Selectivity of saflufenacil applied alone or mixed to glyphosate in maize.

The use of selective herbicides is important for weed management in agricultural crops. Selectivity studies of new molecules are really important to expand the control options of glyphosate-resistant and -tolerant eudicotyledons in corn. The objective of this work was to evaluate the selectivity of the herbicide saflufenacil applied alone in different doses in post-emergence of corn and in a mixture with glyphosate. The design used was randomized blocks, with four replications, with treatments consisting of five doses of saflufenacil, applied alone and in a mixture with a fixed dose of glyphosate, in addition to the weeded control and only glyphosate. At 7, 14, 21 and 28 days after application (DAT), the phytotoxicity of the herbicides to the crop was evaluated. The physiological variables were measured at 35 DAT. At harvest, yield components were determined, in addition to the mass of 1,000 grains and grain yield. The application of the mixture of glyphosate with saflufenacil increases phytotoxicity symptoms and yield losses. Doses of up to 70 g ha-1, applied alone, caused low phytotoxicity to corn and did not interfere in yield. The use of glyphosate + saflufenacil tank mixtures caused decreases in yield of 43.96 and 40.81% when compared, respectively, with the weeded control and the averages of the applications of the herbicides alone. Saflufenacil has the potential to be used in the management of eudicotyledonous weeds, as long as it is not mixed with glyphosate and the dose limit is respected

Conservação e uso dos recursos florestais não madeiráveis da floresta com araucária: Programa Conservabio.

bitstream/item/123223/1/Doc.-238-Conservabio.pd

Efficacy and safety of N-acetyl-GED-0507-34-LEVO gel in patients with moderate-to severe facial acne vulgaris: A phase 2B randomised double-blind, vehicle-controlled trial.

Background: Preliminary in vitro and in vivo studies have supported the efficacy of the peroxisome proliferator-activated receptor-γ (PPARγ) modulator N-acetyl-GED-0507-34-LEVO (NAC-GED) for the treatment of acne-inducing sebocyte differentiation, improving sebum composition and controlling the inflammatory process. Objectives: To evaluate the efficacy and safety of NAC-GED (5% and 2%) in patients with moderate-to-severe facial acne vulgaris. Methods: This double-blind phase II randomized controlled clinical trial was conducted at 36 sites in Germany, Italy and Poland. Patients aged 12-30 years with facial acne, an Investigator Global Assessment (IGA) score of 3-4, and an inflammatory and noninflammatory lesion count of 20-100 were randomized to topical application of the study drug (2% or 5%) or placebo (vehicle), once daily for 12 weeks. The co-primary efficacy endpoints were percentage change from baseline in total lesion count (TLC) and IGA success at week 12; the safety endpoints were adverse events (AEs) and serious AEs. This study was registered with EudraCT (2018-003307-19). Results: Between Q1 in 2019 and Q1 in 2020 450 patients [n = 418 (92·9%) IGA 3; n = 32 (7·1%) IGA 4] were randomly assigned to NAC-GED 5% (n = 150), NAC-GED 2% (n = 150) or vehicle (n = 150). The percentage change in TLC reduction was statistically significantly higher in both the NAC-GED 5% [-57·1%, 95% confidence interval (CI) -60·8 to -53·4; P < 0·001] and NAC-GED 2% (-44·7%, 95% CI -49·1 to -40·1; P < 0·001) groups compared with vehicle (-33·9%, 95% CI -37·6 to -30·2). A higher proportion of patients treated with NAC-GED 5% experienced IGA success (45%, 95% CI 38-53) vs. the vehicle group (24%, 95% CI 18-31; P < 0·001). The IGA success rate was 33% in the NAC-GED 2% group (P = not significant vs. vehicle). The percentage of patients who had one or more AEs was 19%, 16% and 19% in the NAC-GED 5%, NAC-GED 2% and vehicle groups, respectively. Conclusions: The topical application of NAC-GED 5% reduced TLC, increased the IGA success rate and was safe for use in patients with acne vulgaris. Thus, NAC-GED, a new PPARγ modulator, showed an effective clinical response. What is already known about this topic? Acne vulgaris, one of the most common dermatological diseases, affects more than 85% of adolescents. There is a medical need for innovative and safe treatment of acne vulgaris. The peroxisome proliferator-activated receptor-γ (PPARγ) is involved in lipid metabolism and specifically in cell differentiation, sebum production and the inflammatory reaction. What does this study add? N-acetyl-GED-0507-34-LEVO (NAC-GED 5%), a PPARγ modulator, significantly improves acne manifestations in patients with moderate-to-severe acne and is safe and well tolerated. The results suggest that the PPARγ receptor is a novel therapeutic target for acne. The results provide a basis for a large phase III trial to assess the effectiveness and safety profile of NAC-GED in combating a disease that afflicts 80-90% of adolescents

Deviation of the Shape of Bennu from Rotational Figures of Stability

Images of asteroid (101955) Bennu acquired by the OSIRIS-REx mission reveal a rocky world covered in rubble; Shape deviates from hydrostatic surface; Internal friction and/or cohesion even if no tensile strength; Understanding the deviation of the surface from idealized shape may help constrain mechanical properties of the interior; Geologic evolution of Bennu is driven by downslope migration of surface material and rubble; May be caused by YORP-induced spin-up, re-accumulation, impact-induced seismic shaking, thermal stresses, or tidal disruption by close encounters to larger bodies

Conhecimento ecológico local, conservação e uso de recursos vegetais no entorno da Flona de Três Barras: informações preliminares.

