57 research outputs found
Towards Sustainable Aquafeeds: Evaluating Substitution of Fishmeal with Lipid-extracted Microalgal Co-product (Nannochloropsis Oculata) in Diets of Juvenile Nile Tilapia (Oreochromis Niloticus)
- Author
- Publication venue
- Dartmouth Digital Commons
- Publication date
- 31/07/2018
- Field of study
Microalgae companies increasingly seek markets for defatted biomass that is left over after extracting omega-3 rich oil for human nutraceuticals and crude oil for fuels. Such a protein-rich co-product is a promising alternative to unsustainably sourced fishmeal in aquaculture diets. We report the first evaluation of co-product of the marine microalga Nannochloropsis oculata(N. oculata co-product) for replacing fishmeal in diets of Nile tilapia, a globally important aquaculture species. We conducted a nutrient digestibility experiment with N. oculata dried whole cells and N. oculata co-product, followed by an 84-day nutritional feeding experiment with N. oculata co-product. N. oculata co-product, more nutrient-dense than whole cells, had the highest digestibility for lysine, an essential amino acid that is often deficient in terrestrial crop meals; and for 20:5 n-3 EPA, making it a good option for EPA supplementation in tilapia feed. N. oculata co-product, despite containing higher amounts of protein than whole cells, had significantly lower digestibility for crude protein than whole cells. Apparent digestibility coefficients (ADC) of methionine were significantly lower in N. oculata co-product than in whole cells. The nutritional feeding experiment compared diets with N. oculata co-product that replaced fishmeal as follows: 0% replacement in reference diet (fishmeal as 7% of total diet) and test diets with 33%, 66% and 100% replacement of fishmeal (3%, 5.5%, and 8% of total diet, respectively). Results showed the 33% replacement diet yielded fish growth, feed conversion, and survival similar to the reference diet. Reduced digestibility and growth at greater N. oculata co-product inclusion levels may have been due to higher levels of anti-nutrients in co-product than whole cells. All diets yielded a n3:n6 ratio of tilapia fillet that is favorable for human consumption. Depositions of macro minerals and several trace elements in the fillet were not significantly different across diets. Thus, N. oculata co-product, when replacing 33% of fishmeal in tilapia feed, led to fish performance and flesh composition comparable to that of fish fed the reference diet, but its nutrient digestibility needs to be improved to achieve higher replacement levels
Health information use by patients with systemic lupus erythematosus (SLE) pre and during the COVID-19 pandemic
- Author
- Askanase Anca D.
- Bae Sang-Cheol
- Bernatsky Sasha
- Bruce Ian N.
- Cahiz González Juan Carlos
- Cardwell Francesca S.
- Cattoni Teresa G.
- Chin Ricky
- Cho Jiacai
- Choi May Y.
- Clarke Ann Elaine
- Cornet Alain
- Elliott Susan J.
- Fortin Paul R.
- Hanly John G.
- Mak Anselm
- Manzi Susan
- Marion Ashley
- Mielczarek Leanne
- Mosca Marta
- Nieto Romina
- Peschken Christine A.
- Petri Michelle A.
- Pons-Estel Bernardo A.
- Ramsey-Goldman Rosalind
- Romero Díaz Juanita
- Rowbottom Leigha
- Ruiz Irastorza Guillermo
- Shin Jung-Min
- St Pierre Yvan
- Tse Karin
- Urowitz Murray B.
- Wallace Daniel J.
- Publication venue
- 'BMJ'
- Publication date
- 01/01/2022
- Field of study
Objective We conducted an international survey of patients with SLE to assess their access, preference and trust in various health information sources pre-COVID-19 and during the COVID-19 pandemic. Methods Patients with SLE were recruited from 18 observational cohorts, and patients self-reporting SLE were recruited through five advocacy organisations. Respondents completed an online survey from June 2020 to December 2021 regarding the sources of health information they accessed in the 12 months preceding (pre-11 March 2020) and during (post-11 March 2020) the pandemic. Multivariable logistic regressions assessed factors associated with accessing news and social media post-11 March 2020, and self-reporting negative impacts from health information accessed through these sources. Results Surveys were completed by 2111 respondents; 92.8% were female, 76.6% had postsecondary education, mean (SD) age was 48.8 (14.0) years. Lupus specialists and family physicians were the most preferred sources pre-11 March 2020 and post-11 March 2020, yet were accessed less frequently (specialists: 78.5% pre vs 70.2% post, difference -8.3%, 95% CI -10.2% to -6.5%; family physicians: 57.1% pre vs 50.0% post, difference -7.1%, 95% CI -9.2% to -5.0%), while news (53.2% pre vs 62.1% post, difference 8.9%, 95% CI 6.7% to 11.0%) and social media (38.2% pre vs 40.6% post, difference 2.4%, 95% CI 0.7% to 4.2%) were accessed more frequently post-11 March 2020 vs pre-11 March 2020. 17.2% of respondents reported negative impacts from information accessed through news/social media. Those outside Canada, older respondents or with postsecondary education were more likely to access news media. Those in Asia, Latin America or younger respondents were more likely to access social media. Those in Asia, older respondents, males or with postsecondary education in Canada, Asia or the USA were less likely to be negatively impacted. Conclusions Physicians, the most preferred and trusted sources, were accessed less frequently, while news and social media, less trusted sources, were accessed more frequently post-11 March 2020 vs pre-11 March 2020. Increasing accessibility to physicians, in person and virtually, may help reduce the consequences of accessing misinformation/disinformation
Multi-messenger observations of a binary neutron star merger
- Author
- Aab A
- Aartsen MG
- Abbott BP
- Abbott R
- Abbott TD
- Abbott TMC
- Abdalla H
- Abe F
- Abeysekara AU
- Abramo LR
- Abramowski A
- Abreu P
- Acernese F
- Acero F
- Ackermann M
- Ackley K
- Ackley K
- Adams C
- Adams J
- Adams SM
- Adams T
- Addesso P
- Adhikari RX
- Adya VB
- Affeldt C
- Afrough M
- Agarwal B
- Agathos M
- Agatsuma K
- Aggarwal N
- Aglietta M
- Agliozzo C
- Agudo I
- Aguiar OD
- Aguilar JA
- Aharonian F
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- Aiello L
- Ain A
- Ajith P
- Akras S
- Al Samarai I
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- Albuquerque IFM
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- Alighieri S Di Serego
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- Allekotte I
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- Arnaud N
- Array LWA Long Wavelength
- Array MWA Murchison Widefield
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- Artola R
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- Wong KWK
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- Yanez JP
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- Younk PW
- Yu Hang
- Yu Haocun
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- Yushkov A
- Yvert M
- Zaborov D
- Zacharias M
- Zadrozny A
- Zadrozny A
- Zaharijas G
- Zaltzman M
- Zanin R
- Zanolin M
- Zaremba M
- Zarnecki AF
- Zas E
- Zavrtanik D
- Zavrtanik M
- Zdziarski AA
- Zech A
- Zefi F
- Zelenova T
- Zendri J-P
- Zenko T
- Zenteno A
- Zepeda A
- Zertuche L Magaa
- Zevin M
- Zhang AM
- Zhang B-B
- Zhang C
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- Zhang CM
- Zhang F
- Zhang H
- Zhang HM
- Zhang J
- Zhang L
- Zhang M
- Zhang Q
- Zhang S
- Zhang SN
- Zhang T
- Zhang T
- Zhang W
- Zhang WC
- Zhang WZ
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Y-H
- Zhang YF
- Zhang YJ
- Zhang Z
- Zhang ZL
- Zhao C
- Zhao HS
- Zhao JL
- Zhao W
- Zhao XF
- Zheng SJ
- Zhou H
- Zhou J
- Zhou M
- Zhou Z
- Zhu SJ
- Zhu XJ
- Zhu Y
- Zhu YX
- Zhu Z
- Ziegler A
- Zimmerman AB
- Zimmermann B
- Zimnukhov DS
- Ziolkowski M
- Zoll M
- Zong Z
- Zorn J
- Zornoza JD
- Zou CL
- Zuccarello F
- Zucker ME
- Zuniga J
- Zweizig J
- Zywucka N
- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
The Fourteenth Data Release of the Sloan Digital Sky Survey: First Spectroscopic Data from the Extended Baryon Oscillation Spectroscopic Survey and from the Second Phase of the Apache Point Observatory Galactic Evolution Experiment
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- Abazajian K. N.
