Computational investigation of an unsteady non-Newtonian and non-isothermal fluid between coaxial contracting channels: A PCM approach

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Efectividad de la mezcla Fluopyram + Tebuconazole en el control de Alternaria solani en papas

27 p.La papa (Solanum tuberosum L.), como todo cultivo, esta afecto a diversas plagas y enfermedades que lo pueden atacar y disminuir sus rendimientos sustancialmente, por lo que ha sido tema obligado de variadas investigaciones. Dentro de las enfermedades, las más importantes que afectan al cultivo de la papa son Tizón Tardío causado por el hongo Phytophthora infestans y Tizón Temprano ocasionado por el hongo Alternaria solani. Específicamente, el Tizón Temprano de la papa, ataca follaje y tubérculos de la planta, provocando pérdidas en rendimiento que van desde 10% a 50% dependiendo del grado de infección del hongo sobre la planta.Para el control de la enfermedad se han sugerido diversas prácticas culturales, como por ejemplo la utilización de semilla de buena calidad. Paralelamente, el control químico se ha presentado como una alternativa eficiente en el control de la enfermedad.Debido a lo anterior se realizó un ensayo con el objetivo de evaluar la efectividad de la mezcla Fluopyram y Tebuconazole en el control de la enfermedad tizón temprano causado por el hongo Alternaria solani en un cultivo de papas. Se evaluaron diferentes dosis de la mezcla incluyendo una que agregaba un surfactante. Estas mezclas fueron comparadas con un tratamiento testigo y con fungicidas de uso tradicional que tienen como ingrediente activo a Boscalid, Trifloxystrobin, Cyproconazole o Difenoconazole. Los tratamientos se distribuyeron en un diseño de bloques completamente al azar y fueron aplicados durante tres ocasiones: fin de floración, 10 días después de floración y 20 días después de floración. Para medir el efecto de cada uno de los tratamientos se hicieron dos evaluaciones de incidencia y severidad y una evaluación de rendimiento. Los resultados obtenidos a partir de este ensayo demostraron la efectividad de cada uno de los fungicidas sobre la disminución en la incidencia y severidad del ataque del hongo A. solani. Sin embargo no se observaron diferencias estadísticamente significativas entre las mezclas de Fluopyram + Tebuconazole y los fungicidas de uso comercial. En el caso de la evaluación de rendimiento, no se observaron diferencias estadísticamente significativas entre los tratamientos. Palabras clave: Papa; Solanum Tuberosum L; Tizón Temprano; Alternaria solani; Fluopyram; Tebuconazole./ABSTRACT: Potato (Solanum tuberosum L.), like any crop it is affected for many pests and diseases which can decrease yields, turning these problems in to an important research topic. Within, the most important diseases that affect potato we can mention late blight caused by the fungus Phytophthora infestans and early blight produced by the fungus Alternaria solani. Specifically, early blight, affects foliage and tubers of the plant, causing yield losses ranging from 10% to 50% depending on the degree of infection. To control of the disease includes various cultural practices such as the use of good quality seed. In parallel, chemical control has resulted an efficient alternative in the control of the disease. The purpose of this assay it was to evaluate the effectiveness of the active ingredients Fluopyram and Tebuconazole in mixture in the control of early blight caused by the fungus Alternaria solani in a potato. Different doses of the mixture were incorporated in the experiment as treatments, including the addition of a surfactant. These were compared with a control treatment and with fungicides traditionally used such as Boscalid, Trifloxystrobin, Cyproconazole or Difenoconazole. The treatments were distributed in a completely randomized blocks experimental design, being applied three times: at the end of flowering, 10 days after flowering and 20 days after flowering. To measure the effect of each treatment two evaluations of incidence and severity were made. The yield at harvest was also measured. The results of this experiment demonstrated the effectiveness of each of the fungicides evaluated in the reduction of the incidence and severity of the disease. However, no statistically significant differences between the mixtures fluopyram + Tebuconazole and the commercial fungicides were observed. For yield evaluation, no statistically significant differences between treatments were observed. Keywords: Potato; Solanum tuberosum L; Early blight; Alternaria solani; Fluopyram; Tebuconazole

