Asynchronous Online Federated Learning with Reduced Communication Requirements

Online federated learning (FL) enables geographically distributed devices to learn a global shared model from locally available streaming data. Most online FL literature considers a best-case scenario regarding the participating clients and the communication channels. However, these assumptions are often not met in real-world applications. Asynchronous settings can reflect a more realistic environment, such as heterogeneous client participation due to available computational power and battery constraints, as well as delays caused by communication channels or straggler devices. Further, in most applications, energy efficiency must be taken into consideration. Using the principles of partial-sharing-based communications, we propose a communication-efficient asynchronous online federated learning (PAO-Fed) strategy. By reducing the communication overhead of the participants, the proposed method renders participation in the learning task more accessible and efficient. In addition, the proposed aggregation mechanism accounts for random participation, handles delayed updates and mitigates their effect on accuracy. We prove the first and second-order convergence of the proposed PAO-Fed method and obtain an expression for its steady-state mean square deviation. Finally, we conduct comprehensive simulations to study the performance of the proposed method on both synthetic and real-life datasets. The simulations reveal that in asynchronous settings, the proposed PAO-Fed is able to achieve the same convergence properties as that of the online federated stochastic gradient while reducing the communication overhead by 98 percent.Comment: A conference precursor of this work appears in the 2022 IEEE IC

Personalized Graph Federated Learning with Differential Privacy

This paper presents a personalized graph federated learning (PGFL) framework in which distributedly connected servers and their respective edge devices collaboratively learn device or cluster-specific models while maintaining the privacy of every individual device. The proposed approach exploits similarities among different models to provide a more relevant experience for each device, even in situations with diverse data distributions and disproportionate datasets. Furthermore, to ensure a secure and efficient approach to collaborative personalized learning, we study a variant of the PGFL implementation that utilizes differential privacy, specifically zero-concentrated differential privacy, where a noise sequence perturbs model exchanges. Our mathematical analysis shows that the proposed privacy-preserving PGFL algorithm converges to the optimal cluster-specific solution for each cluster in linear time. It also shows that exploiting similarities among clusters leads to an alternative output whose distance to the original solution is bounded, and that this bound can be adjusted by modifying the algorithm's hyperparameters. Further, our analysis shows that the algorithm ensures local differential privacy for all clients in terms of zero-concentrated differential privacy. Finally, the performance of the proposed PGFL algorithm is examined by performing numerical experiments in the context of regression and classification using synthetic data and the MNIST dataset

Self-Sustaining Meteorological Wireless Sensor Networks

Greater distributed production of energy from renewable resources such as solar radiation has increased fluctuations of power on the electrical grid. Current infrastructure has limited ability to handle continued increases in fluctuations. Predicting weather patterns in areas containing a high penetration of solar photovoltaic installations can allow time to switch to energy storage and inform consumers to conserve energy thereby mitigating such fluctuations. Accurate prediction requires data at a high spatial and temporal resolution in hard-to-access areas such as on the rooftops of commercial and government buildings. A low-cost, autonomous, and easily maintained meteorological sensor network can meet these requirements. Through rapid prototyping techniques, specifically in-house 3D printing and open-source technologies, sensor modules are reported that achieve a high degree of durability under direct sunlight and high thermal loads while accurately measuring parameters such as temperature, pressure, humidity, and solar irradiance. The modules are inexpensive, portable, and self-powered

HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials.

BACKGROUND: Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the intended drug target. METHODS: We used single nucleotide polymorphisms in the HMGCR gene, rs17238484 (for the main analysis) and rs12916 (for a subsidiary analysis) as proxies for HMGCR inhibition by statins. We examined associations of these variants with plasma lipid, glucose, and insulin concentrations; bodyweight; waist circumference; and prevalent and incident type 2 diabetes. Study-specific effect estimates per copy of each LDL-lowering allele were pooled by meta-analysis. These findings were compared with a meta-analysis of new-onset type 2 diabetes and bodyweight change data from randomised trials of statin drugs. The effects of statins in each randomised trial were assessed using meta-analysis. FINDINGS: Data were available for up to 223 463 individuals from 43 genetic studies. Each additional rs17238484-G allele was associated with a mean 0·06 mmol/L (95% CI 0·05-0·07) lower LDL cholesterol and higher body weight (0·30 kg, 0·18-0·43), waist circumference (0·32 cm, 0·16-0·47), plasma insulin concentration (1·62%, 0·53-2·72), and plasma glucose concentration (0·23%, 0·02-0·44). The rs12916 SNP had similar effects on LDL cholesterol, bodyweight, and waist circumference. The rs17238484-G allele seemed to be associated with higher risk of type 2 diabetes (odds ratio [OR] per allele 1·02, 95% CI 1·00-1·05); the rs12916-T allele association was consistent (1·06, 1·03-1·09). In 129 170 individuals in randomised trials, statins lowered LDL cholesterol by 0·92 mmol/L (95% CI 0·18-1·67) at 1-year of follow-up, increased bodyweight by 0·24 kg (95% CI 0·10-0·38 in all trials; 0·33 kg, 95% CI 0·24-0·42 in placebo or standard care controlled trials and -0·15 kg, 95% CI -0·39 to 0·08 in intensive-dose vs moderate-dose trials) at a mean of 4·2 years (range 1·9-6·7) of follow-up, and increased the odds of new-onset type 2 diabetes (OR 1·12, 95% CI 1·06-1·18 in all trials; 1·11, 95% CI 1·03-1·20 in placebo or standard care controlled trials and 1·12, 95% CI 1·04-1·22 in intensive-dose vs moderate dose trials). INTERPRETATION: The increased risk of type 2 diabetes noted with statins is at least partially explained by HMGCR inhibition. FUNDING: The funding sources are cited at the end of the paper

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: A pooled analysis of 1018 population-based measurement studies with 88.6 million participants

© The Author(s) 2018. Background: Change in the prevalence of raised blood pressure could be due to both shifts in the entire distribution of blood pressure (representing the combined effects of public health interventions and secular trends) and changes in its high-blood-pressure tail (representing successful clinical interventions to control blood pressure in the hypertensive population). Our aim was to quantify the contributions of these two phenomena to the worldwide trends in the prevalence of raised blood pressure. Methods: We pooled 1018 population-based studies with blood pressure measurements on 88.6 million participants from 1985 to 2016. We first calculated mean systolic blood pressure (SBP), mean diastolic blood pressure (DBP) and prevalence of raised blood pressure by sex and 10-year age group from 20-29 years to 70-79 years in each study, taking into account complex survey design and survey sample weights, where relevant. We used a linear mixed effect model to quantify the association between (probittransformed) prevalence of raised blood pressure and age-group- and sex-specific mean blood pressure. We calculated the contributions of change in mean SBP and DBP, and of change in the prevalence-mean association, to the change in prevalence of raised blood pressure. Results: In 2005-16, at the same level of population mean SBP and DBP, men and women in South Asia and in Central Asia, the Middle East and North Africa would have the highest prevalence of raised blood pressure, and men and women in the highincome Asia Pacific and high-income Western regions would have the lowest. In most region-sex-age groups where the prevalence of raised blood pressure declined, one half or more of the decline was due to the decline in mean blood pressure. Where prevalence of raised blood pressure has increased, the change was entirely driven by increasing mean blood pressure, offset partly by the change in the prevalence-mean association. Conclusions: Change in mean blood pressure is the main driver of the worldwide change in the prevalence of raised blood pressure, but change in the high-blood-pressure tail of the distribution has also contributed to the change in prevalence, especially in older age groups