418 research outputs found

    Evaluation of future climate change impacts on semi-arid Cobres basin in southern Portugal

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    This study evaluated future climate change impacts on hydrological and sediment transport processes for the medium-sized (705 km2) agriculture dominated Cobres basin, Portugal, in the context of anti-desertification strategies. We used the Spatial-Temporal Neyman-Scott Rectangular Pulses (STNSRP) model—RainSim V3, a rainfall conditioned weather generator—ICAAM-WG, developed in this study but based on the modified Climate Research Unit daily weather generator (CRU-WG), and a PBSD hydrological model—SHETRAN, to downscale projections of change. Climate projections were derived from the RCM HadRM3Q0 output, provided by the ENSEMBLES project, for the SRES A1B scenario for the period 2041–2070. The RainSim V3 and ICAAM-WG models are demonstrated to be able to reproduce observed climatology for the period 1981–2010. The SHETRAN model reproduces hourly runoff with Nash-Sutcliffe Efficiency (NSE) of 0.86 for calibration (2004–2006) and 0.74 for validation (2006–2008) for basin outlet; it reproduces hourly sediment discharge with NSE of 0.48 for the storm from October 23rd 2006 to October 27th 2006. We found that future mean climate is drier, with mean annual rainfall decreased by 88 mm (19%), mean annual PET increased 196 mm (16%) and consequent mean annual runoff and sediment yield decreased respectively 48 mm (50%) and 1.06 t/ha/year (45%). The future mean annual AET decreases 41 mm (11%), which occurs mainly in spring indicating a more water-limited future climate for vegetation and crop growth. Under current conditions, November to February is the period in which runoff and sediment yield occur frequently; however, it is reduced to December to January in future, with changes in the occurrence rate of 50%. On the other hand, future wet extremes are more right-skewed. Future annual maximum discharge and sediment discharge decrease for extremes with return periods (T) less than 20 years and the decreases are especially greater for those with T less than 2 years; besides, both quantities present the same or slightly lower magnitudes as those with T larger than 20 years. The annual maximum discharge (sediment discharge) series, under control climate, follows the GEV distribution with location parameter of 64.6 m3/s (164.4 kg/s), scale parameter of 46.5 m3/s (120.3 kg/s) and shape parameter of 0.09 (-0.24); under future climate, the annual maximum discharge series follows the gamma distribution with scale parameter of 75.2 m3/s and shape parameter of 0.97 and the annual maximum sediment discharge series follows the three-parameter lognormal distribution with location parameter of -46.2 kg/s, mean of 5.3 kg/s and standard deviation of 0.78. This study has confirmed the increasing concerns of water scarcity and drought problems in southern Portugal; but it also indicated the mitigation of sediment transport for most of time in the future except heavy events. However, the results should be interpreted carefully since we did not consider possible changes of land-use in the future, as well as the climate and hydrological modelling uncertainties

    PPL2 translesion polymerase is essential for the completion of chromosomal DNA replication in the african trypanosome

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    Faithful copying of the genome is essential for life. In eukaryotes, a single archaeo-eukaryotic primase (AEP), DNA primase, is required for the initiation and progression of DNA replication. Here we have identified additional eukaryotic AEP-like proteins with DNA-dependent primase and/or polymerase activity. Uniquely, the genomes of trypanosomatids, a group of kinetoplastid protozoa of significant medical importance, encode two PrimPol-like (PPL) proteins. In the African trypanosome, PPL2 is a nuclear enzyme present in G2 phase cells. Following PPL2 knockdown, a cell-cycle arrest occurs after the bulk of DNA synthesis, the DNA damage response is activated, and cells fail to recover. Consistent with this phenotype, PPL2 replicates damaged DNA templates in vitro, including templates containing the UV-induced pyrimidine-pyrimidone (6-4) photoproduct. Furthermore, PPL2 accumulates at sites of nuclear DNA damage. Taken together, our results indicate an essential role for PPL2 in postreplication tolerance of endogenous DNA damage, thus allowing completion of genome duplication

    Defining elite athletes: Issues in the study of expert performance in sport psychology

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    © 2014 Elsevier Ltd. Objectives: There has been considerable inconsistency and confusion in the definition of elite/expert athletes in sport psychology research, which has implications for studies conducted in this area and for the field as a whole. This study aimed to: (i) critically evaluate the ways in which recent research in sport psychology has defined elite/expert athletes; (ii) explore the rationale for using such athletes; and (iii) evaluate the conclusions that research in this field draws about the nature of expertise. Design: Conventional systematic review principles were employed to conduct a rigorous search and synthesise findings. Methods: A comprehensive literature search of SPORTDiscus, Academic Search Complete, PsycINFO, and PsycARTICLES was completed in September, 2013 which yielded 91 empirical studies published between 2010 and 2013. The primarily qualitative findings were analysed thematically. Results: Eight ways of defining elite/expert athletes were identified, ranging from Olympic champions to regional level competitors and those with as little as two years of experience in their sport. Three types of rationale were evident in these studies (i.e., "necessity", "exploratory" and "superior"); while findings also indicated that some elite athletes are psychologically idiosyncratic and perhaps even dysfunctional in their behaviour. Finally, only 19 of the 91 included studies provided conclusions about the nature of expertise in sport. Conclusions: This study suggests that the definitions of elite athletes vary on a continuum of validity, and the findings are translated into a taxonomy for classifying expert samples in sport psychology research in future. Recommendations are provided for researchers in this area

    Safety, immunogenicity, and reactogenicity of BNT162b2 and mRNA-1273 COVID-19 vaccines given as fourth-dose boosters following two doses of ChAdOx1 nCoV-19 or BNT162b2 and a third dose of BNT162b2 (COV-BOOST): a multicentre, blinded, phase 2, randomised trial

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    Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an

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    Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis

    Impacts of the Tropical Pacific/Indian Oceans on the Seasonal Cycle of the West African Monsoon

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    The current consensus is that drought has developed in the Sahel during the second half of the twentieth century as a result of remote effects of oceanic anomalies amplified by local land–atmosphere interactions. This paper focuses on the impacts of oceanic anomalies upon West African climate and specifically aims to identify those from SST anomalies in the Pacific/Indian Oceans during spring and summer seasons, when they were significant. Idealized sensitivity experiments are performed with four atmospheric general circulation models (AGCMs). The prescribed SST patterns used in the AGCMs are based on the leading mode of covariability between SST anomalies over the Pacific/Indian Oceans and summer rainfall over West Africa. The results show that such oceanic anomalies in the Pacific/Indian Ocean lead to a northward shift of an anomalous dry belt from the Gulf of Guinea to the Sahel as the season advances. In the Sahel, the magnitude of rainfall anomalies is comparable to that obtained by other authors using SST anomalies confined to the proximity of the Atlantic Ocean. The mechanism connecting the Pacific/Indian SST anomalies with West African rainfall has a strong seasonal cycle. In spring (May and June), anomalous subsidence develops over both the Maritime Continent and the equatorial Atlantic in response to the enhanced equatorial heating. Precipitation increases over continental West Africa in association with stronger zonal convergence of moisture. In addition, precipitation decreases over the Gulf of Guinea. During the monsoon peak (July and August), the SST anomalies move westward over the equatorial Pacific and the two regions where subsidence occurred earlier in the seasons merge over West Africa. The monsoon weakens and rainfall decreases over the Sahel, especially in August.Peer reviewe

    Search for heavy resonances decaying to two Higgs bosons in final states containing four b quarks

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    A search is presented for narrow heavy resonances X decaying into pairs of Higgs bosons (H) in proton-proton collisions collected by the CMS experiment at the LHC at root s = 8 TeV. The data correspond to an integrated luminosity of 19.7 fb(-1). The search considers HH resonances with masses between 1 and 3 TeV, having final states of two b quark pairs. Each Higgs boson is produced with large momentum, and the hadronization products of the pair of b quarks can usually be reconstructed as single large jets. The background from multijet and t (t) over bar events is significantly reduced by applying requirements related to the flavor of the jet, its mass, and its substructure. The signal would be identified as a peak on top of the dijet invariant mass spectrum of the remaining background events. No evidence is observed for such a signal. Upper limits obtained at 95 confidence level for the product of the production cross section and branching fraction sigma(gg -> X) B(X -> HH -> b (b) over barb (b) over bar) range from 10 to 1.5 fb for the mass of X from 1.15 to 2.0 TeV, significantly extending previous searches. For a warped extra dimension theory with amass scale Lambda(R) = 1 TeV, the data exclude radion scalar masses between 1.15 and 1.55 TeV

    Search for supersymmetry in events with one lepton and multiple jets in proton-proton collisions at root s=13 TeV

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    Measurement of the top quark mass using charged particles in pp collisions at root s=8 TeV

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    Search for anomalous couplings in boosted WW/WZ -> l nu q(q)over-bar production in proton-proton collisions at root s=8TeV

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