Envelhecimento ativo na migração de portugueses/as para a Alemanha : narrativas de percurso e retorno

Mestrado em GerontologiaO envelhecimento da população portuguesa é, à semelhança dos restantes países desenvolvidos, uma realidade mundial atual. Atendendo às repercussões políticas, económicas, sociais e na saúde que este fenómeno acarreta, foi desenvolvido, pela Organização Mundial de Saúde, um novo paradigma designado por Envelhecimento Ativo. Apesar do aumento do número de estudos centrados neste paradigma, existem ainda lacunas significativas de investigações que abranjam o Envelhecimento Ativo e a Migração Internacional. Assim, a presente investigação, teve como objetivo geral explorar o processo de Envelhecimento Ativo de portugueses/as no percurso da migração para a Alemanha e de retorno a Portugal. Este estudo foi desenvolvido com base numa abordagem qualitativa através do método da história oral de Paul Thompson. Os dados foram recolhidos por intermédio de entrevistas semiestruturadas, efetuadas a 17 participantes, onze homens e seis mulheres. Os princípios éticos foram respeitados durante todo o processo de investigação. A análise dos dados foi desenvolvida através da análise de conteúdo, com o apoio do programa QSR NVivo. Este estudo abrangeu duas categorias principais: Migração de portugueses/as para a Alemanha e Envelhecimento Ativo e Migração Internacional. Os resultados permitiram concluir que a experiência da migração foi satisfatória, tendo em conta que os objetivos da migração, como a melhoria das condições económicas e a aquisição de uma habitação própria, foram alcançados. A migração proporcionou a obtenção de rendimentos que auxiliaram a melhor qualidade de vida na velhice. A aposentação foi um marco importante para o Envelhecimento Ativo, proporcionando maior disponibilidade temporal e de interesse. A saúde, uma dimensão vulnerável para a maioria das pessoas migrantes, foi também beneficiada pelo processo migratório, devido ao acesso a serviços equitativos e com qualidade superior. De um modo geral, os resultados mostraram que a migração para a Alemanha contribuiu para uma melhor qualidade de vida dos/as participantes, considerando os determinantes do modelo de Envelhecimento Ativo da Organização Mundial de Saúde. A migração proporcionou novas oportunidades para o Envelhecimento Ativo e para uma vida com maior qualidade e dignidade.The aging of the Portuguese population is, like other developed countries, an actual world reality. Given the political, economic, social and health repercussions that this phenomenon leads, the World Health Organization developed a new paradigm called Active Ageing. Despite the increasing number of studies focusing on this paradigm, there are still significant gaps in those researches regarding the Active Ageing and International Migration. So, this research aimed to explore the Active Ageing process of Portuguese people who migrated to Germany and returned to Portugal. This study was developed based on a qualitative approach through the method of oral history of Paul Thompson. The data were collected through semistructured interviews, carried out at 17 participants, eleven men and six women. Ethical principles were respect throughout the research process. Data analysis was done based on content analysis, with the support of the QSR NVivo program. This study included two main categories: Migration of Portuguese people to Germany, and Active Ageing and International Migration. The results allowed concluding that the migration experience was satisfactory, given that the migration goals, such as improved economic conditions and the acquisition of a dwelling, were achieved. The migration has provided the achievement of income that helps better quality of life in old age. The retirement was an important milestone for Active Ageing, providing greater temporal availability of interest. Health, a vulnerable dimension for most migrants also benefited by the migratory process, due to access to the fair services and superior quality. Generally speaking, the results showed that the migration to Germany contributed to a better quality of life of the participants, considering the determinants of active aging model of the World Health Organization. Thus, the migration has provided new opportunities for active aging and a life with higher quality and dignity

Role of the transient receptor potential vanilloid 1 in inflammation and sepsis

The transient receptor potential vanilloid 1 (TRPV1) is a thermoreceptor that responds to noxious temperatures, as well as to chemical agonists, such as vanilloids and protons. In addition, its channel activity is notably potentiated by proinflammatory mediators released upon tissue damage. The TRPV1 contribution to sensory neuron sensitization by proalgesic agents has signaled this receptor as a prime target for analgesic and anti-inflammatory drug intervention. However, TRPV1 antagonists have notably failed in clinical and preclinical studies because of their unwanted side effects. Recent reports have unveiled previously unrecognized anti-inflammatory and protective functions of TRPV1 in several diseases. For instance, this channel has been suggested to play an anti-inflammatory role in sepsis. Therefore, the use of potent TRPV1 antagonists as a general strategy to treat inflammation must be cautiously considered, given the deleterious effects that may arise from inhibiting the population of channels that have a protective function. The use of TRPV1 antagonists may be limited to treating those pathologies where enhanced receptor activity contributes to the inflamed state. Alternatively, therapeutic paradigms, such as reduction of inflammatory-mediated increase of receptor expression in the cell surface, may be a better strategy to prevent abrogation of the TRPV1 subpopulation involved in anti-inflammatory and protective processes