Foi realizado um levantamento etnobotânico no entorno da FLONA de Três Barras com o objetivo de conhecer as principais espécies usadas por moradores de comunidades que interagem com os remanescentes de Floresta Ombrófila Mista. Este levantamento subsidia o Projeto ?Rede para geração do conhecimento na conservação e utilização sustentável dos recursos florestais não madeiráveis da Floresta Ombrófila Mista?, Conservabio, que pretende combinar o conhecimento científico ao conhecimento tradicional. O trabalho foi desenvolvido nas comunidades de Colônia da Escada, Município de Irineópolis, e na comunidade de Campininha, Município de Três Barras, ambas em SC. Foram usadas ferramentas da pesquisa participativa, combinadas às ferramentas da pesquisa etnobotânica. Foram citadas 142 espécies em Colônia da Escada, com total de 362 citações de usos, enquanto que em Campininha foram citadas 97 espécies, totalizando 247 usos. Foram realizadas oficinas para determinar quais seriam as espécies prioritárias, chegando a um consenso sobre aquelas mais importantes em cada comunidade. Para cada espécie foram ainda discutidas as principais demandas existentes entre os moradores locais. A construção desta lista final combina as perspectivas e habilidades dos pesquisadores, interessados na autoecologia das espécies, na genética dessas populações, na organização e manejo das paisagens antrópicas, assim como das cadeias produtivas atuais e potenciais, aos conhecimentos tradicionais locais e demandas dos moradores em relação às espécies.Resumo expandido

Measurement of the cross-section and charge asymmetry of WW bosons produced in proton-proton collisions at s=8\sqrt{s}=8 TeV with the ATLAS detector

This paper presents measurements of the $W^+ \rightarrow \mu^+\nu$ and $W^- \rightarrow \mu^-\nu$ cross-sections and the associated charge asymmetry as a function of the absolute pseudorapidity of the decay muon. The data were collected in proton--proton collisions at a centre-of-mass energy of 8 TeV with the ATLAS experiment at the LHC and correspond to a total integrated luminosity of 20.2~\mbox{fb^{-1}}. The precision of the cross-section measurements varies between 0.8% to 1.5% as a function of the pseudorapidity, excluding the 1.9% uncertainty on the integrated luminosity. The charge asymmetry is measured with an uncertainty between 0.002 and 0.003. The results are compared with predictions based on next-to-next-to-leading-order calculations with various parton distribution functions and have the sensitivity to discriminate between them.Comment: 38 pages in total, author list starting page 22, 5 figures, 4 tables, submitted to EPJC. All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2017-13

Search for chargino-neutralino production with mass splittings near the electroweak scale in three-lepton final states in √s=13 TeV pp collisions with the ATLAS detector

A search for supersymmetry through the pair production of electroweakinos with mass splittings near the electroweak scale and decaying via on-shell W and Z bosons is presented for a three-lepton final state. The analyzed proton-proton collision data taken at a center-of-mass energy of √s=13  TeV were collected between 2015 and 2018 by the ATLAS experiment at the Large Hadron Collider, corresponding to an integrated luminosity of 139  fb−1. A search, emulating the recursive jigsaw reconstruction technique with easily reproducible laboratory-frame variables, is performed. The two excesses observed in the 2015–2016 data recursive jigsaw analysis in the low-mass three-lepton phase space are reproduced. Results with the full data set are in agreement with the Standard Model expectations. They are interpreted to set exclusion limits at the 95% confidence level on simplified models of chargino-neutralino pair production for masses up to 345 GeV

Search for direct stau production in events with two hadronic tau-leptons in root s=13 TeV pp collisions with the ATLAS detector

A search for the direct production of the supersymmetric partners ofτ-leptons (staus) in final stateswith two hadronically decayingτ-leptons is presented. The analysis uses a dataset of pp collisions corresponding to an integrated luminosity of139fb−1, recorded with the ATLAS detector at the LargeHadron Collider at a center-of-mass energy of 13 TeV. No significant deviation from the expected StandardModel background is observed. Limits are derived in scenarios of direct production of stau pairs with eachstau decaying into the stable lightest neutralino and oneτ-lepton in simplified models where the two staumass eigenstates are degenerate. Stau masses from 120 GeV to 390 GeV are excluded at 95% confidencelevel for a massless lightest neutralino

Hemispherical differences in the shape and topography of asteroid (101955) Bennu

We investigate the shape of near-Earth asteroid (101955) Bennu by constructing a high-resolution (20 cm) global digital terrain model from laser altimeter data. By modeling the northern and southern hemispheres separately, we find that longitudinal ridges previously identified in the north extend into the south but are obscured there by surface material. In the south, more numerous large boulders effectively retain surface materials and imply a higher average strength at depth to support them. The north has fewer large boulders and more evidence of boulder dynamics (toppling and downslope movement) and surface flow. These factors result in Bennu’s southern hemisphere being rounder and smoother, whereas its northern hemisphere has higher slopes and a less regular shape. We infer an originally asymmetric distribution of large boulders followed by a partial disruption, leading to wedge formation in Bennu’s history

Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector

Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente