128 research outputs found
P13 CLINICAL SIGNIFICANCE OF DONOR SPECIFIC ANTIBODIES (DSA) IN LIVING RELATED RENAL ALLOGRAFT TRANSPLANT RECIPIENTS: A SINGLE CENTRE EXPERIENCE
Particle density fluctuations
Event-by-event fluctuations in the multiplicities of charged particles and
photons at SPS energies are discussed. Fluctuations are studied by controlling
the centrality of the reaction and rapidity acceptance of the detectors.
Results are also presented on the event-by-event study of correlations between
the multiplicity of charged particles and photons to search for DCC-like
signals.Comment: Talk presented at Quark Matter 2002, Nantes, Franc
Suppression of High-p_T Neutral Pion Production in Central Pb+Pb Collisions at sqrt{s_NN} = 17.3 GeV Relative to p+C and p+Pb Collisions
Neutral pion transverse momentum spectra were measured in p+C and p+Pb
collisions at sqrt{s_NN} = 17.4 GeV at mid-rapidity 2.3 < eta_lab < 3.0 over
the range 0.7< p_T < 3.5 GeV/c. The spectra are compared to pi0 spectra
measured in Pb+Pb collisions at sqrt{s_NN} = 17.3 GeV in the same experiment.
For a wide range of Pb+Pb centralities (N_part < 300) the yield of pi0's with
p_T > 2 GeV/c is larger than or consistent with the p+C or p+Pb yields scaled
with the number of nucleon-nucleon collisions (N_coll), while for central Pb+Pb
collisions with N_part > 350 the pi0 yield is suppressed.Comment: 5 pages, 4 figure
Pion Freeze-Out Time in Pb+Pb Collisions at 158 A GeV/c Studied via pi-/pi+ and K-/K+ Ratios
The effect of the final state Coulomb interaction on particles produced in
Pb+Pb collisions at 158 A GeV/c has been investigated in the WA98 experiment
through the study of the pi-/pi+ and K-/K+ ratios measured as a function of
transverse mass. While the ratio for kaons shows no significant transverse mass
dependence, the pi-/pi+ ratio is enhanced at small transverse mass values with
an enhancement that increases with centrality. A silicon pad detector located
near the target is used to estimate the contribution of hyperon decays to the
pi-/pi+ ratio. The comparison of results with predictions of the RQMD model in
which the Coulomb interaction has been incorporated allows to place constraints
on the time of the pion freeze-out.Comment: 9 pages, 12 figure
Variation in The Vitamin D Receptor Gene is Associated With Multiple Sclerosis in an Australian Population
Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) resulting in accumulating neurological disability. The disorder is more prevalent at higher latitudes. To investigate VDR gene variation using three intragenic restriction fragment length polymorphisms (Apa I, Taq I and Fok I) in an Australian MS case-control population, one hundred and four Australian MS patients were studied with patients classified clinically as Relapsing Remitting MS (RR-MS), Secondary Progressive MS (SP-MS) or Primary Progressive MS (PP-MS). Also, 104 age-, sex-, and ethnicity-matched controls were investigated as a comparative group. Our results show a significant difference of genotype distribution frequency between the case and control groups for the functional exon 9 VDR marker Taq I (p_Gen = 0.016) and interestingly, a stronger difference for the allelic frequency (p_All = 0.0072). The Apa I alleles were also found to be associated with MS (p_All = 0.04) but genotype frequencies were not significantly different from controls (p_Gen = 0.1). The Taq and Apa variants are in very strong and significant linkage disequilibrium (D' = 0.96, P < 0.0001). The genotypic associations are strongest for the progressive forms of MS (SP-MS and PP-MS). Our results support a role for the VDR gene increasing
Fragmentation and Multifragmentation of 10.6A GeV Gold Nuclei
We present the results of a study performed on the interactions of 10.6A GeV
gold nuclei in nuclear emulsions. In a minimum bias sample of 1311 interac-
tions, 5260 helium nuclei and 2622 heavy fragments were observed as Au projec-
tile fragments. The experimental data are analyzed with particular emphasis of
target separation interactions in emulsions and study of criticalexponents.
