60 research outputs found
The Tissue Microlocalisation and Cellular Expression of CD163, VEGF, HLA-DR, iNOS, and MRP 8/14 Is Correlated to Clinical Outcome in NSCLC
- Author
- A Mantovani
- A Puhakka
- A Sica
- Aarti Shikotra
- BO Fabriek
- C Bogdan
- CF Anderson
- CF Mountain
- Chandra M. Ohri
- CM Ohri
- CM Ohri
- CM Ohri
- David A. Waller
- DG Binion
- DJ Schaer
- DM Parkin
- DW Kim
- F Balkwill
- FC Fang
- G Zwadlo
- H Endress
- I Eue
- Ilya Ulasov
- J MacMicking
- JL Perez-Gracia
- JL PĂ©rez-Gracia
- JS Luoma
- K Mahnke
- K Xie
- KE de Visser
- KJ O'Byrne
- L Bingle
- M Baj-Krzyworzeka
- MB Maniecki
- MJ Robinson
- MM Van den Heuvel
- N Ferrara
- P Carrega
- P Poncet
- PA Bradbury
- Peter Bradding
- PG Foukas
- RS Bhardwaj
- Ruth H. Green
- S Gordon
- T Veikkola
- TA Tran
- TJ Welsh
- Publication venue
- Public Library of Science
- Publication date
- 22/07/2011
- Field of study
BACKGROUND: We have previously investigated the microlocalisation of M1 and M2 macrophages in NSCLC. This study investigated the non-macrophage (NM) expression of proteins associated with M1 and M2 macrophages in NSCLC. METHODS: Using immunohistochemistry, CD68(+) macrophages and proteins associated with either a cytotoxic M1 phenotype (HLA-DR, iNOS, and MRP 8/14), or a non-cytotoxic M2 phenotype (CD163 and VEGF) were identified. NM expression of the markers was analysed in the islets and stroma of surgically resected tumours from 20 patients with extended survival (ES) (median 92.7 months) and 20 patients with poor survival (PS) (median 7.7 months). RESULTS: The NM expression of NM-HLA-DR (p<0.001), NM-iNOS (pâ=â0.02) and NM-MRP 8/14 (pâ=â0.02) was increased in ES compared to PS patients in the tumour islets. The tumour islet expression of NM-VEGF, was decreased in ES compared to PS patients (p<0.001). There was more NM-CD163 expression (pâ=â0.04) but less NM-iNOS (pâ=â0.002) and MRP 8/14 (pâ=â0.01) expression in the stroma of ES patients compared with PS patients. The 5-year survival for patients with above and below median NM expression of the markers in the islets was 74.9% versus 4.7% (NM-HLA-DR p<0.001), 65.0% versus 14.6% (NM-iNOS pâ=â0.003), and 54.3% versus 22.2% (NM-MRP 8/14 pâ=â0.04), as opposed to 34.1% versus 44.4% (NM-CD163 pâ=â0.41) and 19.4% versus 59.0% (NM-VEGF pâ=â0.001). CONCLUSIONS: Cell proteins associated with M1 and M2 macrophages are also expressed by other cell types in the tumour islets and stroma of patients with NSCLC. Their tissue and cellular microlocalisation is associated with important differences in clinical outcome
Fixation strength of biocomposite wedge interference screw in ACL reconstruction: effect of screw length and tunnel/screw ratio. A controlled laboratory study
- Author
- A Weiler
- A Weiler
- AF Anderson
- Antonio Herrera
- AR Harvey
- BB Phillips
- C Klein
- CH Brown
- CM Miller
- D Kohn
- Daniel Iglesias
- DE Toutoungi
- DG Nagarkatti
- DL Hamner
- DNM Caborn
- Elena Ibarz
- F Adam
- Fernando MartĂnez
- FR Noyes
- GA Brown
- GB Maletis
- J Nylan
- JB Selby
- JC Brand
- JC Brand Jr
- JD Shapiro
- José Cegoñino
- JP Holden
- JT Nurmi
- JU Buelow
- K Yasuda
- KD Shelbourne
- KL Markolf
- KL Markolf
- LS Matthews
- Luis Gracia
- M Hulstyn
- M Walton
- ME Steiner
- MW Morris
- NM Jomha
- P Kousa
- P Kousa
- PT Simonian
- S Namkoong
- S Rupp
- SA Rodeo
- SL Woo
- SL Woo
- SO Paschal
- T Zantop
- Publication venue
- BioMed Central
- Publication date
- 01/01/2010
- Field of study
<p>Abstract</p> <p>Background</p> <p>Primary stability of the graft is essential in anterior cruciate ligament surgery. An optimal method of fixation should be easy to insert and provide great resistance against pull-out forces.</p> <p>A controlled laboratory study was designed to test the primary stability of ACL tendinous grafts in the tibial tunnel. The correlation between resistance to traction forces and the cross-section and length of the screw was studied.</p> <p>Methods</p> <p>The tibial phase of ACL reconstruction was performed in forty porcine tibias using digital flexor tendons of the same animal. An 8 mm tunnel was drilled in each specimen and two looped tendons placed as graft. Specimens were divided in five groups according to the diameter and length of the screw used for fixation. Wedge interference screws were used. Longitudinal traction was applied to the graft with a Servohydraulic Fatigue System. Load and displacement were controlled and analyzed.</p> <p>Results</p> <p>The mean loads to failure for each group were 295,44 N (Group 1; 9 Ă 23 screw), 564,05 N (Group 2; 9 Ă 28), 614,95 N (Group 3; 9 Ă 35), 651,14 N (Group 4; 10 Ă 28) and 664,99 (Group 5; 10 Ă 35). No slippage of the graft was observed in groups 3, 4 and 5. There were significant differences in the load to failure among groups (ANOVA/P < 0.001).</p> <p>Conclusions</p> <p>Longer and wider interference screws provide better fixation in tibial ACL graft fixation. Short screws (23 mm) do not achieve optimal fixation and should be implanted only with special requirements.</p
