52 research outputs found
CRT-112 “Very” Very Late Stent Thrombosis: Acute Myocardial Infarction From Drug Eluting Stent Thrombosis Occurring Greater Than 5 Years Post-Implantation
Photosensitizer Drug Delivery via an Optical Fiber
: An optical fiber has been developed with a maneuverable miniprobe tip that sparges O2 gas and photodetaches pheophorbide (sensitizer) molecules. Singlet oxygen is produced at the probe tip surface which reacts with an alkene spacer group releasing sensitizer upon fragmentation of a dioxetane intermediate. Optimal sensitizer photorelease occurred when the probe tip was loaded with 60 nmol sensitizer, where crowding of the pheophorbide molecules and self-quenching were kept to a minimum. The fiber optic tip delivered pheophorbide molecules and singlet oxygen to discrete locations. The 60 nmol sensitizer was delivered into petrolatum; however, sensitizer release was less efficient in toluene-d8 (3.6 nmol) where most had remained adsorbed on the probe tip, even after the covalent alkene spacer bond had been broken. The results open the door to a new area of fiber optic-guided sensitizer delivery for the potential photodynamic therapy of hypoxic structures requiring cytotoxic control
A review of 3D first-pass, whole-heart, myocardial perfusion cardiovascular magnetic resonance
TCT-551 Prophylactic Use of Intracoronary Nicardipine in Conjunction with Distal Protection Devices During Vein Graft Intervention: Synergistic Effect of Combining Drugs and Devices
CRT-112 “Very” Very Late Stent Thrombosis: Acute Myocardial Infarction From Drug Eluting Stent Thrombosis Occurring Greater Than 5 Years Post-Implantation
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