Multiplicity distributions of the fast-moving projectile fragments are inves-
tigated. Charged fragment moments, conditional moments as well as two and three
-body asymmetries of the fast moving projectile particles are determined in
terms of the total charge remaining bound in the multiply charged projectile
fragments. Some differences in the average yields of helium nuclei and heavier
fragments are observed, which may be attributed to a target effect. However,
two and three-body asymmetries and conditional moments indicate that the
breakup mechanism of the projectile seems to be independent of target mass. We
looked for evidence of critical point observable in finite nuclei by study the
resulting charged fragments distributions. We have obtained the values for the
critical exponents gamma, beta and tau and compare our results with those at
lower energy experiment (1.0A GeV data). The values suggest that a phase
transition like behavior, is observed.Comment: latex, revtex, 28 pages, 12 figures, 3tables, submitted to Europysics
Journal
Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2015: A systematic analysis for the Global Burden of Disease Study 2015
Background: The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 provides an up-to-date synthesis of the evidence for risk factor exposure and the attributable burden of disease. By providing national and subnational assessments spanning the past 25 years, this study can inform debates on the importance of addressing risks in context.
Methods: We used the comparative risk assessment framework developed for previous iterations of the Global Burden of Disease Study to estimate attributable deaths, disability-adjusted life-years (DALYs), and trends in exposure by age group, sex, year, and geography for 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks from 1990 to 2015. This study included 388 risk-outcome pairs that met World Cancer Research Fund-defined criteria for convincing or probable evidence. We extracted relative risk and exposure estimates from randomised controlled trials, cohorts, pooled cohorts, household surveys, census data, satellite data, and other sources. We used statistical models to pool data, adjust for bias, and incorporate covariates. We developed a metric that allows comparisons of exposure across risk factors—the summary exposure value. Using the counterfactual scenario of theoretical minimum risk level, we estimated the portion of deaths and DALYs that could be attributed to a given risk. We decomposed trends in attributable burden into contributions from population growth, population age structure, risk exposure, and risk-deleted cause-specific DALY rates. We characterised risk exposure in relation to a Socio-demographic Index (SDI).
Findings: Between 1990 and 2015, global exposure to unsafe sanitation, household air pollution, childhood underweight, childhood stunting, and smoking each decreased by more than 25%. Global exposure for several occupational risks, high body-mass index (BMI), and drug use increased by more than 25% over the same period. All risks jointly evaluated in 2015 accounted for 57·8% (95% CI 56·6–58·8) of global deaths and 41·2% (39·8–42·8) of DALYs. In 2015, the ten largest contributors to global DALYs among Level 3 risks were high systolic blood pressure (211·8 million [192·7 million to 231·1 million] global DALYs), smoking (148·6 million [134·2 million to 163·1 million]), high fasting plasma glucose (143·1 million [125·1 million to 163·5 million]), high BMI (120·1 million [83·8 million to 158·4 million]), childhood undernutrition (113·3 million [103·9 million to 123·4 million]), ambient particulate matter (103·1 million [90·8 million to 115·1 million]), high total cholesterol (88·7 million [74·6 million to 105·7 million]), household air pollution (85·6 million [66·7 million to 106·1 million]), alcohol use (85·0 million [77·2 million to 93·0 million]), and diets high in sodium (83·0 million [49·3 million to 127·5 million]). From 1990 to 2015, attributable DALYs declined for micronutrient deficiencies, childhood undernutrition, unsafe sanitation and water, and household air pollution; reductions in risk-deleted DALY rates rather than reductions in exposure drove these declines. Rising exposure contributed to notable increases in attributable DALYs from high BMI, high fasting plasma glucose, occupational carcinogens, and drug use. Environmental risks and childhood undernutrition declined steadily with SDI; low physical activity, high BMI, and high fasting plasma glucose increased with SDI. In 119 countries, metabolic risks, such as high BMI and fasting plasma glucose, contributed the most attributable DALYs in 2015. Regionally, smoking still ranked among the leading five risk factors for attributable DALYs in 109 countries; childhood underweight and unsafe sex remained primary drivers of early death and disability in much of sub-Saharan Africa.
Interpretation: Declines in some key environmental risks have contributed to declines in critical infectious diseases. Some risks appear to be invariant to SDI. Increasing risks, including high BMI, high fasting plasma glucose, drug use, and some occupational exposures, contribute to rising burden from some conditions, but also provide opportunities for intervention. Some highly preventable risks, such as smoking, remain major causes of attributable DALYs, even as exposure is declining. Public policy makers need to pay attention to the risks that are increasingly major contributors to global burden.
Funding: Bill & Melinda Gates Foundation
Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980�2015: a systematic analysis for the Global Burden of Disease Study 2015
Background Improving survival and extending the longevity of life for all populations requires timely, robust evidence on local mortality levels and trends. The Global Burden of Disease 2015 Study (GBD 2015) provides a comprehensive assessment of all-cause and cause-specific mortality for 249 causes in 195 countries and territories from 1980 to 2015. These results informed an in-depth investigation of observed and expected mortality patterns based on sociodemographic measures. Methods We estimated all-cause mortality by age, sex, geography, and year using an improved analytical approach originally developed for GBD 2013 and GBD 2010. Improvements included refinements to the estimation of child and adult mortality and corresponding uncertainty, parameter selection for under-5 mortality synthesis by spatiotemporal Gaussian process regression, and sibling history data processing. We also expanded the database of vital registration, survey, and census data to 14�294 geography�year datapoints. For GBD 2015, eight causes, including Ebola virus disease, were added to the previous GBD cause list for mortality. We used six modelling approaches to assess cause-specific mortality, with the Cause of Death Ensemble Model (CODEm) generating estimates for most causes. We used a series of novel analyses to systematically quantify the drivers of trends in mortality across geographies. First, we assessed observed and expected levels and trends of cause-specific mortality as they relate to the Socio-demographic Index (SDI), a summary indicator derived from measures of income per capita, educational attainment, and fertility. Second, we examined factors affecting total mortality patterns through a series of counterfactual scenarios, testing the magnitude by which population growth, population age structures, and epidemiological changes contributed to shifts in mortality. Finally, we attributed changes in life expectancy to changes in cause of death. We documented each step of the GBD 2015 estimation processes, as well as data sources, in accordance with Guidelines for Accurate and Transparent Health Estimates Reporting (GATHER). Findings Globally, life expectancy from birth increased from 61·7 years (95 uncertainty interval 61·4�61·9) in 1980 to 71·8 years (71·5�72·2) in 2015. Several countries in sub-Saharan Africa had very large gains in life expectancy from 2005 to 2015, rebounding from an era of exceedingly high loss of life due to HIV/AIDS. At the same time, many geographies saw life expectancy stagnate or decline, particularly for men and in countries with rising mortality from war or interpersonal violence. From 2005 to 2015, male life expectancy in Syria dropped by 11·3 years (3·7�17·4), to 62·6 years (56·5�70·2). Total deaths increased by 4·1 (2·6�5·6) from 2005 to 2015, rising to 55·8 million (54·9 million to 56·6 million) in 2015, but age-standardised death rates fell by 17·0 (15·8�18·1) during this time, underscoring changes in population growth and shifts in global age structures. The result was similar for non-communicable diseases (NCDs), with total deaths from these causes increasing by 14·1 (12·6�16·0) to 39·8 million (39·2 million to 40·5 million) in 2015, whereas age-standardised rates decreased by 13·1 (11·9�14·3). Globally, this mortality pattern emerged for several NCDs, including several types of cancer, ischaemic heart disease, cirrhosis, and Alzheimer's disease and other dementias. By contrast, both total deaths and age-standardised death rates due to communicable, maternal, neonatal, and nutritional conditions significantly declined from 2005 to 2015, gains largely attributable to decreases in mortality rates due to HIV/AIDS (42·1, 39·1�44·6), malaria (43·1, 34·7�51·8), neonatal preterm birth complications (29·8, 24·8�34·9), and maternal disorders (29·1, 19·3�37·1). Progress was slower for several causes, such as lower respiratory infections and nutritional deficiencies, whereas deaths increased for others, including dengue and drug use disorders. Age-standardised death rates due to injuries significantly declined from 2005 to 2015, yet interpersonal