157 research outputs found
When the optimal is not the best: parameter estimation in complex biological models
- Author
- A Björck
- A Gara
- B Gompertz
- BC Daniels
- C Kreutz
- C Moles
- Cecilia Suárez
- D Fernández Slezak
- D Marquardt
- Darren R. Flower
- Diego Fernández Slezak
- E Marinari
- F James
- G Cedersund
- G Fracasso
- Guillermo A. Cecchi
- Guillermo Marshall
- Gustavo Stolovitzky
- H Kitano
- IT Jolliffe
- J Freyer
- J Freyer
- J Freyer
- J Freyer
- J Nelder
- J Ward
- JW Zwolak
- JW Zwolak
- K Levenberg
- L Kunz-Schughart
- L Preziosi
- M Ashyraliyev
- M Marusic
- M Marusic
- M Rodriguez-Fernandez
- N Adiga
- P Pacheco
- R Araujo
- R Fletcher
- R Gutenkunst
- R Sutherland
- S Wise
- Y Jiang
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2010
- Field of study
Background: The vast computational resources that became available during the
past decade enabled the development and simulation of increasingly complex
mathematical models of cancer growth. These models typically involve many free
parameters whose determination is a substantial obstacle to model development.
Direct measurement of biochemical parameters in vivo is often difficult and
sometimes impracticable, while fitting them under data-poor conditions may
result in biologically implausible values.
Results: We discuss different methodological approaches to estimate
parameters in complex biological models. We make use of the high computational
power of the Blue Gene technology to perform an extensive study of the
parameter space in a model of avascular tumor growth. We explicitly show that
the landscape of the cost function used to optimize the model to the data has a
very rugged surface in parameter space. This cost function has many local
minima with unrealistic solutions, including the global minimum corresponding
to the best fit.
Conclusions: The case studied in this paper shows one example in which model
parameters that optimally fit the data are not necessarily the best ones from a
biological point of view. To avoid force-fitting a model to a dataset, we
propose that the best model parameters should be found by choosing, among
suboptimal parameters, those that match criteria other than the ones used to
fit the model. We also conclude that the model, data and optimization approach
form a new complex system, and point to the need of a theory that addresses
this problem more generally
Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abud AA
- Abulaiti Y
- Acharya BS
- Achkar B
- Adachi S
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adersberger M
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmadov F
- Ahmed WS
- Ai X
- Aielli G
- Akatsuka S
- Akesson TPA
- Akilli E
- Akimov A
- Al Khoury K
- Alberghi GL
- Albert J
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi A
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- Suster CJE
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- Swiatlowski M
- Swift SP
- Swirski T
- Sydorenko A
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- Tartarelli GF
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- Tayalati Y
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- Thiele F
- Thomas DW
- Thomas JO
- Thomas JP
- Thompson PD
- Thomsen LA
- Thomson E
- Thorpe EJ
- Tikhomirov VO
- Tikhonov YA
- Timoshenko S
- Tipton P
- Tisserant S
- Tobon CAM
- Todome K
- Todorova-Nova S
- Todt S
- Tojo J
- Tokar S
- Tokushuku K
- Tolley E
- Tomiwa KG
- Tomoto M
- Tompkins L
- Tong B
- Tornambe P
- Toro RC
- Torrence E
- Torres H
- Torres RET
- Tosciri C
- Toth J
- Tovey DR
- Traeet A
- Treado CJ
- Trefzger T
- Tresoldi F
- Tricoli A
- Trigger IM
- Trincaz-Duvoid S
- Trischuk DA
- Trischuk W
- Trocme B
- Trofymov A
- Troncon C
- Trovato F
- Truong L
- Trzebinski M
- Trzupek A
- Tsai F
- Tseng JC-L
- Tsiareshka P
- Tsirigotis A
- Tsiskaridze V
- Tskhadadze EG
- Tsopoulou M
- Tsukerman II
- Tsulaia V
- Tsuno S
- Tsybychev D
- Tu Y
- Tudorache A
- Tudorache V
- Tulbure TT
- Tuna AN
- Turchikhin S
- Turgeman D
- Turner RJ
- Turra RT
- Tuts PM
- Tzamarias S
- Tzovara E
- Ucchielli G
- Uchida K
- Ukegawa F
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- Undrus A
- Unel G
- Ungaro FC
- Unno Y
- Uno K
- Urban J
- Urquijo P
- Usai G
- Uysal Z
- Vacek V
- Vachon B
- Vadla KOH
- Vaidya A
- Valderanis C
- Vale MAB
- Valente M
- Valentinetti S
- Valero A
- Valery L
- Vallance RA
- Vallier A
- Van Daalen TR
- Van Gemmeren P
- Van Vulpen I
- Vanadia M
- Vandelli W
- Vandenbroucke M
- Vandewall ER
- Vaniachine A
- Vannicola D
- Vari R
- Varnes EW
- Varni C
- Varol T
- Varouchas D
- Varvell KE
- Vasile ME
- Vasquez GA
- Vazeille F
- Vazquez Furelos D
- Vazquez CJB
- Vazquez JGP
- Veatch J
- Vecchio V
- Veen MJ
- Veloce LM
- Veloso F
- Veneziano S
- Ventura A
- Venturi N
- Vera AMR
- Verbytskyi A
- Vercesi V
- Verducci M
- Vergara JCR
- Vergis C
- Verkerke W
- Vermeulen AT
- Vermeulen JC
- Verzini MJA
- Vetterli MC
- Viaux Maira N
- Vickey T
- Viehhauser GHA
- Vigani L
- Villa M
- Vilucchi E
- Vincter MG
- Virdee GS
- Vishwakarma A
- Vittori C
- Vivarelli I
- Vogel M
- Vokac P
- von Buddenbrock SE
- Von Toerne E
- Vorobel V
- Vorobev K
- Vos M
- Vossebeld JH
- Vozak M
- Vranjes N
- Vrba V
- Vreeswijk M
- Vuillermet R
- Vukotic I
- Wagner P
- Wagner W
- Wagner-Kuhr J
- Wahdan S
- Wahlberg H
- Walbrecht VM
- Walder J
- Walker R
- Walker SD
- Walkowiak W
- Wallangen V
- Wang AM
- Wang AZ
- Wang C
- Wang F
- Wang H
- Wang J
- Wang P
- Wang Q
- Wang R
- Wang R-J
- Wang SM
- Wang W
- Wang WT
- Wang WX
- Wang Y
- Wang Z
- Wanotayaroj C
- Warburton A
- Ward CP
- Wardrope DR
- Warrack N
- Washbrook A
- Watson AT
- Watson MF
- Watts G
- Waugh BM
- Webb AF
- Webb S
- Weber C
- Weber MS
- Weber SA
- Weber SM
- Weidberg AR
- Weingarten J
- Weirich M
- Weiser C
- Wells PS
- Wenaus T
- Wengler T
- Wenig S
- Wermes N
- Werner MD
- Wessels M
- Weston TD
- Whalen K
- Whallon NL
- Wharton AM
- White A
- White AS
- White MJ
- Whiteson D
- Whitmore BW
- Wiedenmann W
- Wiel C
- Wielers M
- Wieseotte N
- Wiglesworth C
- Wiik-Fuchs LAM
- Wilkens HG
- Wilkins LJ
- Williams HH
- Williams S
- Willis C
- Willocq S
- Wingerter-Seez I
- Winkels E
- Winklmeier F
- Winston OJ
- Winter BT
- Wittgen M
- Wobisch M
- Wolf A
- Wolf TMH
- Wolff R
- Wolker R
- Wollrath J
- Wolter MW
- Wolters H
- Wong VWS
- Woods NL
- Worm SD
- Wosiek BK
- Wozniak KW
- Wraight K
- Wu SL
- Wu X
- Wu Y
- Wyatt TR
- Wynne BM
- Xella S
- Xi Z
- Xia L
- Xiao X
- Xiotidis I
- Xu D
- Xu H
- Xu L
- Xu T
- Xu W
- Xu Z
- Yabsley B
- Yacoob S
- Yajima K
- Yallup DP
- Yamaguchi N
- Yamaguchi Y
- Yamamoto A
- Yamatani M
- Yamazaki T
- Yamazaki Y
- Yan Z
- Yang HJ
- Yang HT
- Yang S
- Yang T
- Yang X
- Yang Y
- Yao W-M
- Yap YC
- Yasu Y
- Yatsenko E
- Ye H
- Ye J
- Ye S
- Yeletskikh I
- Yexley MR
- Yigitbasi E
- Yildiz HD
- Yorita K
- Yoshihara K
- Young C
- Young CJS
- Yu J
- Yuan R
- Yue X
- Zaazoua M
- Zabinski B
- Zacharis G
- Zaffaroni E
