Implicaciones del ratio neutrófilos-linfocitos en el tratamiento del cáncer de próstata resistente a la castración metastásico con acetato de abiraterona.

El cáncer de próstata representa uno de los principales problemas de salud pública de cualquier organización sanitaria. La fase de resistencia a la castración, resulta la fase final de la enfermedad y condicionará invariablemente la supervivencia y calidad de vida de estos pacientes. En la última década, se han desarrollado y aprobado múltiples líneas de tratamiento que actúan sobre diferentes dianas terapéuticas para los pacientes con cáncer de próstata resistente a la castración metastásicos (CRPCm). Esto ha supuesto importantes mejoras en supervivencia y calidad de vida. Sin embargo, actualmente, no existe un biomarcador ideal que ayude al clínico a determinar el perfil de paciente con mayor potencial beneficio para cada una de las alternativas terapéuticas disponibles y que resulte útil durante el tratamiento. Se han desarrollado múltiples biomarcadores pronósticos de supervivencia y predictivos de respuesta existiendo varios que han demostrado cierta eficacia para valorar aspectos concretos, pero que, habitualmente, resultan complejos de determinar y solo están disponibles de modo experimental. La inflamación resulta un factor subrogado de actividad biológica en múltiples enfermedades. En el ámbito oncológico, la inflamación es un requisito imprescindible en el desarrollo de la inmunobiología tumoral. El ratio neutrófiloslinfocitos (RNL) resulta un cociente que traduce la respuesta inflamatoria que se está produciendo en el organismo, en nuestro caso como respuesta al tumor (neutrófilos como principales agentes mediadores de la inflamación) y la respuesta antitumoral llevada frente al mismo (mediada preferencialmente por linfocitos). Por tanto, puede ser considerado como un biomarcador independientemente del tipo de tumor y reflejo de la actividad inflamatoria, así como de los mecanismos reguladores de respuesta presentes en el organismo. El objetivo de este estudio es identificar un biomarcador accesible, reproducible y con implicaciones pronósticas independientes proponiendo evaluar el papel del RNL como posible biomarcador en los pacientes con CRPCm en tratamiento con acetato de abiraterona (AA).Medicin

Pre and postoperative care for the outpatient fulguration in superficial bladder tumor. What should know the primary care physician?

Introducción: El objetivo de este trabajo es transmitir al médico de atención primaria los cuidados pre y postoperatorios en la fulguración con láser holmium de la recidiva del tumor vesical superficial. Material y Métodos: Estudio descriptivo de una cohorte de pacientes, llevado a cabo en el Hospital Universitario Morales Meseguer, Murcia (España). Se incluyen 37 pacientes con recidiva de tumor vesical superficial de bajo riesgo, sometidos a fulguración con láser de holmium. Se incluyen en el estudio pacientes con tumor papilar, tamaño ≤15 mm, menos de 5 tumores y sin alteraciones en la coagulación ni alergias a anestésicos locales. Se entregan recomendaciones pre y postoperatorias al paciente que debe conocer el médico de atención primaria, previa y tras la intervención (fulguración vesical ambulatoria con láser de holmium). Se miden complicaciones, dolor tras el procedimiento, satisfacción del paciente. Resultados: La edad media de los pacientes fue de 69.2 años, siendo el 86.5% hombres. El número de lesiones fue de 1.5 ± 0.8 y el tamaño global medio de 5.5 ± 2.7 mm. El tiempo medio de realización del procedimiento endoscópico fue de 12 ± 4.3 minutos. El 100% de los pacientes presentó puntuación en la escala visual analógica del dolor ≤ 3. Sólo 1 caso de hematuria que se resolvió de forma conservadora. Conclusión: El tratamiento con láser holmium de la recidiva tumoral vesical superficial de bajo riesgo de forma ambulatoria es seguro, precisa de profilaxis antibiótica, control del dolor y especial atención a efectos adversos que suelen ser leves.Introduction: The objective of this work is to inform to primary care the pre and postoperative care in holmium laser fulguration of superficial bladder tumor recurrence. Methods: A descriptive study of a cohort of patients, conducted at the University Hospital Morales Meseguer, Murcia (Spain). 37 patients with superficial bladder tumor recurrence undergoing holmium laser fulguration are included. Included in the study patients with papillary tumor size ≤ 15 mm, less than 5 tumors without coagulation disorders or allergies to local anesthetics. Pre and postoperative recommendations are given to the patient to know the family physician, after care and after surgery (outpatient bladder holmium laser fulguration). Complications, pain after the procedure and patient satisfaction were measured. Results: The mean age of the patients was 69.2 years, with 86.5% male. The number of lesions was 1.5 ± 0.8 and the overall average size of 5.5 ± 2.7 mm. The average time for completion of the endoscopic procedure was 12 ± 4.3 minutes. 100% of patients had scores on the visual analog pain scale ≤ 3. Only 1 case of hematuria that resolved conservatively. Conclusion: Holmium laser treatment of in low-risk superficial bladder tumor recurrence ambulatory safe, requires antibiotic prophylaxis, pain management and attention to side effects are usually mild

Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in √s = 7 TeV pp collisions with the ATLAS detector

A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fb−1 of proton–proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric models and in simplified models, significantly extending previous results

Age-Related Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI : Results of the ISACS-STEMI COVID-19 Registry

Background: The constraints in the management of patients with ST-segment elevation myocardial infarction (STEMI) during the COVID-19 pandemic have been suggested to have severely impacted mortality levels. The aim of the current analysis is to evaluate the age-related effects of the COVID-19 pandemic on mechanical reperfusion and 30-day mortality for STEMI within the registry ISACS-STEMI COVID-19. Methods: This retrospective multicenter registry was performed in high-volume PPCI centers on four continents and included STEMI patients undergoing PPCI in March–June 2019 and 2020. Patients were divided according to age (< or ≥75 years). The main outcomes were the incidence and timing of PPCI, (ischemia time longer than 12 h and door-to-balloon longer than 30 min), and in-hospital or 30-day mortality. Results: We included 16,683 patients undergoing PPCI in 109 centers. In 2020, during the pandemic, there was a significant reduction in PPCI as compared to 2019 (IRR 0.843 (95%-CI: 0.825–0.861, p < 0.0001). We found a significant agerelated reduction (7%, p = 0.015), with a larger effect on elderly than on younger patients. Furthermore, we observed significantly higher 30-day mortality during the pandemic period, especially among the elderly (13.6% vs. 17.9%, adjusted HR (95% CI) = 1.55 [1.24–1.93], p < 0.001) as compared to younger patients (4.8% vs. 5.7%; adjusted HR (95% CI) = 1.25 [1.05–1.49], p = 0.013), as a potential consequence of the significantly longer ischemia time observed during the pandemic. Conclusions: The COVID-19 pandemic had a significant impact on the treatment of patients with STEMI, with a 16% reduction in PPCI procedures, with a larger reduction and a longer delay to treatment among elderly patients, which may have contributed to increase in-hospital and 30-day mortality during the pandemic

Age-Related Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry

Background: The constraints in the management of patients with ST-segment elevation myocardial infarction (STEMI) during the COVID-19 pandemic have been suggested to have severely impacted mortality levels. The aim of the current analysis is to evaluate the age-related effects of the COVID-19 pandemic on mechanical reperfusion and 30-day mortality for STEMI within the registry ISACS-STEMI COVID-19. Methods: This retrospective multicenter registry was performed in high-volume PPCI centers on four continents and included STEMI patients undergoing PPCI in March-June 2019 and 2020. Patients were divided according to age (= 75 years). The main outcomes were the incidence and timing of PPCI, (ischemia time longer than 12 h and door-to-balloon longer than 30 min), and in-hospital or 30-day mortality. Results: We included 16,683 patients undergoing PPCI in 109 centers. In 2020, during the pandemic, there was a significant reduction in PPCI as compared to 2019 (IRR 0.843 (95%-CI: 0.825-0.861, p < 0.0001). We found a significant age-related reduction (7%, p = 0.015), with a larger effect on elderly than on younger patients. Furthermore, we observed significantly higher 30-day mortality during the pandemic period, especially among the elderly (13.6% vs. 17.9%, adjusted HR (95% CI) = 1.55 [1.24-1.93], p < 0.001) as compared to younger patients (4.8% vs. 5.7%; adjusted HR (95% CI) = 1.25 [1.05-1.49], p = 0.013), as a potential consequence of the significantly longer ischemia time observed during the pandemic. Conclusions: The COVID-19 pandemic had a significant impact on the treatment of patients with STEMI, with a 16% reduction in PPCI procedures, with a larger reduction and a longer delay to treatment among elderly patients, which may have contributed to increase in-hospital and 30-day mortality during the pandemic

