93 research outputs found
Brain structural changes during juvenile fibromyalgia: relationships with pain, fatigue and functional disability
- Author
- Publication venue
- 'Wiley'
- Publication date
- 01/07/2022
- Field of study
Objective: Juvenile fibromyalgia (FM) is a prevalent chronic pain condition affecting children and adolescents worldwide during a critical period of brain development. To date, no published studies have addressed the pathophysiology of juvenile FM. This study was undertaken to characterize gray matter volume (GMV) alterations in juvenile FM patients for the first time, and to investigate their functional and clinical relevance. Methods: Thirty-four female adolescents with juvenile FM and 38 healthy adolescents underwent a structural magnetic resonance imaging examination and completed questionnaires assessing core juvenile FM symptoms. Using voxel-based morphometry, we assessed between-group GMV differences and associations between GMV and functional disability, fatigue, and pain interference in juvenile FM. We also studied whether validated brain patterns predicting pain, cognitive control, or negative emotion were amplified/attenuated in juvenile FM patients and whether structural alterations reported in adult FM were replicated in adolescents with juvenile FM. Results: Compared to controls, juvenile FM patients showed GMV reductions in the anterior midcingulate cortex (aMCC) region (family-wise error corrected P [PFWE-corr ] = 0.04; estimated with threshold-free cluster enhancement [TFCE]; n = 72) associated with pain. Within the juvenile FM group, patients reporting higher functional disability had larger GMV in inferior frontal regions (PFWE-corr = 0.006; TFCE estimated; n = 34) linked to affective, self-referential, and language-related processes. Last, GMV reductions in juvenile FM showed partial overlap with findings in adult FM, specifically for the anterior/posterior cingulate cortices (P = 0.02 and P = 0.03, respectively; n = 72). Conclusion: Pain-related aMCC reductions may be a structural hallmark of juvenile FM, whereas alterations in regions involved in emotional, self-referential, and language-related processes may predict disease impact on patients' well-being. The partial overlap between juvenile and adult FM findings strengthens the importance of early symptom identification and intervention to prevent the transition to adult forms of the disease
Psychological Reactions to COVID-19: Survey Data Assessing Perceived Susceptibility, Distress, Mindfulness, and Preventive Health Behaviors
- Author
- Publication venue
- ScholarWorks@BGSU
- Publication date
- 30/12/2020
- Field of study
The COVID-19 pandemic created a complex psychological environment for persons in America. A total of 450 USA MTurk workers completed measures of: (a) basic demographic characteristics; (b) health risk factors for COVID-19; (c) perceived susceptibility variables related to COVID-19; (d) COVID-19 preventive health behaviors; and (e) distress, physical symptoms, and quality of life measures. The surveys were completed between April 9, 2020 and April 18, 2020. This recruitment period corresponded to the first 2-3 weeks of lockdown in most of the USA. Follow-up surveys were completed by 151 of the USA participants between June 19, 2020 and July 11, 2020 (approximately 2 months after the first measurement). These data permit evaluation of relationships among demographic variables, COVID-19 stress and coping, COVID-19 preventive health behavior, and the role of mindfulness as a possible moderator of distress as well as a predictor of preventive health behavior. The availability of follow-up data permit longitudinal analyses that provide a stronger basis for causal inference
Understanding Face and Shame: A Servant-Leadership and Face Management Model
- Author
- Bailey K. E.
- Beazley H.
- Bloomquist K. L.
- Bobgan M.
- Branson M. L.
- Broomhall R.
- Broucek F. J.
- Colaizzi P. F.
- Cowles C. S.
- Creswell J. W.
- Dolezal L.
- Elias N.
- Ferch S. R.
- Fitzgibbons R.
- Frankl V. E.
- Giddens A.
- Goffman E.
- Goffman E.
- Greenleaf R. K.
- Gushee D. P.
- Hays R. B.
- Holden D. E.
- Horney K.
- Howe E. M.
- Hutcheson R. G. Jr.
- Johnson D.
- Kroeger C. C.
- Liden R. C.
- Lin Y.
- Lohse K. E.
- Morrison A. P.
- North J.
- Palmer P. J.
- Patterson K.
- Ruether R. R.
- Scazzero P.
- Schirrmacher T.
- Song J.
- Sterland S.
- Straus E. W.
- Sturnick J. A.
- Sun Y.
- Tajfel H.
- Taylor C.
- Ting-Toomey S.
- Ting-Toomey S.
- Ting-Toomey S.
- Tracy K.
- van Kaam A.
- VanVonderen J.
- Webb W. J.
- West T. C.
- Worthington E. L.
- Zhai X. W.
- Publication venue
- Digital Commons @ George Fox University
- Publication date
- 21/01/2019
- Field of study
Clergy can have a negative impact on churches and other individuals when they knowingly or unknowingly attempt to save face, that is, try to protect their standing or reputation. The desire to gain face and the fear of losing face and feeling ashamed will likely permeate clergyâs decision-making processes without even being noticed. This study explores the essence of face and face management and the relationship between face management and two characteristics of servant-leadershipâawareness and healingâin both Chinese and American churches through the methodology of hermeneutic phenomenology. Prior to this study, to my knowledge, no hermeneutic phenomenological research of face management has been conducted in a church setting. Through a review of the literature, four areas are explored: face and shame, face management, servant-leadership, and face, shame, and face management within the church. This study obtained approval from the Institutional Review Board and informed consent from the participants. Three Chinese and three American Christian ministers were chosen to complete a question sheet and participate in two semi-structured interview sessions. A first cycle of open coding and second cycle of pattern coding were used during data analysis. Face experiences are discussed in light of eight major themes: body, triggers, becoming, face concepts, strategies, emotions, servant-leadership, and the church. Findings from the study help build a servant-leadership and face management model, which can offer an anchored approach for clergy and pastoral counselors to address face and shame and to develop therapeutic interventions
The role of benign joint hypermobility in the pain experience in Juvenile Fibromyalgia: an observational study
- Author
- A Gedalia
- A Sacheti
- AG Finley
- Anjali M Desai
- C Carter
- D Buskila
- D Buskila
- D Ofluoglu
- DM Siegel
- DM Wahezi
- F Wolfe
- G Vargas-Alarcon
- H Cohen
- Kenneth Schikler
- M Di Franco
- M Meeus
- MB Yunus
- N Adib
- OF Sendur
- P Beighton
- Philip J Hashkes
- PJ Degotardi
- PJ McGrath
- R Grahame
- R Staud
- RM Bennett
- S Kashikar-Zuck
- S Kashikar-Zuck
- S Stephens
- Steven Spalding
- Susmita Kashikar-Zuck
- Tracy V Ting
- V Leone
- Y Gazit
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar M. S.
- Abdel-Aziz M.
- Abdelrazik M.
- Abdollahi H.
- Abdullah T.
- Abecasis G. R.
- Abedalthagafi M.
- Abel L.
- Abernathy C.
- Abraheem A.
- Abul-Husn N. S.
- Acquilini D.
- Adams C.
- Adams E. L.
- Adams K.
- Adamsara A.
- Adanini O.
- Adeleye O.
- Adra D.
- Afilalo J.
- Afilalo M.
- Afolabi D.
- Afrasiabi Z.
- Agasou A.
- Agrawal S.
- Aguero D.
- Ahmad N.
- Ahmadi S.
- Ahmed A.
- Ahmed C.
- Akeroyd L.
- Akhtar M. N.
- Akinkugbe O.
- Aksentijevich A.
- Al-Afghani H.
- Al-Awdah L.
- Alaamery M.
- Alahmadey Z. Z.
- Alaverdian D.
- Alavere H.
- Albader A.
- Albaiceta G. M.
- Albakri J. K.
- AlBardis H.
- Albeladi M.
- Albesher N.
- Albrich W.
- AlDhawi N.
- Aldridge J.
- Aleagha A. E.
- Alexander P.
- Alfonso J.
- Alghamdi B.
- Alghamdi J.
- Ali A.
- Ali A.
- Ali I. A. M.
- Ali S.
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- Aljawini N.
- AlJohani S.
- Alkwai S.
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- Alldis Z.
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- AlMalik A.
- Almalki F.
- Almohammed I.
- Almutairi M.
- Alotaibi S.
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- Wyllie D. H.
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- Zongo O.
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2â4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genesâincluding reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)âin critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.
- Author
- A Aouacheria
- A Aouacheria
- A Aranovich
- A Ashkenazi
- A Ashkenazi
- A Ashkenazi
- A Bernet
- A Buque
- A Chiche
- A Conte
- A Costanzo
- A Crockford
- A Degterev
- A Degterev
- A Dey
- A Gast
- A Gross
- A Hakkim
- A Hamacher-Brady
- A Hunger
- A Kaczmarek
- A Kamb
- A Koenig
- A Kotschy
- A Letai
- A Linkermann
- A Linkermann
- A Linkermann
- A Linkermann
- A Mousa
- A Muir
- A Mukherjee
- A Nilsson
- A Oberst
- A Oberst
- A Pagotto
- A Pyakurel
- A Rongvaux
- A Rubartelli
- A Sahaboglu
- A Seiler
- A Serrano-Puebla
- A Shamas-Din
- A Sistigu
- A Strasser
- A Strasser
- A Strasser
- A Strasser
- A Strasser
- A Strasser
- A Sumoza-Toledo
- A Sundararaman
- A Tittarelli
- A Trautmann
- A Villunger
- A Witt
- A Zychlinsky
- AA Fatokun
- AA Mailleux
- Aaron Ciechanover
- AB Pardee
- Abhishek D. Garg
- AC Bellail
- AC Schinzel
- AD Garg
- AD Garg
- AD Garg
- AD Garg
- AD Garg
- AD Garg
- AD Garg
- Adi Kimchi
- AE Alsop
- AE Feldstein
- AJ Schile
- AL Anding
- AL Genevois
- Alexey V. Antonov
- AM Chinnaiyan
- AM Distefano
- AM Dudek
- AM Verhagen
- AN Antony
- AN Barclay
- Ana J. GarcĂa-SĂĄez
- Andreas Linkermann
- Andreas Strasser
- Andreas Villunger
- Andrew Oberst
- Andrew Thorburn
- Antonella Sistigu
- AP West
- AR Delbridge
- AT Schneider
- AT Ting
- AT Ting
- Atan Gross
- AV Follis
- AV Jacobsen
- AV Vaseva
- AV Vaseva
- AW Roberts
- B Antonsson
- B Aslan
- B Conradt
- B Fadeel
- B Gerlach
- B Gibert
- B Gooptu
- B McDonald
- B Schellenberg
- B Van Do
- B Xia
- BA Carlson
- BA Hilton
- BA Napier
- BB Aggarwal
- BC Barnhart
- Bertrand Joseph
- Beth Levine
- BG Childs
- BG Childs
- BG Childs
- BG Lambrus
- BG Yipp
- Boris Turk
- Boris Zhivotovsky
- BP Eckelman
- BP Eckelman
- BR Stockwell
- Brent R. Stockwell
- Brian D. Dynlacht
- BT Cookson
- C Bergmann
- C Dominguez-Brauer
- C Du
- C Frezza
- C Gerle
- C Guenebeaud
- C Gunther
- C Gunther
- C Helmke
- C Hernandez
- C Hockings
- C Lood
- C Lopez-Garcia
- C Lopez-Otin
- C Lopez-Otin
- C Louandre
- C Louandre
- C Nelson
- C Oberle
- C Piot
- C Rogers
- C Scaffidi
- C Vanpouille-Box
- C White
- C Xie
- Carlos LĂłpez-OtĂn
- Carmen Garrido
- Catherine Brenner
- CC Wu
- CD Simpson
- CD Wiley
- Cecilia M.P. Rodrigues
- CF Wenceslau
- Christoph Borner
- CJ Kearney
- CK Ea
- CK Lam
- CK McPhee
- CL Buchheit
- CL Buchheit
- CL Buchheit
- CL Case
- Claudio Hetz
- CM Henry
- CN Casson
- Colin S. Duckett
- CP Baines
- CP Baines
- CP Dillon
- CP Dillon
- CP Dillon
- Cristina Muñoz-Pinedo
- CT Tan
- D Brenner
- D Brough
- D Chen
- D Crighton
- D Denton
- D Denton
- D Denton
- D Denton
- D Denton
- D Denton
- D Gatica
- D Goldschneider
- D Kranz
- D Li
- D Malin
- D Martin-Sanchez
- D Merino
- D Munoz-Espin
- D Piani
- D Ren
- D Stojkov
- D Tang
- D Tang
- D Vercammen
- D Vercammen
- D Wallach
- D Weaver
- D Yang
- DA Flusberg
- DA Rodriguez
- Daniel J. Klionsky
- Daolin Tang
- David C. Rubinsztein
- David M. Pereira
- David W. Andrews
- David Wallach
- DC Gray
- DH Cho
- Didac Carmona-Gutierrez
- Dieter Adam
- DJ Baker
- DJ Baker
- DJ Klionsky
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- Domagoj Vucic
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- E Lachaier
- E Lafont
- E Meunier
- E Perez
- E Vacchelli
- E Varfolomeev
