Motivación y estrategias de aprendizaje en los estudiantes reprobados de la carrera de psicología de la Facultad Regional Multidisciplinaria de Carazo de la UNAN-Managua, en el periodo 2014 al I semestre del año 2018

El propósito de esta investigación fue analizar los factores de motivación que influyen el uso de estrategias de aprendizaje de los estudiantes reprobados de la carrera de psicología de la UNAN-FAREM-Carazo, en el periodo 2014 al I semestre del año 2018. Se trata de un estudio cuantitativo, tipo descriptivo con un diseño no experimental, de corte transversal. Para ello se seleccionó una muestra de 16 participantes, 8 masculinos y 8 femeninos con edades que oscilaron entre 18 y 30 años, a quienes se les aplicó la una Escala de Autopercepción de la Motivación Académica adaptada y modificada a la población de estudio la cual contenía ítems, tipo escala Likert. Entre los principales resultados esta la variable motivación extrínseca en su categoría metas relacionadas con la obtención de recompensas externas la cual refleja que el 56,3 % de los estudiantes están de acuerdo que estudian porque quieren tener una vida cómoda en el futuro, mientras que el 43,8 % estudian para obtener un título universitario e integrarse al campo profesional. Opuesto a los datos anteriores el 43,8 % asegura no sentirse motivado con el hecho de recibir una beca y un 37,5 % afirma que los profesores y su metodología no son parte de su motivación para seguir estudiando. Mientras que las estrategias de aprendizaje llevadas a cabo por los estudiantes en la categoría manejo de recurso en cuanto a aprendizaje con otros, el 50 % afirman su preferencia por estudiar solo, contrario a esto el 43,3 % asegura que el trabajo en grupo no resulta eficaz. Por tal razón se recomienda emplear el uso de estrategias de aprendizaje en cuanto al manejo de recursos tales como: tiempo y lugar de estudio, regulación del esfuerzo, aprendizaje con otros y búsqueda de ayuda que permitan a fortalecer conocimientos adquiridos

Zalypsis has in vitro activity in acute myeloid blasts and leukemic progenitor cells through the induction of a DNA damage response

[EN]Although the majority of patients with acute myeloid leukemia initially respond to conventional chemotherapy, relapse is still the leading cause of death, probably because of the presence of leukemic stem cells that are insensitive to current therapies. We investigated the antileukemic activity and mechanism of action of zalypsis, a novel alkaloid of marine origin. The activity of zalypsis was studied in four acute myeloid leukemia cell lines and in freshly isolated blasts taken from patients with acute myeloid leukemia before they started therapy. Zalypsis-induced apoptosis of both malignant and normal cells was measured using flow cytometry techniques. Gene expression profiling and western blot studies were performed to assess the mechanism of action of the alkaloid. Zalypsis showed a very potent antileukemic activity in all the cell lines tested and potentiated the effect of conventional antileukemic drugs such as cytarabine, fludarabine and daunorubicin. Interestingly, zalypsis showed remarkable ex vivo potency, including activity against the most immature blast cells (CD34(+) CD38(-) Lin(-)) which include leukemic stem cells. Zalypsis-induced apoptosis was the result of an important deregulation of genes involved in the recognition of double-strand DNA breaks, such as Fanconi anemia genes and BRCA1, but also genes implicated in the repair of double-strand DNA breaks, such as RAD51 and RAD54. These gene findings were confirmed by an increase in several proteins involved in the pathway (pCHK1, pCHK2 and pH2AX). The potent and selective antileukemic effect of zalypsis on DNA damage response mechanisms observed in acute myeloid leukemia cell lines and in patients' samples provides the rationale for the investigation of this compound in clinical trials

The avoidance of G-CSF and the addition of prophylactic corticosteroids after autologous stem cell transplantation for multiple myeloma patients appeal for the at-home setting to reduce readmission for neutropenic fever