Additive manufactured stoneware fired in microwave furnace

In the context of ceramic manufacturing, additive manufacturing or 3D printing creates new opportunities and perspectives, allowing the fabrication of parts with complex shapes, which by traditional means would be impossible to produce or would be very expensive [1]. This is the case for dinnerware and artworks (stoneware, porcelain and clay-based products). After piece forming, the greenware is gas or electrically fired at high temperatures to achieve its mechanical strength and aesthetic properties. These conventional firing processes usually require long processing times, in the present case taking 10 h to reach temperatures around 1200 °C [2]. In the search for faster firing processes, small size and cup shaped 3D printed stoneware pieces were fired using microwave radiation as the energy source. As microwave radiation has the potential to penetrate the material to be sintered, volumetric heating can be achieved, and faster firing processes are possible to implement without cracks formation and other thermal related defects. Pieces were fired in 10% of the conventional manufacturing time in a six magnetrons (energy sources) microwave furnace [3]. The microwave, the electrically-fast-fired and conventionally-fired pieces are presented in Figure 1. The conventionally-fired pieces are seen as reference samples. Temperature was controlled through a calibrated pyrometer [3], and using Process Temperature Control Rings (PTCR) the temperature of the pieces of (1207 ± 15) °C was determined. An error of only 1.25% was calculated between the temperature measured by the pyrometer and the PTCR in the piece where the pyrometer is measuring the temperature. The PTCR elements give a better representation of the real heating process at its location, concomitantly of each piece when they are placed inside it. The results show that microwave-fast-fired pieces present comparable mechanical strength to the references (10 h electrically fired) and to the electrically fast-fired pieces (41, 46 and 34 (N/mm2), respectively), and present aesthetic features closer to the reference ones. Porosity quantification does not fully agree with the mechanical strength of the pieces, of ~5% for electrically fast-fired, ~9% for the references and ~4% for microwave-fired ones. Overall, microwave heating can be used as an alternative stoneware firing technology, without compromising its quality and features with gains in the manufacturing time. Another advantage attributed to microwave heating is the reduction in the firing temperature, as claimed by the literature [4,5]. However, this possibility still requires confirmation in 3D-printed stoneware.publishe

Rumo a uma sociedade mais justa e mais justa através da Enfermagem do Renascimento de São João de Deus

Background: Was there bioethics before Potter? Certainly yes, and a clear example is the Nursing of San Juan de Dios, father of modern Nursing of the s. XVI. After performing various trades, it will be in Granada where he will reform the socio-health care by observing the great inequalities between people due to a social and individual conscience numbed by the sense of honor; developing a high sense of otherness, being his being, the other, framed within a community. And since the poor were his focus of action, the sick were his priority, since they were the most disadvantaged dying on the streets of Granada. Aim: Therefore, in this study we propose to describe the principle of Justice and Equality in San Juan de Dios through his care, influenced by his Master San Juan de Ávila. Methodology: For this we resort to the historiographic-hermeneutic method, being the documentary sources the texts of the same closest to their time. Results-Conclusion: In them we have been able to observe how their spirituality led them to take care of all kinds of people, being the poor, sick, women and children, the center of their actions. However, he took care of the entire population, awakening solidarity among the entire population, making them co-responsible for all their hospital reform through material and human resources.Introducción: ¿Existía bioética antes de Potter? Ciertamente sí, y un claro ejemplo es la Enfermería de San Juan de Dios, padre de la Enfermería moderna del s. XVI. Tras desempeñar diversos oficios, será en Granada donde reformará la atención socio-sanitaria al observar las grandes desigualdades entre personas por una conciencia social e individual adormecida por el sentido del honor; desarrollando un alto sentido de la alteridad, siendo su ser, el otro, enmarcado dentro de una comunidad. Y siendo los pobres su foco de actuación, los enfermos fueron su prioridad, pues eran los más desfavorecidos muriendo por las calles de Granada. Objetivo: En este estudio nos proponemos describir el principio de Justicia e Igualdad en San Juan de Dios a través de sus cuidados, influido por su Maestro San Juan de Ávila. Metodología: Para ello recurrimos al método historiográfico-hermenéutico, siendo las fuentes documentales los textos de los mismos más cercanos a su tiempo. Resultados-Conclusión: En ellos hemos podido observar cómo su espiritualidad les llevó a atender a todo género de personas, siendo los pobres, enfermos, mujeres y niños, el centro de su actuación. Sin embargo, cuidó a toda la población despertando la solidaridad en toda persona haciéndoles co-responsables de toda su reforma hospitalaria mediante recursos materiales y humanos.Introdução: Havia bioética antes de Potter? Certamente sim, e um exemplo claro é a Enfermagem de San Juan de Dios, pai da Enfermagem moderna do s. XVI. Depois de realizar vários ofícios, será em Granada onde irá reformar o sistema sócio-sanitário observando as grandes desigualdades entre as pessoas devido a uma consciência social e individual entorpecida pelo sentido da honra; desenvolver um alto senso de alteridade, sendo seu ser, o outro, enquadrado em uma comunidade. E como os pobres eram o seu foco de ação, os doentes eram a sua prioridade, pois eram os mais desfavorecidos morrendo nas ruas de Granada. Objetivo: Portanto, neste estudo, propomos descrever o princípio da Justiça e da Igualdade em San Juan de Dios com seus cuidados, influenciados por seu Mestre San Juan de Ávila. Metodologia: Para isso, recorremos ao método historiográfico-hermenêutico, sendo as fontes documentais os textos mais próximos do seu tempo. Resultados-Conclusão: Neles, conseguimos observar como sua espiritualidade os levou a cuidar de todos os tipos de pessoas, sendo pobres, doentes, mulheres e crianças, o centro de suas ações. No entanto, ele cuidou de toda a população, despertando a solidariedade entre toda a população, tornando-os co-responsáveis por toda a reforma hospitalar através de recursos materiais e humanos

Indicadores de observación y competencias en el Prácticum Grados Infantil y Primaria: centro y aula

El trabajo que se presenta está enmarcado en la RED Diseño y desarrollo de una Guía observacional para la implementación del Prácticum de los Grados de Infantil y Primaria, dentro del Programa de REDES de investigación en docencia universitaria del ICE/ Universidad de Alicante. Tomando como referencia las competencias de la asignatura Prácticum que se desarrolla a lo largo de varios periodos, se han establecido una serie de indicadores de observación a nivel de centro y de aula, que nos permitan configurar una Guía observacional como instrumento de observación y análisis de la realidad escolar durante el desarrollo del Prácticum. La metodología utilizada se ha centrado en el trabajo colaborativo de los integrantes de la RED, desde sus diversas experiencias y aportaciones en sus campos profesionales. Los primeros resultados han determinado los seis grandes bloques de indicadores de esta Guía: la organización y gestión del centro; la organización y gestión del aula; el clima del aula y el alumnado; el planteamiento metodológico y la evaluación; la atención a las n.e.e.; y la participación de las familias

Un estudio en RED: Guía observacional en el Prácticum Grados Infantil y Primaria

El trabajo que se presenta está enmarcado en la RED Diseño y desarrollo de una Guía observacional para la implementación del Prácticum de los Grados de Infantil y Primaria, dentro del Programa de REDES de investigación en docencia universitaria del ICE/ Universidad de Alicante. Tomando como referencia las competencias de la asignatura Prácticum que se desarrolla a lo largo de varios periodos, se han establecido una serie de indicadores de observación a nivel de centro y de aula, que nos permitan configurar una Guía observacional como instrumento de observación y análisis de la realidad escolar durante el desarrollo del Prácticum. La metodología utilizada se ha centrado en el trabajo colaborativo de los integrantes de la RED, desde sus diversas experiencias y aportaciones en sus campos profesionales. Los primeros resultados han determinado los seis grandes bloques de indicadores de esta Guía: la organización y gestión del centro; la organización y gestión del aula; el clima del aula y el alumnado; el planteamiento metodológico y la evaluación; la atención a las n.e.e.; y la participación de las familias

DD04107-Derived neuronal exocytosis inhibitor peptides: Evidences for synaptotagmin-1 as a putative target

