84 research outputs found
Amerind Ancestry, Socioeconomic Status and the Genetics of Type 2 Diabetes in a Colombian Population
- Author
- AL Price
- AL Price
- Alberto Villegas
- Alkes Price
- Andrés Ruiz-Linares
- Arti Tandon
- BF Voight
- Constanza Duque
- Cátira Bortolini
- D De Ferranti
- David Reich
- DC Benyshek
- DD Campbell
- Dennis O’Rourke
- Desmond D. Campbell
- E Zeggini
- E Zeggini
- EJ Parra
- G Bedoya
- Gabriel Bedoya
- H King
- H Unoki
- J Diamond
- JC Florez
- JV Neel
- K Yasuda
- KM Waters
- LG Carvajal-Carmona
- LG Carvajal-Carmona
- LI Gardner Jr
- Liliana Franco
- LJ Scott
- M Stumvoll
- Maria V. Parra
- Mark I. McCarthy
- MT Villarreal-Molina
- N Patterson
- Natalia Gallego
- NR Burrows
- P Aschner
- R Chakraborty
- R Saxena
- RC Williams
- S Wang
- TM Pollard
- Tábita Hünemeier
- VL Martinez-Marignac
- WC Knowler
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2012
- Field of study
The “thrifty genotype” hypothesis proposes that the high prevalence of type 2 diabetes (T2D) in Native Americans and admixed Latin Americans has a genetic basis and reflects an evolutionary adaptation to a past low calorie/high exercise lifestyle. However, identification of the gene variants underpinning this hypothesis remains elusive. Here we assessed the role of Native American ancestry, socioeconomic status (SES) and 21 candidate gene loci in susceptibility to T2D in a sample of 876 T2D cases and 399 controls from Antioquia (Colombia). Although mean Native American ancestry is significantly higher in T2D cases than in controls (32% v 29%), this difference is confounded by the correlation of ancestry with SES, which is a stronger predictor of disease status. Nominally significant association (P<0.05) was observed for markers in: TCF7L2, RBMS1, CDKAL1, ZNF239, KCNQ1 and TCF1 and a significant bias (P<0.05) towards OR>1 was observed for markers selected from previous T2D genome-wide association studies, consistent with a role for Old World variants in susceptibility to T2D in Latin Americans. No association was found to the only known Native American-specific gene variant previously associated with T2D in a Mexican sample (rs9282541 in ABCA1). An admixture mapping scan with 1,536 ancestry informative markers (AIMs) did not identify genome regions with significant deviation of ancestry in Antioquia. Exclusion analysis indicates that this scan rules out ∼95% of the genome as harboring loci with ancestry risk ratios >1.22 (at P < 0.05)
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Functional mapping of brain synapses by the enriching activity-marker SynaptoZip
- Author
- A Arena
- A Cetin
- A Follenzi
- A Malgaroli
- A Reiner
- AE Cohen
- B Ceccarelli
- B Granseth
- B Ward
- BE Hetzler
- BF Fosque
- BG Wilhelm
- DS Lorrain
- DS Richardson
- E Grote
- EK O’Shea
- EM Schneider Gasser
- EN Brown
- ES Boyden
- G Grigoryan
- G Miesenböck
- GMI Chowdhury
- H Park
- J Balaji
- J Fölling
- J Lamanna
- JB Kaplan
- JS Marvin
- K Deisseroth
- K Kraszewski
- L Luo
- L Tian
- LA Elferink
- LG Reijmers
- LJ Macpherson
- MY Mastakov
- MZ Lin
- NA O’Rourke
- P Zanos
- RH Chow
- S Karunanithi
- S Peron
- S Sankaranarayanan
- S Takamori
- S Watanabe
- SD Antic
- TA Ryan
- TA Zolnik
- TVP Bliss
- W Denk
- W Sun
- WA Dunn
- WJ Betz
- Y Saheki
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
Ideally, elucidating the role of specific brain circuits in animal behavior would require the ability to measure activity at all involved synapses, possibly with unrestricted field of view, thus even at those boutons deeply located into the brain. Here, we introduce and validate an efficient scheme reporting synaptic vesicle cycling in vivo. This is based on SynaptoZip, a genetically encoded molecule deploying in the vesicular lumen a bait moiety designed to capture upon exocytosis a labeled alien peptide, Synbond. The resulting signal is cumulative and stores the number of cycling events occurring at individual synapses. Since this functional signal is enduring and measurable both online and ex post, SynaptoZip provides a unique method for the analysis of the history of synaptic activity in regions several millimeters below the brain surface. We show its broad applicability by reporting stimulus-evoked and spontaneous circuit activity in wide cortical fields, in anesthetized and freely moving animals
Transcriptomic alterations in the heart of non-obese type 2 diabetic Goto-Kakizaki rats
- Author
- A Aydemir-Koksoy
- A D’Souza
- A D’Souza
- A Meixner
- A Vaag
- AM Adlerberth
- Andrea Sója
- AR Chandna
- BM Herrera
- C Voulgari
- CG Ostenson
- CG Ostenson
- CH Mandavia
- CM O’Rourke
