Development of Resilience Index in Transport Systems

This paper demonstrates the quantification of the resilience index (RI) in transport systems. The transport infrastructure can be managed by using the concepts of resilience. Vugrin, Warren, Ehlen, & Camphouse (2010) emphasized the enhancement of resilience in infrastructure before disasters and the establishment of efficient measures for the recovery of systems in an emergency. The concept of resilience has a significant influence on transport planning and operations for disaster preparation. Lee, Kim, & Lee (2013) investigated the concepts of resilience and examined case studies using valuable asset-management techniques in order to maintain the resilience concepts which should be introduced in transport infrastructure planning and operations. Therefore, this paper presents the RI based on Vurgrin et al. (2010) and Lee et al. (2010). The first part of this paper focuses on the measurement of the RI using the recovery-dependent resilience (Vugrin et al., 2010) in transport infrastructures. For quantifying the RI, we have developed various variables that are used to target an achievable or a desired system performance in disaster recovery efforts. The second part of this paper focuses on the applications of the RI in case studies. The examined cases are road networks in flooded areas, heavy snowfall districts, and landslide occurrence zones. Each case is analyzed for transport costs both under normal and disaster conditions using the transport demand estimation models. Finally, we quantify the RI, which is important for establishing the provision of safety, recovery, and rehabilitation of transport infrastructures in flooding, snowfall, and landslide areas

Housing the Workforce Following the Canterbury Earthquakes in New Zealand

Temporary housing following a large-scale disaster has a positive effect on household welfare and community recovery. Following the 2010 and 2011 Canterbury earthquakes, a shortage of temporary accommodation created barriers for the outside construction workforce to engage in repairs and rebuild in Christchurch. This study investigates the impacts of housing shortages for the overall recovery and the strategies adopted by both households and the workforce in the building industry. Findings suggest that the interplay among the industry strategies and household strategies for securing housing determines the magnitude and scope of economy-wide inflation. One unfortunate consequence of these industry strategies is that the pressures of resource shortages are likely to transit from the construction sector to quake-affected households. These findings have implications on the nature and design of pre and postdisaster planning programs in order to reduce the impacts of housing issues on household welfare and, at the same time, to the meet the needs of the construction sector if the scheduled rebuild works are to be achieved

Episodic Random Accretion and the Cosmological Evolution of Supermassive Black Hole Spins

The growth of supermassive black holes (BHs) located at the centers of their host galaxies comes mainly from accretion of gas, but how to fuel them remains an outstanding unsolved problem in quasar evolution. This issue can be elucidated by quantifying the radiative efficiency parameter ($\eta$) as a function of redshift, which also provides constraints on the average spin of the BHs and its possible evolution with time. We derive a formalism to link $\eta$ with the luminosity density, BH mass density, and duty cycle of quasars, quantities we can estimate from existing quasar and galaxy survey data. We find that $\eta$ has a strong cosmological evolution: at z~2, $\eta \approx 0.3$, and by $z\approx 0$ it has decreased by an order of magnitude, to $\eta\approx 0.03$. We interpret this trend as evolution in BH spin, and we appeal to episodic, random accretion as the mechanism for reducing the spin. The observation that the fraction of radio-loud quasars decreases with increasing redshift is inconsistent with the popular notion that BH spin is a critical factor for generating strong radio jets. In agreement with previous studies, we show that the derived history of BH accretion closely follows the cosmic history of star formation, consistent with other evidence that BHs and their host galaxies coevolve.Comment: 4 page, 2 color figures. Accepted by ApJ

Drosophila orthologue of WWOX, the chromosomal fragile site FRA16D tumour suppressor gene, functions in aerobic metabolism and regulates reactive oxygen species

