18 research outputs found
German S3 guideline "actinic keratosis and cutaneous squamous cell carcinoma" â long version of the update 2023
Actinic keratosis (AK) are common lesions in light-skinned individuals that can potentially progress to cutaneous squamous cell carcinoma (cSCC). Both conditions may be associated with significant morbidity and constitute a major disease burden, especially among the elderly. To establish an evidence-based framework for clinical decision making, the guideline âactinic keratosis and cutaneous squamous cell carcinomaâ was updated and expanded by the topics cutanepus squamous cell carcinoma in situ (Bowenâs disease) and actinic cheilitis. This guideline was developed at the highest evidence level (S3) and is aimed at dermatologists, general practitioners, ear nose and throat specialists, surgeons, oncologists, radiologists and radiation oncologists in hospitals and office-based settings, as well as other medical specialties, policy makers and insurance funds involved in the diagnosis and treatment of patients with AK and cSCC
Modified Gravity and Cosmology
In this review we present a thoroughly comprehensive survey of recent work on
modified theories of gravity and their cosmological consequences. Amongst other
things, we cover General Relativity, Scalar-Tensor, Einstein-Aether, and
Bimetric theories, as well as TeVeS, f(R), general higher-order theories,
Horava-Lifschitz gravity, Galileons, Ghost Condensates, and models of extra
dimensions including Kaluza-Klein, Randall-Sundrum, DGP, and higher
co-dimension braneworlds. We also review attempts to construct a Parameterised
Post-Friedmannian formalism, that can be used to constrain deviations from
General Relativity in cosmology, and that is suitable for comparison with data
on the largest scales. These subjects have been intensively studied over the
past decade, largely motivated by rapid progress in the field of observational
cosmology that now allows, for the first time, precision tests of fundamental
physics on the scale of the observable Universe. The purpose of this review is
to provide a reference tool for researchers and students in cosmology and
gravitational physics, as well as a self-contained, comprehensive and
up-to-date introduction to the subject as a whole.Comment: 312 pages, 15 figure
Reducing morbidity with surgical adhesives following inguinal lymph node dissections for the treatment of malignant skin tumors
Background: Inguinal lymph node dissection (ILND) is associated with a high rate of morbidity. To evaluate the clinical benefit of surgical adhesives to reduce complications in patients undergoing ILND, we compared the use of TissuGlu Surgical Adhesive and ARTISS fibrin sealant with a control population. Material and methods: We conducted a retrospective analysis of patients undergoing ILND for metastatic malignant skin tumors at one hospital, Fachklinik Hornheide (MĂŒnster, Germany), from January 2011 through September 2013, assessing 137 patients with a total of 142 procedures. Results: Complications occurred in 22/60 procedures in the TissuGlu group (TG), in 8/17 in the ARTISS group (AG), and in 29/65 in the control group (CG). Prolonged drainage and seroma were recorded in four (23.5%), and 26 (40%) respectively (non-significant). TG showed less extended drainage vs. CG (p=0.082). Mean daily drain volumes were significantly lower in AG vs. CG (p=0.000). With regard to wound infection, there was a 15% reduction in TG and 74% increase in AG group. Revision surgery was reduced by 36% in TG and increased by 54% in AG. Mean daily drain volumes were significantly lower in AG vs. CG (p=0.000). Mean total post-operative drain volume was lower in TG and AG vs. CG (p<0.001 among groups, CG vs. TG p<0.001, CG vs. AG p<0.001). The mean body mass index (BMI) was significantly higher in patients with complications, 29.4±5.8 vs. 25.3±4.1 (p=0.000).Conclusion: The use of TissuGlu in our ILND patients was associated with a reduction in post-operative wound related complications and the need for revision surgeries compared to the control group. Daily drainage was significantly lower within the first 7 post-operative days with the use of ARTISS, but the benefit was lost due to the higher occurrence of wound infection and revision surgery. BMI above 29 is a risk factor for complications following ILND.(Level of evidence: level IV, retrospective case study
S2k Guidelines for cutaneous basal cell carcinoma - Part 2: Treatment, prevention and follow-up
Basal cell carcinoma (BCC) is the most common malignant tumor among fairâskinned individuals, and its incidence had been steadily rising in the past decades. In order to maintain the highest quality of patient care possible, the German S2k guidelines were updated following a systematic literature search and with the participation of all professional societies and associations involved in the management of the disease. Part 2 addresses issues such as proper risk stratification, the various therapeutic approaches, and prevention as well as followâup of patients with basal cell carcinoma.
Das Basalzellkarzinom (BZK) ist der hĂ€ufigste maligne Tumor der hellhĂ€utigen Bevölkerung mit jĂ€hrlich steigender Inzidenz. Eine Aktualisierung der S2kâLeitlinie unter Beteiligung aller mit dem Krankheitsbild vertrauten Fachgesellschaften sowie vorangegangener Literaturrecherche ist fĂŒr die QualitĂ€t der Versorgung der betroffenen Patienten von essentieller Bedeutung. Im vorliegenden Teil 2 wird zunĂ€chst eine Risikostratifizierung aufgezeigt, bevor die verschiedenen Therapieoptionen diskutiert werden. Zudem werden PrĂ€vention und Nachsorge der Erkrankung behandelt
Malignant Melanoma S3-Guideline "Diagnosis, Therapy and Follow-up of Melanoma"
This first German evidence-based guideline for cutaneous melanoma was developed under the auspices of the German Dermatological Society (DDG) and the Dermatologic Cooperative Oncology Group (DeCOG) and funded by the German Guideline Program in Oncology. The recommendations are based on a systematic literature search, and on the consensus of 32 medical societies, working groups and patient representatives. This guideline contains recommendations concerning diagnosis, therapy and follow-up of melanoma. The diagnosis of primary melanoma based on clinical features and dermoscopic criteria. It is confirmed by histopathologic examination after complete excision with a small margin. For the staging of melanoma, the AJCC classification of 2009 is used. The definitive excision margins are 0.5 cm for in situ melanomas, 1 cm for melanomas with up to 2 mm tumor thickness and 2 cm for thicker melanomas, they are reached in a secondary excision. From 1 mm tumor thickness, sentinel lymph node biopsy is recommended. For stages II and III, adjuvant therapy with interferon-alpha should be considered after careful analysis of the benefits and possible risks. In the stage of locoregional metastasis surgical treatment with complete lymphadenectomy is the treatment of choice. In the presence of distant metastasis mutational screening should be performed for BRAF mutation, and eventually for CKIT and NRAS mutations. In the presence of mutations in case of inoperable metastases targeted therapies should be applied. Furthermore, in addition to standard chemotherapies, new immunotherapies such as the CTLA-4 antibody ipilimumab are available. Regular follow-up examinations are recommended for a period of 10 years, with an intensified schedule for the first three years
S2k Guidelines for Cutaneous Basal Cell Carcinoma - Part 1: Epidemiology, Genetics and Diagnosis
Basal cell carcinoma is the most common malignant tumor among fairâskinned individuals, and its incidence has been rising steadily in the past decades. In order to maintain the highest quality of patient care possible, the German S2k guidelines were updated following a systematic literature search and with the participation of all professional societies and associations involved in the management of the disease. Part 1 highlights new developments in genetics in particular as well as aspects regarding epidemiology, diagnosis, and histology.
Das Basalzellkarzinom ist der hĂ€ufigste maligne Tumor der hellhĂ€utigen Bevölkerung mit jĂ€hrlich steigender Inzidenz. Eine Aktualisierung der S2kâLeitlinie unter Beteiligung aller mit dem Krankheitsbild vertrauten Fachgesellschaften sowie vorangegangener Literaturrecherche ist fĂŒr die QualitĂ€t der Versorgung der betroffenen Patienten von essentieller Bedeutung. Im vorliegenden Teil 1 wird neben Epidemiologie insbesondere auf die neuen Erkenntnisse der Genetik eingegangen sowie Diagnostik und Histologie diskutiert
Zuversichtliche Einladung zu dem Schauspiel, von der traurigen Hinrichtung des Crispi, KĂ€ysers Constantini Magni Aeltesten Sohns, Welches mit gnĂ€digster Bewilligung Des ... Herrn Albert Anthons, Der Vier Grafen des Heil. Römischen Reichs, Grafens zu Schwartzburg und Hohnstein ... An statt des ordentlichen Herbst-Actus Auf unsern Schul Theatro zu Belustigung der studierenden Jugend, Den 24. 25. und 26. November allezeit Nachmittags um 2. Uhr soll fĂŒrgestellet werden unter der Direction
ZUVERSICHTLICHE EINLADUNG ZU DEM SCHAUSPIEL, VON DER TRAURIGEN HINRICHTUNG DES CRISPI, KĂYSERS CONSTANTINI MAGNI AELTESTEN SOHNS, WELCHES MIT GNĂDIGSTER BEWILLIGUNG DES ... HERRN ALBERT ANTHONS, DER VIER GRAFEN DES HEIL. RĂMISCHEN REICHS, GRAFENS ZU SCHWARTZBURG UND HOHNSTEIN ... AN STATT DES ORDENTLICHEN HERBST-ACTUS AUF UNSERN SCHUL THEATRO ZU BELUSTIGUNG DER STUDIERENDEN JUGEND, DEN 24. 25. UND 26. NOVEMBER ALLEZEIT NACHMITTAGS UM 2. UHR SOLL FĂRGESTELLET WERDEN UNTER DER DIRECTION
Zuversichtliche Einladung zu dem Schauspiel, von der traurigen Hinrichtung des Crispi, KĂ€ysers Constantini Magni Aeltesten Sohns, Welches mit gnĂ€digster Bewilligung Des ... Herrn Albert Anthons, Der Vier Grafen des Heil. Römischen Reichs, Grafens zu Schwartzburg und Hohnstein ... An statt des ordentlichen Herbst-Actus Auf unsern Schul Theatro zu Belustigung der studierenden Jugend, Den 24. 25. und 26. November allezeit Nachmittags um 2. Uhr soll fĂŒrgestellet werden unter der Direction ([1])
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