- Abhishek Prakash
- Adam D. Myers
- Adam J. Burgasser
- Adam S. Bolton
- Aghamousa A.
- Aghamousa A.
- Ahn C. P.
- Aihara H.
- Alain Gueguen
- Alam S.
- Albareti F. D.
- Albrecht A.
- Aldo Serenelli
- Aleksandar M. Diamond-Stanic
- Alex Hagen
- Alexis Finoguenov
- Alfonso Aragón-Salamanca
- Alice Deconto Machado
- Alice Pisani
- Alina Streblyanska
- Amy Jones
- Ana E. García Pérez
- Anand Raichoor
- Anders F.
- Andrea Merloni
- Andres Almeida
- Andres Meza
- Andreu Font-Ribera
- Andrew R. Casey
- Aniruddha R. Thakar
- Anna Bárbara de Andrade Queiroz
- Anne-Marie Weijmans
- Annie C. Robin
- Anže Slosar
- Ariel G. Sánchez
- Arthur Davis Eigenbrot
- Arturo Manchado
- Ashley J. Ross
- Ashley Spindler
- Ata M.
- Audrey Oravetz
- Axel de la Macorra
- Axel Schwope
- Baitian Tang
- Barbara J. Souter
- Barrera-Ballesteros J. K.
- Basílio Xavier Santiago
- Bau-Ching Hsieh
- Bautista J. E.
- Bela Abolfathi
- Benjamin Alan Weaver
- Bernardo Cervantes Sodi
- Bershady M. A.
- Bizyaev D.
- Blanton M. R.
- Borja Anguiano
- Bovy J.
- Brett H. Andrews
- Brian Cherinka
- Britt Lundgren
- Bruce A. Gillespie
- Budavári T.
- Bundy K.
- Caleb I. Cañas
- Camilo Eduardo Jimenez Angel
- Cannon A. J.
- Cano-Díaz M.
- Carles Badenes
- Carlos Allende Prieto
- Carlos Román-Zúñiga
- Casey A. R.
- Catherine J. Grier
- Chad F. Bender
- Changbom Park
- Charles C. Kirkpatrick IV
- Charling Tao
- Chelsea L. MacLeod
- Cheng Li
- Cheng Zhao
- Chia-Hsun Chuang
- Christian Andres Bradna Diaz
- Christian Nitschelm
- Christian R. Hayes
- Christophe Balland
- Christophe Yèche
- Christopher J. Duckworth
- Christy Tremonti
- Claudia Maraston
- Colless M.
- Comparat J.
- Cristina Chiappini
- Cui X.-Q.
- Curtis Bartosz
- D. A. García-Hernández
- D. S. Aguado
- Dalcanton J. J.
- Dan Long
- Daniel Goddard
- Daniel J. Eisenstein
- Daniel Oravetz
- Daniel Thomas
- Dante Minniti
- David G. Whelan
- David H. Weinberg
- David Kirkby
- David L. Nidever
- David R. Law
- David Schlegel
- David V. Stark
- David W. Hogg
- David Wake
- Dawson K. S.
- Dawson K. S.
- Demitri Muna
- Dennis Stello
- Diane Feuillet
- Diogo Souto
- Dmitry Bizyaev
- Dominic Bates
- Dominika Wylezalek
- Donald P. Schneider
- Drew Chojnowski
- Dustin Lang
- Edward Schlafly
- Eisenstein D. J.
- Emma Fernández Alvar
- Eric Armengaud
- Eric Aubourg
- Eric Emsellem
- Eric Jullo
- Eric Wilcots
- Erik Aquino Ortíz
- Etienne Burtin
- Eva-Maria Mueller
- Fabienne Bastien
- Fahim Sakil Khan
- Falk Baumgarten
- Felipe Antonio Santana Rojas
- Filiz Ak
- Flavia Dell’Agli
- Florian Beutler
- Francesco Belfiore
- Francisco Muller-Sanchez
- Francisco Prada
- Francisco-Shu Kitaura
- Fred Hearty
- Friedrich Anders
- Frieman J. A.
- Furnell K. E.
- Gabriela Aguilar
- Gabriele da Silva Ilha
- Gail Zasowski
- Garrett Ebelke
- Garrett Somers
- Genaro Suárez
- Ghazaleh Erfanianfar
- Gillian R. Knapp
- Gilmore G.
- Gong-Bo Zhao
- Gordon Freischlad
- Graziano Rossi
- Grier C. J.
- Gu M.
- Guangtun Zhu
- Guillermo A. Blanc
- Guillermo J. Damke
- Gunn J. E.
- Gunn J. E.
- Guy S. Stringfellow
- Haeun Chung
- Hai Fu
- Hannah Richstein
- Hans-Walter Rix
- Hector Hernandez Toledo
- Hee-Jong Seo
- Henrik Jönsson
- Ho Seong Hwang
- Holtzman J. A.
- Hong Guo
- Hongyu Li
- Hsi-An Pan
- Hu Zou
- Hutchinson T. A.
- Héctor Gil-Marín
- Hélion du Mas des Bourboux
- Ian D. McGreer
- Irene Cruz-Gonzalez
- Isabelle Pâris
- Ismael Perez-Fournon
- Ivan Lacerna
- Ivan Minchev
- J. G. Fernandez-Trincado
- J. Ted Mackereth
- Jaderson S. Schimoia
- Jaime Vargas-González
- James W. Davidson
- Jamie Dyer
- Jamie Tayar
- Janaina Correa do Nascimento
- Jason A. S. Hunt
- Jason E. Ybarra
- Jean-Marc Le Goff
- Jean-Paul Kneib
- Jeffrey A. Newman
- Jeffrey D. Crane
- Jennifer A. Johnson
- Jennifer Sobeck
- Jensen T. W.