- CM Strunz
- Csaba Csonka
- D Franceschini
- D Hilfiker-Kleiner
- DG Rokosh
- DJ Smyth
- DP Cury
- DR Whiting
- EE Mulvihill
- EK Podewski
- EL Barr
- EM Gaber
- G Danaei
- G Huang
- Gergő Szűcs
- GF Kocsis
- H Bugger
- H Ghanaat-Pour
- H Zhou
- J Berrou
- J Galli
- J Movassat
- J Nie
- J Salazar
- J Salazar
- J Wang
- J Wang
- J Xu
- JE Manson
- JO Hiltunen
- Judit Pipis
- JW Son
- KA Salem
- Katalin Éder
- KT Douglas
- L Schladt
- L Wang
- LC Zhao
- LG Puskas
- LH Xie
- M Asrih
- M Dalton
- M Lappas
- M Palmer
- M Shanmugam
- M Sárközy
- M Sárközy
- M Sárközy
- MH Ghattas
- MP Chandler
- MT Weirauch
- Márta Sárközy
- Márton Pipicz
- N Dhalla
- N Ishizaki
- N Shaw
- N Wagner
- NM Bhatt
- NS Dhalla
- O Abdul-Rahman
- P Werner
- P Zimmet
- PW Wilson
- Péter Ferdinandy
- R Muniyappa
- Renáta Gáspár
- RM Bell
- S Devanathan
- S Korkmaz-Icöz
- S Rubler
- S Wild
- SD Solomon
- T Csont
- T Csont
- T Grönholm
- T L’Ecuyer
- T Wang
- Tamás Csont
- V Mohan
- V Skov
- Veronika Fekete
- WC Willett
- X Liu
- X Sun
- Y Goto
- Y Goto
- Y Iizuka
- YK Bando
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND: There is a spectacular rise in the global prevalence of type 2 diabetes mellitus (T2DM) due to the worldwide obesity epidemic. However, a significant proportion of T2DM patients are non-obese and they also have an increased risk of cardiovascular diseases. As the Goto-Kakizaki (GK) rat is a well-known model of non-obese T2DM, the goal of this study was to investigate the effect of non-obese T2DM on cardiac alterations of the transcriptome in GK rats. METHODS: Fasting blood glucose, serum insulin and cholesterol levels were measured at 7, 11, and 15 weeks of age in male GK and control rats. Oral glucose tolerance test and pancreatic insulin level measurements were performed at 11 weeks of age. At week 15, total RNA was isolated from the myocardium and assayed by rat oligonucleotide microarray for 41,012 genes, and then expression of selected genes was confirmed by qRT-PCR. Gene ontology and protein-protein network analyses were performed to demonstrate potentially characteristic gene alterations and key genes in non-obese T2DM. RESULTS: Fasting blood glucose, serum insulin and cholesterol levels were significantly increased, glucose tolerance and insulin sensitivity were significantly impaired in GK rats as compared to controls. In hearts of GK rats, 204 genes showed significant up-regulation and 303 genes showed down-regulation as compared to controls according to microarray analysis. Genes with significantly altered expression in the heart due to non-obese T2DM includes functional clusters of metabolism (e.g. Cyp2e1, Akr1b10), signal transduction (e.g. Dpp4, Stat3), receptors and ion channels (e.g. Sln, Chrng), membrane and structural proteins (e.g. Tnni1, Mylk2, Col8a1, Adam33), cell growth and differentiation (e.g. Gpc3, Jund), immune response (e.g. C3, C4a), and others (e.g. Lrp8, Msln, Klkc1, Epn3). Gene ontology analysis revealed several significantly enriched functional inter-relationships between genes influenced by non-obese T2DM. Protein-protein interaction analysis demonstrated that Stat is a potential key gene influenced by non-obese T2DM. CONCLUSIONS: Non-obese T2DM alters cardiac gene expression profile. The altered genes may be involved in the development of cardiac pathologies and could be potential therapeutic targets in non-obese T2DM
Operation and performance of the ATLAS Tile Calorimeter in Run 1
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
- Abeloos B
- Abhayasinghe DK
- Abidi SH
- Abouelfadl 
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abulaiti Y
- Acharya BS
- Adachi S
- Adamczyk L
- Adelman J
- Adersberger M
- Adiguzel A
- Adye T
- Affolder AA
- Afik Y
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmadov F
- Aielli G
- Akatsuka S
- Akerstedt H
- Akilli E
- Akimov AV
- Alberghi GL
- Albert J
- Albicocco P
- Alconada Verzini MJ
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexopoulos T
- Alhroob M
- Ali B
- Alimonti G
- Alison J
- Alkire SP
- Allaire C
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso A
- Alonso F
- Alpigiani C
- Alshehri AA
- Alstaty MI
- Alvarez 
- Alviggi MG
- Amadio BT
- Amaral Coutinho Y
- Ambroz L
- Amelung C
- Amidei D
- Amor 
- Amoroso S
- Amrouche CS
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders JK
- Anderson KJ
- Andreazza A
- Andrei V
- Anelli CR
- Angelidakis S
- Angelozzi I
- Angerami A
- Anisenkov AV
- Annovi A
- Antel C
- Anthony MT
- Antonelli M
- Antrim DJA
- Anulli F
- Aoki M
- Aperio Bella L
- Arabidze G
- Arai Y
- Araque JP
- Araujo Ferraz V
- Arce ATH
- Ardell RE