Neurocisticercose no estado do Rio Grande do Norte: relato de oito casos
- Author
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Anandamide Induces Sperm Release from Oviductal Epithelia through Nitric Oxide Pathway in Bovines
- Author
- A Fazeli
- AA Amoako
- AC Howlett
- Ana MarĂa Franchi
- C O'Flaherty
- C Roessner
- CA Vercelli
- Claudia Osycka-Salut
- CR Ward
- DG Demuth
- DS Bredt
- E de Lamirande
- E HerradĂłn
- Elba Pereyra
- F Francavilla
- H Kojima
- H Meiser
- H Schuel
- H Wang
- Haibin Wang
- HL Galantino-Homer
- I Revah
- IM Poblete
- J Lapointe
- JJ Parrish
- JJ Parrish
- JY Chun
- M Cella
- M Ghasemi
- M Maccarrone
- M Maccarrone
- M Rosselli
- MA Lee
- MarĂa Gracia Gervasi
- MarĂa Laura Ribeiro
- Maximiliano Cella
- MB Grisham
- MB Herrero
- MB Herrero
- MB Herrero
- MG Gervasi
- MG Gervasi
- MG Signorello
- ML Hou
- MM Bradford
- MR El-Talatini
- NL Cross
- P Bosch
- PC Rodriguez
- PC Rodriguez
- PE Visconti
- R Gualtieri
- R Lefebvre
- R Talevi
- RA Ross
- RHF Hunter
- RM Palmer
- S Aquila
- S Munro
- S Perez Martinez
- SA Törnblom
- Silvina Perez-Martinez
- SR Bartlett
- SS Suarez
- TT Smith
- V Di Marzo
- WA Devane
- X Sun
- Y Fukui
- Publication venue
- Public Library of Science
- Publication date
- Field of study
Mammalian spermatozoa are not able to fertilize an egg immediately upon ejaculation. They acquire this ability during their transit through the female genital tract in a process known as capacitation. The mammalian oviduct acts as a functional sperm reservoir providing a suitable environment that allows the maintenance of sperm fertilization competence until ovulation occurs. After ovulation, spermatozoa are gradually released from the oviductal reservoir in the caudal isthmus and ascend to the site of fertilization. Capacitating-related changes in sperm plasma membrane seem to be responsible for sperm release from oviductal epithelium. Anandamide is a lipid mediator that participates in the regulation of several female and male reproductive functions. Previously we have demonstrated that anandamide was capable to release spermatozoa from oviductal epithelia by induction of sperm capacitation in bovines. In the present work we studied whether anandamide might exert its effect by activating the nitric oxide (NO) pathway since this molecule has been described as a capacitating agent in spermatozoa from different species. First, we demonstrated that 1 ”M NOC-18, a NO donor, and 10 mM L-Arginine, NO synthase substrate, induced the release of spermatozoa from the oviductal epithelia. Then, we observed that the anandamide effect on sperm oviduct interaction was reversed by the addition of 1 ”M L-NAME, a NO synthase inhibitor, or 30 ”g/ml Hemoglobin, a NO scavenger. We also demonstrated that the induction of bull sperm capacitation by nanomolar concentrations of R(+)-methanandamide or anandamide was inhibited by adding L-NAME or Hemoglobin. To study whether anandamide is able to produce NO, we measured this compound in both sperm and oviductal cells. We observed that anandamide increased the levels of NO in spermatozoa, but not in oviductal cells. These findings suggest that anandamide regulates the sperm release from oviductal epithelia probably by activating the NO pathway during sperm capacitation
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
- Abdelmonem SA
- Abdo WF
- Abellan AN
- AbellĂĄn AN
- AbellĂĄn AN
- AbellĂĄn AN
- Abrams ST
- Ackerley C
- Acuña M
- Adda M
- Adhikari NK
- Adriano G
- Adrie C
- Affatato R
- Affatato R
- Afonso-Rivero D
- Agarossi A
- Agarwal LK
- Ageeva T
- Agrawal R
- Aguayo-DeHoyos E
- Aguilar AL
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguirregabyria M
- Ahmadnia E
- Ahn C
- Ahn JY
- Ahn JY
- Ahn MY
- Ahn MY
- Aitken LM
- Akalaev R
- Akbarzadeh A
- Akcan-Arikan A
- Akhlagh SH
- Akhtar N
- AKI Research Group
- Akiduki N
- Akin S
- Akizuki N
- Akkoc T
- Ala-Kokko T
- Alanio A
- Albaiceta GM
- Albaladejo P
- Alberto F
- Albuisson E
- Alcala MA
- AlcĂĄzar L
- Aldabo-Pallas T
- Aldana NN
- Aldecoa C
- AlegrĂa L
- Alejandro R
- Alejo GC
- Alejos RM
- Alexandrova E
- Algarte R
- Algarte R
- Algieri I
- Algora-Weber A
- Alhamdi Y
- Aliaga FA
- Aliberti S
- Alkan A
- Almudena PM
- Almudevar PM
- Almudevar PM
- Almudévar PM
- Altıntas ND
- Alvarez J
- Alves SC
- Alzola LM
- Amargianitakis V
- Amaro R
- Amato MB
- Ambler M
- Amerongen MP
- Amininejad T
- Amor LL
- Amorim V
- Anand RK
- Andersen LW
- Andersson S
- Andoh K
- Andrade AH
- Andrade AH
- Andrade AH
- Andrade G
- Andreis DT
- Andreis DT
- Annane D
- Antonelli M
- Antoniadou A
- Antonio C
- Antonucci E
- AntĂłn DG
- Anzueto A
- Appiani F
- Aquevedo A
- Aragon C
- Araujo NJ
- Araujo VF
- ARIAM registry of adult cardiac surgery
- ARIAM-ANDALUCIA
- Arias CC
- Arias N
- Arias-Verdu MD
- Arias-Verdu MD
- Arias-Verdu MD
- Armaganidis A
- Arora MK
- Arora N
- Arrigo M
- Arslantas MK
- Artiguenave M
- Aslanian P
- Aspide R