- Jeremy Darling
- Jesus Hernandez
- Jiamin Hou
- Jianhui Lian
- Jing Sun
- Jo Bovy
- Joel C. Zinn
- Joel R. Brownstein
- Johan Comparat
- Johanna Teske
- John Donor
- John Ruan
- John Wilson
- Jon A. Holtzman
- Jonathan Brinkmann
- Jonathan C. Bird
- Jonay I. González Hernández
- Jorge Barrera-Ballesteros
- Jorge Sanchez Almeida
- Jose Alberto Vazquez
- Jose Ruiz
- Joseph Gelfand
- Joshua D. Simon
- José R. Sánchez-Gallego
- Juan José Downes
- Julia M. Comerford
- Julia O’Connell
- Julian Bautista
- Julien Guy
- Juna A. Kollmeier
- Jura Borissova
- Kai Zhang
- Kaike Pan
- Karen Kinemuchi
- Karen L. Masters
- Kathleen A. Barger
- Kathleen Grabowski
- Katia Cunha
- Keivan Stassun
- Kelly Holley-Bockelmann
- Kevin Bundy
- Kevin Covey
- Kirpal Nandra
- Kollmeier J. A.
- Kyle B. Westfall
- Kyle Dawson
- LaMassa S. M.
- LaMassa S. M.
- Lang D.
- Lang D.
- Laszlo Szigeti
- Laureijs R.
- Law D. R.
- Law D. R.
- Lihwai Lin
- Lin L.
- Linder E.
- Lluís Galbany
- Luis Alberto Garma Oehmichen
- Luiz da Costa
- M. Jordan Raddick
- MacLeod C. L.
- Madrid J. P.
- Majewski S. R.
- Manuchehr Taghizadeh-Popp
- Mara Salvato
- Marc Pinsonneault
- Marcio Antonio Geimba Maia
- Marcos Lima
- Marcos Pellejero-Ibanez
- Margala D.
- Maria Argudo-Fernández
- Mariana Cano-Díaz
- Mariana Vargas-Magaña
- Mariangela Bernardi
- Marie-Claude Cousinou
- Matthew A. Bershady
- Matthew M. Pieri
- Matthew Melendez
- Matthew Shetrone
- Matthias Steinmetz
- Meg Urry
- Meisner A. M.
- Melissa Ness
- Meng Yang
- Metin Ata
- Michael Blomqvist
- Michael Eracleous
- Michael R. Blanton
- Michael R. Merrifield
- Michael S. Talbot
- Michael Shull
- Michele Cappellari
- Miguel Angel C. de Icaza Lizaola
- Mike Skrutskie
- Mita Tembe
- Morganson E.
- Myers A. D.
- Médéric Boquien
- Nadia Zakamska
- Nathalie Palanque-Delabrouille
- Nathan De Lee
- Nelson Padilla
- Ness M.
- Nicholas W. Troup
- Nicolas Clerc
- Nicole Vogt
- Nicolás G. Busca
- Nidever D. L.
- Niv Drory
- O. Valenzuela
- Olga Zamora
- Pasquier Noterdaeme
- Patricia Tissera
- Patrick Gaulme
- Patrick Hall
- Patrick Petitjean
- Paul Harding
- Paul J. Green
- Pauline Zarrouk
- Pedro Alonso Palicio
- Peter Doohyun Choi
- Peter Frinchaboy
- Pinsonneault M. H.
- Prakash A.
- Preethi Nair
- Pâris I.
- R. Garcia-Dias
- Rachael Beaton
- Rafael Fernando Cirolini
- Rebecca Smethurst
- Remco van den Bosch
- Renbin Yan
- Ricardo Carrera
- Ricardo P. Schiavon
- Ricardo R. Muñoz
- Richard M. McDermid
- Richard R. Lane
- Rita Tojeiro
- Rob A. Williams
- Robert C. Nichol
- Rockosi C.
- Rogemar A. Riffel
- Roger E. Cohen
- Rogério Riffel
- Rossana Ruggeri
- Ruan J. J.
- Rui Marques-Chaves
- Ryan James Oelkers
- Sako M.
- Samantha Penny
- Sandro Barboza Rembold
- Sandro Villanova
- Sara Lucatello
- Saskia Hekker
- Schultheis M.
- Scott F. Anderson
- Scott W. Fleming
- Sebastien Peirani
- Sebastián F. Sánchez
- Sergio Rodríguez Torres
- Shen Y.
- Shen Y.
- Shiyin Shen
- Smee S. A.
- Sofia Meneses-Goytia
- Steinmetz M.
- Sten Hasselquist
- Stephanie Escoffier
- Stephen Bailey
- Steven Majewski
- Stoughton C.
- Suvrath Mahadevan
- Suzanne Hawley
- Sylvain de la Torre
- Szabolcs Meszaros
- Sánchez S. F.
- Sánchez S. F.
- Sánchez S. F.
- Taniya Parikh
- Thaisa Storchi-Bergmann
- Thomas Masseron
- Timothy A. Hutchinson
- Timothy C. Beers
- Timothée Delubac
- Ting Xiao
- Tom Dwelly
- Tonima Tasnim Ananna
- Verne Smith
- Victoria de Sainte Agathe
- Violeta Gonzalez-Perez
- Vivek Mariappan
- Vivienne Wild
- Vladimir Avila-Reese
- Voges W.
- Víctor Silva Aguirre
- W. M. Wood-Vasey
- Wake D. A.
- Weijmans A.-M.
- Weijmans A.-M.
- Will J. Percival
- William J. Schuster
- William Nielsen Brandt
- Xiaohui Fan
- Yan R.
- Yan R.
- Yan R.
- Yanny B.
- Yanping Chen
- Yeisson Osorio
- Yilen Gómez Maqueo Chew
- York D. G.
- Young-Bae Lee
- Yu Liang
- Yue Shen
- Yuting Wang
- Yvonne P. Elsworth
- Zach Pace
- Zacharias N.
- Zasowski G.
- Zheng Zheng
- Zheng Zheng
- Zhi-Min Zhou
- Zucker D. B.
- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2018
- Field of study
The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) has been in operation since 2014 July. This paper describes the second data release from this phase, and the 14th from SDSS overall (making this Data Release Fourteen or DR14). This release makes the data taken by SDSS-IV in its first two years of operation (2014–2016 July) public. Like all previous SDSS releases, DR14 is cumulative, including the most recent reductions and calibrations of all data taken by SDSS since the first phase began operations in 2000. New in DR14 is the first public release of data from the extended Baryon Oscillation Spectroscopic Survey; the first data from the second phase of the Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE-2), including stellar parameter estimates from an innovative data-driven machine-learning algorithm known as "The Cannon"; and almost twice as many data cubes from the Mapping Nearby Galaxies at APO (MaNGA) survey as were in the previous release (N = 2812 in total). This paper describes the location and format of the publicly available data from the SDSS-IV surveys. We provide references to the important technical papers describing how these data have been taken (both targeting and observation details) and processed for scientific use. The SDSS web site (www.sdss.org) has been updated for this release and provides links to data downloads, as well as tutorials and examples of data use. SDSS-IV is planning to continue to collect astronomical data until 2020 and will be followed by SDSS-V
Multi-messenger Observations of a Binary Neutron Star Merger
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- (Deeper DWF
- Aartsen M. G.