Synthesis and reactions of 9,10-dihydro-9,10-ethanoanthracene-11,12-diacid hydrazides

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Eco-Friendly Synthesis, Biological Evaluation, and In Silico Molecular Docking Approach of Some New Quinoline Derivatives as Potential Antioxidant and Antibacterial Agents

A new series of quinoline derivatives 5–12 were efficiently synthesized via one-pot multicomponent reaction (MCR) of resorcinol, aromatic aldehydes, β-ketoesters, and aliphatic/aromatic amines under solvent-free conditions. All products were obtained in excellent yields, pure at low-cost processing, and short time. The structures of all compounds were characterized by means of spectral and elemental analyses. In addition, all the synthesized compounds 5–12 were in vitro screened for their antioxidant and antibacterial activity. Moreover, in silico molecular docking studies of the new quinoline derivatives with the target enzymes, human NAD (P)H dehydrogenase (quinone 1) and DNA gyrase, were achieved to endorse their binding affinities and to understand ligand–enzyme possible intermolecular interactions. Compound 9 displayed promising antioxidant and antibacterial activity, as well as it was found to have the highest negative binding energy of -9.1 and -9.3 kcal/mol for human NAD (P)H dehydrogenase (quinone 1) and DNA gyrase, respectively. Further, it complied with the Lipinski’s rule of five, Veber, and Ghose. Therefore, the quinoline analogue 9 could be promising chemical scaffold for the development of future drug candidates as antioxidant and antibacterial agents

Effect of Acupuncture on Body Weight Reduction and Inflammatory Mediators in Egyptian Obese Patients

AIM: Aim of this study was to examine the effectiveness of body acupuncture on body weight loss, routine laboratory tests and pro-inflammatory markers.METHODOLOGY: The study was performed on eighty obese patients. They were divided into three groups according to their body mass index. Subjects received acupuncture for three- six months in combination with a low-calorie diet. They were assessed pre and post acupuncture, by anthropometric measurement, routine laboratory tests and, tumor necrosis factor- alpha (TNF-α), interleukin- 6 (IL-6), and high sensitivity C-reactive protein (hsCRP) levels in serum.RESULTS: The pre-acupuncture results showed significant difference between the three grades of obesity and the controls regarding TNFα, IL-6 and hsCRP. We found significant reduction in anthropometric measurement of adiposity after acupuncture. In comparing the pre &post acupuncture results of TNF-α, IL-6 and hsCRP showed high significant reduction after acupuncture. There are highly significant decrease in kidney function (creatinine and uric acid) and lipid profile (cholesterol and triglycerides) and fasting blood glucose, but there was no significant difference in urea, SGPT, SGOT, HDL and LDL.CONCLUSION: Body acupuncture in combination with diet restriction was found to be effective for weight loss and also reduction of the inflammatory reactions. Acupuncture could be used as a synergistic treatment option for obesity control

Core Microbial Functional Activities in Ocean Environments Revealed by Global Metagenomic Profiling Analyses

