Desarrollo de un Modelo 3D para un Sistema Infotainment

At present, we are witnessing the constant advance in the development of technologies for the automotive industry. Every day, there are significant advances and improvements to provide greater comfort to passengers. One of the vehicle technologies that are especially under development is designing specific user interfaces for infotainment systems and different types of interaction, for example, the implementation of 3D user interfaces to provide feedback to the user. These interfaces can be created from technologies available on the market, both free and private software for designing 3D models, and the development of Human Machine Interfaces used in the automotive industry. This article describes the process followed to develop a functional interface from technologies for 3D modeling and interface design. This interface provides visual feedback to the user that allows understanding of what is happening in the vehicle.En la actualidad somos testigos del constante avance en el desarrollo de tecnologías para la industria automotriz donde cada día hay avances y mejoras significativas para brindar mayor comodidad a los pasajeros. Una de las tecnologías del vehículo que está especialmente en desarrollo es el diseño de interfaces de usuario específicas para sistemas infotainment y diferentes tipos de interacción, por ejemplo, la implementación de interfaces de usuario 3D para proporcionar retroalimentación al usuario. Estas interfaces se pueden crear a partir de tecnologías disponibles en el mercado, tanto de software libre como privado para el diseño de modelos 3D y para el desarrollo de Interfaces Humano Máquina utilizados en la industria automotriz. Este artículo describe el proceso que se llevó a cabo para el desarrollo de una interfaz funcional a partir de tecnologías para el modelado 3D y diseño de interfaces. Dicha interfaz proporciona una retroalimentación visual al usuario que permite comprender lo que sucede en el vehículo

Maternal dietary patterns and acute leukemia in infants: results from a case control study in Mexico

BackgroundChildhood cancer is the leading cause of disease-related mortality among children aged 5–14 years in Mexico, with acute leukemia being the most common cancer among infants. Examining the overall dietary patterns allows for a comprehensive assessment of food and nutrient consumption, providing a more predictive measure of disease risk than individual foods or nutrients. This study aims to evaluate the association between maternal dietary patterns during pregnancy and the risk of acute leukemia in Mexican infants.MethodsA hospital-based case–control study was conducted, comparing 109 confirmed acute leukemia cases with 152 age-matched controls. All participants (≤24 months) were identified at hospitals in Mexico City between 2010 and 2019. Data on a posteriori dietary patterns and other relevant variables were collected through structured interviews and dietary questionnaires. Multivariate logistic regression was employed to estimate the association between maternal dietary patterns during pregnancy and the risk of acute leukemia in infants.ResultsThe “Balanced & Vegetable-Rich” pattern, characterized by a balanced consumption of various food groups and higher vegetable intake, exhibited a negative association with acute leukemia when compared to the “High Dairy & Cereals” Pattern (adjusted odds ratio [OR] = 0.51; 95% confidence interval [CI]: 0.29, 0.90). We observed that mothers who gave birth to girls and adhered to a healthy dietary pattern during pregnancy exhibited significantly lower odds of their children developing AL compared to those who gave birth to boys [OR = 0.32 (95% CI 0.11, 0.97)]. Our results underscore the significance of maternal nutrition as a modifiable factor in disease prevention and the importance of prenatal health education

Multi-messenger observations of a binary neutron star merger

On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

Approaching Optimal Nonlinear Dimensionality Reduction by a Spiking Neural Network

This work deals with the presentation of a spiking neural network as a means for efficiently solving the reduction of dimensionality of data in a nonlinear manner. The underneath neural model, which can be integrated as neuromorphic hardware, becomes suitable for intelligent processing in edge computing within Internet of Things systems. In this sense, to achieve a meaningful performance with a low complexity one-layer spiking neural network, the training phase uses the metaheuristic Artificial Bee Colony algorithm with an objective function from the principals in the machine learning science, namely, the modified Stochastic Neighbor Embedding algorithm. To demonstrate this fact, complex benchmark data were used and the results were compared with those generated by a reference network with continuous-sigmoid neurons. The goal of this work is to demonstrate via numerical experiments another method for training spiking neural networks, where the used optimizer comes from metaheuristics. Therefore, the key issue is defining the objective function, which can relate optimally the information at both sides of the spiking neural network. Certainly, machine learning techniques have advanced in defining efficient loss functions that can become suitable objective function candidates in the metaheuristic training phase. The practicality of these ideas is shown in this article. We use MSE values for evaluating the relative quality of the results and also co-ranking matrices

Desarrollo de un Modelo 3D para un Sistema Infotainment

At present, we are witnessing the constant advance in the development of technologies for the automotive industry. Every day, there are significant advances and improvements to provide greater comfort to passengers. One of the vehicle technologies that are especially under development is designing specific user interfaces for infotainment systems and different types of interaction, for example, the implementation of 3D user interfaces to provide feedback to the user. These interfaces can be created from technologies available on the market, both free and private software for designing 3D models, and the development of Human Machine Interfaces used in the automotive industry. This article describes the process followed to develop a functional interface from technologies for 3D modeling and interface design. This interface provides visual feedback to the user that allows understanding of what is happening in the vehicle.En la actualidad somos testigos del constante avance en el desarrollo de tecnologías para la industria automotriz donde cada día hay avances y mejoras significativas para brindar mayor comodidad a los pasajeros. Una de las tecnologías del vehículo que está especialmente en desarrollo es el diseño de interfaces de usuario específicas para sistemas infotainment y diferentes tipos de interacción, por ejemplo, la implementación de interfaces de usuario 3D para proporcionar retroalimentación al usuario. Estas interfaces se pueden crear a partir de tecnologías disponibles en el mercado, tanto de software libre como privado para el diseño de modelos 3D y para el desarrollo de Interfaces Humano Máquina utilizados en la industria automotriz. Este artículo describe el proceso que se llevó a cabo para el desarrollo de una interfaz funcional a partir de tecnologías para el modelado 3D y diseño de interfaces. Dicha interfaz proporciona una retroalimentación visual al usuario que permite comprender lo que sucede en el vehículo

Hyperlipidemic microenvironment conditionates damage mechanisms in human chondrocytes by oxidative stress

Abstract Background Currently, two pathogenic pathways describe the role of obesity in osteoarthritis (OA); one through biomechanical stress, and the other by the contribution of systemic inflammation. The aim of this study was to evaluate the effect of free fatty acids (FFA) in human chondrocytes (HC) expression of proinflammatory factors and reactive oxygen species (ROS). Methods HC were exposed to two different concentrations of FFA in order to evaluate the secretion of adipokines through cytokines immunoassays panel, quantify the protein secretion of FFA-treated chondrocytes, and fluorescent cytometry assays were performed to evaluate the reactive oxygen species (ROS) production. Results HC injury was observed at 48 h of treatment with FFA. In the FFA-treated HC the production of reactive oxygen species such as superoxide radical, hydrogen peroxide, and the reactive nitrogen species increased significantly in a at the two-dose tested (250 and 500 μM). In addition, we found an increase in the cytokine secretion of IL-6 and chemokine IL-8 in FFA-treated HC in comparison to the untreated HC. Conclusion In our in vitro model of HC, a hyperlipidemia microenvironment induces an oxidative stress state that enhances the inflammatory process mediated by adipokines secretion in HC