- Abbott B. P.
- Abbott R.
- Abbott T. D.
- Abbott T. M. C.
- Abe F.
- Acernese F.
- Acero F.
- Ackermann M.
- Ackley K.
- Adams C.
- Adams J.
- Adams S. M.
- Adams T.
- Addesso P.
- Adhikari R. X.
- Adya V. B.
- Affeldt C.
- Afrough M.
- Agarwal B.
- Agathos M.
- Agatsuma K.
- Aggarwal N.
- AGILE Team
- Agliozzo C.
- Aguiar O. D.
- Aguilar J. A.
- Ahlers M.
- Ahrens M.
- Aiello L.
- Ain A.
- Ajith P.
- Albert A.
- Alexander K. D.
- Allam S.
- Allen B.
- Allen G.
- Allison J. R.
- Allocca A.
- Altin P. A.
- Altmann D.
- Amati L.
- Amato A.
- Ananyeva A.
- Andeen K.
- Anderson J. P.
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- Anderson T.
- Anderson W. G.
- Andreoni I.
- André M.
- Angelova S. V.
- Anghinolfi M.
- Angus C. R.
- Annis J.
- Ansseau I.
- ANTARES Collaboration
- Antier S.
- Anton G.
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- Anupama G. C.
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- Appert S.
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- Ast M.
- AST3
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- AstroSat Cadmium Zinc Telluride Imager Team
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- Aubert J.-J.
- Aublin J.
- Auffenberg J.
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- Australia Telescope Compact Array ATCA:
- Australian SKA Pathfinder ASKAP:
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- 'American Astronomical Society'
- Publication date
- 28/10/2022
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later
designated GW170817) with merger time 12:41:04 UTC was observed through
gravitational waves by the Advanced LIGO and Advanced Virgo detectors.
The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray
burst (GRB 170817A) with a time delay of ∼ 1.7 {{s}} with respect to
the merger time. From the gravitational-wave signal, the source was
initially localized to a sky region of 31 deg2 at a
luminosity distance of {40}-8+8 Mpc and with
component masses consistent with neutron stars. The component masses
were later measured to be in the range 0.86 to 2.26 {M}ȯ
. An extensive observing campaign was launched across the
electromagnetic spectrum leading to the discovery of a bright optical
transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC
4993 (at ∼ 40 {{Mpc}}) less than 11 hours after the merger by the
One-Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The
optical transient was independently detected by multiple teams within an
hour. Subsequent observations targeted the object and its environment.
Early ultraviolet observations revealed a blue transient that faded
within 48 hours. Optical and infrared observations showed a redward
evolution over ∼10 days. Following early non-detections, X-ray and
radio emission were discovered at the transient’s position ∼ 9
and ∼ 16 days, respectively, after the merger. Both the X-ray and
radio emission likely arise from a physical process that is distinct
from the one that generates the UV/optical/near-infrared emission. No
ultra-high-energy gamma-rays and no neutrino candidates consistent with
the source were found in follow-up searches. These observations support
the hypothesis that GW170817 was produced by the merger of two neutron
stars in NGC 4993 followed by a short gamma-ray burst (GRB 170817A) and
a kilonova/macronova powered by the radioactive decay of r-process
nuclei synthesized in the ejecta.</p
Potential therapeutic approaches for modulating expression and accumulation of defective lamin A in laminopathies and age-related diseases
- Author
- A Duenas-Gonzalez
- A Duenas-Gonzalez
- A Dumont
- A Elimadi
- A Faggiano
- A Ferree
- A Gross
- A Guidarelli
- A Liacini
- A Palumbo
- A Peter
- A Roscic
- A Vasquez
- A Williams
- AA Adjei
- AD Balgi
- AE Chernoff
- AF Cashen
- AJ Mastrangelo
- Alex Zhavoronkov
- Alexey Moskalev
- AM Pendas
- AO Konrady
- AP Ugalde
- AS Chan
- AS Tsvetkov
- AY Bedikian
- B Becattini
- B Calabretta
- B Fontaine-Bisson
- B Fuks
- B Klein
- B Ravikumar
- BB Jesus de
- BC Capell
- BC Capell
- BG Hoffstrom
- BM Wasko
- C Hu
- C Huynh
- C Newman
- C Rose
- C Sessa
- C Stey
- C Travelli
- C Weyer
- C Wurthmann
- CB Page
- CD Ragnauth
- CD Zorrilla
- CE Ashley
- CH Hsu
- CJ Kenyon
- CL Bjornson
- CL Moulson
- CM Hartford
- CP Zhang
- CQ Zhao
- CR Arnt
- CR Burtner
- CY Chen
- D Chen
- D Constantinescu
- D Constantinescu
- D Ioan
- D Kuck
- D Kuck
- D Lee
- D Mereles
- D Ofori-Adjei
- D Vara
- D Yang
- DC Butler
- DJ Goussetis
- DJ Stravopodis
- DM Heijink
- DR Gough
- DS Kim
- DS Scherr
- DS Sharpe
- E Kaminskas
- E Maubec
- E Meshorer
- E Morselli
- E Petit
- E Raymond
- E Strom
- EA Curry 3rd
- EA Komarova
- EA Olsen
- EC Kivuva
- EK Benson
- ET Lam
- ET Tsilou
- F Christian
- F Lin
- F Lyko
- FG Osorio
- FG Osorio
- FG Osorio
- FI Arnaldez
- FV Din
- G Chouinard
- G Marino
- G Wu
- GD Pennock
- GR Campbell
- GV Naccarelli
- H Akasaka
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- H Kawakita
- H Kim
- H Kimura
- H Liang
- H Merskey
- H Mitsuhashi
- H Takeuchi
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- HG Xia
- HJ Jung
- HL Yeh
- I Jialal
- I Varela
- I Weidenfeld
- IC Lopez-Mejia
- ID Podmore
- IG Stiell
- IJ Diel
- IJ Furlong
- IM Shih
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- J Halaschek-Wiener
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- JH Lai
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- JJ Gills
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- JK Molitoris
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- JL Mesa
- JL Scarlett
- JM Bridger
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- JN Badham
- JP Gagne
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- JP Magalhaes de
- JR Berenson
- JW Tullai
- K Ariyoshi-Kishino
- K Cao
- K Cao
- K Duesing
- K Jing
- K McLean
- K Shimada
- Kieran J. Guinan
- KN Conneely
- KR Owen
- L Cai
- L Jia
- L Lim
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- LG Fong
- LG Fong
- LP Xia
- LR Goldfrank
- M Bahro
- M Columbaro
- M Dam
- M Deininger
- M Eriksson
- M McCall
- M Urbanek
- Maria Litovchenko
- MC Wei
- MD Bareford
- ML Marino
- MP Curran
- MV Blagosklonny
- N Bae
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- N Singh
- N Sylvius
- N Takebe
- N Xiong
- NI Steinle
- NR Pumford
- P Hundeshagen
- P Mainguet
- P Major
- P Maycotte
- P Scaffidi
- P Scaffidi
- PB Tirupathi Pichiah
- PG Komarov
- PL Cole
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- Q Jiang
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- Q Zhang
- R Damico
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- RA Hegele
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- RJ Lutz
- RJ Yanez-Munoz
- RK Lin
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- S Cherqui
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- S Reddy
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- S Schenone
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- SD Georgatos
- SE Nsimba
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- SH Yang
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- SY Chen
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- T Dechat
- T Dechat
- T Dechat
- T Tomita
- T Zhang
- TB Brunner
- The International HapMap Consortium
- TS Bekaii-Saab
- U Kruger
- V Cenni
- V Deretic
- V Krishnan
- VA Rao
- VL Verstraeten
- W Bursch
- W Chu
- WA Vloten van
- WE Stehbens
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- X Feng
- X Li
- X Zeng
- Y Chen
- Y Fujisaka
- Y Maekawa
- Y Murase
- Y Pan
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- Y Rajawat
- Y Tong
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- Z Liu
- Z Liu
- Zeljka Smit-McBride
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 31/01/2024
- Field of study
Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
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- Abdul Rasheed A.