- Arduh FA
- Argos FC
- Arguin J-
- Argyropoulos S
- Armadans R
- Armbruster AJ
- Armitage LJ
- Armstrong A
- Arnaez O
- Arnold H
- Arratia M
- Arslan O
- Artamonov A
- Artoni G
- Artz S
- Asai S
- Asbah N
- Ashkenazi A
- Asimakopoulou EM
- Asquith L
- Assamagan K
- Astalos R
- Astigarraga ME
- Atkin RJ
- Atkinson M
- Atlay NB
- Auerbach B
- Augsten K
- Avolio G
- Avramidou R
- Axen B
- Ayoub MK
- Azuelos G
- Álvarez Piqueras D
- Åkesson TPA
- Baas AE
- Baca MJ
- Bachacou H
- Bachas K
- Backes M
- Bagnaia P
- Bahilo JJL
- Bahmani M
- Bahrasemani H
- Bailey AJ
- Baines JT
- Bajic M
- Bakalis C
- Baker OK
- Bakker PJ
- Baldin EM
- Balek P
- Balli F
- Balunas WK
- Balz J
- Banas E
- Bandyopadhyay A
- Banerjee S
- Bannoura AAE
- Barak L
- Barbe WM
- Barberio EL
- Barberis D
- Barbero M
- Barillari T
- Barisits M
- Barkeloo J
- Barklow T
- Barlow N
- Barnea R
- Barnes SL
- Barnett BM
- Barnett RM
- Barnovska-Blenessy Z
- Baroncelli A
- Barone G
- Barr AJ
- Barranco Navarro L
- Barreiro Guimarães da Costa J
- Barreiro F
- Bartoldus R
- Barton AE
- Bartos P
- Basalaev A
- Bassalat A
- Bates RL
- Batista SJ
- Batlamous S
- Batley JR
- Battaglia M
- Bauce M
- Bauer F
- Bauer KT
- Bawa HS
- Beacham JB
- Beattie MD
- Beau T
- Beauchemin PH
- Bechtle P
- Beck HC
- Beck HP
- Becker K
- Becker M
- Becot C
- Beddall A
- Beddall AJ
- Bednyakov VA
- Bedognetti M
- Bee CP
- Beermann TA
- Begalli M
- Begel M
- Behera A
- Behr JK
- Bell AS
- Bella G
- Bellagamba L
- Bellerive A
- Bello FA
- Bellomo M
- Belotskiy K
- Belyaev NL
- Benary O
- Benchekroun D
- Bender M
- Benekos N
- Benhammou Y
- Benhar Noccioli E
- Benitez J
- Benjamin DP
- Benoit M
- Bensinger JR
- Bentvelsen S
- Beresford L
- Beretta M
- Berge D
- Bergeaas Kuutmann E
- Berger N
- Bergsten LJ
- Beringer J
- Berlendis S
- Bernard NR
- Bernardi G
- Bernius C
- Bernlochner FU
- Berry T
- Berta P
- Bertella C
- Bertoli G
- Bertram IA
- Besjes GJ
- Bessidskaia Bylund O
- Bessner M
- Besson N
- Bethani A
- Bethke S
- Betti A
- Bevan AJ
- Beyer J
- Bianchi RM
- Biebel O
- Biedermann D
- Bielski R
- Bierwagen K
- Biesuz NV
- Biglietti M
- Billoud TRV
- Bindi M
- Bingul A
- Bini C
- Biondi S
- Bisanz T
- Biswal JP
- Bittrich C
- Bjergaard DM
- Black JE
- Black KM
- Blair RE
- Blazek T
- Bloch I
- Blocker C
- Blue A
- Blumenschein U
- Blunier D
- Bobbink GJ
- Bobrovnikov VS
- Bocchetta SS
- Bocci A
- Boerner D
- Bogavac D
- Bogdanchikov AG
- Bohm C
- Boisvert V
- Bokan P
- Bold T
- Boldyrev AS
- Bolz AE
- Bomben M
- Bona M
- Bonilla JS
- Boonekamp M
- Borisov A
- Borissov G
- Bortfeldt J
- Bortoletto D
- Bortolotto V
- Boscherini D
- Bosman M
- Bossio Sola JD
- Bostanabad M
- Bouaouda K
- Boudreau J
- Bouhova-Thacker EV
- Boumediene D
- Bourdarios C
- Boutle SK
- Boveia A
- Boyd J
- Boyko IR
- Bozson AJ
- Bracinik J
- Brahimi N
- Brandt A
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- Braren F
- Bratzler U
- Brau B
- Brau JE
- Breaden Madden WD
- Brendlinger K
- Brennan AJ
- Brenner L
- Brenner R
- Bressler S
- Brickwedde B
- Briglin DL
- Britton D
- Britzger D
- Brock I
- Brock R
- Brooijmans G
- Brooks T
- Brooks WK
- Brost E
- Broughton JH
- Brown H
- Bruckman de Renstrom PA
- Bruncko D
- Bruni A
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- Bruni LS
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- Brunt BH
- Bruschi M
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- Bryant P
- Bryngemark L
- Buanes T
- Buat Q
- Buchholz P
- Buckley AG
- Budagov IA
- Bugge MK
- Bulekov O
- Bullock D
- Burch TJ
- Burdin S
- Burgard CD
- Burger AM
- Burghgrave B
- Burka K
- Burke S
- Burmeister I
- Burr JTP
- Busato E
- Buschmann E
- Bussey P
- Butler JM
- Buttar CM
- Butterworth JM
- Butti P
- Buttinger W
- Buzatu A
- Buzykaev AR
- Bührer F
- Büscher D
- Büscher V
- Cabras G
- Cabrera Urbán S
- Caforio D
- Cai H
- Cairo VMM
- Cakir I
- Cakir O
- Calace N
- Calafiura P
- Calandri A
- Calderini G
- Calfayan P
- Callea G
- Caloba LP
- Calvente Lopez S
- Calvet D
- Calvet S
- Calvet TP
- Calvetti M
- Camacho Toro R
- Camarda S
- Camarri P
- Cameron D
- Caminal 
- Camincher C
- Campana S
- Campanelli M
- Camplani A
- Campoverde A
- Canale V
- Cano Bret M
- Cantero J
- Cao T
- Cao Y
- Capeans Garrido MDM
- Caprini I
- Caprini M
- Capua M
- Carbone RM
- Cardarelli R
- Cardillo FC
- Carli I
- Carli T
- Carlino G
- Carlson BT
- Carminati L
- Carney RMD
- Caron S
- Carquin E
- Carrá S
- Carrillo-Montoya GD
- Casadei D
- Casado MP
- Casha AF
- Casolino M
- Casper DW
- Castelijn R
- Castillo Gimenez V
- Castillo FL
- Castro NF
- Catinaccio A
- Catmore JR
- Cattai A
- Caudron J
- Cavaliere V
- Cavallaro E
- Cavalli D
- Cavalli-Sforza M
- Cavasinni V
- Celebi E
- Ceradini F
- Cerda Alberich L
- Cerqueira AS
- Cerri A
- Cerrito L
- Cerutti F
- Cervelli A
- Cetin SA
- Chafaq A
- Chakraborty D
- Chan SK
- Chan WS
- Chan YL
- Chang P
- Chapman JD
- Charlton DG
- Chau CC
- Chavez Barajas CA
- Che S
- Chegwidden A
- Chekanov S
- Chekulaev SV
- Chelkov GA
- Chelstowska MA
- Chen C
- Chen CH
- Chen H
- Chen J
- Chen J
- Chen S
- Chen SJ
- Chen X
- Chen Y
- Chen Y
- Cheng HC
- Cheng HJ
- Cheplakov A
- Cheremushkina E
- Cherkaoui El Moursli R
- Cheu E
- Cheung K
- Chevalier L
- Chiarella V
- Chiarelli G
- Chiodini G
- Chisholm AS
- Chitan A
- Chiu I
- Chiu YH
- Chizhov MV
- Choi K
- Chomont AR
- Chouridou S
- Chow YS
- Christodoulou V
- Chu MC
- Chudoba J
- Chuinard AJ
- Chwastowski JJ
- Chytka L
- Ciaccio A
- Ciaccio L
- Cinca D
- Cindro V
- Cioară IA
- Ciocio A
- Cirotto F
- Citron ZH
- Citterio M
- Clark A
- Clark MR
- Clark PJ
- Clement C
- Clemente WK
- Coadou Y
- Cobal M
- Coccaro A
- Cochran J
- Coimbra AEC
- Colasurdo L
- Cole B
- Colijn AP
- Collot J
- Conde Muiño P
- Coniavitis E
- Connell SH
- Connelly IA
- Constantinescu S
- Conventi F
- Cooper-Sarkar AM
- Cormier F
- Cormier KJR
- Corradi M
- Correia AM
- Corrigan EE
- Corriveau F
- Cortes-Gonzalez A
- Costa MJ
- Costanzo D
- Cottin G
- Cowan G
- Cox BE
- Crane J
- Cranmer K
- Crawley SJ
- Creager RA
- Cree G
- Crescioli F
- Crépé-Renaudin S
- Cristinziani M
- Croft V
- Crosetti G
- Cueto A
- Cuhadar Donszelmann T
- Cukierman AR
- Cunha 
- Curatolo M
- Cúth J
- Czekierda S
- Czodrowski P
- Da Via C
- Da 
- Dabrowski W
- Dado T
- Dahbi S
- Dai T
- Dallaire F
- Dallapiccola C
- Dam M
- Damp J
- Dandoy JR
- Daneri MF
- Dang NP
- Dann ND
- Danninger M
- Dao V
- Darbo G
- Darmora S
- Dartsi O
- Dattagupta A
- Daubney T
- Davey W
- David C
- Davidek T
- Davis DR
- Davydov Y
- Dawe E
- Dawson I
- De Asmundis R
- De Benedetti A
- De Castro S
- De Cecco S
- De Groot N
- de Jong P
- De la Torre H
- De Lorenzi F
- De Maria A
- De Moura 
- De Pedis D
- De Salvo A
- De Sanctis U
- De Santo A
- De Vasconcelos Corga K
- De Vivie 
- De 
- De 
- De K
- Debenedetti C
- Dedovich DV
- Dehghanian N
- Del Gaudio M
- Del Peso J
- Delgado A
- Delgove D
- Deliot F
- Delitzsch CM
- Della Pietra M
- Della Volpe D
- Dell’Acqua A
- Dell’Asta L
- Delmastro M
- Delporte C
- Delsart PA
- DeMarco DA
- Demers S
- Demichev M
- Denisov SP
- Denysiuk D
- Derendarz D
- Derkaoui JE
- Derue F
- Dervan P
- Desch K
- Deterre C
- Dette K
- Devesa MR
- Deviveiros PO
- Dewhurst A
- Dhaliwal S
- Di 
- Di 
- Di 
- Di 
- Di 
- Di 
- Di 
- Di 
- Di 
- Di 
- Di 
- Di 
- Diaconu C
- Diamond M
- Dias 
- Dias FA
- Diaz LP
- Diaz MA
- Dickinson J
- Diehl EB
- Dietrich J
- Dimitrievska A
- Dingfelder J
- Dittus F
- Díez Cornell S
- Djama F
- Djobava T
- Djuvsland JI
- Do 
- Do 
- Dobre M
- Dodsworth D
- Doglioni C
- Dolejsi J
- Dolezal Z
- Donadelli M
- Donato C
- Donini J
- Dopke J
- Doria A
- Dortz O
- Dos 
- Dova MT
- Doyle AT
- Drechsler E
- Dreyer E
- Dreyer T
- Dris M
- Du Y
- Duarte-Campderros J
- Dubinin F
- Dubreuil A
- Duchovni E
- Duckeck G
- Ducourthial A
- Ducu OA
- Duda D
- Dudarev A
- Dudder AC
- Duffield EM
- Duflot L
- Dumancic M
- Dumitriu AE
- Duncan AK
- Dunford M
- Duperrin A
- Duran 
- Durglishvili A
- Duschinger D
- Dutta B
- Duvnjak D
- Dührssen M
- Dülsen C
- Düren M
- Dyndal M
- Dysch S
- Dziedzic BS
- D’amen G
- D’Auria S
- D’Eramo L
- D’onofrio A
- D’Onofrio M
- Eckardt C
- Ecker KM
- Edgar RC
- Eifert T
- Eigen G
- Einsweiler K
- Ekelof T
- El Kacimi M
- El Kosseifi R
- Ellajosyula V
- Ellert M
- Ellinghaus F
- Elliot AA
- Ellis N
- Elmsheuser J
- Elsing M
- Emeliyanov D
- Enari Y
- Ennis JS
- Epland MB
- Erdmann J
- Ereditato A
- Errede S
- Escalier M
- Escobar C
- Esposito B
- Estrada 
- Etienvre AI
- Etzion E
- Evans H
- Ezhilov A
- Ezzi M
- Fabbri F
- Fabbri L
- Fabiani V
- Facini G
- Faisca 
- Fakhrutdinov RM
- Falciano S
- Falke PJ
- Falke S
- Faltova J
- Fang Y
- Fanti M
- Farbin A
- Farilla A
- Farina EM
- Farooque T
- Farrell S
- Farrington SM
- Farthouat P
- Fassi F
- Fassnacht P
- Fassouliotis D
- Faucci Giannelli M
- Favareto A
- Fawcett WJ
- Fayard L
- Fedin OL
- Fedorko W
- Feickert M
- Feigl S
- Feligioni L
- Feng C
- Feng EJ
- Feng M
- Fenton MJ
- Fenyuk AB
- Feremenga L
- Ferrando J
- Ferrari A
- Ferrari P
- Ferrari R
- Ferreira de Lima DE
- Ferrer A
- Ferrere D
- Ferretti C
- Fiedler F
- Filipčič A
- Filthaut F
- Finelli KD
- Fiolhais MCN
- Fiorini L
- Fischer C
- Fisher WC
- Flaschel N
- Fleck I
- Fleischmann P
- Fletcher RRM
- Flick T
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- Zorbas TG
- Zou R
- Zur 
- Zwalinski L
- Ženiš T
- Živković L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
The Tile Calorimeter is the hadron calorimeter covering the central region of the ATLAS experiment at the Large Hadron Collider. Approximately 10,000 photomultipliers collect light from scintillating tiles acting as the active material sandwiched between slabs of steel absorber. This paper gives an overview of the calorimeter’s performance during the years 2008–2012 using cosmic-ray muon events and proton–proton collision data at centre-of-mass energies of 7 and 8TeV with a total integrated luminosity of nearly 30 fb−1. The signal reconstruction methods, calibration systems as well as the detector operation status are presented. The energy and time calibration methods performed excellently, resulting in good stability of the calorimeter response under varying conditions during the LHC Run 1. Finally, the Tile Calorimeter response to isolated muons and hadrons as well as to jets from proton–proton collisions is presented. The results demonstrate excellent performance in accord with specifications mentioned in the Technical Design Report
Search for supersymmetry in events with four or more leptons in √s =13 TeV pp collisions with ATLAS
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdinov O
- Abeloos B
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abreu R
- Abulaiti Y
- Acharya BS
- Adachi S
- Adamczyk L
- Adelman J
- Adersberger M
- Adye T
- Affolder AA
- Afik Y
- Agatonovic-Jovin T
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahlen SP
- Ahmadov F
- Aielli G
- Akatsuka S
- Akerstedt H
- Akilli E
- Akimov AV
- Alberghi GL
- Albert J
- Albicocco P
- Alconada Verzini MJ
- Alderweireldt SC
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexopoulos T
- Alhroob M
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- Aliev M
- Alimonti G
- Alison J
- Alkire SP
- Allbrooke BMM
- Allen BW
- Allport PP
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- Alstaty MI
- Alvarez Gonzalez B
- Alviggi MG
- Amadio BT
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- Amor Dos Santos SP
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- Anders JK
- Anderson KJ
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- Angelidakis S
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- Zimmermann S
- Zinonos Z
- Zinser M
- Ziolkowski M
- Zobernig G
- Zoccoli A
- Zou R
- zur Nedden M
- Zwalinski L
- Álvarez Piqueras D
- Åkesson TPA
- Šfiligoj T
- Ženiš T
- Živković L
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2018
- Field of study
Results from a search for supersymmetry in events with four or more charged leptons (electrons, muons and taus) are presented. The analysis uses a data sample corresponding to 36.1 fb −1 of proton-proton collisions delivered by the Large Hadron Collider at s √ =13 TeV and recorded by the ATLAS detector. Four-lepton signal regions with up to two hadronically decaying taus are designed to target a range of supersymmetric scenarios that can be either enriched in or depleted of events involving the production and decay of a Z boson. Data yields are consistent with Standard Model expectations and results are used to set upper limits on the event yields from processes beyond the Standard Model. Exclusion limits are set at the 95% confidence level in simplified models of General Gauge Mediated supersymmetry, where higgsino masses are excluded up to 295 GeV. In R -parity-violating simplified models with decays of the lightest supersymmetric particle to charged leptons, lower limits of 1.46 TeV, 1.06 TeV, and 2.25 TeV are placed on wino, slepton and gluino masses, respectively
Measurement of the t¯tZ and t¯tW cross sections in proton-proton collisions at √s=13 TeV with the ATLAS detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abbott DC
- Abdinov O
- Abeloos B
- Abhayasinghe DK
- Abidi SH
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- Zhemchugov A
- Zheng Z
- Zhong D
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- Zhulanov V
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zobernig G
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zur Nedden M
- Zwalinski L
- Álvarez Piqueras D
- Åkesson TPA
- Šfiligoj T
- Ženiš T
- Živković L
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2019
- Field of study
