APLICACIÓN DE LA METODOLOGIA LEAN SIX SIGMA PARA EL DESARROLLO DE UN PLAN DE MEJORA PARA LA GESTION DE PROCESO EN UNA PYME DEL SECTOR METALMECÁNICO

The research called Application of the Lean Six Sigma Methodology for the Development of an Improvement Plan for Process Management in a SME of the Metalworking Sector, has as its purpose the structured approach of the elements of the production process that are limiting its production capacity. The Lean Six Sigma methodology through its systematic method will allow to Define, Measure, Analyze, Improve and Control the entire production system of the company, so that the results obtained positively impact the level of productivity of the company and allow it to meet satisfactorily meet the demands of its customers through high-quality products. For this, during the implementation phases of the Lean Six Sigma methodology, tools will be applied to reduce and / or eliminate defects in the production process and allow the gathering of information for the standardization of operations, the identification of waste and optimization. of the production process. KEYWORDS: Methodology, Continuous Improvement, Process Management, SMEs, Productivity, Quality.Tesi

Zooplankton biomass and community structure in the estero de Punta Banda

"Las variaciones espacio-temporales de la biomasa y estructura de la comunidad del zooplancton en el Estero de Punta Banda fueron investigadas durante primavera y verano de 1985. El intervalo de variación de los promedios mensuales de la biomasa (0.9 a 7.8 ml/10m3)y la abundancia (2.7 a 12.1 x 103 Ind/m3) fueron del mismo orden de magnitud que los reportados en otras lagunas costeras mexicanas. Aunque la variabilidad espacial de la biomasa durante los diferentes muestreos no fue significante, la biomasa del zooplancton presentó alta variación temporal. Las variaciones de corto periodo de la biomasa del zooplancton no estuvieron correlacionadas con la temperatura o salinidad del agua; sin embargo, los promedios mensuales de la biomasa del zooplancton estuvieron positivamente correlacionados con los promedios mensuales de la temperatura y salinidad del agua superficial. Las poblaciones de zooplancton estuvieron dominadas por Acartia califomiensis.""The spatio-temporal variations of zooplankton biomass and structure in the Estero de Punta Banda were investigated durin 9 spring and summer 1985. The range of the mean zooplankton biomass (0.9 to 7.8 ml/m3 ) and abundance (2.7 to 12.1 x 103 org/m3) were of the same order of magnitude as in other coastal lagoons. Although the zooplankton biomass spatial variability during the sampling was not significant, the zooplankton biomass presented high temporal variability. The short-term zooplankton biomass variations were not significantly correlated with water temperature or salinity; however, the monthly mean values of zooplankton biomasa were positively correlated with the monthly mean values of surface water temperature and salinity. The zooplankton populations were dominated by Acattia califomiensis.

Measurement of the cross-section and charge asymmetry of WW bosons produced in proton-proton collisions at s=8\sqrt{s}=8 TeV with the ATLAS detector

This paper presents measurements of the $W^+ \rightarrow \mu^+\nu$ and $W^- \rightarrow \mu^-\nu$ cross-sections and the associated charge asymmetry as a function of the absolute pseudorapidity of the decay muon. The data were collected in proton--proton collisions at a centre-of-mass energy of 8 TeV with the ATLAS experiment at the LHC and correspond to a total integrated luminosity of 20.2~\mbox{fb^{-1}}. The precision of the cross-section measurements varies between 0.8% to 1.5% as a function of the pseudorapidity, excluding the 1.9% uncertainty on the integrated luminosity. The charge asymmetry is measured with an uncertainty between 0.002 and 0.003. The results are compared with predictions based on next-to-next-to-leading-order calculations with various parton distribution functions and have the sensitivity to discriminate between them.Comment: 38 pages in total, author list starting page 22, 5 figures, 4 tables, submitted to EPJC. All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2017-13

Search for chargino-neutralino production with mass splittings near the electroweak scale in three-lepton final states in √s=13 TeV pp collisions with the ATLAS detector

A search for supersymmetry through the pair production of electroweakinos with mass splittings near the electroweak scale and decaying via on-shell W and Z bosons is presented for a three-lepton final state. The analyzed proton-proton collision data taken at a center-of-mass energy of √s=13  TeV were collected between 2015 and 2018 by the ATLAS experiment at the Large Hadron Collider, corresponding to an integrated luminosity of 139  fb−1. A search, emulating the recursive jigsaw reconstruction technique with easily reproducible laboratory-frame variables, is performed. The two excesses observed in the 2015–2016 data recursive jigsaw analysis in the low-mass three-lepton phase space are reproduced. Results with the full data set are in agreement with the Standard Model expectations. They are interpreted to set exclusion limits at the 95% confidence level on simplified models of chargino-neutralino pair production for masses up to 345 GeV

Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector

Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente

Tracking the physicochemical stability of teduglutide (Revestive®) clinical solutions over time in different storage containers

Hospital condition; Long-term stability study; TeduglutideCondició hospitalària; Estudi d'estabilitat a llarg termini; TeduglutidaCondición hospitalaria; Estudio de estabilidad a largo plazo; TeduglutidaTeduglutide, the active ingredient of the medicine Revestive® (5 mg), is a recombinant therapeutic peptide that mimics the effects of the endogenous glucagon-like peptide 2 (GLP-2). It stimulates intestinal growth, adaptation and function in patients with Short Bowel Syndrome who are dependent on parenteral nutrition. The Summary of Product Characteristics recommends immediate use of the reconstituted solutions and the discarding of any subsequent surplus. This study aims to carry out a long-term stability study that reproduces hospital conditions of use which provide sound evidence regarding the use of teduglutide surplus beyond the Summary Product Characteristics recommendations. We conducted a stability study of teduglutide solutions prepared from a 5 mg vial of Revestive®. Some of the solutions were stored in their original vial after reconstitution, while others were repackaged in plastic syringes to evaluate their physicochemical stability over time. For this purpose, we applied a set of previously validated analytical methodologies to evaluate the main critical quality attributes of teduglutide, i.e., primary (including post-tralational modifications), secondary and tertiary structures, aggregates, particulate, concentration and pH. The results indicate that the solutions maintain high physicochemical stability over time, regardless of the storage temperature (4ºC or −20ºC) or the storage container (vials or syringes). This research provides new data on the stability of Revestive® that will be of great value to hospital pharmacists. This comprehensive assessment of the physicochemical long-term stability of TGT has demonstrated that under the storage conditions and over the period studied here, the medicine maintains its quality, efficacy and safety profiles.Fundación Andaluza de Farmacia Hospitalaria (Spain); Hospital Paediatrics Pharmacy Unit of the Hospital Vall d′ Hebron (Barcelona, Spain); Junta de Andalucia (Spain), Universidad de Granada (Spain)

Enzymatic dynamic kinetic resolution of racemic N-formyl- and N-carbamoyl-amino acids using immobilized L-N-carbamoylase and N-succinyl-amino acid racemase.

Taking advantage of the catalytic promiscuity of L-carbamoylase from Geobacillus stearothermophilus CECT43 (BsLcar) and N-succinyl-amino acid racemase from Geobacillus kaustophilus CECT4264 (GkNSAAR), we have evaluated the production of different optically pure L-α-amino acids starting from different racemic N-formyl- and N-carbamoyl-amino acids using a dynamic kinetic resolution approach. The enzymes were immobilized on two different solid supports, resulting in improved stability of the enzymes in terms of thermostability and storage when compared to the enzymes in solution. The bienzymatic system retained up to 80 % conversion efficiency after 20 weeks at 4 °C and up to 90 % after 1 week at 45 °C. The immobilization process also resulted in a great enhancement of the activity of BsLcar toward N-formyl-tryptophan, showing for the first time that substrate specificity of L-carbamoylases can be influenced by this approach. The system was effective for the biosynthesis of natural and unnatural L-amino acids (enantiomeric excess (e.e.) >99.5 %), such as L-methionine, L-alanine, L-tryptophan, L-homophenylalanine, L-aminobutyric acid, and L-norleucine, with a higher performance toward N-formyl-α-amino acid substrates. Biocatalyst reuse was studied, and after 10 reaction cycles, over 75 % activity remained.post-print1047 K

Use of Schizosaccharomyces strains for wine fermentation? Effect on the wine composition and food safety

Schizosaccharomyceswas initially considered as a spoilage yeast because of the production of undesirable metabolites such as acetic acid, hydrogen sulfide, or acetaldehyde, but it currently seems to be of great value in enology.o ced Nevertheless, Schizosaccharomyces can reduce all of the malic acid in must, leading to malolactic fermentation. Malolactic fermentation is a highly complicated process in enology and leads to a higher concentration of biogenic amines, so the use of Schizosaccharomyces pombe can be an excellent tool for assuring wine safety. Schizosaccharomyces also has much more potential than only reducing the malic acid content, such as increasing the level of pyruvic acid and thus the vinylphenolic pyranoanthocyanin content. Until now, few commercial strains have been available and little research on the selection of appropriate yeast strains with such potential has been conducted. In this study, selected and wild Sc. pombe strains were used along with a Saccharomyces cerevisiae strain to ferment red grape must. The results showed significant differences in several parameters including non-volatile and volatile compounds, anthocyanins, biogenic amines and sensory parameters