- Asyralyyeva G
- Ataman S
- Ataman S
- Atchade E
- Atchade E
- Atchasiri S
- Athapattu P
- Atkins G
- Aublanc M
- Aublanc M
- Augustin P
- Augustin P
- Auquier P
- Avilés-Jurado FX
- Avramidis V
- Ayala LY
- Aydin M
- Azevedo JC
- Azevedo JR
- Aznar GP
- Babalis D
- Babini G
- Bachli EB
- Bader A
- Bader A
- Baena J
- Baidya DK
- Baikova VN
- Bakker J
- BalcĂĄzar LC
- BalcĂĄzar LC
- Baldassarri R
- Baldwin CE
- Balik M
- Ball I
- Ballin A
- Balsera B
- Banderas-Bravo ME
- Banderas-Bravo ME
- Bandert A
- Bangstad IL
- Baptista N
- Baquero JD
- Barbadillo S
- Barberet G
- Barberet G
- Barberet G
- Barbier J
- Barcenilla F
- Barea-Mendoza JA
- Barinas OD
- Baron AV
- Barrachina LG
- Barral M
- Basile-Filho A
- Bassi GL
- Bates D
- Battistini M
- Bauer M
- Bauer PR
- Baumstarck K
- Baumstarck K
- Bawin M
- Bazan N
- Bañeras J
- Beane A
- Beduneau G
- Beduneau G
- Beduneau G
- Beeharry SD
- Beerepoot M
- Begzjav T
- Beishuizen A
- Bell C
- Belletti A
- Bellissimo-Rodrigues F
- Belloli A
- Bellomo R
- Bellver BQ
- Belmonte R
- Ben-Hamouda N
- Bendel S
- Bendel S
- Benyamina M
- Beretta S
- Berg R
- Bergantino B
- Berghmans J
- Bernal FF
- Berric A
- Berrutti D
- Berthelsen RE
- Bertini P
- Bertini P
- Berto MB
- Besevli SG
- Bestle MH
- Bettex D
- Bettex DA
- Beunders R
- Bhasin D
- Bhattal MK
- Bhide S
- Bianchi I
- Bianchi I
- Bianzina S
- Bianzina S
- Bianzina S
- Bishop J
- Bissenova N
- Bisso MC
- Blans MJ
- Blobner M
- Bloomer MJ
- Blot K
- Blot S
- Blot S
- Boa F
- Bobi Q
- Bodingbauer M
- BodĂ M
- Boer C
- Bogossian E
- Bonet S
- Bonn M
- Bonnet M
- Borges FK
- Bouadma L
- Boucekine M
- Bougouin W
- Bourenne J
- Boyd JG
- Boyd JG
- Bozbay S
- Bozza F
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- Brandon RB
- Braschi A
- Braschi A
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- Brasseur A
- Brasseur A
- Brasseur A
- Braune S
- Brazzi L
- Breitkreutz R
- Brianti R
- Brioni M
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- Brock N
- Brody DL
- Brook R
- Brousseau C
- Brown K
- Brugger SC
- Brugger SC
- Bruno F
- Bruno K
- Brusasco C
- Brusasco C
- Brusasco C
- Bruyere O
- Bucknall T
- Buddi S
- Buise M
- Buitinck SH
- Buranavanich P
- Bureau C
- Burle JF
- Burtin P
- Busico M
- Butler MB
- Butrov AV
- Caballero CH
- Caballero J
- Cabello JT
- Cabello JT
- Cabrera AR
- Cabrera JL
- Cabrera JL
- Cabrini L
- Cairus C
- Cakin O
- Caliskan K
- Calpe P
- Calvo CP
- Calvo SA
- Camargo M
- Cambronero JA
- Cameron C
- Campbell R
- Campelo FA
- Campelo FA
- Campos LM
- Cannesson M
- CAPCRI Study
- Capellier G
- Carbonara M
- Cardellino S
- Cardenas CL
- Cariou A
- Cariou A
- Carlesso E
- Carmona AF
- Carmona SA
- Carmona SA
- Carmona SA
- Carmona SA
- Carone M
- Carpio D
- CarratalĂĄ A
- Carreira MM
- Carrero-GĂłmez F
- Carreño ER
- Carreño R
- Carvalho JP
- Carvalho KV
- Casals XN
- Casals XN
- Cassina T
- Castañeda DP
- Castellana D
- Castellanos A
- Castellanos A
- Castillo-Lorente E
- Castillo-Lorente E
- Catalan M
- CatalĂĄn RM
- Catena E
- Catena E
- Cauwenberghs H
- Cavalcanti D
- Cavalheiro AM
- Cavalier E
- Cavicchi FZ
- Cavicchi FZ
- Cengiz M
- Ceriani R
- Cermelli S
- CeroviÄ O
- Cha YS
- Chabanne R
- Chacon-Alves S
- Champigneulle B
- Champigneulle B
- Chan KC
- Chan KK
- Chan WS
- Chang CH
- Chang WY
- Chao A
- Chao A
- Chao AS
- Chao HC
- Chaouat M
- Charitidou E
- Charpentier C
- Charpentier J
- Charron C
- Chatelon J
- Chaudhari HK
- Chaussard M
- Chavanon O
- Chaves S
- Chelly J
- Chemam S
- Chen CM
- Chen CM
- Chen CW
- Chen CW
- Chen GQ
- Chen L
- Chen YS
- Chen YS
- Chen YS
- Cheng CC
- Cheng CC
- Cheng CC
- Cheng CC
- Cheng KC
- Cheng YJ
- Chernyshuk S
- Chevret S
- Chhor V
- Chiang CC
- Chiang CH
- Chiang CH
- Chiang CH
- Chiappa C
- Chiou KR
- Chiou KR
- Chiou KR
- Chiu LC
- Chiumello D
- Chiurazzi C
- Chiurazzi C
- Cho Y
- Cho YJ
- Cho YJ
- Choi JY
- Choi JY
- Choi KS
- Choi S
- Choi YJ
- Choi YY
- Chok L
- Cholkraisuwat J
- Cholley B
- Chondropoulos S
- Chou W
- Chouris I
- Chouvarda I
- Christopher KB
- Chrétien JM
- Chrétien JM
- Chrétien JM
- Chumaev A
- Chung CR
- Churchill K
- Chytas A
- Cinel I
- Cinnella G
- Citerio G
- Citerio G
- Clavel M
- Clemente EA
- Clermont G
- Cleyet M
- Cohen Y
- Colaprico A
- Colino L
- Collange O
- Colombo A
- Colombo A
- Colson P
- Combes A
- Concha P
- Connolly B
- Constan A
- Constan A
- Constan A
- Conte V
- Conti G
- Conti G
- Contreras KM
- Contreras MR
- Cook DJ
- Coombs M
- Cordeiro CP
- Cordero M
- Cordolcini V
- Cordovilla-Guardia S
- CordĂłn J
- Corona A
- Corona A
- Corradi F
- Corradi F
- Corradi F
- Correa-Chamorro E
- Corte FD
- Cortes ML
- Corzo L
- Coss-Bu JA
- Coss-Bu JA
- Costa MI
- Costa RC
- Costa RC
- Costa RC
- Costanzo E
- Cotoia A
- Cottini SR
- Cottle D
- Cotton H
- Cotton H
- Courant P
- Cowan R
- Creagh-Brown B
- Cressoni M
- Creteur J
- Creteur J
- Creteur J
- Creteur J
- Creteur J
- Creteur J
- Creteur J
- Creteur J
- Crimella F
- Cron N
- Cuellar AI
- Cui N
- Cunha MM
- Curiel-Balsera E
