershing T
- Petrossian-Byrne R
- Pienaar J
- Piepke A
- Pieramico G
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- Porzio D
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- Qi J
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- Quevedo F
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- Rajado Silva M
- Ramanathan K
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- Redigolo D
- Reichard S
- Reichenbacher J
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- Rischbieter GRC
- Rocchetti A
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- Rosero R
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- Rushton T
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- Sparmann TJ
- Stancu I
- Steidl M
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- Strigari LE
- Subotic D
- Suerfu B
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- Sumner TJ
- Szabo P
- Szydagis M
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- Takeuchi Y
- Tan P-L
- Taricco C
- Taylor WC
- Temples DJ
- Terliuk A
- Terman PA
- Thers D
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- ThĂŒmmler T
- Tiedt DR
- Timalsina M
- To WH
- Toennies F
- Tong Z
- Toschi F
- Tovey DR
- Tranter J
- Trask M
- Trinchero GC
- Tripathi M
- Tronstad DR
- Trotta R
- Tsai YD
- Tunnell CD
- Turner WG
- Ueno R
- Urquijo P
- Utku U
- Vaitkus A
- Valerius K
- van der Grinten MGD
- Vassilev E
- Vecchi S
- Velan V
- Vetter S
- Vincent AC
- Vittorio L
- Volta G
- von Krosigk B
- von Piechowski M
- Vorkapic D
- Wagner CEM
- Wang AM
- Wang B
- Wang JJ
- Wang L-T
- Wang M
- Wang W
- Wang Y
- Wang Y
- Watson JR
- Wei Y
- Weinheimer C
- Weisman E
- Weiss M
- Wenz D
- West SM
- Whitis TJ
- Williams M
- Wilson MJ
- Winkler D
- Wittweg C
- Wolf J
- Wolf T
- Wolfs FLH
- Woodford S
- Woodward D
- Wright CJ
- Wu P
- Wu VHS
- Wurm M
- WĂŒstling S
- Xia Q
- Xiang X
- Xing Y
- Xu D
- Xu J
- Xu Z
- Yamashita M
- Yamazaki R
- Yan H
- Yang L
- Yang Y
- Ye J
- Yeh M
- Young I
- Yu HB
- Yu TT
- Yuan L
- Zavattini G
- Zerbo S
- Zhang Y
- Zhong M
- Zhou N
- Zhou X
- Zhu T
- Zhu Y
- Zhuang Y
- Zopounidis JP
- Zuber K
- Zupan J
- Ć imkovic F
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2023
- Field of study
The nature of dark matter and properties of neutrinos are among the most pressing issues in contemporary particle physics. The dual-phase xenon time-projection chamber is the leading technology to cover the available parameter space for weakly interacting massive particles, while featuring extensive sensitivity to many alternative dark matter candidates. These detectors can also study neutrinos through neutrinoless double-beta decay and through a variety of astrophysical sources. A next-generation xenon-based detector will therefore be a true multi-purpose observatory to significantly advance particle physics, nuclear physics, astrophysics, solar physics, and cosmology. This review article presents the science cases for such a detector
The presence and absence of periplasmic rings in bacterial flagellar motors correlates with stator type.
- Author
- Publication venue
- 'eLife Sciences Publications, Ltd'
- Publication date
- 16/01/2019
- Field of study
The bacterial flagellar motor, a cell-envelope-embedded macromolecular machine that functions as a cellular propeller, exhibits significant structural variability between species. Different torque-generating stator modules allow motors to operate in different pH, salt or viscosity levels. How such diversity evolved is unknown. Here, we use electron cryo-tomography to determine the in situ macromolecular structures of three Gammaproteobacteria motors: Legionella pneumophila, Pseudomonas aeruginosa, and Shewanella oneidensis, providing the first views of intact motors with dual stator systems. Complementing our imaging with bioinformatics analysis, we find a correlation between the motor's stator system and its structural elaboration. Motors with a single H+-driven stator have only the core periplasmic P- and L-rings; those with dual H+-driven stators have an elaborated P-ring; and motors with Na+ or Na+/H+-driven stators have both their P- and L-rings embellished. Our results suggest an evolution of structural elaboration that may have enabled pathogenic bacteria to colonize higher-viscosity environments in animal hosts
Calling cell biologists to try cryo-ET
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
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