Mexico's Health System: More Comprehensive Reform Needed

Jason Lakin discusses and critiques a Policy Forum that reviews 25 years of reform to the Mexican health system and argues that more comprehensive reform is needed

Tracing the cosmic growth of supermassive black holes to z~3 with Herschel

We study a sample of Herschel selected galaxies within the Great Observatories Origins Deep Survey-South and the Cosmic Evolution Survey fields in the framework of the Photodetector Array Camera and Spectrometer (PACS) Evolutionary Probe project. Starting from the rich multiwavelength photometric data sets available in both fields, we perform a broad-band spectral energy distribution decomposition to disentangle the possible active galactic nucleus (AGN) contribution from that related to the host galaxy. We find that 37 per cent of the Herschel-selected sample shows signatures of nuclear activity at the 99 per cent confidence level. The probability of revealing AGN activity increases for bright (L 1−1000 > 10 11 L ? ) star-forming galaxies at z > 0.3, becoming about 80 per cent for the brightest (L 1−1000 > 10 12 L ? ) Infrared (IR) galaxies at z≥1. Finally, we reconstruct the AGN bolometric luminosity function and the supermassive black hole growth rate across cosmic time up to z ∼ 3 from a far-IR perspective. This work shows general agreement with most of the panchromatic estimates from the literature, with the global black hole growth peaking at z ∼ 2 and reproducing the observed local black hole mass density with consistent values of the radiative efficiency Erad (∼0.07)

The Eighth Data Release of the Sloan Digital Sky Survey: First Data from SDSS-III

The Sloan Digital Sky Survey (SDSS) started a new phase in August 2008, with new instrumentation and new surveys focused on Galactic structure and chemical evolution, measurements of the baryon oscillation feature in the clustering of galaxies and the quasar Ly alpha forest, and a radial velocity search for planets around ~8000 stars. This paper describes the first data release of SDSS-III (and the eighth counting from the beginning of the SDSS). The release includes five-band imaging of roughly 5200 deg^2 in the Southern Galactic Cap, bringing the total footprint of the SDSS imaging to 14,555 deg^2, or over a third of the Celestial Sphere. All the imaging data have been reprocessed with an improved sky-subtraction algorithm and a final, self-consistent photometric recalibration and flat-field determination. This release also includes all data from the second phase of the Sloan Extension for Galactic Understanding and Evolution (SEGUE-2), consisting of spectroscopy of approximately 118,000 stars at both high and low Galactic latitudes. All the more than half a million stellar spectra obtained with the SDSS spectrograph have been reprocessed through an improved stellar parameters pipeline, which has better determination of metallicity for high metallicity stars.Comment: Astrophysical Journal Supplements, in press (minor updates from submitted version

Detection of three gamma-ray burst host galaxies at z ∼ 6

The American Astronomical Society. All rights reserved.Long-duration gamma-ray bursts (GRBs) allow us to pinpoint and study star-forming galaxies in the early universe, thanks to their orders of magnitude brighter peak luminosities compared to other astrophysical sources, and their association with the deaths of massive stars. We present Hubble Space Telescope Wide Field Camera 3 detections of three Swift GRB host galaxies lying at redshifts z = 5.913 (GRB 130606A), z = 6.295 (GRB 050904), and z = 6.327 (GRB 140515A) in the F140W (wide-JH band, λobs ∼ 1.4μm) filter. The hosts have magnitudes (corrected for Galactic extinction) of mλobsAB = 26.34-0.16+0.14, 27.56-0.22+0.18, and 28.30-0.33+0.25, respectively. In all three cases, the probability of chance coincidence of lower redshift galaxies is ≲2%, indicating that the detected galaxies are most likely the GRB hosts. These are the first detections of high-redshift () GRB host galaxies in emission. The galaxies have luminosities in the range 0.1-0.6 Lz=6∗(with M1600∗ = -20.95±0.12) and half-light radii in the range 0.6-0.9 kpc. Both their half-light radii and luminosities are consistent with existing samples of Lyman-break galaxies at z∼6. Spectroscopic analysis of the GRB afterglows indicate low metallicities ([M/H]≲-1) and low dust extinction (AV ≲ 0.1) along the line of sight. Using stellar population synthesis models, we explore the implications of each galaxy's luminosity for its possible star-formation history and consider the potential for emission line metallicity determination with the upcoming James Webb Space Telescope. © 2016

Criteria for priority setting of HIV/AIDS interventions in Thailand: a discrete choice experiment

Contains fulltext : 87849.pdf (publisher's version ) (Open Access)BACKGROUND: Although a sizeable budget is available for HIV/AIDS control in Thailand, there will never be enough resources to implement every programme for all target groups at full scale. As such, there is a need to prioritize HIV/AIDS programmes. However, as of yet, there is no evidence on the criteria that should guide the priority setting of HIV/AIDS programmes in Thailand, including their relative importance. Also, it is not clear whether different stakeholders share similar preferences. METHODS: Criteria for priority setting of HIV/AIDS interventions in Thailand were identified in group discussions with policy makers, people living with HIV/AIDS (PLWHA), and community members (i.e. village health volunteers (VHVs)). On the basis of these, discrete choice experiments were designed and administered among 28 policy makers, 74 PLWHA, and 50 VHVs. RESULTS: In order of importance, policy makers expressed a preference for interventions that are highly effective, that are preventive of nature (as compared to care and treatment), that are based on strong scientific evidence, that target high risk groups (as compared to teenagers, adults, or children), and that target both genders (rather than only men or women). PLWHA and VHVs had similar preferences but the former group expressed a strong preference for care and treatment for AIDS patients. CONCLUSIONS: The study has identified criteria for priority setting of HIV/AIDS interventions in Thailand, and revealed that different stakeholders have different preferences vis-a-vis these criteria. This could be used for a broad ranking of interventions, and as such as a basis for more detailed priority setting, taking into account also qualitative criteria

Polycyclic aromatic hydrocarbon emission in powerful high-redshift radio galaxies

We present the mid-infrared (IR) spectra of seven of the most powerful radio-galaxies known to exist at 1.5 < z < 2.6. The radio emission of these sources is dominated by the AGN with 500 MHz luminosities in the range 10^(27.8)–10^(29.1) W Hz^(−1). The AGN signature is clearly evident in the mid-IR spectra; however, we also detect polycyclic aromatic hydrocarbon emission, indicative of prodigious star formation at a rate of up to ∼1000 M_⊙ yr^(−1). Interestingly, we observe no significant correlation between AGN power and star formation in the host galaxy. We also find most of these radio galaxies to have weak 9.7 μm silicate absorption features (τ_(9.7 μm) < 0.8) which implies that their mid-IR obscuration is predominantly due to the dusty torus that surrounds the central engine, rather than the host galaxy. The tori are likely to have an inhomogeneous distribution with the obscuring structure consisting of individual clouds. We estimate that these radio galaxies have already formed the bulk of their stellar mass and appear to lie at a stage in their evolution where the obscured AGN dominates the energy output of the system but star formation is also prevalent

Mechanism of KMT5B haploinsufficiency in neurodevelopment in humans and mice.

Pathogenic variants in KMT5B, a lysine methyltransferase, are associated with global developmental delay, macrocephaly, autism, and congenital anomalies (OMIM# 617788). Given the relatively recent discovery of this disorder, it has not been fully characterized. Deep phenotyping of the largest (n = 43) patient cohort to date identified that hypotonia and congenital heart defects are prominent features that were previously not associated with this syndrome. Both missense variants and putative loss-of-function variants resulted in slow growth in patient-derived cell lines. KMT5B homozygous knockout mice were smaller in size than their wild-type littermates but did not have significantly smaller brains, suggesting relative macrocephaly, also noted as a prominent clinical feature. RNA sequencing of patient lymphoblasts and Kmt5b haploinsufficient mouse brains identified differentially expressed pathways associated with nervous system development and function including axon guidance signaling. Overall, we identified additional pathogenic variants and clinical features in KMT5B-related neurodevelopmental disorder and provide insights into the molecular mechanisms of the disorder using multiple model systems

Sloan Digital Sky Survey IV: Mapping the Milky Way, Nearby Galaxies, and the Distant Universe

We describe the Sloan Digital Sky Survey IV (SDSS-IV), a project encompassing three major spectroscopic programs. The Apache Point Observatory Galactic Evolution Experiment 2 (APOGEE-2) is observing hundreds of thousands of Milky Way stars at high resolution and high signal-to-noise ratios in the near-infrared. The Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey is obtaining spatially resolved spectroscopy for thousands of nearby galaxies (median $z\sim 0.03$). The extended Baryon Oscillation Spectroscopic Survey (eBOSS) is mapping the galaxy, quasar, and neutral gas distributions between $z\sim 0.6$ and 3.5 to constrain cosmology using baryon acoustic oscillations, redshift space distortions, and the shape of the power spectrum. Within eBOSS, we are conducting two major subprograms: the SPectroscopic IDentification of eROSITA Sources (SPIDERS), investigating X-ray AGNs and galaxies in X-ray clusters, and the Time Domain Spectroscopic Survey (TDSS), obtaining spectra of variable sources. All programs use the 2.5 m Sloan Foundation Telescope at the Apache Point Observatory; observations there began in Summer 2014. APOGEE-2 also operates a second near-infrared spectrograph at the 2.5 m du Pont Telescope at Las Campanas Observatory, with observations beginning in early 2017. Observations at both facilities are scheduled to continue through 2020. In keeping with previous SDSS policy, SDSS-IV provides regularly scheduled public data releases; the first one, Data Release 13, was made available in 2016 July