Gender Difference in the Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry

Background. Several reports have demonstrated the impact of the COVID-19 pandemic on the management and outcome of patients with ST-segment elevation myocardial infarction (STEMI). The aim of the current analysis is to investigate the potential gender difference in the effects of the COVID-19 pandemic on mechanical reperfusion and 30-day mortality for STEMI patients within the ISACS-STEMI COVID-19 Registry. Methods. This retrospective multicenter registry was performed in high-volume primary percutaneous coronary intervention (PPCI) centers on four continents and included STEMI patients undergoing PPCIs in March–June 2019 and 2020. Patients were divided according to gender. The main outcomes were the incidence and timing of the PPCI, (ischemia time ≥ 12 h and door-to-balloon ≥ 30 min) and in-hospital or 30-day mortality. Results. We included 16683 STEMI patients undergoing PPCIs in 109 centers. In 2020 during the pandemic, there was a significant reduction in PPCIs compared to 2019 (IRR 0.843 (95% CI: 0.825–0.861, p < 0.0001). We did not find a significant gender difference in the effects of the COVID-19 pandemic on the numbers of STEMI patients, which were similarly reduced from 2019 to 2020 in both groups, or in the mortality rates. Compared to prepandemia, 30-day mortality was significantly higher during the pandemic period among female (12.1% vs. 8.7%; adjusted HR [95% CI] = 1.66 [1.31–2.11], p < 0.001) but not male patients (5.8% vs. 6.7%; adjusted HR [95% CI] = 1.14 [0.96–1.34], p = 0.12). Conclusions. The COVID-19 pandemic had a significant impact on the treatment of patients with STEMI, with a 16% reduction in PPCI procedures similarly observed in both genders. Furthermore, we observed significantly increased in-hospital and 30-day mortality rates during the pandemic only among females. Trial registration number: NCT 04412655

Impact of Smoking Status on Mortality in STEMI Patients Undergoing Mechanical Reperfusion for STEMI : Insights from the ISACS–STEMI COVID-19 Registry

The so-called “smoking paradox”, conditioning lower mortality in smokers among STEMI patients, has seldom been addressed in the settings of modern primary PCI protocols. The ISACS– STEMI COVID-19 is a large-scale retrospective multicenter registry addressing in-hospital mortality, reperfusion, and 30-day mortality among primary PCI patients in the era of the COVID-19 pandemic. Among the 16,083 STEMI patients, 6819 (42.3%) patients were active smokers, 2099 (13.1%) previous smokers, and 7165 (44.6%) non-smokers. Despite the impaired preprocedural recanalization (p < 0.001), active smokers had a significantly better postprocedural TIMI flow compared with nonsmokers (p < 0.001); this was confirmed after adjustment for all baseline and procedural confounders, and the propensity score. Active smokers had a significantly lower in-hospital (p < 0.001) and 30-day (p < 0.001) mortality compared with non-smokers and previous smokers; this was confirmed after adjustment for all baseline and procedural confounders, and the propensity score. In conclusion, in our population, active smoking was significantly associated with improved epicardial recanalization and lower in-hospital and 30-day mortality compared with previous and non-smoking histor

Results of the ISACS-STEMI COVID-19 Registry

Publisher Copyright: © 2023 by the authors.Background. Several reports have demonstrated the impact of the COVID-19 pandemic on the management and outcome of patients with ST-segment elevation myocardial infarction (STEMI). The aim of the current analysis is to investigate the potential gender difference in the effects of the COVID-19 pandemic on mechanical reperfusion and 30-day mortality for STEMI patients within the ISACS-STEMI COVID-19 Registry. Methods. This retrospective multicenter registry was performed in high-volume primary percutaneous coronary intervention (PPCI) centers on four continents and included STEMI patients undergoing PPCIs in March–June 2019 and 2020. Patients were divided according to gender. The main outcomes were the incidence and timing of the PPCI, (ischemia time ≥ 12 h and door-to-balloon ≥ 30 min) and in-hospital or 30-day mortality. Results. We included 16683 STEMI patients undergoing PPCIs in 109 centers. In 2020 during the pandemic, there was a significant reduction in PPCIs compared to 2019 (IRR 0.843 (95% CI: 0.825–0.861, p < 0.0001). We did not find a significant gender difference in the effects of the COVID-19 pandemic on the numbers of STEMI patients, which were similarly reduced from 2019 to 2020 in both groups, or in the mortality rates. Compared to prepandemia, 30-day mortality was significantly higher during the pandemic period among female (12.1% vs. 8.7%; adjusted HR [95% CI] = 1.66 [1.31–2.11], p < 0.001) but not male patients (5.8% vs. 6.7%; adjusted HR [95% CI] = 1.14 [0.96–1.34], p = 0.12). Conclusions. The COVID-19 pandemic had a significant impact on the treatment of patients with STEMI, with a 16% reduction in PPCI procedures similarly observed in both genders. Furthermore, we observed significantly increased in-hospital and 30-day mortality rates during the pandemic only among females. Trial registration number: NCT 04412655.publishersversionpublishe

Impact of chronic obstructive pulmonary disease on short-term outcome in patients with ST-elevation myocardial infarction during COVID-19 pandemic: insights from the international multicenter ISACS-STEMI registry

Background Chronic obstructive pulmonary disease (COPD) is projected to become the third cause of mortality worldwide. COPD shares several pathophysiological mechanisms with cardiovascular disease, especially atherosclerosis. However, no definite answers are available on the prognostic role of COPD in the setting of ST elevation myocardial infarction (STEMI), especially during COVID-19 pandemic, among patients undergoing primary angioplasty, that is therefore the aim of the current study. Methods In the ISACS-STEMI COVID-19 registry we included retrospectively patients with STEMI treated with primary percutaneous coronary intervention (PCI) between March and June of 2019 and 2020 from 109 high-volume primary PCI centers in 4 continents. Results A total of 15,686 patients were included in this analysis. Of them, 810 (5.2%) subjects had a COPD diagnosis. They were more often elderly and with a more pronounced cardiovascular risk profile. No preminent procedural dissimilarities were noticed except for a lower proportion of dual antiplatelet therapy at discharge among COPD patients (98.9% vs. 98.1%, P = 0.038). With regards to short-term fatal outcomes, both in-hospital and 30-days mortality occurred more frequently among COPD patients, similarly in pre-COVID-19 and COVID-19 era. However, after adjustment for main baseline differences, COPD did not result as independent predictor for in-hospital death (adjusted OR [95% CI] = 0.913[0.658-1.266], P = 0.585) nor for 30-days mortality (adjusted OR [95% CI] = 0.850 [0.620-1.164], P = 0.310). No significant differences were detected in terms of SARS-CoV-2 positivity between the two groups. Conclusion This is one of the largest studies investigating characteristics and outcome of COPD patients with STEMI undergoing primary angioplasty, especially during COVID pandemic. COPD was associated with significantly higher rates of in-hospital and 30-days mortality. However, this association disappeared after adjustment for baseline characteristics. Furthermore, COPD did not significantly affect SARS-CoV-2 positivity. Trial registration number: NCT 04412655 (2nd June 2020)

Cosmic dust fluxes in the atmospheres of Earth, Mars and Venus

The ablation of cosmic dust injects a range of metals into planetary upper atmospheres. In addition, dust particles which survive atmospheric entry can be an important source of organic material at a planetary surface. In this study the contribution of metals and organics from three cosmic dust sources – Jupiter-Family comets (JFCs), the Asteroid belt (AST), and Halley-Type comets (HTCs) – to the atmospheres of Earth, Mars and Venus is estimated by combining a Chemical Ablation Model (CABMOD) with a Zodiacal Cloud Model (ZoDy). ZoDy provides the mass, velocity, and radiant distributions for JFC, AST, and HTC particles. JFCs are shown to be the main mass contributor in all three atmospheres (68% for Venus, 70% Earth, and 52% for Mars), providing a total input mass for Venus, Earth and Mars of 31 ± 18 t d⁻¹, 28 ± 16 t d⁻¹ and 2 ± 1 t d⁻¹, respectively. The mass contribution of AST particles increases with heliocentric distance (6% for Venus, 9% for Earth, and 14% for Mars). A novel multiphase treatment in CABMOD, tested experimentally in a Meteoric Ablation Simulator, is implemented to quantify atmospheric ablation from both the silicate melt and Fe-Ni metal domains. The ratio of Fe:Ni ablation fluxes at Earth, Mars and Venus are predicted to be close to their CI chondritic ratio of 18, in agreement with mass spectrometric measurements of Fe+:Ni+ = 20.0–₈.₀+¹³·⁰ in the terrestrial ionosphere. In contrast, lidar measurements of the neutral atoms at Earth indicate Fe:Ni = 38 ± 11, and observations by the Neutral Gas and Ion Mass Spectrometer on the MAVEN spacecraft at Mars indicate Fe+:Ni+ = 43–₁₀+¹³. Given the slower average entry velocity of cosmic dust particles at Mars, the accretion rate of unmelted particles in Mars represents 60% of the total input mass, of which a significant fraction of the total unmelted mass (22%) does not reach an organic pyrolysis temperature (~900 K), leading to a flux of intact carbon of 14 kg d⁻¹. This is significantly smaller than previous estimates