Autologous stem cell transplantation (ASCT) remains the standard of care for young multiple myeloma (MM) patients; indeed, at-home ASCT has been positioned as an appropriate therapeutic strategy. However, despite the use of prophylactic antibiotics, neutropenic fever (NF) and hospital readmissions continue to pose as the most important limitations in the outpatient setting. It is possible that the febrile episodes may have a non-infectious etiology, and engraftment syndrome could play a more significant role. The aim of this study was to analyze the impact of both G-CSF withdrawal and the addition of primary prophylaxis with corticosteroids after ASCT. Between January 2002 and August 2018, 111 MM patients conditioned with melphalan were managed at-home beginning +1 day after ASCT. Three groups were established: Group A (n = 33) received standard G-CSF post-ASCT; group B (n = 32) avoided G-CSF post-ASCT; group C (n = 46) avoided G-CSF yet added corticosteroid prophylaxis post-ASCT. The incidence of NF among the groups was reduced (64%, 44%, and 24%; P2 (OR 6.1; P = 0.002) and G-CSF avoidance plus corticosteroids (OR 0.1; P<0.001); and for hospital readmission: age �60 years (OR 14.6; P = 0.04) and G-CSF avoidance plus corticosteroids (OR 0.07; P = 0.05. G-CSF avoidance and corticosteroid prophylaxis post ASCT minimize the incidence of NF in MM patients undergoing at-home ASCT. This approach should be explored in a prospective randomized clinical trial

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight NCD Risk Factor Collaboration (NCD-RisC)

From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based studies with 187 million participants. Changes in the prevalence of underweight and total obesity, and to a lesser extent severe obesity, are largely driven by shifts in the distribution of BMI, with smaller contributions from changes in the shape of the distribution. In East and Southeast Asia and sub-Saharan Africa, the underweight tail of the BMI distribution was left behind as the distribution shifted. There is a need for policies that address all forms of malnutrition by making healthy foods accessible and affordable, while restricting unhealthy foods through fiscal and regulatory restrictions

Cytochemical and biochemical evidences for a complex tridimensional structure of the hamster zona pellucida

Zona pellucida (ZP) is an extracellular matrix that surrounds eggs and pre-implantation embryos and is required for in vivo fertility. A key event in successful fertilization is sperm binding to the surface of the ZP. It has been previously described that the hamster sperm binds mainly the outer region of the ZP which corresponds to the porous region in contact with the cumulus cells. Using ultrastructural cytochemistry approaches with an antibody developed against porcine ZP, this study shows that the pig ZP shares epitopes with some rodent species like hamster, rat and mouse. In the hamster, these epitopes are located mainly in the outer region of the ZP of preovulatory and ovulated oocytes. By means of biochemical approaches it was demonstrated that 1) the antibody is specific for the native hamster ZP3, 2) four different bands with a molecular weight of 67, 60, 48 and 38 kDa after Nlinked deglycosylation suggesting that the hamster ZP is formed by four proteins, and 3) the different composition observed in the outer region of the hamster ZP could be due to a specific supramolecular structure that makes some epitopes accessible for the antibodies. In summary, this study provides evidence that the different composition observed in the different regions of the ZP is mediated by a different organization of the components of the ZP produced during the oocyte maturation. This different organization could be responsible for the different sperm binding affinity observed for sperm to the outer region versus the inner region of the ZP

A new big data triclustering approach for extracting three-dimensional patterns in precision agriculture

Precision agriculture focuses on the development of site-specific harvest considering the variability of each crop area. Vegetation indices allow the study and delineation of different characteristics of each field zone, generally invisible to the naked-eye. This paper introduces a new big data triclustering approach based on evolutionary algorithms. The algorithm shows its capability to discover three-dimensional pat-terns on the basis of vegetation indices from vine crops. Different vegetation indices have been tested to find different patterns in the crops. The results reported using a vineyard crop located in Portugal depicts four areas with different moisture stress particularities that can lead to changes in the management of the vineyard. Furthermore, scalability studies have been performed, showing that the proposed algorithm is suitable for dealing with big datasets.Ministerio de Ciencia e Innovación PID2020-117954RBJunta de Andalucía PY20-00870Junta de Andalucía UPO-138516Fundação para a Ciência e a Tecnologia (FCT) UIDB/00066/202

Collection de contes de chimie et de génétique ​​pour la promotion de nouvelles vocations scientifiques

Se han escrito diez narraciones que incluyen contenidos básicos de Química y de Genética. Su lectura y reflexión podrá clarificar conceptos que, en ocasiones, se aprenden sin entender su verdadero significado y, tal entendimiento, podrá contribuir a incrementar el interés por la ciencia y al fomento de nuevas vocaciones científicas.Ten stories have been written that include basic contents of Chemistry and Genetics. Its reading and reflection will be able to clarify concepts that, at times, are learned without understanding their true meaning and, such understanding, may contribute to increasing interest in science and promoting new scientific vocations.Dix histoires ont été écrites qui incluent le contenu de base de la chimie et de la génétique. Sa lecture et sa réflexion permettront de clarifier des concepts qui, parfois, s'apprennent sans en comprendre le vrai sens et, cette compréhension, peuvent contribuer à accroître l'intérêt pour la science et à promouvoir de nouvelles vocations scientifiques.Depto. de Química InorgánicaFac. de Ciencias QuímicasFALSEsubmitte

Easix Score Correlates With Endothelial Dysfunction Biomarkers and Predicts Risk of Acute Graft-Versus-Host Disease After Allogeneic Transplantation

Plasma biomarkers of endothelial dysfunction have been postulated for the diagnosis and prognosis of acute graft-versus-host disease (aGVHD). However, their use is not validated in clinical practice yet. The endothelial activation and stress index (EASIX), a simple score based on routine laboratory parameters, is considered to be an indirect marker of endothelial damage. High value of EASIX was correlated with worse non-relapse mortality (NRM) and overall survival (OS) and a high risk of sinusoidal obstructive syndrome (SOS) and transplant-associated thrombotic microangiopathy (TA-TMA).This study investigates the predictive value of plasma biomarkers and the EASIX score for the prediction of aGVHD.We assessed VCAM-1, TNFR1, and VWF:Ag plasma levels, and EASIX score before allogeneic hematopoietic stem cell transplantation (allo-HSCT), and on days 0, +3, +7, +14, and +21 in an experimental cohort (n=33). EASIX was transformed to a base-2 logarithm to perform the analysis. For the most relevant biomarkers, we estimate the optimal cut-off values and the discriminatory ability to differentiate patients with high-risk of aGVHD. The conclusions obtained in the experimental cohort were validated in a large cohort of 321 patients at the same institution.Plasma biomarkers and EASIX showed similar post-transplant dynamics consisting of a progressive increase. Multivariate analysis showed an association between high TNFR1 levels and Log-2 EASIX score on day +7 post-transplant with an increased likelihood of developing aGVHD (HR 1, P=0.002; HR 2.31, P=0.013, respectively). Patients with TNFR1 ≥1300 ng/mL (HR 7.19, P=0.006) and Log2-EASIX ≥3 (HR 14.7, P<0.001) at day +7 post-transplant were more likely to develop aGVHD with high predictive accuracy (C-index of 74% and 81%, respectively). In the validation cohort, patients with Log2-EASIX ≥ 3 on day +7 post-transplant presented a significantly higher incidence of grade II-IV aGVHD (HR 1.94, P=0.004) independent of GVHD prophylaxis (HR 0.38, P=0.004), conditioning regimen (HR 0.59, P=0.02) and type of donor (HR 2.38, P=0.014).Differential degree of endothelial damage can be measured using both EASIX score and plasma biomarkers in the early post-transplant period. Patients at risk of developing aGVHD could be easily identified by a high EASIX score. Both indicators of endothelial activation represent a promising approach to predict aGVHD.Published by Elsevier Inc