- Curiel-Balsera E
- Curinga M
- Curtis A
- Cuthbertson BH
- Cutuli SL
- CĂąmara M
- D'Arsigny C
- da Silva SL
- da Silva VZ
- Daga-Ruiz D
- Dalhuisen A
- Dalorzo M
- Damas P
- Dambrosio M
- DamÄs JK
- Das Neves A
- David H
- Davis C
- Davis P
- Day A
- de Abreu MG
- De Backer A
- De Brito-Ashurst I
- De Cassai A
- De Freitas FF
- De Gasperi A
- de Hoyos EA
- De la Calle-Pedrosa N
- de la Fuente MV
- De La Fuente-Martos C
- De La Fuente-Martos C
- De La Rica AS
- De la Torre MA
- De Maglie M
- De Maglie M
- de Molina FJ
- De Morton N
- de Oca Sandoval MA
- De Pascale G
- De Rosa S
- De Sanctis F
- De Silva AP
- De Sousa I
- de Vera AP
- de Wilde W
- De Zani D
- Deblier I
- DeBrunnar R
- Del Arco A
- Del Moral OL
- Del Olmo R
- Del Rosario CG
- Del Sorbo L
- Delgado CP
- Delgado MJ
- Delgado-Amaya M
- Demirkiran O
- Demoule A
- Denehy L
- Der Kinderen EP
- Descotte E
- Deshpande K
- Desmard M
- Desmard M
- Deveugele M
- Deye N
- Di Bello F
- Di Giancamillo M
- Di Gravio V
- Di Gregorio A
- Di Mussi R
- Di Rosso R
- Diaz DD
- Diaz P
- Dilek M
- Dilly MP
- Dima E
- Dimitroulakis K
- Dimitrov BD
- Dimitrov BD
- Dimopoulou IK
- Dinh A
- Divatia JV
- Dixon J
- Doganci M
- Doglia JA
- Doherty P
- Dolset RA
- Dominguez JP
- DomĂnguez JP
- Donald CL
- Donnino M
- Doorduin J
- Dorent R
- Dos Reis Miranda D
- Dos Santos HP
- Dougall PC
- Doyle J
- Doyle J
- Drover J
- Duarte R
- Dubois EA
- Dubrawski A
- DubĂł S
- Dudas G
- Dudoignon E
- Dumas F
- Dunthorne E
- Duran N
- Durand M
- Durovray JD
- Durrant J
- Duzgun M
- DĂaz E
- DĂaz JJ
- DĂaz M
- DĂaz PV
- DĂŒnser MW
- E Silva ZC
- E YY
- Ebeling G
- Echeverri JE
- EcheverrĂa JG
- Ediboglu O
- Ediboglu O
- Egea-Guerero JJ
- Egginton JS
- Egi M
- El Adawy AS
- El Hamid MA
- El Hossainy R
- El Sayed E
- El Sayed F
- El Sayed I
- El-Hamamsy M
- El-Keraie A
- Eladawy S
- Elbers PW
- Elgendy M
- Eliet J
- Emmanuel J
- Emmerich M
- Encina B
- Endacott R
- Endacott R
- Engelberts D
- ENVIN-HELICS Study Group
- Erb J
- Erdogan M
- Eroles AA
- Escalada SH
- Escalada SH
- Escoval A
- EscribĂĄ A
- EscĂłrcio S
- Eslami S
- Espinasse F
- Espinel E
- Estagnasie P
- Esteban A
- Estella A
- Estenssoro E
- Evelein-Brugman S
- Facchin F
- Faivre V
- Fang M
- Fanzaghi P
- Farias P
- Faulds MC
- Fave G
- Feehan A
- Feijoo AM
- Feliot E
- Ferez MA
- Fernandes MJ
- Fernandes N
- Fernandez NG
- Fernandez R
- Fernandez-Zamora MD
- FernĂĄndez IF
- FernĂĄndez L
- FernĂĄndez MV
- FernĂĄndez PA
- FernĂĄndez-Barat L
- Fernåndez-Mondéjar E
- FernĂĄndez-Ortega JF
- Ferraz AB
- Ferrero-Calleja J
- Ferri F
- Ferry A
- Ferré A
- FerrĂłn FR
- FerrĂłn FR
- Fiks T
- Fiks T
- FilekoviÄ S
- Filho CA
- Filho CA
- Filho CA
- Filipe E
- FINNRESUSCI Study Group
- Fischer G
- Fleischmann E
- Fless K
- Floccard B
- Flowers E
- Follin A
- Follin A
- Fong KY
- Fontaiña LP
- Fontana V
- Fontenot T
- Forel JM
- Forni L
- Forni L
- Forni LG
- Forni LG
- Forni LG
- Fournel E
- Fox B
- Franchi P
- Francioni JE
- Francioni JE
- Franco JF
- Frantzeskaki F
- Frantzeskaki F
- Frat JP
- Frat JP
- Frat JP
- Freile MT
- Frenzel T
- Frigeni B
- Frithiof R
- Fritz C
- FROG ICU Investigators
- Fromentin M
- Frontera PR
- Fuentes M
- Fumagalli F
- Fumagalli F
- Fumis RR
- Fushimi K
- GabĂĄn-DĂez Ă
- Gadgil S
- Gaide-Chevronnay L
- Gainnier M
- Gaite FB
- Gaizauskas E
- Gajic O
- Galache JA
- Gallego-Corpa AI
- Gameiro J
- Gancedo CH
- Gandini L
- Gando S
- Gando S
- Gando S
- Gando S
- Gandola A
- Gandolfi S
- Ganuza MS
- Garcia IP
- Garcia IP
- Garcia M
- Garcia PK
- Garcia-Alvarez JM
- Garcia-Alvarez JM
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- Garcia-Gigorro R
- GarcĂa MF
- GarcĂa-MartĂnez MV
- GarcĂa-Olivares P
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- Gavrychenko D
- Gayat E
- Geantot MA
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- Gemmell LK
- Genc D
- GenĂšve C
- Georgopoulos D
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- GETGAG Working Group
- GETGAG/SEMICYUC
- Ghabina S
- Ghazal S
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- Gherli T
- Ghosh S
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- Giannopoulos A
- Giesinger RE
- Gigorro RG
- Gil EM
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- Gimillo MR
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- Gioia A
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- Godinho I
- Godoy K
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- Goodwin S
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- Gordillo-Brenes A
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- Gordon M
- Gordon M
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- Goto T
- Gottlieb J
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- Gracia RM
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- Granillo JF
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- Grossestreuer A
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- Harm S
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- HernĂĄndez G
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- Heyne T
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- Hidalgo C
- Hikasa Y
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- Hirayama T
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- Houzé S
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- Howes D
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- Hrachovina M
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- Hravnak M
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- Hutchison R
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- Idei M
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- Itenov TS
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- Janotka M
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- Jardim JJ
- Jardim M
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- Jovaisa T
- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
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- Jung K
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- Kaczirek K
- Kaese S
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- Kalenka A
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- Komuro T
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- Kongpolprom N
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- Kostalas M
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- Kubota K
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- Lafaurie M
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- Wetz A
- Weyer CM
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- Wiesner O
- Wijayatilake DS
- Wildenberg L
- Wilks M
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- WIND study group
- Winder-Rhodes S
- Witter T
- Wolf M
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- Wong Y
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- Yamamoto H
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- Yamazaki A
- Yan WW
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- Yang JH
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- Yang YL
- Yasuda H
- Yatabe T
- Yebenes JC
- Yeh YC
- Yemets H
- Yergaliyeva A
- Yılmaz G
- Yilmazer F
- Yodice P
- Yokoyama M
- Yonis H
- Yonis H
- Yonis H
- Yoon SZ
- Yoruk F
- Yoshida K
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshihiro S
- Yoshitake E
- You KM
- Youn AM
- Young A
- Yu KM
- Yumoto T
- Yuzawa J
- Yuzawa J
- Zabaletta WJ
- Zabini D
- Zahorec M
- Zaien I
- Zakynthinos S
- Zanello M
- Zani D
- Zarantonello F
- Zayas B
- Zepeda EM
- Zeroual N
- Zerva L
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- Zhou JC
- Zhou JC
- Zhou JX
- Zhovnir V
- Zibandah N
- Zijlstra F
- Zimmerman J
- Zogheib E
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- Zogheib E
- Zullino V
- Zwaag J
- ZĂœkovĂĄ I
- Ălvarez JT
- Ălvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Multi-messenger observations of a binary neutron star merger
- Author
- Aab A
- Aartsen MG
- Abbott BP
- Abbott R
- Abbott TD
- Abbott TMC
- Abdalla H
- Abe F
- Abeysekara AU
- Abramo LR
- Abramowski A
- Abreu P
- Acernese F
- Acero F
- Ackermann M
- Ackley K
- Ackley K
- Adams C
- Adams J
- Adams SM
- Adams T
- Addesso P
- Adhikari RX
- Adya VB
- Affeldt C
- Afrough M
- Agarwal B
- Agathos M
- Agatsuma K
- Aggarwal N
- Aglietta M
- Agliozzo C
- Agudo I
- Aguiar OD
- Aguilar JA
- Aharonian F
- Ahlers M
- Ahrens M
- Aiello L
- Ain A
- Ajith P
- Akras S
- Al Samarai I
- Albert A
- Albert A
- Albuquerque IFM
- Albury JM
- Alcaniz JS
- Alexander KD
- Alfaro R
- Alighieri S Di Serego
- Allam S
- Allekotte I
- Allen B
- Allen G
- Allison J
- Allison JR
- Allocca A
- Almela A
- Altin PA
- Altmann D
- Alvarez C
- Alvarez JD
- Alvarez M Dovale
- Alvarez-Muiz J
- Amati L
- Amato A
- An T
- Ananyeva A
- Anastasi GA
- Anchordoqui L
- Andeen K
- Anderson JP
- Anderson SB
- Anderson T
- Anderson WG
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- Andre M
- Andreoni I
- Andreoni I
- Andringa S
- Angelova SV
- Anghinolfi M
- Angner EO
- Angus CR
- Annis J
- Ansseau I
- Antier S
- Anton G
- Antonelli LA
- Antonelli LA
- Anupama GC
- Aoki K
- Aoki W
- Appert S
- Aptekar RL
- Arai K
- Arakawa M
- Aramo C
- Araya MC
- Arcavi I
- Arceo R
- Ardid M
- Areeda JS
- Aresu G
- Argan A
- Argelles C
- Arnaud N
- Array LWA Long Wavelength
- Array MWA Murchison Widefield
- Arrieta M
- Arsene N
- Arteaga-Velzquez JC
- Artola R
- Arun KG
- Asakura Y
- Asaoka Y
- Ascenzi S
- Ashall C
- Ashley MCB
- Ashton G
- Asorey H
- Assis P
- Ast M
- Aston SM
- Astone P
- Atallah DV
- ATLAS
- Atwood WB
- Aubert J-J
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- Auffenberg J
- Aufmuth P
- Aulbert C
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- Austin C
- Avgitas T
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- Awad A Kuotb
- Axani S
- Baar S
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- Badescu AM
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- Bagherpour H