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- George S.
- George V.
- Georgiou D.
- Gerdes L.
- Gettings S.
- Giannopoulou S.
- Gibani M.
- Gibb C.
- Gibbison B.
- Gibbons K.
- Gibson A.
- Gill L.
- Gillesen A.
- Gillian A.
- Gilliland D.
- Gillott R.
- Gilmour K.
- Gipson A.
- Glasgow S.
- Glover Bengtsson J.
- Glynn S.
- Gnanalingam C.
- Godden E.
- Godson E.
- Goldacre R.
- Goodall J.
- Goodenough B.
- Goodwin E.
- Goodwin J.
- Goonasekara M.
- Gorsuch T.
- Gosai J.
- Gotham D.
- Gould N.
- Gould S.
- Gourbault L.
- Gowans S.
- Gower H.
- Graham J.
- Grahamslaw J.
- Grana G.
- Grant A.
- Grant D.
- Gray A.
- Gray G.
- Gray J.
- Gray K.
- Grayson A.
- Green A.
- Green C.
- Green Christopher A.
- Green N.
- Greene D.
- Greenhalgh A.
- Gregory K.
- Greig J.
- Gresty J.
- Grey G.
- Griffin B.
- Griffin M.
- Grobovaite E.
- Groome R.
- Grover H.
- Grubb N.
- Grundy J.
- Guerin J.
- Gureviciute A.
- Gurung Rai S.
- Gurung L.
- Hackney P.
- Hadfield D.
- Hadfield S.
- Haider N.
- Haigh K.
- Haile V.
- Hainey S.
- Hall A.
- Hall C.
- Hall E.
- Hall J.
- Hallas J.
- Halls H.
- Hamdollah-Zadeh M.
- Hameed B.
- Hamid I.
- Hamilton G.
- Hamilton M.
- Hamilton S.
- Hammans B.
- Hammersley S.
- Hammond S.
- Hamoodi I.
- Hampshire K.
- Hampson L.
- Hanci O.
- Handrean S.
- Handzewniak N.
- Haney S.
- Hanison E.
- Hannington A.
- Hanrath A.
- Hanson A.
- Hanson H.
- Hanson J.
- Hanson S.
- Harden L.
- Harding Z.
- Hardman S.
- Hargreaves C.
- Harin A.
- Harman T.
- Harper C.
- Harper H.
- Harris J.
- Harris M.
- Harrison D.
- Harrison M.
- Harrison R.
- Harrison S.
- Harrod E.
- Hartrey W.
- Harvey A.
- Harvey M.
- Haslam J.
- Hastings B.
- Havinden-Williams M.
- Hawker L.
- Hayat A.
- Haynes Richard
- Hays C.
- Haysom S.
- Hazelton T.
- Hazenberg P.
- Headon E.
- Health records (for the RECOVERY Collaborative Group)
- Hector G.
- Heddon S.
- Henry J.
- Henshall D.
- Hernandez F.
- Herrington W.
- Heslop P.
- Hester S.
- Hey S.
- Heywood J.
- Hicks J.
- Hicks S.
- Higgins L.
- Hill P.
- Hilton J.
- Hindle A.
- Hindmarsh A.
- Hine P.
- Hird C.
- Hobson S.
- Hodgen L.
- Hodgkinson S.
- Hodgson H.
- Hodgson S.
- Hogg L.
- Hoggett L.
- Holden C.
- Holdhof N.
- Holland L.
- Hollands M.
- Holling N.
- Holmes R.
- Holt L.
- Hope S.
- Hopkins B.
- Horby Peter W.
- Horrobin C.
- Horsley A.
- Hough M.
- Houghton C.
- Houghton K.
- Houlihan R.
- Housely K.
- How L.
- Howard L.
- Howard M.
- Howard S.
- Howard-Sandy L.
- Howell A.
- Howie L.
- Hrycaiczuk J.
- Htwe S.
- Hudak A.
- Hudson H.
- Hughes G.
- Hughes H.
- Hughes S.
- Hulbert R.
- Hull D.
- Hull R.
- Hulme A.
- Hulme P.
- Hum R.
- Hunt L.
- Hunter E.
- Hunter K.
- Hunter N.
- Hunter S.
- Hurditch E.
- Hurley K.
- Hussain A.
- Hussain S.
- Hussain Y.
- Hutchinson C.
- Hutton P.
- Hyslop M.
- Ibrahim A.
- Ibrahim M.
- Ijaz M.
- Ilyas F.
- Ingham J.
- Ingram T.
- Ionita A.
- Iqbal J.
- Iqbal M.
- Irons R.
- Irving R.
- Islam S.
- Islim A.
- Ismail O.
- Iwanikiw S.
- Jack C.
- Jackman S.
- Jackson B.
- Jackson S.
- Jacob J.
- Jacob P.
- Jacques N.
- Jafar A.
- Jagannathan V.
- Jaime F.
- Jaki Thomas
- Jaly Y.
- Jama R.
- Jamal A.
- Jamal S.
- James L.
- Jameson J.
- Janes K.
- Japp D.
- Jarman C.
- Jarvis C.
- Jarvis R.
- Jastrzebska P.
- Jeebun V.
- Jeffery Katie
- Jeffreys N.
- Jeffs B.
- Jenkins P.
- Jennings F.
- Jennings V.