A measurement of the associated production of a top-quark pair (t¯t) with a vector boson (W, Z) in proton-proton collisions at a center-of-mass energy of 13 TeV is presented, using 36.1 fb−1 of integrated luminosity collected by the ATLAS detector at the Large Hadron Collider. Events are selected in channels with two same- or opposite-sign leptons (electrons or muons), three leptons or four leptons, and each channel is further divided into multiple regions to maximize the sensitivity of the measurement. The t¯tZ and t¯tW production cross sections are simultaneously measured using a combined fit to all regions. The best-fit values of the production cross sections are σt¯tZ=0.95±0.08stat±0.10syst pb and σt¯tW=0.87±0.13stat±0.14syst pb in agreement with the Standard Model predictions. The measurement of the t¯tZ cross section is used to set constraints on effective field theory operators which modify the t¯tZ vertex
Search for flavour-changing neutral current top-quark decays t → qZ in proton-proton collisions at \sqrt{s} = 13 TeV with the ATLAS detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdinov O
- Abeloos B
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abulaiti Y
- Acharya BS
- Adachi S
- Adam ER
- Adamczyk L
- Adelman J
- Adersberger M
- Adye T
- Affolder AA
- Afik Y
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmadov F
- Aielli G
- Akatsuka S
- Akerstedt H
- Akilli E
- Akimov AV
- Alberghi GL
- Albert J
- Albicocco P
- Alconada Verzini MJ
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexopoulos T
- Alhroob M
- Ali B
- Aliev M
- Alimonti G
- Alison J
- Alkire SP
- Allaire C
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso A
- Alonso F
- Alpigiani C
- Alshehri AA
- Alstaty MI
- Alvarez Gonzalez B
- Alviggi MG
- Amadio BT
- Amaral Coutinho Y
- Amelung C
- Amidei D
- Amor Dos Santos SP
- Amoroso S
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders JK
- Anderson KJ
- Andreazza A
- Andrei V
- Angelidakis S
- Angelozzi I
- Angerami A
- Anisenkov AV
- Annovi A
- Antel C
- Antonelli M
- Antonov A
- Antrim DJA
- Anulli F
- Aoki M
- Aperio Bella L
- Arabidze G
- Arai Y
- Araque JP
- Araujo Ferraz V
- Arce ATH
- Ardell RE
- Arduh FA
- Arguin J-F
- Argyropoulos S
- Arik M
- Armbruster AJ
- Armitage LJ
- Arnaez O
- Arnold H
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- Artamonov A
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- Atlay NB
- Augsten K
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- Bachas K
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- Bahrasemani H
- Baines JT
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- Baker OK
- Bakker PJ
- Bakshi Gupta D
- Baldin EM
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- Balli F
- Balunas WK
- Banas E
- Bandyopadhyay A
- Banerjee S
- Bannoura AAE
- Barak L
- Barberio EL
- Barberis D
- Barbero M
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- Barisits M-S
- Barkeloo JT
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- Barnes SL
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- Barreiro Guimarães da Costa J
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- Basalaev A
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- Battaglia M
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- Bauer KT
- Bawa HS
- Beacham JB
- Beattie MD
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- Beauchemin PH
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- Beddall A
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- Bednyakov VA
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- Black JE
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- Blunier D
- Bobbink GJ
- Bobrovnikov VS
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- Bogavac D
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- Boscherini D
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- Bossio Sola JD
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- Bouhova-Thacker EV
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- Boutle SK
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- Boyko IR
- Bozson AJ
- Bracinik J
- Brandt A
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- Brau B
- Brau JE
- Breaden Madden WD
- Brendlinger K
- Brennan AJ
- Brenner L
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- Bressler S
- Briglin DL
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- Britton D
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- Bruckman de Renstrom PA
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- Bruschi M
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- Buchholz P
- Buckley AG
- Budagov IA
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- Bullock D
- Burch TJ
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- Burgard CD
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- Burmeister I
- Burr JTP
- Buschmann E
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- Butler JM
- Buttar CM
- Butterworth JM
- Butti P
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- Yajima K
- Yallup DP
- Yamaguchi D
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- Yigitbasi E
- Yildirim E
- Yorita K
- Yoshihara K
- Young C
- Young CJS
- Yu J
- Yu J
- Yuen SPY
- Yusuff I
- Zabinski B
- Zacharis G
- Zaidan R
- Zaitsev AM
- Zakharchuk N
- Zalieckas J
- Zaman A
- Zambito S
- Zanzi D
- Zeitnitz C
- Zemaityte G
- Zeng JC
- Zeng Q
- Zenin O
- Zerwas D
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- Zhang L
- Zhang M
- Zhang P
- Zhang R
- Zhang R
- Zhang X
- Zhang Y
- Zhang Z
- Zhao X
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zhou B
- Zhou C
- Zhou L
- Zhou M
- Zhou M
- Zhou N
- Zhou Y
- Zhu CG
- Zhu H
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- Zhu Y
- Zhuang X
- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann S
- Zinonos Z
- Zinser M
- Ziolkowski M
- Zobernig G
- Zoccoli A
- Zou R
- zur Nedden M
- Zwalinski L
- Álvarez Piqueras D
- Åkesson TPA
- Šfiligoj T
- Ženiš T
- Živković L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 31/07/2018
- Field of study
A search for flavour-changing neutral-current processes in top-quark decays is presented. Data collected with the ATLAS detector from proton-proton collisions at the Large Hadron Collider at a centre-of-mass energy of s√=13 TeV, corresponding to an integrated luminosity of 36.1 fb−1, are analysed. The search is performed using top-quark pair events, with one top quark decaying through the t → qZ (q = u, c) flavour-changing neutral-current channel, and the other through the dominant Standard Model mode t → bW. Only Z boson decays into charged leptons and leptonic W boson decays are considered as signal. Consequently, the final-state topology is characterized by the presence of three isolated charged leptons (electrons or muons), at least two jets, one of the jets originating from a b-quark, and missing transverse momentum from the undetected neutrino. The data are consistent with Standard Model background contributions, and at 95% confidence level the search sets observed (expected) upper limits of 1.7 × 10−4 (2.4 × 10−4) on the t → uZ branching ratio and 2.4 × 10−4 (3.2 × 10−4) on the t → cZ branching ratio, constituting the most stringent limits to date.
Open image in new windo
Search for excited electrons singly produced in proton–proton collisions at \sqrt{s} = 13 TeV with the ALAS experiment at the LHC
- Author
- Aaboud M
- Aad G
- Abbott B
- Abbott DC
- Abdinov O
- Abeloos B
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abulaiti Y
- Acharya BS
- Adachi S
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adersberger M
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- Agapopoulou C
- Agheorghiesei C
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- Alberich LC
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- Aleksandrov IN
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- Zabinski B
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- Zhang Z
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- Zhao Z
- Zhemchugov A
- Zheng Z
- Zhong D
- Zhou B
- Zhou C
- Zhou M
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- Zinonos Z
- Ziolkowski M
- Zobernig G
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zwalinski L
- Åkesson TPA
- Šfiligoj T
- Ženiš T
- Živković L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/09/2019
- Field of study
A search for excited electrons produced in pp collisions at s√ = 13 TeV via a contact interaction qq¯→ee∗ is presented. The search uses 36.1 fb −1 of data collected in 2015 and 2016 by the ATLAS experiment at the Large Hadron Collider. Decays of the excited electron into an electron and a pair of quarks ( eqq¯ ) are targeted in final states with two electrons and two hadronic jets, and decays via a gauge interaction into a neutrino and a W boson ( νW ) are probed in final states with an electron, missing transverse momentum, and a large-radius jet consistent with a hadronically decaying W boson. No significant excess is observed over the expected backgrounds. Upper limits are calculated for the pp→ee∗→eeqq¯ and pp→ee∗→eνW production cross sections as a function of the excited electron mass me∗ at 95% confidence level. The limits are translated into lower bounds on the compositeness scale parameter Λ of the model as a function of me∗ . For me∗<0.5 TeV , the lower bound for Λ is 11 TeV . In the special case of me∗=Λ , the values of me∗<4.8 TeV are excluded. The presented limits on Λ are more stringent than those obtained in previous searches
CNV Analysis in Tourette Syndrome Implicates Large Genomic Rearrangements in COL8A1 and NRXN1.
- Author
- A Itsara
- Abhishek Nag
- AG Ercan-Sencicek
- AJ Verkerk
- AK Merikangas
- Ana V. Valencia-Duarte
- Andrés Ruiz-Linares
- B Xu
- Barbara Kremeyer
- Carol A. Mathews
- David L. Pauls
- Desmond D. Campbell
- Dongmei Yu
- Ed Cook
- Eduardo Fournier
- Elena G. Bochukova
- Gabriel Bedoya
- Ge Zhang
- H Liu
- Heike Muller
- I Herzberg
- I Herzberg
- I. Sadaf Farooqi
- Isabel C. Rivas
- JA O’Rourke
- Jeremiah M. Scharf
- JF Abelson
- Jharley Garcia
- JM Scharf
- JT Glessner
- Julio Cardona
- K Wang
- Kai Wang
- L Saccomani
- Lauren M. McGrath
- LG Carvajal-Carmona
- Luis D. Herrera
- M Karayiorgou
- MA Fox
- Mauricio Cuartas
- MM Robertson
- MW State
- MW State
- Nelson B. Freimer
- RA Clarke
- RA Price
- Roxana Romero
- S Wang
- Sandra C. Mesa
- SE Stewart
- SK Sundaram
- T Hubert
- T Vrijenhoek
- Thomas L. Lowe
- TV Fernandez
- Victor I. Reus
- Vincent Plagnol
- William Cornejo
- Publication venue
- Publication date
- 01/01/2013
- Field of study
Tourette syndrome (TS) is a neuropsychiatric disorder with a strong genetic component. However, the genetic architecture of TS remains uncertain. Copy number variation (CNV) has been shown to contribute to the genetic make-up of several neurodevelopmental conditions, including schizophrenia and autism. Here we describe CNV calls using SNP chip genotype data from an initial sample of 210 TS cases and 285 controls ascertained in two Latin American populations. After extensive quality control, we found that cases (N = 179) have a significant excess (P = 0.006) of large CNV (>500 kb) calls compared to controls (N = 234). Amongst 24 large CNVs seen only in the cases, we observed four duplications of the COL8A1 gene region. We also found two cases with ∼400kb deletions involving NRXN1, a gene previously implicated in neurodevelopmental disorders, including TS. Follow-up using multiplex ligation-dependent probe amplification (and including 53 more TS cases) validated the CNV calls and identified additional patients with rearrangements in COL8A1 and NRXN1, but none in controls. Examination of available parents indicates that two out of three NRXN1 deletions detected in the TS cases are de-novo mutations. Our results are consistent with the proposal that rare CNVs play a role in TS aetiology and suggest a possible role for rearrangements in the COL8A1 and NRXN1 gene regions
Quantitative fractographic analysis of impact fracture surfaces of steel R73
- Author
- B Hampoelz
- C Cabernard
- C Couwenbergs
- C Couwenbergs
- C Hoege
- C Kozlowski
- C Panbianco
- CR Cowan
- CWH Berends
- DC Bergmann
- DDGD Srinivasan
- DH Park
- EL Grishchuk
- EM Gusnowski
- G Albertson
- GG Tall
- GG Tall
- H Bringmann
- HA Hess
- HR Horvitz
- J Huang
- JA Kaltschmidt
- JA Knoblich
- JA Knoblich
- JA Knoblich
- JA Raaijmakers
- JE Sulston
- K Afshar
- K Afshar
- K Afshar
- K Colombo
- K Kimura
- K Thyagarajan
- KG Miller
- KG Miller
- KH Siller
- KJ Kemphues
- L Laan
- L Martin-mccaffrey
- LE Krueger
- LG Guilgur
- M Gabay
- M Galli
- M Galli
- M Gotta
- M Gotta
- M Schaefer
- M Schaefer
- M-FB Tsou
- MA Lorson
- NB David
- Q Du
- RJ Kimple
- RR Zwaal
- S Kotak
- S Kotak
- S Redemann
- SA Fietz
- SE Williams
- SK Bowman
- SM O’Rourke
- T Kiyomitsu
- T Lechler
- T Nguyen-Ngoc
- X Morin
- Y Bei
- Y Bellaïche
- Y Hao
- Y Izumi
- Z Pan
- Publication venue
- Інститут проблем міцності ім. Г.С. Писаренко НАН України
- Publication date
- 01/01/2008
- Field of study
Macroscopic images offracture surfaces of Charpy test specimens of steel R73 were studied, where bright spots in images represent cleavage facets or ductile dimples, respectively, both in special orientations. Within image analysis, they may be taken for the most significant textural element. Being the brightest patches in the image, they can be extracted by thresholding. Their counts and area distribution are closely related to temperature and impact energy.Выполнены исследования макроизображений поверхностей разрушений образцов Шарпи из стали R73. При специальных условиях ориентации поверхностей разрушения видны яркие участки на изображениях, соответствующие граням скола или ямкам вязкого разрушения. Эти участки могут быть использованы в качестве основного элемента текстуры для обработки изображения. Поскольку эти участки на изображениях являются наиболее яркими, их можно отсеять путем настройки порогового уровня освещенности. Результаты расчета относительной доли их площади тесно коррелируют с температурой и энергией ударного разрушения
- …