Infliximab in ulcerative colitis

Infliximab, a monoclonal anti-TNF-α antibody, is commonly used for treatment of moderate to severe Crohn’s disease (CD). Its role in the treatment for ulcerative colitis (UC) remains controversial. We review the role of TNF-α in the pathogenesis of UC and describe the randomized, double-blind, placebo-controlled trials and systematic reviews that assess the efficacy of infliximab in the treatment of moderate to severe UC

A geographically flexible approach for mapping the Wildland-Urban Interface integrating fire activity data

The Wildland-Urban Interface (WUI) is the area where houses and natural vegetation meet or intermingle. WUI areas are exposed to an increased hazard of wildfires and have significantly expanded worldwide in the past few decades. In this study, we developed a new empirical approach for mapping the WUI by generating a WUI index based on the juxtaposition among buildings, vegetation, and the fire history of the study area. We first calculated the percentage coverage of buildings and three different fuel typologies within circular moving windows with radii of 100, 250, and 500 m, and then acquired the fire history data between 2012 and 2021 for Israel and the West Bank (Palestinian Authority) from the VIIRS active fires remote sensing product. We defined the WUI as cells where the combination of vegetation cover and building cover had more VIIRS fire detections than expected by chance. To assess the effects of using broad vs. local scale parameterizations on resulting WUI maps, we repeated this process twice, first using national-scale data, and then separately in four distinct geographic regions. We assessed the congruence in the amounts and patterns of WUI in regions as mapped by information from these two analysis scales. We found that the WUI in Israel and the West Bank ranged from 0.5% to 1.7%, depending on fuel type and moving window radius. The scale of parameterization (national vs. regional) affected the WUI patterns only in one of the regions, whose characteristics differed markedly than the rest of the country. Our new method differs from existing WUI mapping methods as it is empirical and geographically flexible. These two traits allow it to robustly map the WUI in other countries with different settlement, fuel, climate and wildfire characteristics

Molecular imaging of cell death in vivo by a novel small molecule probe

Apoptosis has a role in many medical disorders, therefore assessment of apoptosis in vivo can be highly useful for diagnosis, follow-up and evaluation of treatment efficacy. ApoSense is a novel technology, comprising low molecular-weight probes, specifically designed for imaging of cell death in vivo. In the current study we present targeting and imaging of cell death both in vitro and in vivo, utilizing NST-732, a member of the ApoSense family, comprising a fluorophore and a fluorine atom, for both fluorescent and future positron emission tomography (PET) studies using an 18F label, respectively. In vitro, NST-732 manifested selective and rapid accumulation within various cell types undergoing apoptosis. Its uptake was blocked by caspase inhibition, and occurred from the early stages of the apoptotic process, in parallel to binding of Annexin-V, caspase activation and alterations in mitochondrial membrane potential. In vivo, NST-732 manifested selective uptake into cells undergoing cell-death in several clinically-relevant models in rodents: (i) Cell-death induced in lymphoma by irradiation; (ii) Renal ischemia/reperfusion; (iii) Cerebral stroke. Uptake of NST-732 was well-correlated with histopathological assessment of cell-death. NST-732 therefore represents a novel class of small-molecule detectors of apoptosis, with potential useful applications in imaging of the cell death process both in vitro and in vivo

ApoSense: a novel technology for functional molecular imaging of cell death in models of acute renal tubular necrosis

Purpose: Acute renal tubular necrosis (ATN), a common cause of acute renal failure, is a dynamic, rapidly evolving clinical condition associated with apoptotic and necrotic tubular cell death. Its early identification is critical, but current detection methods relying upon clinical assessment, such as kidney biopsy and functional assays, are insufficient. We have developed a family of small molecule compounds, ApoSense, that is capable, upon systemic administration, of selectively targeting and accumulating within apoptotic/necrotic cells and is suitable for attachment of different markers for clinical imaging. The purpose of this study was to test the applicability of these molecules as a diagnostic imaging agent for the detection of renal tubular cell injury following renal ischemia. Methods: Using both fluorescent and radiolabeled derivatives of one of the ApoSense compounds, didansyl cystine, we evaluated cell death in three experimental, clinically relevant animal models of ATN: renal ischemia/reperfusion, radiocontrast-induced distal tubular necrosis, and cecal ligature and perforation-induced sepsis. Results: ApoSense showed high sensitivity and specificity in targeting injured renal tubular epithelial cells in vivo in all three models used. Uptake of ApoSense in the ischemic kidney was higher than in the non-ischemic one, and the specificity of ApoSense targeting was demonstrated by its localization to regions of apoptotic/necrotic cell death, detected morphologically and by TUNEL staining. Conclusion: ApoSense technology should have significant clinical utility for real-time, noninvasive detection of renal parenchymal damage of various types and evaluation of its distribution and magnitude; it may facilitate the assessment of efficacy of therapeutic interventions in a broad spectrum of disease states

Pair-Wise Cointegration in Long-Run Growth Models

This paper presents a novel theoretical and empirical approach to the analysis of long-run economic growth. It shows that most traditional theoretical models share the feature of pair-wise cointegration among the main variables. An augmented Kaldor model is proposed in contrast to the standard production function. The empirical analysis employs non- stationary panel techniques on two groups of countries to show that pair- wise cointegration exists among GDP, physical capital, human capital, and trade openness

Barbarians at the British Museum: Anglo-Saxon Art, Race and Religion

A critical historiographical overview of art historical approaches to early medieval material culture, with a focus on the British Museum collections and their connections to religion