- Jerry D.
- Jimenez Gil A.
- Johal S.
- John A.
- John M.
- Johnson G.
- Johnston B.
- Johnston S.
- Johnstone D.
- Johnstone E.
- Jones A.
- Jones B.
- Jones E.
- Jones G.
- Jones J.
- Jones P.
- Jones R.
- Jones S.
- Jones T.
- Jordache R.
- Jose S.
- Joseph G.
- Joseph R.
- Josiah B.
- Ju Wen Kwek A.
- Judge P.
- Juszczak Edmund
- Kailey A.
- Kalayi R.
- Kamath P.
- Kamfose M.
- Kanabar D.
- Kapoor R.
- Karunaratne N.
- Kaur J.
- Kausar Z.
- Kavanagh S.
- Kay S.
- Kayappurathu J.
- Ke M.
- Keating L.
- Keddie-Gray E.
- Kelly E.
- Kelly R.
- Kelly S.
- Kendall E.
- Kennedy A.
- Kennedy M.
- Keogan L.
- Khan A.
- Khan M.
- Khan W.
- Khatun T.
- Khin H.
- Khurana C.
- Kibutu F.
- Kidd M.
- Kidney S.
- Kim M.
- Kimber A.
- King A.
- King J.
- King S.
- King-Oakley E.
- Kirk J.
- Kirkham E.
- Kirkpatrick L.
- Kitching T.
- Kitto L.
- Knight A.
- Knight F.
- Knight Marian
- Knight S.
- Knowles C.
- Knowles L.
- Koch O.
- Koe Y.
- Koirata A.
- Kolakaluri E.
- Kononen M.
- Koo H.
- Kosmidis C.
- Kothandaraman E.
- Koukou K.
- Kountourgioti A.
- Krasauskas K.
- Krishnamurthy V.
- Krizak S.
- Krupej S.
- Kudsk-Iversen S.
- Kudzinskas A.
- Kumar R.
- Kurani A.
- Kurdy M.
- Kuriakose K.
- Kyere-Diabour T.
- Kyi N.
- Labao J.
- Lacson M.
- Ladan Z.
- Lagnado A.
- Lalloo David
- Lalloo F.
- Lamb L.
- Lamb T.
- Landray Martin J.
- Lane N.
- Lang A.
- Lang S.
- Langley M.
- Langoya C.
- Lassa S.
- Latham S.
- Latham V.
- Laurenson M.
- Law H.
- Lawless L.
- Lawrence G.
- Lawrence H.
- Lawrie R.
- Lay M.
- Lazo M.
- Le V.
- Leach L.
- Leandro L.
- Lee S.
- Lees D.
- Legge H.
- Leitch D.
- Lemoine N.
- Lennon K.
- Levett C.
- Levynska A.
- Lewis H.
- Lewis J.
- Lewis K.
- Lewis L.
- Lewis N.
- Liao A.
- Lim Wei Shen
- Linares C.
- Lindergard G.
- Lindsay M.
- Lipscomb G.
- Lipscomb K.
- Little J.
- Liu P.
- Liu S.
- Lloyd A.
- Lloyd O.
- Lo S.
- Loader D.
- Local Clinical Centre staff (for the RECOVERY Collaborative Group)
- Lock S.
- Locke T.
- Lockett T.
- Lodhia K.
- Lofthouse M.
- Logan M.
- Logue C. A.
- Lokanathan S.
- Lomme K.
- Looby L.
- Lopez P.
- Lord R.
- Loro F.
- Lovell M.
- Low A.
- Low S.
- Lowe C.
- Lowsby R.
- Luintel A.
- Luke H.
- Luke J.
- Lunn M.
- Luo J.
- Lye A.
- Lyell B.
- Lynch D.
- Mabb H.
- Macfarlane J.
- Macfarlane L.
- MacInnes L.
- MacIntyre I.
- Mackay L.
- MacKenzie J.
- Mackey A.
- Mackintosh C.
- Macmahon M.
- MacRaild A.
- Madden A.
- Madeja N.
- Mafham Marion
- Magnaye L.
- Maharajh A.
- Mahaveer A.
- Mahdi H.
- Maheswaran A.
- Mahmood W.
- Mahmood Z.
- Mahony E.
- Mahungu T.
- Mair L.
- Majekdunmi T.
- Majumdar Jaydip
- Malein Flora
- Mancinelli R.
- Mandal S.
- Manderson L.
- Mandeville J.
- Mane T.
- Manso K.
- Mansour M.
- Marecka M.
- Maren D.
- Margabanthu G.
- Margaritopoulos G.
- Maria del Rocio F.
- Mariano V.
- Marks B.
- Marks P.
- Marriott C.
- Marriott N.
- Marsden P.
- Marshall A.
- Martin H.
- Martin K.
- Martin M.
- Martinez Garrido J.
- Maseda D.
- Mashate S.
- Masih S.
- Masoli M.
- Mathen S.
- Mather N.
- Mathew B.
- Mathews J.
- Mathioudakis A.
- Matila D.
- Matisa E.
- Matkins E.
- Matovu E.
- Matthews C.
- May P.
- Mayanagao I.
- Mayer J.
- Mayo T.
- Mazhani T.
- McAlinden P.
- McAndrew J.
- McBrearty C.
- McBride E.
- McCafferty G.
- McCann C.
- McCarthy E.
- McCorkindale A.
- McCrae J.
- McCullagh I.
- McCullagh L.
- McCullough K.
- McCullough S.
- McCurrach F.
- McDermott J.
- McDonald S.
- McDonnell N.
- McEleavy I.
- McEvoy E.
- McGhee C.
- McGrath B.
- McIntyre K.
- Mckie H.
- Mckie L.
- McLachlan H.
- McLarty N.
- McLeish M.
- McLure S.
- McMahon G.
- McMaster P.
- McMillan N.
- McMullen H.
- McNeill C.
- McNeill J.
- McNelis U.
- McNulty M.
- McSorland D.
- Mead J.
- Meakin O.
- Mears K.
- Mediana A.
- Medine R.
- Meghani N.
- Megson S.
- Mehar A.
- Mehra R.
- Meiring J.
- Melander S.
- Mellor F.
- Mellor Z.
- Melville A.
- Melville J.
- Membrey H.
- Mendonca C.
- Mentzer A.
- Meredith M.
- Merron P.
- Metcalfe B.
- Metryka A.
- Mew L.
- Mguni N.
- Miah N.
- Micallef D.
- Michalak N.
- Michalec O.
- Middle J.
- Middleton J.
- Middleton M.
- Millard J.
- Miller J.
- Millett L.
- Milligan H.
- Millington K.
- Millington S.
- Millward H.
- Minton J.
- Mishra A.
- Mishra B.
- Mistry H.
- Mital D.
- Mitchell B.
- Mitchelmore P.
- Mitra S.
- Moatt E.
- Mohamed O.
- Mohammed O.
- Mok J.
- Molina M.
- Molloy A.
- Monaghan H.