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- Balasubramanian A
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- Balzer A
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- Bannister KW
- Barayoga JC
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- Barbiellini G
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- Baret B
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- Barkett K
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- Barron JP
- Barsotti L
- Barsuglia M
- Barta D
- Barthelmy SD
- Bartlett J
- Bartos I
- Barway S
- Barway S
- Barwick SW
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- Basti A
- Bastieri D
- Batch JC
- Bauer FE
- Bauer FE
- Baum V
- Bawaj M
- Bay R
- Bayley JC
- Bazzan M
- Bazzano A
- Bchele M
- Beardmore AP
- Beardsley A
- Beatty JJ
- Becerril A
- Becherini Y
- Bechtol K
- Becker KH
- Becsy B
- Beer C
- Bejger M
- Belahcene I
- Belhorma B
- Bell AS
- Bellazzini R
- Bellido JA
- Bellm E
- Belmont-Moreno E
- Benetti S
- Benkhali F Ait
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- BenZvi SY
- Berat C
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- Berisso M Gomez
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- Bilenko IA
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- Bisht A
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- Bissaldi E
- Biteau J
- Bitossi M
- Biwer C
- Bizouard MA
- Blackburn JK
- Blackburn L
- Blackman J
- Blackwell R
- Blaess SG
- Blagorodnova N
- Blair CD
- Blair DG
- Blair RM
- Blanchard P
- Blanco A
- Bland PA
- Blandford RD
- Blaufuss E
- Blazek J
- Bleve C
- Bloemen S
- Bloom ED
- Blot S
- Bock O
- Bode N
- Boer M
- Bogaert G
- Bohacova M
- Bohe A
- Bohm C
- Boisson C
- Bolmont J
- Bond IA
- Bondu F
- Bonifazi C
- Bonilla E
- Bonino R
- Bonnand R
- Bonnefoy S
- Bonoli S
- Booler T
- Boom BA
- Bordas P
- Bork R
- Bormuth R
- Borner M
- Borodai N
- Bos F
- Boschi V
- Bose D
- Bose S
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- Bossie K
- Botner O
- Bottacini E
- Bottcher M
- Botti AM
- Botticella MT
- Bouffanais Y
- Bourbeau E
- Bourbeau J
- Bourret S
- Bouwhuis MC
- Bozzi A
- Bozzo E
- Brack J
- Bradaschia C
- Bradascio F
- Brady PR
- Branchesi M
- Brancus I
- Brandt S
- Brau JE
- Braun J
- Braun J
- Bravo O Martinez
- Brayeur L
- Breeveld AA
- Bregeon J
- Bregeon J
- Brenzke M
- Bretz H-P
- Bretz T
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- Bridgeman A
- Briechle FL
- Briggs MS
- Brillet A
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- Brocato E
- Brockill P
- Broderick JW
- Broida JE
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- Brown IS
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- Buckley DAH
- Buckley-Geer E
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- Bueno A
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- Buikema A
- Buitink S
- Bulgarelli A
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- Bulik T
- Bulla M
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- Buonanno A
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- Burgman A
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- Burns E
- Burrows DN
- Buscemi M
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- Buson S
- Bustillo J Caldern
- Busto J
- Butler NR
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- Buttu M
- Buy C
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- Caballero-Mora KS
- Caballero-Mora KS
- Cabero M
- Cabral J
- Caccianiga L
- Cadonati L
- Cagnoli G
- Cahillane C
- Callister TA
- Calloni E
- CALTECH GROWTH JAGWAR
- Cameron RA
- Camilo F
- Camp JB
- Campana S
- Camuccio R
- Cancio A
- Canepa M
- Canfora F
- Canizares P
- Cannella C
- Cannizzaro G
- Cannon KC
- Cano Z
- Cao H
- Cao J
- Cao XL
- Capaccioli M
- Capano CD
- Capasso M
- Capistrn T
- Capocasa E
- Capone A
- Capozzi D
- Cappellaro E
- Caputo R
- Caramete L
- Caraveo P
- Caraveo PA
- Carbognani F
- Carboni G
- Cardenas B Vargas
- Cardillo M
- Caria T
- Caride S
- Carlin JL
- Carney MF
- Caroff S
- Carosi A
- Carr J
- Carramiana A
- Carretti E
- Cartier R
- Caruso R
- Carver T
- Casadio C
- Casado A Lopez
- Casanova S
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- Casasola V
- Casella P
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- Casey J
- Casier M
- Castander FJ
- Castangia P
- Castellina A
- Castellon A
- Castellon JL Nilo
- Castillo J Alvarez
- Castillo M
- Castro JM Gonzalez
- Castro ML Diaz
- Castro-Tirado AJ
- Casu S
- Catalani F
- Cataldi G
- Cattaneo PW
- Caudill S
- Cavagli M
- Cavalier F
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- Cavazzuti E
- Cazon L
- Cella G
- Celli S
- Cenko SB
- Cepeda CB
- Cerd-Durn P
- Ceron JM Castro
- Cerretani G
- Cerruti M
- Cerutti AC Cobos
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- Schroder FG
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- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transientâs position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.