violence and war claimed increasingly more lives in some regions, particularly in the Middle East. In 2015, rotaviral enteritis (rotavirus) was the leading cause of under-5 deaths due to diarrhoea (146�000 deaths, 118�000�183�000) and pneumococcal pneumonia was the leading cause of under-5 deaths due to lower respiratory infections (393�000 deaths, 228�000�532�000), although pathogen-specific mortality varied by region. Globally, the effects of population growth, ageing, and changes in age-standardised death rates substantially differed by cause. Our analyses on the expected associations between cause-specific mortality and SDI show the regular shifts in cause of death composition and population age structure with rising SDI. Country patterns of premature mortality (measured as years of life lost YLLs) and how they differ from the level expected on the basis of SDI alone revealed distinct but highly heterogeneous patterns by region and country or territory. Ischaemic heart disease, stroke, and diabetes were among the leading causes of YLLs in most regions, but in many cases, intraregional results sharply diverged for ratios of observed and expected YLLs based on SDI. Communicable, maternal, neonatal, and nutritional diseases caused the most YLLs throughout sub-Saharan Africa, with observed YLLs far exceeding expected YLLs for countries in which malaria or HIV/AIDS remained the leading causes of early death. Interpretation At the global scale, age-specific mortality has steadily improved over the past 35 years; this pattern of general progress continued in the past decade. Progress has been faster in most countries than expected on the basis of development measured by the SDI. Against this background of progress, some countries have seen falls in life expectancy, and age-standardised death rates for some causes are increasing. Despite progress in reducing age-standardised death rates, population growth and ageing mean that the number of deaths from most non-communicable causes are increasing in most countries, putting increased demands on health systems. Funding Bill & Melinda Gates Foundation. © 2016 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY licens
Software performance of the ATLAS track reconstruction for LHC run 3
Charged particle reconstruction in the presence
of many simultaneous proton–proton (pp) collisions in the
LHC is a challenging task for the ATLAS experiment’s reconstruction software due to the combinatorial complexity. This
paper describes the major changes made to adapt the software
to reconstruct high-activity collisions with an average of 50 or
more simultaneous pp interactions per bunch crossing (pileup) promptly using the available computing resources. The
performance of the key components of the track reconstruction chain and its dependence on pile-up are evaluated, and
the improvement achieved compared to the previous software
version is quantified. For events with an average of 60 pp collisions per bunch crossing, the updated track reconstruction
is twice as fast as the previous version, without significant
reduction in reconstruction efficiency and while reducing the
rate of combinatorial fake tracks by more than a factor two
Search for direct production of electroweakinos in final states with one lepton, jets and missing transverse momentum in pp collisions at √s = 13 TeV with the ATLAS detector
Searches for electroweak production of wino-like chargino pairs, χ˜
+
1 χ˜
−
1
, and of
wino-like chargino and next-to-lightest neutralino, χ˜
±
1 χ˜
0
2
, are presented. The models explored
assume that the charginos decay into a W boson and the lightest neutralino, χ˜
±
1 → W±χ˜
0
1
.
The next-to-lightest neutralinos are degenerate in mass with the chargino and decay to χ˜
0
1
and
either a Z or a Higgs boson, χ˜
0
2 → Zχ˜
0
1
or hχ˜
0
1
. The searches exploit the presence of a single
isolated lepton and missing transverse momentum from the W boson decay products and the
lightest neutralinos, and the presence of jets from hadronically decaying Z or W bosons or from
the Higgs boson decaying into a pair of b-quarks. The searches use 139 fb−1 of √
s = 13 TeV
proton-proton collisions data collected by the ATLAS detector at the Large Hadron Collider
between 2015 and 2018. No deviations from the Standard Model expectations are found, and
95% confdence level exclusion limits are set. Chargino masses ranging from 260 to 520 GeV
are excluded for a massless χ˜
0
1
in chargino pair production models. Degenerate chargino and
next-to-lightest neutralino masses ranging from 260 to 420 GeV are excluded for a massless
χ˜
0
1
for χ˜
0
2 → Zχ˜
0
1
. For decays through an on-shell Higgs boson and for mass-splitting between
χ˜
±
1
/χ˜
0
2
and χ˜
0
1
as small as the Higgs boson mass, mass limits are improved by up to 40 GeV
in the range of 200–260 GeV and 280–470 GeV compared to previous ATLAS constraints
- …