Agility training in football players: a systematic review

El objetivo de la presente revisión sistemática fue revisar el estado actual de la investigación sobre entrenamiento de agilidad y ver cómo se puede mejorar la agilidad en futbolistas. Para ello se realizó una búsqueda en la base de datos Medline/Pubmed para encontrar todos los estudios publicados hasta el 1 de diciembre de 2014 bajo las siguientes palabras clave: “agility training soccer”. Se encontraron 20 publicaciones que cubrían los criterios de inclusión. Según los artículos, la agilidad de los futbolistas se puede mejorar tanto en pretemporada como en temporada o una vez acabada la temporada. La mejora de la agilidad se puede conseguir con entrenamiento de pesas, con entrenamiento pliométrico, con entrenamiento combinado de fuerza y resistencia, con entrenamiento de contraste (isométrico + pliometría), mediante juegos con balón en espacios reducidos, a través de entrenamientos de esprines con cambios de dirección, mediante el método de entrenamiento: velocidad, agilidad y rapidez, con programas de entrenamiento neuromuscular, y a través de programas de calentamiento. Se han observado mejoras tanto en futbolistas amateur como en profesionales, y oscilan desde un 0.8% de mejora hasta un 22.8%.The purpose of the review was to look in the scientific literature how to improve the agility in footballers. The Medline/Pubmed database was used to find out all articles published until December 1 of 2014 using the following key words: “agility training soccer”. A total of 20 studies were found according to the inclusion criteria. The agility in footballers can be improved in preseason, during the season, and out of the season. The improvement in agility can be obtained through weight lifting, plyometric training, combined training of strength and endurance, contrast training (isometric + plyometric), with small-sided games, change of direction sprint training, with the speed, agility and quickness training method, with neuromuscular programs, and also with warm-up training program. The improvements were observed in both amateur and professional football players, ranging from 0.8% to 22.8% of improvement.peerReviewe

Entrenamiento de agilidad en futbolistas: una revisión sistemática

El objetivo de la presente revisión sistemática fue revisar el estado actual de la investigación sobre entrenamiento de agilidad y ver cómo se puede mejorar la agilidad en futbolistas. Para ello se realizó una búsqueda en la base de datos Medline/Pubmed para encontrar todos los estudios publicados hasta el 1 de diciembre de 2014 bajo las siguientes palabras clave: “agility training soccer”. Se encontraron 20 publicaciones que cubrían los criterios de inclusión. Según los artículos, la agilidad de los futbolistas se puede mejorar tanto en pretemporada como en temporada o una vez acabada la temporada. La mejora de la agilidad se puede con-seguir con entrenamiento de pesas, con entrenamiento pliométrico, con entrenamiento combinado de fuerza y resistencia, con entrenamiento de contraste (isométrico + pliometría), mediante juegos con balón en espacios reducidos, a través de entrenamientos de esprines con cambios de dirección, mediante el método de entrena-miento: velocidad, agilidad y rapidez, con programas de entrenamiento neuromuscular, y a través de programas de calentamiento. Se han observado mejoras tanto en futbolistas amateur como en profesionales, y oscilan desde un 0.8% de mejora hasta un 22.8%The purpose of the review was to look in the scientific literature how to improve the agility in footballers. The Medline/Pubmed database was used to find out all articles published until December 1 of 2014 using the following key words: “agility training soccer”. A total of 20 studies were found according to the inclusion criteria. The agility in footballers can be improved in preseason, during the season, and out of the season. The improvement in agility can be obtained through weight lifting, plyometric training, combined training of strength and endurance, contrast training (isometric + plyometric), with small-sided games, change of direction sprint training, with the speed, agility and quickness training method, with neuromuscular programs, and also with warm-up training program. The improvements were observed in both amateur and professional football players, ranging from 0.8% to 22.8% of improvement.Actividad Física y Deport

Towards a Semantic-Aware Collaborative Working Environment

Collaborative Working Environments (CWEs) enable an efficient collaboration between professionals, specially those settled in different locations of a company or stakeholders from different companies. This can be of great help for small and medium enterprises (SMEs), as an effective way to share information. However, it can be difficult for SMEs to have access to a fully integrated CWE providing different tools (e.g., videoconferencing, instant messaging, etc.). Currently, they may define a CWE as a combination of heterogeneous and non-integrated tools which are not able to share information between them. An integrated CWE would provide SMEs with the necessary means to collaborate, making information exchange easier.&nbsp

Effectiveness of an intervention for improving drug prescription in primary care patients with multimorbidity and polypharmacy:Study protocol of a cluster randomized clinical trial (Multi-PAP project)

