Healthy Homes Neighbor to Neighbor Model

Ensuring the over health and well-being of a community is dependent not only on the healthcare professionals and resources in that community, but also the accessibility and reach of healthcare knowledge. Healthy Androscoggin established The Neighbor to Neighbor Healthy Homes Program in 2018 in order to spread awareness about environmental health risks in the homes of New Mainers by promoting community-held healthcare knowledge. The New Mainers working with Healthy Androscoggin are community members who have recently resettled in Maine from different African origin countries. The aim of the Neighbor to Neighbor Program, which is a branch of the Healthy Homes Initiative, is to identify and mitigate the most prevalent environmental health risks in the homes of New Mainers in Lewiston, Maine. Healthy Androscoggin collaborated with ambassadors from different African origin countries to educate their friends, families, and neighbors in order to share the Healthy Homes Education and behaviors that are affordable, attainable, and long-lasting. Healthy Androscoggin created and administered two surveys over the course of three weeks in order to evaluate the initial transfer and retention of healthcare knowledge among participating neighbors. Through a partnership between Bates College Environmental Studies Program and Healthy Androscoggin, we developed a third survey that was conducted eight months after the initial Healthy Homes Education session. The third survey aimed to identify what Healthy Homes behaviors were difficult to maintain, if the neighbors remembered all of the information from the initial education session, and if participants noticed changes in their personal health. The surveys consisted of both ‘yes/no’ and narrative questions in which ambassadors followed-up with neighbors about their experience in the program. The results from all three surveys were analyzed in order to recognize the current environmental health concerns among New Mainers, determine the overall success of the health education model, and inform future directions for the program. One major finding from the third survey was that 100 percent of the participants noticed changes in their overall health over the eight-month program period. In addition, 80 percent of the participating neighbors shared their Healthy Homes education with friends, family, and peers not formally enrolled in the program. This demonstrates that the program will continue to function even without the initial education provided by Healthy Androscoggin. Furthermore, this suggests that Healthy Androscoggin successfully promoted community-held healthcare knowledge about environmental health risks in Lewiston was established. Survey 3 also identified a new health concern among New Mainers that had not been explicitly addressed by the program. Some participating neighbors were concerned that their homes were not equipped with carbon monoxide detectors or that the existing detectors were not 3 functioning properly. Perhaps the most noteworthy findings from the third survey was that the Healthy Homes information assisted participants as they searched for new homes, thus encouraging tenants to advocate for their health. One third of participants from Survey 3 moved to new homes over the course of the eight months and explained that their decision to move and criteria for a new home was informed by the Healthy Homes Education. Lastly, multiple neighbors expressed a need for additional support when communicating with landlords about hazards such as lead and radon exposure. This alludes to the broader, systematic barriers that prevent those who are disproportionately impacted by environmental hazards from gaining true autonomy and control over their health. It is clear from the survey results that individual and community actions were successful in promoting community held healthcare knowledge. However, these actions can only go so far without structural, social, and political support

Titan airglow spectra from Cassini Ultraviolet Imaging Spectrograph (UVIS): EUV analysis

peer reviewedaudience: researcher, professional, studentWe present the first UV airglow observations of Titan's atmosphere by the Ultraviolet Imaging Spectrograph (UVIS) on Cassini. Using one spectral channel in the EUV from 561-1182 Å and one in the FUV from 1115-1913 Å, UVIS observed the disk on 13 December, 2004 at low solar activity. The EUV spectrum consists of three band systems of N[SUB]2[/SUB] (b [SUP]1[/SUP]∏[SUB]u[/SUB], b' [SUP]1[/SUP]∑[SUB]u[/SUB] [SUP]+[/SUP], c[SUB]4[/SUB]' [SUP]1[/SUP]∑[SUB]u[/SUB] [SUP]+[/SUP] -> X [SUP]1[/SUP]∑[SUB]g[/SUB] [SUP]+[/SUP]), while the FUV spectrum consists of one (a [SUP]1[/SUP]∏[SUB]g[/SUB] -> X [SUP]1[/SUP]∑[SUB]g[/SUB] [SUP]+[/SUP]). Both the EUV and FUV spectra contain many N I and N II multiplets that are produced primarily by photodissociative ionization. Spectral intensities of the N[SUB]2[/SUB] c[SUB]4[/SUB]' [SUP]1[/SUP]∑[SUB]u[/SUB] [SUP]+[/SUP](v' = 0) -> X [SUP]1[/SUP]∑[SUB]g[/SUB] [SUP]+[/SUP](v'' = 0-2) progression from 950-1010 Å are resolved for the first time. The UVIS observations reveal that the c[SUB]4[/SUB]' [SUP]1[/SUP]∑[SUB]u[/SUB] [SUP]+[/SUP](0) -> X [SUP]1[/SUP]∑[SUB]g[/SUB] [SUP]+[/SUP] (0) vibrational band near 958 Å is weak and undetectable, and that N I multiplets near 953.2 and 964.5 Å are present instead. Magnetospheric particle excitation may be weak or sporadic, since the nightside EUV spectrum on this orbit shows no observable nitrogen emission features and only H Ly-β