15 pags, 8 figs, 3 tabs. -- Supplementary data to this article can be found online at https://doi.org/10.1016/j.bioorg.2021.105231.The analgesic peptide DD04107 (Pal-EEMQRR-NH2) and its acetylated analogue inhibit α-calcitonin gene-related peptide (α-CGRP) exocytotic release from primary sensory neurons. Examining the crystal structure of the SNARE-Synaptotagmin-1(Syt1) complex, we hypothesized that these peptides could inhibit neuronal exocytosis by binding to Syt1, hampering at least partially its interaction with the SNARE complex. To address this hypothesis, we first interrogate the role of individual side-chains on the inhibition of α-CGRP release, finding that E1, M3, Q4 and R6 residues were crucial for activity. CD and NMR conformational analysis showed that linear peptides have tendency to adopt α-helical conformations, but the results with cyclic analogues indicated that this secondary structure is not needed for activity. Isothermal titration calorimetry (ITC) measurements demonstrate a direct interaction of some of these peptides with Syt1-C2B domain, but not with Syt7-C2B region, indicating selectivity. As expected for a compound able to inhibit α-CGRP release, cyclic peptide derivative Pal-E-cyclo[EMQK]R-NH2 showed potent in vivo analgesic activity, in a model of inflammatory pain. Molecular dynamics simulations provided a model consistent with KD values for the interaction of peptides with Syt1-C2B domain, and with their biological activity. Altogether, these results identify Syt1 as a potential new analgesic target.This work was supported by the Spanish Ministerio de Economía y Competitividad (MINECO-FEDER), RTI2018-097189-C2 and CTQ2017-84371-P), and the Spanish National Research Council (CSIC, 201880E109, 201980E030). The NMR experiments were performed in the “Manuel Rico” NMR laboratory, LMR, CSIC, a node of the Spanish Large-Scale National Facility ICTS R-LRB. We thank Prof. Josep Rizo and R. Voleti (Dept. Biophysics, Biochemistry and Pharmacology, UT Southwestern Medical Center, Dallas, USA) for providing the clones required for expressing Syt1 and Syt7 proteins. SG-R and AB belong to the Instituto de Investigación Sanitaria del Principado de Asturias (ISPA).Peer reviewe

Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children

We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-alpha 2 in 10 patients: IFN-alpha 2 only in three, IFN-alpha 2 plus IFN-omega in five, and IFN-alpha 2, IFN-omega plus IFN-beta in two; IFN-omega only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-alpha 2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-omega in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-alpha 2 only (OR [95% CI] = 67.6 [5.7-9,196.6]) than for auto-Abs neutralizing IFN-. only (OR [95% CI] = 2.6 [1.2-5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6-35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1-9.6]) of IFN-omega and/or IFN-alpha 2

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

Effectiveness, safety/tolerability of OBV/PTV/r ± DSV in patients with HCV genotype 1 or 4 with/without HIV-1 co-infection, chronic kidney disease (CKD) stage IIIb-V and dialysis in Spanish clinical practice - Vie-KinD study

Limited data are available on the effectiveness and tolerability of direct-acting antivirals (DAAs) therapies in the real world for HCV-infected patients with comorbidities. This study aimed to describe the effectiveness of OBV/PTV/r ± DSV (3D/2D regimen) with or without ribavirin (RBV) in HCV or HCV/HIV co-infected patients with GT1/GT4 and CKD (IIIb-V stages), including those under hemodialysis and peritoneal dialysis in routine clinical practice in Spain in 2015.Non-interventional, retrospective, multicenter data collection study in 31 Spanish sites. Socio-demographic, clinical variables, study treatment characteristics, effectiveness and tolerability data were collected from medical records.Data from 135 patients with a mean age (SD) of 58.3 (11.4) years were analyzed: 92.6% GT1 (81.6% GT1b and 17.6% GT1a) and 7.4% GT4, 14 (10.4%) HIV/HCV co-infected, 19.0% with fibrosis F3 and 28.1% F4 by FibroScan®, 52.6% were previously treated with pegIFN and RBV. 11.1%, 14.8% and 74.1% of patients had CKD stage IIIb, IV and V respectively. 68.9% of patients were on hemodialysis; 8.9% on peritoneal dialysis and 38.5% had history of renal transplant. A total of 125 (96.2%) of 135 patients were treated with 3D, 10 (7.4%) with 2D and 30.4% received RBV. The overall intention-to-treat (ITT) sustained virologic response at week 12 (SVR12) was 92.6% (125/135) and the overall modified-ITT (mITT) SVR12 was 99.2% (125/126). The SVR12 rates (ITT) per sub-groups were: HCV mono-infected (91.7%), HCV/HIV co-infected (100%), GT1 (92.0%), GT4 (100%), CKD stage IIIb (86.7%), stage IV (95%) and stage V (93%). Among the 10 non-SVR there was only 1 virologic failure (0.7%); 4 patients had missing data due lost to follow up (3.0%) and 5 patients discontinued 3D/2D regimen (3.7%): 4 due to severe adverse events (including 3 deaths) and 1 patient´s decision.These results have shown that 3D/2D regimens are effective and tolerable in patients with advanced CKD including those in dialysis with GT 1 or 4 chronic HCV mono-infection and HIV/HCV coinfection in a real-life cohort. The overall SVR12 rates were 92.6% (ITT) and 99.2% (mITT) without clinically relevant changes in eGFR until 12 weeks post-treatment. These results are consistent with those reported in clinical trials