- Zahreddine J
- Zaitsev AM
- Zakareishvili T
- Zakharchuk N
- Zambito S
- Zanzi D
- Zaripovas DR
- Zeissner S
- Zeitnitz C
- Zemaityte G
- Zeng JC
- Zenin O
- Zenis T
- Zerwas D
- Zgubic M
- Zhang B
- Zhang DF
- Zhang G
- Zhang H
- Zhang J
- Zhang L
- Zhang M
- Zhang R
- Zhang S
- Zhang X
- Zhang Y
- Zhang Z
- Zhao P
- Zhao Z
- Zhemchugov A
- Zheng Z
- Zhong D
- Zhou B
- Zhou C
- Zhou M
- Zhou MS
- Zhou N
- Zhou Y
- Zhu C
- Zhu CG
- Zhu H
- Zhu HL
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zhulanov V
- Zieminska D
- Zimine N
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zu Theenhausen HM
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente
Hepatitis B surface gene variants isolated from blood donors with overt and occult HBV infection in north eastern Egypt
- Author
- A Abe
- A Bartholomeusz
- A Katsoulidou
- A Youssef
- Abeer Elkady
- AM El-Sherif
- AM Ismail
- CH Huang
- D Candotti
- E Brojer
- E Mansour
- H Yotsuyanagi
- HL Zaaijer
- IT Shin
- J Yuan
- JP Allain
- KQ Hu
- M Ragheb
- M Romero
- M Sofian
- MA Attia
- MM Sherif
- MO Japhet
- Mohamed Aboelmagd
- Mohamed Hassan
- Mohamed Mandour
- Mostafa Ragheb
- N Saudy
- Nader Nemr
- Nashaat Soliman
- Nevene Ramsis
- NM Araujo
- P Garmiri
- Rania Kishk
- S Levicnik-Stezinar
- S Mohammed Abdullah
- S Shalaby
- Sayuki Iijima
- SF Altschul
- Shuko Murakami
- SR Mohebbi
- X Zheng
- Y Tanaka
- Yasuhito Tanaka
- ZN Said
- ZN Said
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Characterisation of a rare, reassortant human G10P[14] rotavirus strain detected in Honduras
- Author
- Araujo IT
- Bourdett-Stanziola L
- Castello AA
- Cortese MM
- Cowley D
- de Oliveira LH
- de Oliveira LH
- Desai R
- Dina J Castro Banegas
- Do LP
- Doan YH
- Doro R
- Doro R
- Ghosh S
- Gloria Rey-Benito
- Guindon S
- Heiman EM
- Hull JJ
- Jere KC
- Ka Ian Tam
- Kunchala Rungsrisuriyachai
- Linhares AC
- Mandal P
- Mathew D Esona
- Matthijnssens J
- Matthijnssens J
- Matthijnssens J
- Medici MC
- Michael D Bowen
- Nakagomi O
- Osbourne Quaye
- Parashar UD
- Payne DC
- Potgieter AC
- Quaye O
- Seheri M
- Steyer A
- Sunando Roy
- Tam KI
- Tamura K
- Tate JE
- Varshney B
- Yamamoto D
- Ziqian Xu
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
A Deep Insight into the Sialome of Rhodnius neglectus, a vector of chagas disease
- Author
- A Fontaine
- A Stintzi
- A van de Locht
- A W. S. de Oliveira
- B Breugelmans
- B Schlott
- BH Sandler
- BJ Mans
- C Noeske-Jungblut
- Carla Nunes de Araújo
- CC Hsu
- CC Hsu
- CH Yeh
- CM Costa
- D Georgieva
- D Steverding
- D Trevisan-Silva
- David Neves
- DE Champagne
- DE Champagne
- DE Champagne
- DR Flower
- DR Hoffman
- DR Hoffman
- E Calvo
- Eric Calvo
- EW Davie
- F Abad-Franch
- F Guhl
- G Leboulle
- GM Gibbs
- H Jiang
- H Nielsen
- HG Hergenhahn
- IM Francischetti
- Ionizete Garcia da Silva
- IT Campos
- Izabela Marques Dourado Bastos
- JA Irving
- Jaime M. Santana
- JC Rau
- JF Andersen
- JG Valenzuela
- JJ Calvete
- JM Ribeiro
- JM Ribeiro
- JM Ribeiro
- JM Ribeiro
- JM Ribeiro
- José M. C. Ribeiro
- João Victor de Araújo Oliveira
- JT Simpson
- K Mende
- K Oikonomopoulou
- K Stocker
- KR Stark
- KS Fang
- L Feitosa
- M Kalafatis
- M Kalafatis
- M Tegoni
- MA Larkin
- Marcelo Valle de Sousa
- MM LAVOIPIERRE
- NM Hooper
- P Fuentes-Prior
- P Pelosi
- P Takac
- Paula Beatriz Santiago
- Paulo Filemon Pimenta
- PG Gettins
- PP Prevot
- PP Prevot
- PSd Almeida
- R Amino
- R Charlab
- R de Marco