Iron bioavailability and cardiopulmonary function during ascent to very high altitude

Lette

"If we use the strength of diversity among researchers we can only improve the quality and impact of our research": Issues of equality, diversity, inclusion, and transparency in the process of applying for research funding

This paper sets out the recommendations that have emerged from a six-month-long exploration and discussion of the processes that take place before research is submitted for funding: the ‘pre-award’ environment. Our work concentrated on how this environment is experienced by researchers at all career stages and from a variety of backgrounds, demographics, and disciplines, as well as by research managers and research support professionals. In the later stages of our exploration, representatives from research funders were also involved in the discussions. The primary component of this project was an analysis of pre-award activities and processes at UK universities, using information collated from workshops with researchers and research management and support staff. The findings of this analysis were presented as a workflow diagram, which was then used to surface issues relating to equality, diversity, inclusion, and transparency in context. The workflow diagram and the issues highlighted by it were used to structure discussions at a symposium for a range of research stakeholders, held in Bristol, UK, in January 2023. The recommendations set out in this paper are drawn from discussions that took place at that event. This paper is not an exhaustive landscape analysis, nor a review of existing research and practice in the area of pre-award processes or of recent thinking on the topics of equality, diversity, and inclusion (EDI). Instead, it aims to summarise and encapsulate the suggestions put forward by the stakeholders during the symposium. These recommendations, from experienced professionals working in the field, are based on their encounters with the issues raised in the project. They do not solely relate to those working on pre-award processes, but may also apply to funders, policymakers, university leaders, and professional associations, since many of the challenges flagged in our research are systemic and cultural, and reach far beyond the research office

Anatomical Alterations of the Visual Motion Processing Network in Migraine with and without Aura

BACKGROUND: Patients suffering from migraine with aura (MWA) and migraine without aura (MWoA) show abnormalities in visual motion perception during and between attacks. Whether this represents the consequences of structural changes in motion-processing networks in migraineurs is unknown. Moreover, the diagnosis of migraine relies on patient's history, and finding differences in the brain of migraineurs might help to contribute to basic research aimed at better understanding the pathophysiology of migraine. METHODS AND FINDINGS: To investigate a common potential anatomical basis for these disturbances, we used high-resolution cortical thickness measurement and diffusion tensor imaging (DTI) to examine the motion-processing network in 24 migraine patients (12 with MWA and 12 MWoA) and 15 age-matched healthy controls (HCs). We found increased cortical thickness of motion-processing visual areas MT+ and V3A in migraineurs compared to HCs. Cortical thickness increases were accompanied by abnormalities of the subjacent white matter. In addition, DTI revealed that migraineurs have alterations in superior colliculus and the lateral geniculate nucleus, which are also involved in visual processing. CONCLUSIONS: A structural abnormality in the network of motion-processing areas could account for, or be the result of, the cortical hyperexcitability observed in migraineurs. The finding in patients with both MWA and MWoA of thickness abnormalities in area V3A, previously described as a source in spreading changes involved in visual aura, raises the question as to whether a “silent” cortical spreading depression develops as well in MWoA. In addition, these experimental data may provide clinicians and researchers with a noninvasively acquirable migraine biomarker

Oral abstracts 3: RA Treatment and outcomesO13. Validation of jadas in all subtypes of juvenile idiopathic arthritis in a clinical setting

