Developing High Entropy Alloys for Nuclear Applications

High entropy alloys (HEAs) were developed for their desirability of strength, hardness, and corrosion, wear, and radiation resistance. This makes them ideal for nuclear applications in advanced reactors. High entropy alloys are characterized as alloys containing at least 5 principal elements, each with an atomic percentage between 5 and 35% [1]. A process for fabrication and characterization of these alloys entails ball milling and spark plasma sintering (SPS), then characterization tools such as x-ray diffraction (XRD) and scanning electron microscopy (SEM). [1] D. B. Miracle and O. N. Senkov, “A critical review of high entropy alloys and related concepts,” Acta materialia, vol. 122, pp. 448-511, 2017

The role of the aryl hydrocarbon receptor-interacting protein gene in familial

CONTEXT: Mutations have been identified in the aryl hydrocarbon receptor-interacting protein (AIP) gene in familial isolated pituitary adenomas (FIPA). It is not clear, however, how this molecular chaperone is involved in tumorigenesis. OBJECTIVE: AIP sequence changes and expression were studied in FIPA and sporadic adenomas. The function of normal and mutated AIP molecules was studied on cell proliferation and protein-protein interaction. Cellular and ultrastructural AIP localization was determined in pituitary cells. PATIENTS: Twenty-six FIPA kindreds and 85 sporadic pituitary adenoma patients were included in the study. RESULTS: Nine families harbored AIP mutations. Overexpression of wild-type AIP in TIG3 and HEK293 human fibroblast and GH3 pituitary cell lines dramatically reduced cell proliferation, whereas mutant AIP lost this ability. All the mutations led to a disruption of the protein-protein interaction between AIP and phosphodiesterase-4A5. In normal pituitary, AIP colocalizes exclusively with GH and prolactin, and it is found in association with the secretory vesicle, as shown by double-immunofluorescence and electron microscopy staining. In sporadic pituitary adenomas, however, AIP is expressed in all tumor types. In addition, whereas AIP is expressed in the secretory vesicle in GH-secreting tumors, similar to normal GH-secreting cells, in lactotroph, corticotroph, and nonfunctioning adenomas, it is localized to the cytoplasm and not in the secretory vesicles. CONCLUSIONS: Our functional evaluation of AIP mutations is consistent with a tumor-suppressor role for AIP and its involvement in familial acromegaly. The abnormal expression and subcellular localization of AIP in sporadic pituitary adenomas indicate deranged regulation of this protein during tumorigenesis

[Christian pamphlets. Vol. 3]

1 v. : ill. ; 23 cm.American Board of Commissioners for Foreign Missions / A.P. Peabody -- Sketches of missions / S.C. Bartlettt -- Plea for foreign missions / S.C. Bartlett -- Will Christianity prevail in India? / E. Bissell -- Ordination of missionaries -- Dr. Anderson's work on the Hawaiian Islands / A.P. Peabody -- Personal piety as related to the missionary work / A.D. Smith -- Christianity designed for the world / W. Adams -- Motives to the missionary work.E.L. Cleaveland -- Missionary enterprise a true development of the life of the church / J.B. Condit -- Home missions / A. Barnes -- Man's duty, in relation to the Lord's work / R.S. Storrs -- Our country for the sake of the world / D. H. Riddle -- American church / L. Bacon -- Catalytic power of the gospel / e. Hitchcock -- Nation saved from its prosperity only by the gospel / L.P. Hickok -- Home missions / R.S. Storrs -- American emigration / J.M. Sturtevant -- Missionary a witness for Christ / J.B. Shaw -- Work, and the workemen / W.T. Dwight -- Home missionary

[Christian pamphlets.

E.L. Cleaveland -- Missionary enterprise a true development of the life of the church / J.B. Condit -- Home missions / A. Barnes -- Man's duty, in relation to the Lord's work / R.S. Storrs -- Our country for the sake of the world / D. H. Riddle -- American church / L. Bacon -- Catalytic power of the gospel / e. Hitchcock -- Nation saved from its prosperity only by the gospel / L.P. Hickok -- Home missions / R.S. Storrs -- American emigration / J.M. Sturtevant -- Missionary a witness for Christ / J.B. Shaw -- Work, and the workemen / W.T. Dwight -- Home missionary.American Board of Commissioners for Foreign Missions / A.P. Peabody -- Sketches of missions / S.C. Bartlettt -- Plea for foreign missions / S.C. Bartlett -- Will Christianity prevail in India? / E. Bissell -- Ordination of missionaries -- Dr. Anderson's work on the Hawaiian Islands / A.P. Peabody -- Personal piety as related to the missionary work / A.D. Smith -- Christianity designed for the world / W. Adams -- Motives to the missionary work.Mode of access: Internet