- R Gurgel-Goncalves
- R Gurgel-Goncalves
- R Gurgel-Gonçalves
- R Gurgel-Gonçalves
- R Kelwick
- R Luo
- Rayner Myr L. Queiroz
- RB da Silveira
- RB da Silveira
- RJ Gould
- RM Queiroz
- RN Araujo
- RP Soares
- S Fitzpatrick
- S Karim
- S Kumar
- S Porter
- SF Altschul
- Sébastien Charneau
- T Friedrich
- TA Hall
- Tainá Raiol
- TC Assumpcao
- TC Assumpcao
- TC Assumpcao
- TC Assumpção
- TC Assumpção
- Teresa C. F. Assumpção
- TF Huang
- TF Huang
- TM Antalis
- VL Rodrigues
- W Bode
- W Jiang
- W-Y He
- WB Wu
- WB Wu
- WR Montfort
- WS Leal
- X Xu
- Y Yamazaki
- Y Zhang
- YL Tseng
- Z Liang
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/04/2016
- Field of study
Background Triatomines are hematophagous insects that act as vectors of Chagas disease. Rhodnius neglectus is one of these kissing bugs found, contributing to the transmission of this American trypanosomiasis. The saliva of hematophagous arthropods contains bioactive molecules responsible for counteracting host haemostatic, inflammatory, and immuneresponses. Methods/Principal Findings Next generation sequencing and mass spectrometry-based protein identification were performed to investigate the content of triatomine R. neglectus saliva.We deposited 4,230 coding DNA sequences (CDS) in GenBank. A set of 636 CDS of proteins of putative secretory nature was extracted from the assembled reads, 73 of them confirmed by proteomic analysis. The sialome of R. neglectus was characterized and serine protease transcripts detected. The presence of ubiquitous protein families was revealed, including lipocalins, serine protease inhibitors, and antigen-5. Metalloproteases, disintegrins, and odorant binding protein families were less abundant. Conclusions/Significance The data presented improve our understanding of hematophagous arthropod sialomes, and aid in understanding hematophagy and the complex interplay among vectors and their vertebrate hosts
Hospitalization due to norovirus and genotypes of rotavirus in pediatric patients, state of Espírito Santo
- Author
- Araujo IT
- Araujo IT
- Atmar RL
- Beuret C
- Blanton LH
- Boom R
- Borges AM
- Cardoso DD
- Carvalho-Costa FA
- Clark B
- Colomba C
- Costa PSS
- Das BK
- de Wit MA
- de Wit MA
- de Wit MA
- Débora Maria Pires Gonçalves Barreira
- Estes MK
- Fankhauser RL
- Fretz R
- Gallimore CI
- Gentsch JR
- Glass RI
- Gurgel RQ
- Hansman GS
- Herring AJ
- Iturriza-Gomara M
- José Paulo Gagliardi Leite
- Kapikian AZ
- Ketene Wernek Saick
- Kirkwood CD
- Kirkwood CD
- Leandro Rua Ribeiro
- Lee N
- Leite JP
- Liliana Cruz Spano
- Linhares AC
- Marize Pereira Miagostovich
- Marks PJ
- Marshall JA
- Martella V
- Medici MC
- Moreno-Espinosa S
- Oh DY
- Okitsu-Negishi S
- Pereira HG
- Pietruchinski E
- Rafael Souto de Oliveira Giuberti
- Rockx B
- Rosa e Silva ML
- Santos N
- Santos N
- Santos N
- Santos N
- Soares CC
- Straub TM
- Subekti DS
- Victoria M
- Volotão EM
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Neoadjuvant treatment of pancreatic adenocarcinoma: a systematic review and meta-analysis of 5520 patients
- Author
- A Andriulli
- A Barbour
- A Jesus-Acosta De
- A Mahadevan
- A Paniccia
- A Wang-Gillam
- AD Parmar
- AP Gulati
- BA Boone
- C Cassinotto
- C Hajj
- C Milandri
- C RFd
- C Tinchon
- CB Begg
- Chandrakanth Are
- CM Kang
- CR Ferrone
- CW Tzeng
- CW Tzeng
- D Habermehl
- D Moher
- D Schellenberg
- D Tinkl
- Davendra P.S. Sohal
- DB Evans
- DB Evans
- DB Evans
- DD Hoff Von
- DJ Hartman
- DP Sohal
- DW Maximous
- E Sadot
- EH Jensen
- Eileen M. O’Reilly
- EJ Kim
- EM O'Reilly
- ES James
- ES Rosmarakis
- F Bednar
- F Leone
- F Motoi
- F Polistina
- G Barugola
- Gautam K. Malhotra
- GC Mattiucci
- GR Varadhachary
- GR Varadhachary
- H Eguchi
- H Golcher
- H Mahaseth
- H Oettle
- H Tajima
- H Tajima
- H Takahashi
- HA Burris 3rd
- I Epelboym
- IR Cho
- IT Konstantinidis
- J Fatima
- J He
- J Landry
- JB Rose
- JB Stokes
- JE Faris
- JK Bjerregaard
- JL Lee
- JM Herman
- JM Herman
- JM Winter
- JP Neoptolemos
- JP Neoptolemos
- JY Wo
- K Sahora
- K Sahora
- K Sahora
- KA Bickenbach
- KC Conlon
- KC Cuneo
- KD Miller
- KK Christians
- KS Gunturu
- KT Chen
- KT Papalezova
- L Marthey
- Lynette M. Smith
- M Alagappan
- M Alline
- M Blazer
- M Chllamma
- M Egger
- M Kobayashi
- M Mizuma
- M Patel
- M Shinoto
- M Sho
- M Suker
- MA Tempero
- Mashaal Dhir
- MD Chuong
- MH Katz
- MH Katz
- MK Gurka
- MM Assifi
- MM Corsini
- MP Callery
- MS Rajagopalan
- Nathan Bahary
- ND Arvold
- NF Esnaola
- Nicholas A. Hein
- O Turrini
- OM Rashid
- PF Peddi
- PJ Hosein
- PJ Loehrer Sr
- R Alvarez
- R Kapoor
- R Scodan Le
- R Wilkowski
- RA Abrams
- RJ McClaine
- RL Araujo
- RL Siegel
- RM Minter
- S Chakraborty
- S Gillen
- S Satoi
- S Tsai
- SE Combs
- T Conroy
- T Ioka
- TS Hong
- V Cetin
- VN Nyaga
- W Small Jr
- WF Regine
- WH Sherman
- Y Takeda
- Y Tomimaru
- Y-J Chao
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Measurement of the cross section for inclusive isolated-photon production in pp collisions at √s=13TeV using the ATLAS detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdinov O
- Abeloos B
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abreu R
- Abulaiti Y
- Acharya BS
- Adachi S
- Adamczyk L
- Adelman J
- Adersberger M
- Adye T
- Affolder AA
- Afik Y
- Agatonovic-Jovin T
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahlen SP
- Ahmadov F
- Aielli G
- Akatsuka S
- Akerstedt H
- Akesson TPA
- Akilli E
- Akimov AV
- Alberghi GL
- Albert J
- Albicocco P
- Alconada Verzini MJ
- Alderweireldt SC
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexopoulos T
- Alhroob M
- Ali B
- Aliev M
- Alimonti G
- Alison J
- Alkire SP
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso A
- Alonso F
- Alpigiani C
- Alshehri AA
- Alstaty MI
- Alvarez Piqueras D
- Alviggi MG
- Amadio BT
- Amelung C
- Amidei D
- Amor Dos Santos SP
- Amoroso S
- Amundsen G
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders JK
- Anderson KJ
- Andreazza A
- Andrei V
- Angelidakis S
- Angelozzi I
- Angerami A
- Anisenkov AV
- Anjos N
- Annovi A
- Antel C
- Antonelli M
- Antonov A
- Antrim DJ
- Anulli F
- Aoki M
- Arabidze G
- Arai Y
- Araque JP
- Araujo Ferraz V
- Araya ST
- Arce ATH
- Ardell RE
- Arduh FA
- Arguin J-F
- Argyropoulos S
- Arik M
- Armbruster AJ
- Armitage LJ
- Arnaez O
- Arnold H
- Arratia M
- Arslan O
- Artamonov A
- Artoni G
- Artz S
- Asai S
- Asbah N
- Ashkenazi A
- Asquith L
- Assamagan K
- Astalos R
- Astigarraga MEP
- Atkinson M
- Atlay NB
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- Konya B
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- Koperny S
- Kopp AK
- Korcyl K
- Kordas K
- Korn A
- Korol AA
- Korolkov I
- Korolkova EV
- Kortner O
- Kortner S
- Kosek T
- Kostyukhin VV
- Kotwal A
- Koulouris A
- Kourkoumeli-Charalampidi A
- Kourkoumelis C
- Kourlitis E
- Kouskoura V
- Kowalewska AB
- Kowalewski R
- Kowalski TZ
- Kozakai C
- Kozanecki W
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- Kunigo T
- Kupco A
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- Kurth MG
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- Kuwertz ES
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- Lanfermann MC
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- Laplace S
- Laporte JF
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- Lavrijsen W
- Law AT
- Laycock P
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- Lazzaroni M
- Le Dortz O
- Le Guirriec E
- Le Quilleuc EP
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- Leite MAL
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- Loebinger FK
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- Zimine NI
- Zimmermann C
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- Zivkovic L
- Zobernig G
- Zoccoli A
- Zou R
- zur Nedden M
- Zwalinski L
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Inclusive isolated-photon production in pp collisions at a centre-of-mass energy of 13TeVis studied with the ATLAS detector at the LHC using a data set with an integrated luminosity of 3.2fb−1. The cross section is measured as a function of the photon transverse energy above 125GeVin different regions of photon pseudorapidity. Next-to-leading-order perturbative QCD and Monte Carlo event-generator predictions are compared to the cross-section measurements and provide an adequate description of the data
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
- Author
- A Abbate
- A Abhyankar
- A Adams
- A Agafina
- A Akyea-Djamson
- A Alan
- A Alfieri
- A Alfrey
- A Alvarisqueta
- A Amos
- A Anadiotis
- A Anneveldt
- A Antolick
- A Arthur
- A Aslam
- Abaci F
- Abdullakutty J
- Abhaichand R
- Abib E Jr
- Aboufakher R
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- Zirlik A
- Zucchetti C
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.
Measurements of integrated and differential cross sections for isolated photon pair production in pp collisions at √s=8 TeV with the ATLAS detector
- Author
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- Aad G
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- Abdallah J
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- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2017
- Field of study
A measurement of the production cross section for two isolated photons in proton-proton collisions at a center-of-mass energy of √s=8 TeV is presented. The results are based on an integrated luminosity of 20.2 fb−1 recorded by the ATLAS detector at the Large Hadron Collider. The measurement considers photons with pseudorapidities satisfying |ηγ|40GeV and EγT,2>30 GeV for the two leading photons ordered in transverse energy produced in the interaction. The background due to hadronic jets and electrons is subtracted using data-driven techniques. The fiducial cross sections are corrected for detector effects and measured differentially as a function of six kinematic observables. The measured cross section integrated within the fiducial volume is 16.8 ± 0.8 pb . The data are compared to fixed-order QCD calculations at next-to-leading-order and next-to-next-to-leading-order accuracy as well as next-to-leading-order computations including resummation of initial-state gluon radiation at next-to-next-to-leading logarithm or matched to a parton shower, with relative uncertainties varying from 5% to 20%
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