- Monsell K.
- Montasser M.
- Montgomery Alan
- Moon A.
- Moon J.
- Moonan M.
- Moore F.
- Moores R.
- Morales J.
- Moran L.
- Moray G.
- Morgan A.
- Morgan L.
- Morgan-Smith E.
- Morilla J.
- Morley W.
- Morris L.
- Morris P.
- Morris S.
- Morrison S.
- Morrissey M.
- Morrow A.
- Moss S.
- Moth G.
- Motherwell N.
- Moulton H.
- Mounce G.
- Mtuwa S.
- Muazzam A.
- Mudawi D.
- Mulcahy M.
- Mulligan S.
- Mumford Andrew
- Munavvar Mohammed
- Munt S.
- Murphy S.
- Murray C.
- Murray D.
- Murray I.
- Murray K.
- Murray L.
- Murthy M.
- Mutch C.
- Muzengi N.
- Mwaura E.
- Nafei M.
- Nagarajan T.
- Naglik L.
- Naguib M.
- Naicker K.
- Naisbitt J.
- Nandani A.
- Nandwani T.
- Nasa S.
- Natarajan N.
- Nathvani M.
- Navarra H.
- Naveed S.
- Naz M.
- Neal A.
- Nelson B.
- Nelson S.
- Nethercott D.
- Newby D.
- Newman T.
- Newport R.
- Ng S.
- Ngumo A.
- Nicholas N.
- Nicholas P.
- Nickson I.
- Nicol R.
- Nightingale T.
- Nilsson A.
- Ninan P.
- Nirmalan M.
- Nixon J.
- Nizam Ud Din K.
- Noe H.
- Norton R.
- Nourein K.
- Nunn K.
- Nunn M.
- Nunnick J.
- Nurgat Z.
- Nuttall A.
- Nwajiugo P.
- Oboh C.
- Obukofe R.
- Odam M.
- Odedra K.
- Odell N.
- Offord P.
- Ohia U.
- Okeke T.
- OKell E.
- Oliver A.
- Oliver J.
- Oliver Z.
- Oomatia A.
- Oram R.
- Oreilly C.
- Osadcow A.
- Osanlou R.
- Osborne N.
- Osborne R.
- Osborne W.
- Osei-Bobie J.
- Oxlade R.
- O’Brien R.
- O’Callaghan C.
- O’Connor G.
- O’Donovan C.
- O’Farrell S.
- O’Riordan D.
- O’Sullivan E.
- Padden G.
- Page I.
- Page S.
- Pagett K.
- Pajak S.
- Pakou G.
- Palacios A.
- Palfrey H.
- Pandya T.
- Panes A.
- Pantin C.
- Parambil V.
- Parashar S.
- Parekh A.
- Parekh D.
- Parker B.
- Parker J.
- Parker S.
- Parkinson A.
- Passby L.
- Passey S.
- Patachako J.
- Patel M.
- Patel P.
- Patel S.
- Patience A.
- Patten S.
- Patterson C.
- Patterson L.
- Pauls L.
- Paulus S.
- Payne B.
- Payne E.
- Payne R.
- Peacock L.
- Pearce J.
- Pearson K.
- Peasley A.
- Peggie H.
- Pelham C.
- Penman C.
- Penman J.
- Penman R.
- Percival R.
- Perez E.
- Periyasamy L.
- Perry A.
- Perry M.
- Pessoa-Amorim Guilherme
- Peters C.
- Peterson A.
- Peto Leon
- Petrova B.
- Pezard-Snell M.
- Phelan P.
- Philbin J.
- Phillips N.
- PI M.
- Pick S.
- Pickard J.
- Pickering G.
- Piercy C.
- Pinches H.
- Pine K.
- Pinjala M.
- Pitchford M.
- Pleass R.
- Plowright M.
- Plumptre C.
- Pomery F.
- Poole L.
- Porter D.
- Porter L.
- Potter A.
- Potts J.
- Poustie V.
- Power N.
- Poyner E.
- Pradhan V.
- Prady H.
- Prasath S.
- Pratt A.
- Pratt S.
- Preiss D.
- Prest C.
- Price A.
- Price C.
- Price D.
- Price K.
- Price L.
- Price V.
- Price-Eland R.
- Priest A.
- Prince C.
- Pringle S.
- Pristopan V.
- Priyash V.
- Prudon Benjamin
- Pugh L.
- Purdue C.
- Purdy R.
- Pursell M.
- Purvis S.
- Putensen D.
- Pyart E.
- Quek E.
- Quigley J.
- Quindoyos J.
- Quinn T.
- Rabinowicz S.
- Rafique J.
- Rahman M.
- Rai S.
- Raithatha A.
- Rajasri A.
- Ramanan A.
- Ramasamy M.
- Ramchandani A.
- Ramirez J.
- Rampling T.
- Ramsay J.
- Ramshaw A.
- Rana G.
- Rand J.
- Rank H.
- Rankhelawon R.
- Rasheed A.
- Ratcliffe S.
- Raw J.
- Razvi Z.
- RECOVERY Collaborative Group
- Redknap I.
- Redman N.
- Rees A.
- Rees M.
- Rees S.
- Rehman Z.
- Reilly M.
- Reith C.
- Renshaw S.
- Rey S.
- Reynard C.
- Reynolds H.
- Rhodes J.
- Rice E.
- Rice M.
- Rice N.
- Richardson E.
- Richardson N.
- Rigby L.
- Riley M.
- Riley P.
- Ripley D.
- Rishton C.
- Riste M.
- Ritchings A.
- Rivera Ortega P.
- Robbins E.
- Roberts V.
- Robertson C.
- Robertson J.
- Robertson N.
- Robinson J.
- Robinson L.
- Robinson S.
- Robson S.
- Roderick M.
- Rodger A.
- Rodgers A.
- Rodgers N.
- Rodgers P.
- Roehr C.
- Rogers J.
- Rogers S.
- Rogers T.
- Rook C.
- Rooney L.
- Rosby E.
- Rose A.
- Rose Z.
- Ross I.
- Rothman A.
- Rothwell J.
- Roughley L.
- Rowan Kathryn
- Rowan N.
- Rowe A.
- Rowe N.
- Rowley M.
- Rudenko A.
- Rule R.
- Rushmer J.
- Ryan A.
- Ryan L.
- Ryan P.
- Rybka E.
- Ryder S.
- Salberg A.
- Saleh M.
- Salih H.
- Salman R.
- Salmon R.
- Sam M.
- Sam S.
- Saminathan S.
- Sammons E.
- Sammut D.
- Sampson J.
- Samuel M.
- Samuel Y.
- Sanchez Gonzalez A.
- Sanchez V.
- Sandercock Peter
- Sangombe M.
- Sanju M.
- Santosh R.
- Sarfatti A.
- Sarkar R.
- Sarwar Z.
- Sathyanarayanan L.
- Saunderson A.
- Scaletta D.
- Scanlon D.
- Scarratt L.
- Scattergood S.
- Schadenberg A.