Background: Juvenile Arthritis Disease Activity Score (JADAS) is a 4 variable composite disease activity (DA) score for JIA (including active 10, 27 or 71 joint count (AJC), physician global (PGA), parent/child global (PGE) and ESR). The validity of JADAS for all ILAR subtypes in the routine clinical setting is unknown. We investigated the construct validity of JADAS in the clinical setting in all subtypes of JIA through application to a prospective inception cohort of UK children presenting with new onset inflammatory arthritis. Methods: JADAS 10, 27 and 71 were determined for all children in the Childhood Arthritis Prospective Study (CAPS) with complete data available at baseline. Correlation of JADAS 10, 27 and 71 with single DA markers was determined for all subtypes. All correlations were calculated using Spearman's rank statistic. Results: 262/1238 visits had sufficient data for calculation of JADAS (1028 (83%) AJC, 744 (60%) PGA, 843 (68%) PGE and 459 (37%) ESR). Median age at disease onset was 6.0 years (IQR 2.6-10.4) and 64% were female. Correlation between JADAS 10, 27 and 71 approached 1 for all subtypes. Median JADAS 71 was 5.3 (IQR 2.2-10.1) with a significant difference between median JADAS scores between subtypes (p < 0.01). Correlation of JADAS 71 with each single marker of DA was moderate to high in the total cohort (see Table 1). Overall, correlation with AJC, PGA and PGE was moderate to high and correlation with ESR, limited JC, parental pain and CHAQ was low to moderate in the individual subtypes. Correlation coefficients in the extended oligoarticular, rheumatoid factor negative and enthesitis related subtypes were interpreted with caution in view of low numbers. Conclusions: This study adds to the body of evidence supporting the construct validity of JADAS. JADAS correlates with other measures of DA in all ILAR subtypes in the routine clinical setting. Given the high frequency of missing ESR data, it would be useful to assess the validity of JADAS without inclusion of the ESR. Disclosure statement: All authors have declared no conflicts of interest. Table 1Spearman's correlation between JADAS 71 and single markers DA by ILAR subtype ILAR Subtype Systemic onset JIA Persistent oligo JIA Extended oligo JIA Rheumatoid factor neg JIA Rheumatoid factor pos JIA Enthesitis related JIA Psoriatic JIA Undifferentiated JIA Unknown subtype Total cohort Number of children 23 111 12 57 7 9 19 7 17 262 AJC 0.54 0.67 0.53 0.75 0.53 0.34 0.59 0.81 0.37 0.59 PGA 0.63 0.69 0.25 0.73 0.14 0.05 0.50 0.83 0.56 0.64 PGE 0.51 0.68 0.83 0.61 0.41 0.69 0.71 0.9 0.48 0.61 ESR 0.28 0.31 0.35 0.4 0.6 0.85 0.43 0.7 0.5 0.53 Limited 71 JC 0.29 0.51 0.23 0.37 0.14 -0.12 0.4 0.81 0.45 0.41 Parental pain 0.23 0.62 0.03 0.57 0.41 0.69 0.7 0.79 0.42 0.53 Childhood health assessment questionnaire 0.25 0.57 -0.07 0.36 -0.47 0.84 0.37 0.8 0.66 0.4

Prevalence and architecture of de novo mutations in developmental disorders.

The genomes of individuals with severe, undiagnosed developmental disorders are enriched in damaging de novo mutations (DNMs) in developmentally important genes. Here we have sequenced the exomes of 4,293 families containing individuals with developmental disorders, and meta-analysed these data with data from another 3,287 individuals with similar disorders. We show that the most important factors influencing the diagnostic yield of DNMs are the sex of the affected individual, the relatedness of their parents, whether close relatives are affected and the parental ages. We identified 94 genes enriched in damaging DNMs, including 14 that previously lacked compelling evidence of involvement in developmental disorders. We have also characterized the phenotypic diversity among these disorders. We estimate that 42% of our cohort carry pathogenic DNMs in coding sequences; approximately half of these DNMs disrupt gene function and the remainder result in altered protein function. We estimate that developmental disorders caused by DNMs have an average prevalence of 1 in 213 to 1 in 448 births, depending on parental age. Given current global demographics, this equates to almost 400,000 children born per year

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements