Family-Centered Preventive Intervention for Military Families: Implications for Implementation Science

In this paper, we report on the development and dissemination of a preventive intervention, Families OverComing Under Stress (FOCUS), an eight-session family-centered intervention for families facing the impact of wartime deployments. Specific attention is given to the challenges of rapidly deploying a prevention program across diverse sites, as well as to key elements of implementation success. FOCUS, developed by a UCLA-Harvard team, was disseminated through a large-scale demonstration project funded by the United States Bureau of Navy Medicine and Surgery (BUMED) beginning in 2008 at 7 installations and expanding to 14 installations by 2010. Data are presented to describe the range of services offered, as well as initial intervention outcomes. It proved possible to develop the intervention rapidly and to deploy it consistently and effectively

Plant identification illustrated glossary [1991]

Reprinted July 1991. Facts and recommendations in this publication may no longer be valid. Please look for up-to-date information in the OSU Extension Catalog: http://extension.oregonstate.edu/catalo

Placental 11-Beta Hydroxysteroid Dehydrogenase Methylation Is Associated with Newborn Growth and a Measure of Neurobehavioral Outcome

Background: There is growing evidence that the intrauterine environment can impact the neurodevelopment of the fetus through alterations in the functional epigenome of the placenta. In the placenta, the HSD11B2 gene encoding the 11-beta hydroxysteroid dehydrogenase enzyme, which is responsible for the inactivation of maternal cortisol, is regulated by DNA methylation, and has been shown to be susceptible to stressors from the maternal environment. Methodology/Principal Findings: We examined the association between DNA methylation of the HSD11B2 promoter region in the placenta of 185 healthy newborn infants and infant and maternal characteristics, as well as the association between this epigenetic variability and newborn neurobehavioral outcome assessed with the NICU Network Neurobehavioral Scales. Controlling for confounders, HSD11B2 methylation extent is greatest in infants with the lowest birthweights (P = 0.04), and this increasing methylation was associated with reduced scores of quality of movement (P = 0.04). Conclusions/Significance: These results suggest that factors in the intrauterine environment which contribute to birth outcome may be associated with placental methylation of the HSD11B2 gene and that this epigenetic alteration is in turn associated with a prospectively predictive early neurobehavioral outcome, suggesting in some part a mechanism for th

Arcilla bentonítica cubana: composición, estructura y caracterización textural

The physic and chemical characterization of the bentonite clay from the Chiqui Gómez deposit, central Cuba, (Cuban bentonite clay) shows that it is mainly constituted by sodium montmorillonite (>90%), with a structural formula for one-layer unit determined as (Na3.99Al0.01)(Al1.11Fe3+0.49Mg0.18Ti0.07)(Ca0.24Na0.15K0.01)O10(OH)2. The Cuban bentonite clay has a specific surface area of 80m2g-1, a pore volume of about 0.0776 cm3g-1, 61 % porosity and both N2 adsorption?desorption isotherms exhibited a hysteresis loop of IV type. The thermogravimetric analyses (TGA) of studied mineral presents the first endothermic peak, characteristic of montmorillonite, in 48.1 ºC and others less accentuated (80.8, 94.0, 119.8 ºC) characteristic of sodium montmorillonite, that corresponds to the loss of water, and can be extended up to 250 ºC. The FT-IR spectra showed the existence of Si-OH, Al-Al-OH, Al-Fe-OH, Al-Mg-OH and Si-O-Si functional groups in all clay samples, bands between 1120 and 461 cm-1 correspond to phyllosilicate structures and OH stretching vibrations were observed. pH at the point of zero charge (pHPZC) obtained has a value of 8.1, which allows montmorillonite to be classified as basic.La caracterización física y química de la arcilla bentonítica del depósito Chiqui Gómez, en el centro de Cuba, muestra que está constituida mayoritariamente (>90%) por montmorillonita sódica, con una formula estructural para una capa unitaria establecida como (Na3.99Al0.01)(Al1.11Fe3+ 0.49Mg0.18Ti0.07)(Ca0.24Na0.15K0.01)O10(OH)2. Las arcillas de bentonita cubana tienen una superficie específica de 80 m2 g -1 , un volumen de poro de aproximadamente 0,0776 cm3 g -1 y una porosidad de 61%. Ambas isotermas de desorción-desorción de N2 exhibieron una isoterma de histéresis de tipo IV. El análisis TGA muestra que la bentonita estudiada presenta el primer pico endotérmico, característico de la montmorillonita, en 48,1 ºC y otros menos acentuados (80.8, 94.0, 119.8 ºC) característicos de la montmorillonita sódica, que corresponde a la pérdida de agua, pudiendo extenderse hasta 250 ºC. Los espectros FT-IR mostraron la existencia de grupos funcionales Si-OH, Al-Al-OH, Al-Fe-OH, Al-Mg-OH y Si-OSi en todas las muestras de arcilla, las bandas entre 1120 y 461 cm-1 corresponden a estructuras de filosilicatos y se observaron vibraciones de estiramiento OH. El pH en el punto de carga cero (pHPZC) obtenido tiene un valor de 8.1, lo que permite clasificar la montmorillonita como básica.Fil: Quero Jiménez, Pedro César. Universidad Central Marta Abreu de Las Villas; Cuba. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Arias Felipe, Lester Alejandro. Universidad Central Marta Abreu de Las Villas; CubaFil: Prieto García, Julio Omar. Universidad Central Marta Abreu de Las Villas; CubaFil: Jorge Rodríguez, María Elisa. Universidad Central Marta Abreu de Las Villas; CubaFil: De la Torre López, Jorge Basilio. Universidad Central Marta Abreu de Las Villas; CubaFil: Montenegro, Osvaldo Norman. Universidad Central Marta Abreu de Las Villas; CubaFil: Molina Ruíz, Reinaldo. Universidad Central Marta Abreu de Las Villas; CubaFil: Tiscornia, Ines Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigaciones en Catálisis y Petroquímica "Ing. José Miguel Parera". Universidad Nacional del Litoral. Instituto de Investigaciones en Catálisis y Petroquímica "Ing. José Miguel Parera"; Argentin

Fortalecimiento en fiscalización municipal para contribuir al incremento en las recaudaciones alcaldía municipal de Nagarote periodo 2020 -2021

El presente trabajo de investigación destaca la necesidad que tiene la Municipalidad de Nagarote de Fortalecer el área de fiscalización que actualmente no está funcionando de manera adecuada por carecer de personal especializado, logística y capacitación, lo que ha provocado la contratación de personal externo para realizar revisiones puntuales que no trascienden en cuanto al potencial recaudatorio que podría alcanzarse, es por ello que nuestro tema ejemplifica que al fortalecer el área, se lograra de alguna manera incrementar los ingresos tributarios. La fiscalización es un conjunto de tareas que tiene la finalidad de instar a los contribuyentes a cumplir con sus obligaciones tributarias, la cual representa el controlar, vigilar o inspeccionar las acciones de otra u otras personas. En términos generales los procesos de fiscalización comprenden un conjunto de tareas que tienen por finalidad instar a los contribuyentes a cumplir su obligación tributaria; cautelando el correcto, íntegro y oportuno pago de los impuestos. La auditoría tributaria es una actividad de permanente fiscalización, la cual consiste en verificar la exactitud de las declaraciones a través de la revisión de los antecedentes tributarios y documentación facilitada por los contribuyentes. La Auditoría Tributaria Municipal, se define como la verificación racional de los registros contables y de la documentación, con el fin de determinar la exactitud e integridad de la contabilidad. Consiste en investigar las cuentas del balance, de las cuentas de resultados, de la documentación, registro y operaciones efectuadas por una empresa, que tiene como propósito comprobar que los tributos se hayan determinados de acuerdo con las normas técnicas que regulan la contabilidad y cumpliendo con las disposiciones legales contenidas en el Plan de Arbitrios decreto 455 y demás leyes que correspondan aplicar

EuFRATE: European FPGA Radiation-hardened Architecture for Telecommunications

The EuFRATE project aims to research, develop and test radiation-hardening methods for telecommunication payloads deployed for Geostationary-Earth Orbit (GEO) using Commercial-Off-The-Shelf Field Programmable Gate Arrays (FPGAs). This project is conducted by Argotec Group (Italy) with the collaboration of two partners: Politecnico di Torino (Italy) and Technische Universit¨at Dresden (Germany). The idea of the project focuses on high-performance telecommunication algorithms and the design and implementation strategies for connecting an FPGA device into a robust and efficient cluster of multi-FPGA systems. The radiation-hardening techniques currently under development are addressing both device and cluster levels, with redundant datapaths on multiple devices, comparing the results and isolating fatal errors. This paper introduces the current state of the project’s hardware design description, the composition of the FPGA cluster node, the proposed cluster topology, and the radiation hardening techniques. Intermediate stage experimental results of the FPGA communication layer performance and fault detection techniques are presented. Finally, a wide summary of the project’s impact on the scientific community is provided

Relationships among Polycyclic Aromatic Hydrocarbon–DNA Adducts, Proximity to the World Trade Center, and Effects on Fetal Growth

Polycyclic aromatic hydrocarbons (PAHs) are toxic pollutants released by the World Trade Center (WTC) fires and various urban combustion sources. Benzo[a]pyrene (BaP) is a representative member of the class of PAHs. PAH–DNA adducts, or BaP–DNA adducts as their proxy, provide a measure of chemical-specific genetic damage that has been associated with increased risk of adverse birth outcomes and cancer. To learn whether PAHs from the WTC disaster increased levels of genetic damage in pregnant women and their newborns, we analyzed BaP–DNA adducts in maternal (n = 170) and umbilical cord blood (n = 203) obtained at delivery from nonsmoking women who were pregnant on 11 September 2001 and were enrolled at delivery at three downtown Manhattan hospitals. The mean adduct levels in cord and maternal blood were highest among newborns and mothers who resided within 1 mi of the WTC site during the month after 11 September, intermediate among those who worked but did not live within this area, and lowest in those who neither worked nor lived within 1 mi (reference group). Among newborns of mothers living within 1 mi of the WTC site during this period, levels of cord blood adducts were inversely correlated with linear distance from the WTC site (p = 0.02). To learn whether PAHs from the WTC disaster may have affected birth outcomes, we analyzed the relationship between these outcomes and DNA adducts in umbilical cord blood, excluding preterm births to reduce variability. There were no independent fetal growth effects of either PAH–DNA adducts or environmental tobacco smoke (ETS), but adducts in combination with in utero exposure to ETS were associated with decreased fetal growth. Specifically, a doubling of adducts among ETS-exposed subjects corresponded to an estimated average 276-g (8%) reduction in birth weight (p = 0.03) and a 1.3-cm (3%) reduction in head circumference (p = 0.04). The findings suggest that exposure to elevated levels of PAHs, indicated by PAH–DNA adducts in cord blood, may have contributed to reduced fetal growth in women exposed to the WTC event

The protein structure initiative structural genomics knowledgebase

The Protein Structure Initiative Structural Genomics Knowledgebase (PSI SGKB, http://kb.psi-structuralgenomics.org) has been created to turn the products of the PSI structural genomics effort into knowledge that can be used by the biological research community to understand living systems and disease. This resource provides central access to structures in the Protein Data Bank (PDB), along with functional annotations, associated homology models, worldwide protein target tracking information, available protocols and the potential to obtain DNA materials for many of the targets. It also offers the ability to search all of the structural and methodological publications and the innovative technologies that were catalyzed by the PSI's high-throughput research efforts. In collaboration with the Nature Publishing Group, the PSI SGKB provides a research library, editorials about new research advances, news and an events calendar to present a broader view of structural biology and structural genomics. By making these resources freely available, the PSI SGKB serves as a bridge to connect the structural biology and the greater biomedical communitie

Nulliparity enhances the risk of second primary malignancy of the breast in a cohort of women treated for thyroid cancer

<p>Abstract</p> <p>Background</p> <p>Many studies have reported an increased risk of developing a second primary malignancy (SPM) of the breast in women treated for thyroid cancer. In this study, we investigated several potential risk factors for this association. The aim of this retrospective cohort study was to identify a subgroup of women surgically treated for papillary thyroid cancer that may benefit from more careful breast cancer screening.</p> <p>Methods</p> <p>A total of 101 women surgically treated for papillary thyroid cancer from 1996 to 2009 with subsequent follow-up were interviewed by phone regarding personal risk factors and lifestyle habits. Only 75 questionnaires could be evaluated due to a 25.7% rate of patients not retrieved or refusing the interview. Data analysis was performed using a multivariate logistic model.</p> <p>Results</p> <p>The standardised incidence ratio (SIR) for breast cancer was 3.58 (95% IC 1.14 - 8.37). Our data suggest a protective effect of multiparity on the development of a SPM of the breast (O.R. 0.15; 95% IC 0.25 - 0.86). Significant associations were not found with other known risk factors including Body Mass Index (BMI), age at first tumour, concurrent metabolic diseases, smoking, physical activity and familiarity.</p> <p>Conclusions</p> <p>This study confirms that a higher incidence of SPM of the breast is observed in women treated for papillary thyroid cancer. Additionally, this risk is increased by nulliparity, thus a strict breast screening program for nulliparous women treated for thyroid cancer may be advisable.</p