Metagenomics-based functional profiling analysis is an effective means of gaining deeper insight into the composition of marine microbial populations and developing a better understanding of the interplay between the functional genome content of microbial communities and abiotic factors. Here we present a comprehensive analysis of 24 datasets covering surface and depth-related environments at 11 sites around the world's oceans. The complete datasets comprises approximately 12 million sequences, totaling 5,358 Mb. Based on profiling patterns of Clusters of Orthologous Groups (COGs) of proteins, a core set of reference photic and aphotic depth-related COGs, and a collection of COGs that are associated with extreme oxygen limitation were defined. Their inferred functions were utilized as indicators to characterize the distribution of light- and oxygen-related biological activities in marine environments. The results reveal that, while light level in the water column is a major determinant of phenotypic adaptation in marine microorganisms, oxygen concentration in the aphotic zone has a significant impact only in extremely hypoxic waters. Phylogenetic profiling of the reference photic/aphotic gene sets revealed a greater variety of source organisms in the aphotic zone, although the majority of individual photic and aphotic depth-related COGs are assigned to the same taxa across the different sites. This increase in phylogenetic and functional diversity of the core aphotic related COGs most probably reflects selection for the utilization of a broad range of alternate energy sources in the absence of light.This work was supported by King Abdullah University for Science and Technology Global Collaborative Partners (GCR) program. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript

How do religious norms diffuse? Institutional translation and international change in a post-secular world society

This article draws from Habermasian post-secular theory to broaden the scope of Constructivist research on norm dynamics beyond its current Western-centric focus. In an increasingly post-secular world society, we conceptualize the mechanism of institutional translation to explain processes of norm diffusion whereby culturally situated ‘thick’ norms acquire a ‘thinner’ ethical status via a dialogical process of normative contestation across diverse ethical perspectives. Institutional translation differs from, but also complements, mechanisms of norm diffusion, such as persuasion and localization, by illustrating how norms conceived and promoted by non-Western religious-based actors can acquire global legitimacy within the institutions of the international liberal order. The article investigates the explanatory value of this framework through an empirical analysis of two contrasting cases of norm promotion by the Organization of Islamic Conference at the United Nations. The first case considers the global diffusion of the norm of dialogue of civilizations as an example of successful institutional translation. The second case illustrates the failed diffusion of the norm against th

Search for squarks and gluinos in events with isolated leptons, jets and missing transverse momentum at s√=8 TeV with the ATLAS detector

The results of a search for supersymmetry in final states containing at least one isolated lepton (electron or muon), jets and large missing transverse momentum with the ATLAS detector at the Large Hadron Collider are reported. The search is based on proton-proton collision data at a centre-of-mass energy s√=8 TeV collected in 2012, corresponding to an integrated luminosity of 20 fb−1. No significant excess above the Standard Model expectation is observed. Limits are set on supersymmetric particle masses for various supersymmetric models. Depending on the model, the search excludes gluino masses up to 1.32 TeV and squark masses up to 840 GeV. Limits are also set on the parameters of a minimal universal extra dimension model, excluding a compactification radius of 1/R c = 950 GeV for a cut-off scale times radius (ΛR c) of approximately 30

Measurements of fiducial and differential cross sections for Higgs boson production in the diphoton decay channel at s√=8 TeV with ATLAS

Measurements of fiducial and differential cross sections are presented for Higgs boson production in proton-proton collisions at a centre-of-mass energy of s√=8 TeV. The analysis is performed in the H → γγ decay channel using 20.3 fb−1 of data recorded by the ATLAS experiment at the CERN Large Hadron Collider. The signal is extracted using a fit to the diphoton invariant mass spectrum assuming that the width of the resonance is much smaller than the experimental resolution. The signal yields are corrected for the effects of detector inefficiency and resolution. The pp → H → γγ fiducial cross section is measured to be 43.2 ±9.4(stat.) − 2.9 + 3.2 (syst.) ±1.2(lumi)fb for a Higgs boson of mass 125.4GeV decaying to two isolated photons that have transverse momentum greater than 35% and 25% of the diphoton invariant mass and each with absolute pseudorapidity less than 2.37. Four additional fiducial cross sections and two cross-section limits are presented in phase space regions that test the theoretical modelling of different Higgs boson production mechanisms, or are sensitive to physics beyond the Standard Model. Differential cross sections are also presented, as a function of variables related to the diphoton kinematics and the jet activity produced in the Higgs boson events. The observed spectra are statistically limited but broadly in line with the theoretical expectations