Common chromosomal fragile sites FRA3B and FRA16D are frequent sites of DNA instability in cancer, but their contribution to cancer cell biology is not yet understood. Genes that span these sites (FHIT and WWOX, respectively) are often perturbed (either increased or decreased) in cancer cells and both are able to suppress tumour growth. While WWOX has some tumour suppressor characteristics, its normal role and functional contribution to cancer has not been fully determined. We find that a significant proportion of Drosophila Wwox interactors identified by proteomics and microarray analyses have roles in aerobic metabolism. Functional relationships between Wwox and either CG6439/isocitrate dehydrogenase (Idh) or Cu–Zn superoxide dismutase (Sod) were confirmed by genetic interactions. In addition, altered levels of Wwox resulted in altered levels of endogenous reactive oxygen species. Wwox (like FHIT) contributes to pathways involving aerobic metabolism and oxidative stress, providing an explanation for the ‘non-classical tumour suppressor’ behaviour of WWOX. Fragile sites, and the genes that span them, are therefore part of a protective response mechanism to oxidative stress and likely contributors to the differences seen in aerobic glycolysis (Warburg effect) in cancer cells

Differential gene expression in human granulosa cells from recombinant FSH versus human menopausal gonadotropin ovarian stimulation protocols

<p>Abstract</p> <p>Background</p> <p>The study was designed to test the hypothesis that granulosa cell (GC) gene expression response differs between recombinant FSH and human menopausal gonadotropin (hMG) stimulation regimens.</p> <p>Methods</p> <p>Females < 35 years-old undergoing IVF for tubal or male factor infertility were prospectively randomized to one of two stimulation protocols, GnRH agonist long protocol plus individualized dosages of (1) recombinant (r)FSH (Gonal-F) or (2) purified human menopausal gonadotropin (hMG; Menopur). Oocytes were retrieved 35 h post-hCG, and GC were collected. Total RNA was extracted from each GC sample, biotinylated cRNA was synthesized, and each sample was run on Human Genome Bioarrays (Applied Microarrays). Unnamed genes and genes with <2-fold difference in expression were excluded.</p> <p>Results</p> <p>After exclusions, 1736 genes exhibited differential expression between groups. Over 400 were categorized as signal transduction genes, ~180 as transcriptional regulators, and ~175 as enzymes/metabolic genes. Expression of selected genes was confirmed by RT-PCR. Differentially expressed genes included A kinase anchor protein 11 (AKAP11), bone morphogenetic protein receptor II (BMPR2), epidermal growth factor (EGF), insulin-like growth factor binding protein (IGFBP)-4, IGFBP-5, and hypoxia-inducible factor (HIF)-1 alpha.</p> <p>Conclusions</p> <p>Results suggest that major differences exist in the mechanism by which pure FSH alone versus FSH/LH regulate gene expression in preovulatory GC that could impact oocyte maturity and developmental competence.</p

Weakened growth of cropland‐N2O emissions in China associated with nationwide policy interventions

This study was supported by the National Natural Science Foundation of China (41671464; 7181101181), the National Key Research and Development Program of China (2016YFD0800501; 2018YFC0213304), 111 Project (B14001), the GCP-INI Global N2O Budget and the INMS Asia Demo Activities. The input of P.S. contributes to the UK-China Virtual Joint Centre on Nitrogen ìN-Circleî funded by the Newton Fund via UK BBSRC/NERC (BB/N013484/1). We acknowledged Eric Ceschia, Kristiina Regina, Dario Papale, and the NANORP for sharing a part of observation data.Peer reviewedPostprin

Neutrophils in cancer: neutral no more

Neutrophils are indispensable antagonists of microbial infection and facilitators of wound healing. In the cancer setting, a newfound appreciation for neutrophils has come into view. The traditionally held belief that neutrophils are inert bystanders is being challenged by the recent literature. Emerging evidence indicates that tumours manipulate neutrophils, sometimes early in their differentiation process, to create diverse phenotypic and functional polarization states able to alter tumour behaviour. In this Review, we discuss the involvement of neutrophils in cancer initiation and progression, and their potential as clinical biomarkers and therapeutic targets

Spin dynamics in semiconductors

This article reviews the current status of spin dynamics in semiconductors which has achieved a lot of progress in the past years due to the fast growing field of semiconductor spintronics. The primary focus is the theoretical and experimental developments of spin relaxation and dephasing in both spin precession in time domain and spin diffusion and transport in spacial domain. A fully microscopic many-body investigation on spin dynamics based on the kinetic spin Bloch equation approach is reviewed comprehensively.Comment: a review article with 193 pages and 1103 references. To be published in Physics Reports

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts