Implementation of absolute quantification in small-animal SPECT imaging: Phantom and animal studies

Purpose: Presence of photon attenuation severely challenges quantitative accuracy in single-photon emission computed tomography (SPECT) imaging. Subsequently, various attenuation correction methods have been developed to compensate for this degradation. The present study aims to implement an attenuation correction method and then to evaluate quantification accuracy of attenuation correction in small-animal SPECT imaging. Methods: Images were reconstructed using an iterative reconstruction method based on the maximum-likelihood expectation maximization (MLEM) algorithm including resolution recovery. This was implemented in our designed dedicated small-animal SPECT (HiReSPECT) system. For accurate quantification, the voxel values were converted to activity concentration via a calculated calibration factor. An attenuation correction algorithm was developed based on the first-order Chang’s method. Both phantom study and experimental measurements with four rats were used in order to validate the proposed method. Results: The phantom experiments showed that the error of �15.5% in the estimation of activity concentration in a uniform region was reduced to +5.1% when attenuation correction was applied. For in vivo studies, the average quantitative error of �22.8 � 6.3% (ranging from �31.2% to �14.8%) in the uncorrected images was reduced to +3.5 � 6.7% (ranging from �6.7 to +9.8%) after applying attenuation correction. Conclusion: The results indicate that the proposed attenuation correction algorithm based on the first-order Chang’s method, as implemented in our dedicated small-animal SPECT system, significantly improves accuracy of the quantitative analysis as well as the absolute quantification

Study of Fast Transient Pressure Drop in VVER-1000 Nuclear Reactor Using Acoustic Phenomenon

This article aims to simulate the sudden and fast pressure drop of VVER-1000 reactor core coolant, regarding acoustic phenomenon. It is used to acquire a more accurate method in order to simulate the various accidents of reactor core. Neutronic equations should be solved concurrently by means of DRAGON 4 and DONJON 4 coupling codes. The results of the developed package are compared with WIMS/CITATION and final safety analysis report of Bushehr VVER-1000 reactor (FSAR). Afterwards, time dependent thermal-hydraulic equations are answered by employing Single Heated Channel by Sectionalized Compressible Fluid method. Then, the obtained results were validated by the same transient simulation in a pressurized water reactor core. Then, thermal-hydraulic and neutronic modules are coupled concurrently by use of producing group constants regarding the thermal feedback effect. Results were compared to the mentioned transient simulation in RELAP5 computer code, which show that mass flux drop is sensed at the end of channel in several milliseconds which causes heat flux drop too. The thermal feedback resulted in production of some perturbations in the changes of these parameters. The achieved results for this very fast pressure drop represent accurate calculations of thermoneutronic parameters fast changes

Common-Ground-Type Single-Source High Step-Up Cascaded Multilevel Inverter for Transformerless PV Applications

The cascaded multilevel inverter (CMI) is one type of common inverter in industrial applications. This type of inverter can be synthesized either as a symmetric configuration with several identical H-bridge (HB) cells or as an asymmetric configuration with non-identical HB cells. In photovoltaic (PV) applications with the CMI, the PV modules can be used to replace the isolated dc sources; however, this brings inter-module leakage currents. To tackle the issue, the single-source CMI is preferred. Furthermore, in a grid-tied PV system, the main constraint is the capacitive leakage current. This problem can be addressed by providing a common ground, which is shared by PV modules and the ac grid. This paper thus proposes a topology that fulfills the mentioned requirements and thus, CMI is a promising inverter with wide-ranging industrial uses, such as PV applications. The proposed CMI topology also features high boosting capability, fault current limiting, and a transformerless configuration. To demonstrate the capabilities of this CMI, simulations and experimental results are provided

A new boost switched capacitor seven-level grid-tied inverter

In this paper, a new switched capacitor-based multilevel inverter structure is suggested. The proposed topology can generate seven-level output voltage waveform using ten power electronic switches and two floating capacitors. This structure has the ability to boost the input DC voltage, up to 1.5 times. Although this topology can generate an output waveform with large number of levels, it does not increase the voltage stress on the power electronic switches. There is no need for capacitor voltage balancing in this structure since the capacitors are balanced through charging and discharging modes of operation. In addition, the suggested switched capacitor inverter reduces the number of input dc power supplies and uses a single dc source such as a photovoltaic (PV) panel. Since the proposed inverter is an neutral point clamp based multilevel inverter topology, the leakage current is minimized and as a result the overall efficiency of the proposed system is increased. The operation modes and steady-state analysis of the proposed structure are explained in detail. In order to validate the feasibility of the proposed topology, some experimental results are presented in the grid connected mode of operation

Implementation of absolute quantification in small-animal SPECT imaging: Phantom and animal studies

Purpose: Presence of photon attenuation severely challenges quantitative accuracy in single-photon emission computed tomography (SPECT) imaging. Subsequently, various attenuation correction methods have been developed to compensate for this degradation. The present study aims to implement an attenuation correction method and then to evaluate quantification accuracy of attenuation correction in small-animal SPECT imaging. Methods: Images were reconstructed using an iterative reconstruction method based on the maximum-likelihood expectation maximization (MLEM) algorithm including resolution recovery. This was implemented in our designed dedicated small-animal SPECT (HiReSPECT) system. For accurate quantification, the voxel values were converted to activity concentration via a calculated calibration factor. An attenuation correction algorithm was developed based on the first-order Chang’s method. Both phantom study and experimental measurements with four rats were used in order to validate the proposed method. Results: The phantom experiments showed that the error of �15.5% in the estimation of activity concentration in a uniform region was reduced to +5.1% when attenuation correction was applied. For in vivo studies, the average quantitative error of �22.8 � 6.3% (ranging from �31.2% to �14.8%) in the uncorrected images was reduced to +3.5 � 6.7% (ranging from �6.7 to +9.8%) after applying attenuation correction. Conclusion: The results indicate that the proposed attenuation correction algorithm based on the first-order Chang’s method, as implemented in our dedicated small-animal SPECT system, significantly improves accuracy of the quantitative analysis as well as the absolute quantification

An improved nine‐level switched capacitor‐based inverter with voltage boosting capability and limitation of capacitor current spikes for PV applications

To proceed to a net zero carbon world and to mitigate the environmental challenges associated with it, integration speed of renewable energy sources such as photovoltaic (PV) systems has been increased around the world. Here, an improved switched-capacitor based nine-level inverter is introduced for PV applications. This topology has several benefits such as, voltage boosting feature, using a single DC source, reduction of capacitor charging current spike and extendable input voltage. This inverter produces nine-level output voltage waveform using single power supply. This topology, using identical two capacitors in parallel with a single DC source, can boost the input voltage. In this inverter to limit spike current of capacitor charging mode, an inductor is placed in the charging path of capacitors with a parallel diode. The power losses and overall efficiency analysis of the improved inverter are considered. To verify the accurate performance of inverter under a step change on power flows, simulation results are obtained by MATLAB/Simulink software and presented. To highlight the benefits of the inverter, a comparison of improved topology with most recent topologies is performed. Finally, to verify the feasibility and performance of the improved inverter, experimental results of a 770 W grid-tied prototype are presented

Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-Adjusted life-years for 29 cancer groups, 1990 to 2017 : A systematic analysis for the global burden of disease study

Importance: Cancer and other noncommunicable diseases (NCDs) are now widely recognized as a threat to global development. The latest United Nations high-level meeting on NCDs reaffirmed this observation and also highlighted the slow progress in meeting the 2011 Political Declaration on the Prevention and Control of Noncommunicable Diseases and the third Sustainable Development Goal. Lack of situational analyses, priority setting, and budgeting have been identified as major obstacles in achieving these goals. All of these have in common that they require information on the local cancer epidemiology. The Global Burden of Disease (GBD) study is uniquely poised to provide these crucial data. Objective: To describe cancer burden for 29 cancer groups in 195 countries from 1990 through 2017 to provide data needed for cancer control planning. Evidence Review: We used the GBD study estimation methods to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-Adjusted life-years (DALYs). Results are presented at the national level as well as by Socio-demographic Index (SDI), a composite indicator of income, educational attainment, and total fertility rate. We also analyzed the influence of the epidemiological vs the demographic transition on cancer incidence. Findings: In 2017, there were 24.5 million incident cancer cases worldwide (16.8 million without nonmelanoma skin cancer [NMSC]) and 9.6 million cancer deaths. The majority of cancer DALYs came from years of life lost (97%), and only 3% came from years lived with disability. The odds of developing cancer were the lowest in the low SDI quintile (1 in 7) and the highest in the high SDI quintile (1 in 2) for both sexes. In 2017, the most common incident cancers in men were NMSC (4.3 million incident cases); tracheal, bronchus, and lung (TBL) cancer (1.5 million incident cases); and prostate cancer (1.3 million incident cases). The most common causes of cancer deaths and DALYs for men were TBL cancer (1.3 million deaths and 28.4 million DALYs), liver cancer (572000 deaths and 15.2 million DALYs), and stomach cancer (542000 deaths and 12.2 million DALYs). For women in 2017, the most common incident cancers were NMSC (3.3 million incident cases), breast cancer (1.9 million incident cases), and colorectal cancer (819000 incident cases). The leading causes of cancer deaths and DALYs for women were breast cancer (601000 deaths and 17.4 million DALYs), TBL cancer (596000 deaths and 12.6 million DALYs), and colorectal cancer (414000 deaths and 8.3 million DALYs). Conclusions and Relevance: The national epidemiological profiles of cancer burden in the GBD study show large heterogeneities, which are a reflection of different exposures to risk factors, economic settings, lifestyles, and access to care and screening. The GBD study can be used by policy makers and other stakeholders to develop and improve national and local cancer control in order to achieve the global targets and improve equity in cancer care. © 2019 American Medical Association. All rights reserved.Peer reviewe

Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.

The Global Burden of Diseases, Injuries and Risk Factors 2017 includes a comprehensive assessment of incidence, prevalence, and years lived with disability (YLDs) for 354 causes in 195 countries and territories from 1990 to 2017. Previous GBD studies have shown how the decline of mortality rates from 1990 to 2016 has led to an increase in life expectancy, an ageing global population, and an expansion of the non-fatal burden of disease and injury. These studies have also shown how a substantial portion of the world's population experiences non-fatal health loss with considerable heterogeneity among different causes, locations, ages, and sexes. Ongoing objectives of the GBD study include increasing the level of estimation detail, improving analytical strategies, and increasing the amount of high-quality data. METHODS: We estimated incidence and prevalence for 354 diseases and injuries and 3484 sequelae. We used an updated and extensive body of literature studies, survey data, surveillance data, inpatient admission records, outpatient visit records, and health insurance claims, and additionally used results from cause of death models to inform estimates using a total of 68 781 data sources. Newly available clinical data from India, Iran, Japan, Jordan, Nepal, China, Brazil, Norway, and Italy were incorporated, as well as updated claims data from the USA and new claims data from Taiwan (province of China) and Singapore. We used DisMod-MR 2.1, a Bayesian meta-regression tool, as the main method of estimation, ensuring consistency between rates of incidence, prevalence, remission, and cause of death for each condition. YLDs were estimated as the product of a prevalence estimate and a disability weight for health states of each mutually exclusive sequela, adjusted for comorbidity. We updated the Socio-demographic Index (SDI), a summary development indicator of income per capita, years of schooling, and total fertility rate. Additionally, we calculated differences between male and female YLDs to identify divergent trends across sexes. GBD 2017 complies with the Guidelines for Accurate and Transparent Health Estimates Reporting