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- Xu L
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- Xue R
- Yagnik A
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- Yap HL
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- Yassaee A
- Ye H
- Ye H
- Yegnaram S
- Yeh E
- Yin N
- Yip CP
- Yong J
- Yu HC
- Yu S
- Yu T
- Yu Y
- Yuan D
- Yuan F
- Yuan J
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- Yuan Y
- Yuliana A
- Zaimi D
- Zakynthinos S
- Zamudio D
- Zangrillo A
- Zapata DDM
- Zbitnew G
- Zeidan L
- Zeng Q
- Zerman L
- Zettergren J
- Zhang B
- Zhang E
- Zhang H
- Zhang H
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- Zhang M
- Zhang Q
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- Zhang X
- Zhang X
- Zhang X
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Y
- Zhao B
- Zhao B
- Zhao C
- Zhao J
- Zhao J
- Zhao L
- Zhao L
- Zhao S
- Zhao T
- Zhao W
- Zhao W
- Zhao X
- Zhen J
- Zheng K
- Zheng L
- Zheng T
- Zhong Y
- Zhou C
- Zhou D
- Zhou H
- Zhou H
- Zhou J
- Zhou J
- Zhou J
- Zhou X-J
- Zhu X
- Zhu X
- Zhu Y
- Zhu Z
- Zhuang X
- Zilis G
- Zin NHM
- Zingerle N
- Zingg U
- Zoerner F
- Zonneveldt H
- Zou X
- Zoulamoglou M
- Zsisku L
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44Â 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700
Parasite spread at the domestic animal - wildlife interface: anthropogenic habitat use, phylogeny and body mass drive risk of cat and dog flea (Ctenocephalides spp.) infestation in wild mammals
- Author
- A Gelman
- A Gelman
- A Lawrence
- A Psaroulaki
- A Troyo
- AB Pedersen
- AL Lawrence
- BA Han
- BD Patterson
- BL Blagburn
- BR Krasnov
- BR Krasnov
- CA Bradley
- DA Poo-Muñoz
- DG Streicker
- DM Tompkins
- DM Tompkins
- DR Brooks
- E Hoberg
- E Matisoo-Smith
- EA Abouheif
- EP Hoberg
- FJ Sorvillo
- G Dobler
- G Földvåri
- G Kaewmongkol
- G Kaewmongkol
- GJ Canto
- GM Dunnet
- H Wilman
- I Bitam
- J Tenquist
- J Ć lapeta
- JA Patz
- Jan Ć lapeta
- JCA Gower
- JD Hadfield
- JDMCMC Hadfield
- Jennifer M. Seddon
- JLN Wood
- K Wells
- K Wells
- KA Murray
- KE Jones
- KL Evans
- Konstans Wells
- LA Durden
- LF Grogan
- M Begon
- M Gracia
- M Kulbicki
- M Visser
- MC Horta
- MK Rust
- MK Rust
- MR Springborn
- Nicholas J. Clark
- NJ Clark
- NJ Clark
- NJ Clark
- OJ Pung
- OR Bininda-Emonds
- P de Villemereuil
- PJ Baker
- PM Linardi
- PR Stephens
- R Loveridge
- RA Thompson
- RD Adlard
- RJ Eisen
- S Ducatez
- S Liccioli
- S Morand
- S Pavoine
- S Pavoine
- S Pilosof
- SB Araujo
- SNM Zain
- SS Myers
- T Kernif
- TS Doherty
- TS Doherty
- WK Reeves
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Spillover of parasites at the domestic animal - wildlife interface is a pervasive threat to animal health. Cat and dog fleas (Ctenocephalides felis and C. canis) are among the world's most invasive and economically important ectoparasites. Although both species are presumed to infest a diversity of host species across the globe, knowledge on their distributions in wildlife is poor. We built a global dataset of wild mammal host associations for cat and dog fleas, and used Bayesian hierarchical models to identify traits that predict wildlife infestation probability. We complemented this by calculating functional-phylogenetic host specificity to assess whether fleas are restricted to hosts with similar evolutionary histories, diet or habitat niches.Over 130 wildlife species have been found to harbour cat fleas, representing nearly 20% of all mammal species sampled for fleas. Phylogenetic models indicate cat fleas are capable of infesting a broad diversity of wild mammal species through ecological fitting. Those that use anthropogenic habitats are at highest risk. Dog fleas, by contrast, have been recorded in 31 mammal species that are primarily restricted to certain phylogenetic clades, including canids, felids and murids. Both flea species are commonly reported infesting mammals that are feral (free-roaming cats and dogs) or introduced (red foxes, black rats and brown rats), suggesting the breakdown of barriers between wildlife and invasive reservoir species will increase spillover at the domestic animal - wildlife interface.Our empirical evidence shows that cat fleas are incredibly host-generalist, likely exhibiting a host range that is among the broadest of all ectoparasites. Reducing wild species' contact rates with domestic animals across natural and anthropogenic habitats, together with mitigating impacts of invasive reservoir hosts, will be crucial for reducing invasive flea infestations in wild mammals
Evaluation of appendicitis risk prediction models in adults with suspected appendicitis
- Author
- Abbas Sh
- Abbas Sh
- Abbassi Oa
- Abbott T
- Abdelgadir Am
- Abdelrahman A
- Abdelrahman M
- Abdelrahman M
- Abdelwahed A
- Abellan M
- AbellĂĄn Am
- AbellĂĄn Am
- Abulafi M
- Acharya A
- Acosta A
- Adam Me
- Adams Re
- Adegbola So
- Adegbola So
- Adimonye A
- Adnan M
- Afshar S
- Agresta F
- Agua Ia
- Aguayo Jl
- Agudo Ar
- Ahad A
- Ahel J
- Ahern Dp
- Ahmad A
- Ahmed B
- Ahmed G
- Ahmed Os
- Ahmed Os
- Ahmed S
- Ainsworth P
- Ais G
- Ais G
- Aisoni F
- Akbari K
- Akhtar K
- Akinsola O
- Akram F
- Al-Faham Z
- Al-Khafaji N
- Al-Khyatt W
- Al-Musawi S
- Al-Sarireh B
- Al-Sheikh M
- Alagna V
- Alani M
- Alberca-Paramo A
- Aldrey I
- Alexander R
- Alhammali T
- Alhammali T
- Ali M
- Aljorfi A
- Allen M
- Allington J
- Alonzo A
- Alshafei A
- Altomare Ma
- Alvarez Cm
- Alvarez E
- Alvarez-Gallego M
- Amaducci E
- Amarasinghe R
- Amayo A
- Ambrona-Zafra D
- Amin V
- Ammendola M
- Amtul N
- Amtul N
- Amuthalingam T
- Anandan L
- Anania G
- Anania M
- Anderson Dj
- Anderson O
- Andolfi E
- Andreani Sm
- Andreani Sm
- Andrews B
- Ang A
- Ang A
- Angelieri D
- Angelini M
- Angrisani M
- Anguita F
- Ansaloni L
- Ansari A
- Aravind B
- Archer Je
- Arcuri Ga
- Arcuri Ga
- Aremu Ma
- Arenal-Vera Jj
- Aresu S
- Aresu S
- Argenio G
- Argenti F
- Armellini A
- Arnau M
- Arredondo J
- Arroyo A
- Arshad F
- Arunachalam S
- Arunachalam S
- Arunachalam S
- Aruparayil N
- Asensio-Gomez L
- Ashmore Dl
- Ashmore Dl
- Ashour O
- Ashraf N
- Asmadi Aa
- Assaf N
- Assaf N
- Assaf N
- Athersmith Mj
- Atzeni J
- Avalapati H
- Avanzolini A
- Avanzolini A
- Awokoya Oo
- AyllĂłn-GĂĄmez S
- Ayube-Brown J
- Azabdaftari A
- Azevedo J
- Azevedo Jm
- Baddams Ts
- Badenoch T
- Badii B
- Badran A
- Baeza-Murcia M
- Bagga R
- Baginski A
- Bailey Ja
- Bailey S
- Bailey S
- Bailon-Cuadrado M
- Baird C
- Bairos F
- Baker B
- Balai Ej
- Balasubramaniam A
- Balestra F
- Ball A
- Ball A
- Ball A.
- Ballabio M
- Ballester Mm
- Bandyopadhyay Sk
- Banks A
- Bansal H
- Baraghini M
- Barbosa L
- Barker T
- Barker T
- Barnieh W
- Baronio G
- Baronio G
- Barrie A
- Barter Ca
- Bartoli A
- Bascuas-Rodrigo B
- Baseggio M
- Bastianpillai J
- Bawa S
- Baz-Figueroa C
- BazĂĄn-Hinojo Mc
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- Bedoya S
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- Berry B
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- Bhangu A. Nepogodiev D
- Bhangu A
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- Brennan S
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- Brewer H
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- Bronder C
- Brown A
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- Brown Ce
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- Campagnaro T
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- Campbell U
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- Castagnoli G
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- CerdĂĄn-Santacruz C
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- Chatzikonstantinou M
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- De Freitas S
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- De Prizio M
- De-La-Herranz-Guerrero P
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- De-Marchi Ja
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- Dean Ea
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- Delgado-Plasencia Lj
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- GarcĂa-Granero A
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- GarcĂa-Gutierrez C
- GarcĂa-Novoa A
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- GarcĂa-Rivera Co
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- Payne Re
- PayĂĄ-Llorente C
- PayĂĄ-Llorente C
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- PellicanĂČ Ga
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- Pietrabissa A
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- Pila U
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- Pinkney Td
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- Pinna E
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- Piu F
- Planellas P
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- Poacher A
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- Redondo-Calvo Fj
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- Santamaria C
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- Santarrufina-MartĂnez S
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- Sarmah P
- Sarmah P
- Sarmah P
- Sarveswaran J
- Sasia D
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- Savino G
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- Singh S
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- Singhal T
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- Zorrilla L
- Zuin M
- Zurleni Tz
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2019
- Field of study
Background
Appendicitis is the most common general surgical emergency worldwide, but its diagnosis remains challenging. The aim of this study was to determine whether existing risk prediction models can reliably identify patients presenting to hospital in the UK with acute right iliac fossa (RIF) pain who are at low risk of appendicitis.
Methods
A systematic search was completed to identify all existing appendicitis risk prediction models. Models were validated using UK data from an international prospective cohort study that captured consecutive patients aged 16â45âyears presenting to hospital with acute RIF in March to June 2017. The main outcome was best achievable model specificity (proportion of patients who did not have appendicitis correctly classified as low risk) whilst maintaining a failure rate below 5 per cent (proportion of patients identified as low risk who actually had appendicitis).
Results
Some 5345 patients across 154 UK hospitals were identified, of which twoâthirds (3613 of 5345, 67·6 per cent) were women. Women were more than twice as likely to undergo surgery with removal of a histologically normal appendix (272 of 964, 28·2 per cent) than men (120 of 993, 12·1 per cent) (relative risk 2·33, 95 per cent c.i. 1·92 to 2·84; Pâ<â0·001). Of 15 validated risk prediction models, the Adult Appendicitis Score performed best (cutâoff score 8 or less, specificity 63·1 per cent, failure rate 3·7 per cent). The Appendicitis Inflammatory Response Score performed best for men (cutâoff score 2 or less, specificity 24·7 per cent, failure rate 2·4 per cent).
Conclusion
Women in the UK had a disproportionate risk of admission without surgical intervention and had high rates of normal appendicectomy. Risk prediction models to support shared decisionâmaking by identifying adults in the UK at low risk of appendicitis were identified
Model-based operational guidelines of a bioprocess for biological nitrogen removal and complete stabilisation of anaerobically digested sewage sludge
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
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