This study was funded by the Fondo de Investigaciones Sanitarias ISCIII (Grant Numbers PI15/00276, PI15/00572, PI15/00996), REDISSEC (Project Numbers RD12/0001/0012, RD16/0001/0005), and the European Regional Development Fund ("A way to build Europe").Background: Multimorbidity is associated with negative effects both on people's health and on healthcare systems. A key problem linked to multimorbidity is polypharmacy, which in turn is associated with increased risk of partly preventable adverse effects, including mortality. The Ariadne principles describe a model of care based on a thorough assessment of diseases, treatments (and potential interactions), clinical status, context and preferences of patients with multimorbidity, with the aim of prioritizing and sharing realistic treatment goals that guide an individualized management. The aim of this study is to evaluate the effectiveness of a complex intervention that implements the Ariadne principles in a population of young-old patients with multimorbidity and polypharmacy. The intervention seeks to improve the appropriateness of prescribing in primary care (PC), as measured by the medication appropriateness index (MAI) score at 6 and 12months, as compared with usual care. Methods/Design: Design:pragmatic cluster randomized clinical trial. Unit of randomization: family physician (FP). Unit of analysis: patient. Scope: PC health centres in three autonomous communities: Aragon, Madrid, and Andalusia (Spain). Population: patients aged 65-74years with multimorbidity (≥3 chronic diseases) and polypharmacy (≥5 drugs prescribed in ≥3months). Sample size: n=400 (200 per study arm). Intervention: complex intervention based on the implementation of the Ariadne principles with two components: (1) FP training and (2) FP-patient interview. Outcomes: MAI score, health services use, quality of life (Euroqol 5D-5L), pharmacotherapy and adherence to treatment (Morisky-Green, Haynes-Sackett), and clinical and socio-demographic variables. Statistical analysis: primary outcome is the difference in MAI score between T0 and T1 and corresponding 95% confidence interval. Adjustment for confounding factors will be performed by multilevel analysis. All analyses will be carried out in accordance with the intention-to-treat principle. Discussion: It is essential to provide evidence concerning interventions on PC patients with polypharmacy and multimorbidity, conducted in the context of routine clinical practice, and involving young-old patients with significant potential for preventing negative health outcomes. Trial registration: Clinicaltrials.gov, NCT02866799Publisher PDFPeer reviewe

The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

Background: Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study is to investigate associations between mortality and variables measured during the first three days of mechanical ventilation in patients with COVID-19 intubated at ICU admission. Methods: Multicenter, observational, cohort study includes consecutive patients with COVID-19 admitted to 44 Spanish ICUs between February 25 and July 31, 2020, who required intubation at ICU admission and mechanical ventilation for more than three days. We collected demographic and clinical data prior to admission; information about clinical evolution at days 1 and 3 of mechanical ventilation; and outcomes. Results: Of the 2,095 patients with COVID-19 admitted to the ICU, 1,118 (53.3%) were intubated at day 1 and remained under mechanical ventilation at day three. From days 1 to 3, PaO2/FiO2 increased from 115.6 [80.0-171.2] to 180.0 [135.4-227.9] mmHg and the ventilatory ratio from 1.73 [1.33-2.25] to 1.96 [1.61-2.40]. In-hospital mortality was 38.7%. A higher increase between ICU admission and day 3 in the ventilatory ratio (OR 1.04 [CI 1.01-1.07], p = 0.030) and creatinine levels (OR 1.05 [CI 1.01-1.09], p = 0.005) and a lower increase in platelet counts (OR 0.96 [CI 0.93-1.00], p = 0.037) were independently associated with a higher risk of death. No association between mortality and the PaO2/FiO2 variation was observed (OR 0.99 [CI 0.95 to 1.02], p = 0.47). Conclusions: Higher ventilatory ratio and its increase at day 3 is associated with mortality in patients with COVID-19 receiving mechanical ventilation at ICU admission. No association was found in the PaO2/FiO2 variation

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an

Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis

Search for new particles in events with energetic jets and large missing transverse momentum in proton-proton collisions at root s=13 TeV

A search is presented for new particles produced at the LHC in proton-proton collisions at root s = 13 TeV, using events with energetic jets and large missing transverse momentum. The analysis is based on a data sample corresponding to an integrated luminosity of 101 fb(-1), collected in 2017-2018 with the CMS detector. Machine learning techniques are used to define separate categories for events with narrow jets from initial-state radiation and events with large-radius jets consistent with a hadronic decay of a W or Z boson. A statistical combination is made with an earlier search based on a data sample of 36 fb(-1), collected in 2016. No significant excess of events is observed with respect to the standard model background expectation determined from control samples in data. The results are interpreted in terms of limits on the branching fraction of an invisible decay of the Higgs boson, as well as constraints on simplified models of dark matter, on first-generation scalar leptoquarks decaying to quarks and neutrinos, and on models with large extra dimensions. Several of the new limits, specifically for spin-1 dark matter mediators, pseudoscalar mediators, colored mediators, and leptoquarks, are the most restrictive to date.Peer reviewe

Combined searches for the production of supersymmetric top quark partners in proton-proton collisions at root s=13 TeV

A combination of searches for top squark pair production using proton-proton collision data at a center-of-mass energy of 13 TeV at the CERN LHC, corresponding to an integrated luminosity of 137 fb(-1) collected by the CMS experiment, is presented. Signatures with at least 2 jets and large missing transverse momentum are categorized into events with 0, 1, or 2 leptons. New results for regions of parameter space where the kinematical properties of top squark pair production and top quark pair production are very similar are presented. Depending on themodel, the combined result excludes a top squarkmass up to 1325 GeV for amassless neutralino, and a neutralinomass up to 700 GeV for a top squarkmass of 1150 GeV. Top squarks with masses from 145 to 295 GeV, for neutralino masses from 0 to 100 GeV, with a mass difference between the top squark and the neutralino in a window of 30 GeV around the mass of the top quark, are excluded for the first time with CMS data. The results of theses searches are also interpreted in an alternative signal model of dark matter production via a spin-0 mediator in association with a top quark pair. Upper limits are set on the cross section for mediator particle masses of up to 420 GeV

Search for supersymmetry in events with one lepton and multiple jets in proton-proton collisions at root s=13 TeV

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