- Schafers J.
- Schneblen W.
- Schofield E.
- Schumacher N.
- Schunke N.
- Scobie A.
- Scoones T.
- Scott A.
- Scott C.
- Scullion A.
- Seaton I.
- Sedano J.
- Segovia M.
- Selby F.
- Sellers K.
- Sen N.
- Sengupta A.
- Sewdin T.
- Seymour J.
- Shah H.
- Shah R.
- Shah S.
- Shaibu A.
- Shanahan T.
- Sharaf H.
- Sharma B.
- Sharma O.
- Sharma S.
- Sharp L.
- Sharratt P.
- Shaw D.
- Shaw J.
- Shawcross A.
- Shea D. O.
- Sheffield J.
- Shehata Z.
- Shenton J.
- Shepherd A.
- Shepherd K.
- Shepherd L.
- Sheppeard R.
- Sheridan H.
- Sheridan R.
- Sherwin S.
- Shibly S.
- Shiham F.
- Shilladay C.
- Shillitoe B.
- Shioi C.
- Shirley K.
- Shurlock J.
- Shurmer Jack
- Siamia L.
- Siddle E.
- Sime R.
- Simpson A.
- Simpson D.
- Simpson J.
- Simpson M.
- Simpson P.
- Sinclair S.
- Singh C.
- Singh S.
- Singhal P.
- Sithiravel S.
- Sivanadarajah S.
- Skaria A.
- Skehan N.
- Skinner T.
- Skinner V.
- Skorko A.
- Slack A.
- Slade H.
- Small E.
- Smallridge A.
- Smart B.
- Smith C.
- Smith E.
- Smith H.
- Smith J.
- Smith L.
- Smith M.
- Smith N.
- Smith P.
- Smith R.
- Smith S.
- Smith T.
- Smith V.
- Snell D.
- Sobande T.
- Sobrino Diaz A.
- Solly R.
- Soni G.
- Soor P.
- Soothill G.
- Soren J.
- Spiller W.
- Spring O.
- Squires G.
- Squires J.
- Squires R.
- Srinivasan R.
- Stagg W.
- Stanton A.
- Staplin Natalie
- Starnes D.
- Steer J.
- Stefania V.
- Stefanowska P.
- Stephens A.
- Stephensen D.
- Stephenson E.
- Sterrenburg M.
- Stevens W.
- Stevenson A.
- Stevenson S.
- Steward M.
- Stewart C.
- Stewart K.
- Stewart Richard
- Stickley J.
- Stirrup S.
- Stock S.
- Stockdale A.
- Stone B.
- Stone S.
- Storey I.
- Stratton E.
- Stratton J.
- Stubbs A.
- Stuttard M.
- Subudhi C.
- Sugden P.
- Sukumaran A.
- Sundar S.
- Surtees M.
- Sutherland R.
- Sutherland S.
- Sutu M.
- Swanson-Low C.
- Swart T.
- Swift E.
- Swist-Szulik K.
- Sykes D.
- Sykes E.
- Symon D.
- Syndercombe A.
- T-Michael H.
- Tadros M.
- Tague L.
- Tahir H.
- Tait J.
- Talbot P.
- Tallent R.
- Tallon B.
- Tanney C.
- Tanton E.
- Taribagil P.
- Tarr E.
- Tasiou A.
- Tate A.
- Taylor C.
- Taylor J.
- Taylor K.
- Taylor L.
- Taylor R.
- Taylor-Siddons M.
- Teasdale F.
- Teasdale J.
- Teasdale K.
- Tebbutt J.
- Telfer A.
- Tempany J.
- Tereszkowski-Kaminski R.
- Tewkesbury D.
- Thake M.
- Thakker M.
- Thamu B.
- Thet P.
- Thomas A.
- Thomas E.
- Thomas K.
- Thomas R.
- Thomas S.
- Thompson E.
- Thompson J.
- Thompson K.
- Thompson R.
- Thornton D.
- Thornton J.
- Thornton S.
- Thorpe S.
- Thrasyvoulou L.
- Thraves H.
- Thu-Ta P.
- Thwaites Guy
- Tilbey S.
- Timerick J.
- Timmins A.
- Tinkler H.
- Tipper J.
- Tivenan H.
- Todd S.
- Tohfa M.
- Toohey C.
- Topham K.
- Topping M.
- Tousis R.
- Trevelyan M.
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- UK National Institute for Health Research Clinical Research Network (for the RECOVERY Collaborative Group)
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- Publication venue
- Nature Publishing Group
- Publication date
- Field of study
Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Towards sustainable aquafeeds: Evaluating substitution of fishmeal with lipid-extracted microalgal co-product (Nannochloropsis oculata) in diets of juvenile Nile tilapia (Oreochromis niloticus).
- Author
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2018
- Field of study
Microalgae companies increasingly seek markets for defatted biomass that is left over after extracting omega-3 rich oil for human nutraceuticals and crude oil for fuels. Such a protein-rich co-product is a promising alternative to unsustainably sourced fishmeal in aquaculture diets. We report the first evaluation of co-product of the marine microalga Nannochloropsis oculata (N. oculata co-product) for replacing fishmeal in diets of Nile tilapia, a globally important aquaculture species. We conducted a nutrient digestibility experiment with N. oculata dried whole cells and N. oculata co-product, followed by an 84-day nutritional feeding experiment with N. oculata co-product. N. oculata co-product, more nutrient-dense than whole cells, had the highest digestibility for lysine, an essential amino acid that is often deficient in terrestrial crop meals; and for 20:5 n-3 EPA, making it a good option for EPA supplementation in tilapia feed. N. oculata co-product, despite containing higher amounts of protein than whole cells, had significantly lower digestibility for crude protein than whole cells. Apparent digestibility coefficients (ADC) of methionine were significantly lower in N. oculata co-product than in whole cells. The nutritional feeding experiment compared diets with N. oculata co-product that replaced fishmeal as follows: 0% replacement in reference diet (fishmeal as 7% of total diet) and test diets with 33%, 66% and 100% replacement of fishmeal (3%, 5.5%, and 8% of total diet, respectively). Results showed the 33% replacement diet yielded fish growth, feed conversion, and survival similar to the reference diet. Reduced digestibility and growth at greater N. oculata co-product inclusion levels may have been due to higher levels of anti-nutrients in co-product than whole cells. All diets yielded a n3:n6 ratio of tilapia fillet that is favorable for human consumption. Depositions of macro minerals and several trace elements in the fillet were not significantly different across diets. Thus, N. oculata co-product, when replacing 33% of fishmeal in tilapia feed, led to fish performance and flesh composition comparable to that of fish fed the reference diet, but its nutrient digestibility needs to be improved to achieve higher replacement levels
Proximate analysis, and gross energy, essential amino acid and fatty acid profiles of the reference and test diets.
- Author
- Publication venue
- Publication date
- Field of study
<p>Proximate analysis, and gross energy, essential amino acid and fatty acid profiles of the reference and test diets.</p
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