- E Venereau
- E Zandi
- E Zandi
- EA Miao
- Edward A. Miao
- EF Lee
- EH Cheng
- EH Cheng
- EH Hinchcliffe
- EJ Park
- Eleonora Candi
- Eli Arama
- Emad S. Alnemri
- Emily H. Cheng
- Emre Sayan
- Enrico Lugli
- Eric H. Baehrecke
- Erwin F. Wagner
- Evripidis Gavathiotis
- EY Bassoy
- Eyal Gottlieb
- F Basit
- F Chalmin
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- F Edlich
- F Ghiringhelli
- F Ke
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- F Llambi
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- F Llambi
- F Loison
- F Madeo
- F Martin-Sanchez
- F McNab
- F Meitinger
- F Mille
- F Pietrocola
- F Todt
- F Wartha
- FB Chekeni
- FC Kischkel
- Feng Shao
- FK Chan
- FK Chan
- FL Scott
- FM Menzies
- FM Menzies
- FR Greten
- Francesca Bernassola
- Francesco Cecconi
- Francesco Di Virgilio
- Francis K.-M. Chan
- Frank Madeo
- G Brumatti
- G Casinelli
- G Denecker
- G Dewson
- G Droga-Mazovec
- G Ichim
- G Ichim
- G Kroemer
- G Kroemer
- G Kroemer
- G Monaco
- G Nunez
- G Quarato
- G Sun
- Gabriel A. Rabinovich
- Gabriel Nuñez
- Gerald M. Cohen
- Gerry Melino
- Gian Maria Fimia
- GO Latunde-Dada
- GP Sims
- GS Salvesen
- Guido Kroemer
- GW Dorn 2nd
- Gwenola Manic
- Gyorgy Hajnoczky
- Gyorgy Szabadkai
- H Appelqvist
- H Dai
- H Dai
- H Du
- H Hsu
- H Imai
- H Inoue
- H Inuzuka
- H Kazama
- H Kim
- H Kim
- H Li
- H Li
- H Otera
- H Parker
- H Puthalakath
- H Puthalakath
- H Sakahira
- H Wajant
- H Wang
- H Wang
- H Wang
- H Wang
- H Wang
- H Wang
- H Yang
- H Yang
- H Yuan
- H Yuan
- H Yuan
- H Zhang
- H Zhang
- HA Park
- Hamsa Puthalakath
- Hans-Uwe Simon
- HC Chen
- HE Kamber Kaya
- Henning Walczak
- Herbert W. Virgin
- Hidenori Ichijo
- Hinrich Gronemeyer
- HL Tang
- I Adkins
- I Amelio
- I Jaco
- I Jorgensen
- I Jorgensen
- I Jorgensen
- I Maejima
- I Martins
- I Marzo
- I Poursaitidis
- I Sturmlechner
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- IE Dumitriu
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- Ilio Vitale
- IP Nezis
- IP Nezis
- IR Powley
- Isaac S. Harris
- Ivano Amelio
- J Alanko
- J Bove
- J Brojatsch
- J Campisi
- J Cedervall
- J Chai
- J Chai
- J Chang
- J Desai
- J Desai
- J Ding
- J Ding
- J Fitamant
- J Fombonne
- J Fucikova
- J Fullgrabe
- J Fullgrabe
- J Geng
- J Gilloteaux
- J He
- J He
- J Hitomi
- J Huai
- J Huun
- J Karch
- J Kaur
- J Kers
- J Kim
- J Li
- J Lin
- J Liu
- J Maelfait
- J Majkut
- J Michels
- J Nunnari
- J Nylandsted
- J Parrish
- J Pecot
- J Puccini
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- J Shi
- J Shi
- J Shi
- J Silke
- J Sosna
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- J Suzuki
- J Suzuki
- J Warne
- J Wu
- J Xu
- J Yang
- J Yu
- J Zhang
- J Zhao
- J Zou
- J. Marie Hardwick
- JA DiDonato
- JA Ewald
- JA Hagar
- JA Mason
- JA Rickard
- James A. Wells
- Jan Paul Medema
- JC Acosta
- JC Hamann
- JD Bernet
- JE Chipuk
- JE Chipuk
- JE Kokoszka
- JE Vince
- JE Vince
- Jean-Christophe Marine
- Jean-Claude Martinou
- Jeffery D. Molkentin
- Jerry E. Chipuk
- JH Woo
- JI Jun
- JJ Guan
- JJ Schulman
- JL Lin
- JM Bravo-San Pedro
- JM Brouwer
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- JM Gump
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- JM Jamison
- JM Mulcahy Levy
- JM Murphy
- JMM Levy
- Jochen H.M. Prehn
- John A. Cidlowski
- John J. Lemasters
- John M. Abrams
- John Silke
- John W. Elrod
- Josef M. Penninger
- JP Coppe
- JP Friedmann Angeli
- JPF Angeli
- JQ Kwong
- JQ Kwong
- JT Sockolosky
- JU Schweichel
- Juan R. Cubillos-Ruiz
- Junying Yuan
- JV Brower
- JV Lu
- JW Harper
- JW Upton
- JW Upton
- K Csomos
- K Eichholz
- K Huang
- K Kawane
- K Li
- K Martinod
- K Mills
- K Moriwaki
- K Moriwaki
- K Newton
- K Newton
- K Newton
- K Ruckdeschel
- K Schleich
- K Schleich
- K Segawa
- K Segawa
- K Sharma
- K Shimada
- K Tada
- K Tracy
- K Vlantis
- K Wang
- K Yacobi-Sharon
- K Zhang
- Karen H. Vousden
- Katiuscia Bianchi
- KD Metzler
- KD Metzler
- KE Gascoigne
- KE Lawlor
- Kevin M. Ryan
- KF Hsu
- KG Fleten
- KH Jang
- KH Szymczyk
- KJ Mackenzie
- KJ Neelsen
- KJ Oh
- KJ Weigel
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- KK David
- KL Lu
- KL OâNeill
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- L Antonioli
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- L Aram
- L Bezu
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- L Burri
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- L Deng
- L Dorstyn
- L Duprez
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- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
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- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
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- L Grosse
- L Groth-Pedersen
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- L Jiang
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- Lorenzo Galluzzi
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- Luca Scorrano
- Lucia Altucci
- LY Li
- M Aziz
- M Bonora
- M Bonora
- M Bonora
- M Castedo
- M Castedo
- M Castedo
- M Castedo
- M Castets
- M Colombini
- M Conrad
- M Dannappel
- M Demaria
- M Demaria
- M Demers
- M Ditzel
- M Enari
- M Fricker
- M Gao
- M Gao
- M Grandin
- M Grandin
- M Gyrd-Hansen
- M Haemmerle
- M Hayano
- M Hoare
- M Jamal-Hanjani
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- M Krajcovic
- M Krajcovic
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- M Mihara
- M Morshed
- M Moulin
- M Muzio
- M Naito
- M Nguyen-Chi
- M Obeid
- M Onizawa
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- M Pasparakis
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- M Serrano
- M Storer
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- M Wang
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- M Yabas
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- MA OâDonnell
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- Marcus E. Peter
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- Marja JÀÀttelÀ
- Markus Rehm
- Mathieu J. M. Bertrand
- Matthew G. Vander Heiden
- Mauro Piacentini
- MB Fuertes
- MC Bonnet
- MC Tanzer
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- MF Luciani
- MG Heiden Vander
- MG Heiden Vander
- Michael Karin
- Michael O. Hengartner
- Michael Overholtzer
- Michal Malewicz
- Michelangelo Campanella
- Michele Pagano
- Mikhail V. Blagosklonny
- MJ Barsoum
- MJ Bertrand
- MJ Eliasson
- MJ Phillips
- MJ White
- MK Ruhland
- ML Coleman
- ML Goodall
- ML Sassano
- MM Aranha
- MM Coissieux
- Mohanish Deshmukh
- Moshe Oren
- MP Baar
- MP Boldin
- MP Boldin
- MP Chao
- MP Luna-Vargas
- MP Soares
- MR Elliott
- MR Sprick
- MT Gyparaki
- MT Lotze
- MV Clement
- MX Li
- N Ahmed
- N Bidere
- N Branzk
- N Echeverry
- N Fricker
- N Furth
- N Kayagaki
- N Kayagaki
- N Kayagaki
- N Lalaoui
- N Peltzer
- N Peltzer
- N Plotegher
- N Robinson
- N Rodic
- N Takahashi
- N Vanlangenakker
- N Vanlangenakker
- N Yagoda
- N Yatim
- N Yatim
- N Zamzami
- N Zamzami
- N Zamzami
- Navdeep S. Chandel
- NE Sharpless
- NE Sharpless
- Nektarios Tavernarakis
- NF Trincheri
- NH Petersen
- Nickolai A. Barlev
- Nicola Di Daniele
- Nicolas G. Bazan
- NJ Curtin
- NJ Ganem
- NM Fofaria
- NW Werneburg
- O Florey
- O Florey
- O Joubert
- O Julien
- O Julien
- O Kepp
- O Kepp
- O Kepp
- O Kepp
- O Micheau
- O Micheau
- O Schmidt
- O Surova
- O Zilka
- OH Jeon
- Oliver Kepp
- P Amini
- P Bouillet
- P Bouillet
- P Boya
- P Boya
- P Broz
- P Fernando
- P Fernando
- P Gelebart
- P Guha
- P Kranz
- P Krimpenfort
- P Lan
- P Li
- P Li
- P Liu
- P Mandal
- P Matarrese
- P Matzinger
- P Mehlen
- P Mehlen
- P Paoli
- P Pihan
- P Scaffidi
- P Tsapras
- P Vandenabeele
- P Vandenabeele
- P Xia
- PA Elustondo
- PA Kreuzaler
- PA Lang
- Paolo Pinton
- Pascal Meier
- Patricia Boya
- Patrick Mehlen
- Patrizia Agostinis
- PD Bhola
- PE Czabotar
- PE Czabotar
- Peter E. Czabotar
- Peter Vandenabeele
- PF Connolly
- Philipp J. Jost
- Philippe P. Juin
- Pierre Golstein
- PJ Jost
- PL Zeeuwen
- PN Harter
- PS Welz
- Q Cai
- Q Fu
- Q Hu
- Q Huang
- Q Remijsen
- Q Remijsen
- Q Remijsen
- Q Sun
- Q Sun
- Q Wan
- Q Zhang
- Q Zhao
- R Brigelius-Flohe
- R Dumitru
- R Feltham
- R Gomez-Sintes
- R Kang
- R Majeti
- R Mukherjee
- R Salvador-Gallego
- R Skouta
- R Velaithan
- R Weinlich
- R Weinlich
- R Wilson
- R Yosef
- RA Aglietti
- RA Irvine
- RA Olie
- Ralph J. DeBerardinis
- RC Coll
- RD Abeysinghe
- ReDP Del
- RF Dielschneider
- RG Lichtenstein
- Richard A. Knight
- Richard A. Lockshin
- Richard N. Kitsis
- RJ Thapa
- RJ Youle
- RM Perciavalle
- Rosario Rizzuto
- RR Rayavarapu
- RS Whelan
- Ruggero De Maria
- S Aits
- S Aluvila
- S Alvarez-Diaz
- S Arakawa
- S Bleicken
- S Bleicken
- S Botton De
- S Buttner
- S Buttner
- S Buttner
- S Caielli
- S Chiba
- S Cornillon
- S Cornillon
- S Dawar
- S Dawar
- S Dey
- S Doll
- S Dolma
- S Einsele-Scholz
- S Fulda
- S Gascon
- S Grootjans
- S He
- S Hemmers
- S Hofmans
- S Horn
- S Iyer
- S Jang
- S Jouan-Lanhouet
- S Karstedt von
- S Krishna
- S Krishna
- S Kupka
- S Lippens
- S Lisi
- S Ma
- S Mansilla
- S McComb
- S McComb
- S Morioka
- S Nagata
- S Nagata
- S Naghdi
- S Ohsawa
- S Orozco
- S Pawaria
- S Piao
- S Qiu
- S Saita
- S Shalini
- S Shalini
- S Shanmughapriya
- S Shimizu
- S Shimizu
- S Solier
- S Sun
- S Suzuki
- S Tan
- S Torii
- S Wang
- S Wen
- S Xu
- S Yoon
- S Yoon
- S Yousefi
- S Yousefi
- S Zamorano
- S Zelenay
- S Zhu
- SA Andrabi
- SA Andrabi
- SA Andrabi
- SA Conos
- SA Lipton
- SA Oakes
- Sam W. Lee
- SB Berger
- SB Ma
- SB Willingham
- Scott J. Dixon
- Scott W. Lowe
- SE Kim
- SE Kim
- Seamus J. Martin
- SH Baek
- Sharad Kumar
- Shazib Pervaiz
- Shigekazu Nagata
- Simone Fulda
- SJ Clarke
- SJ Dixon
- SJ Dixon
- SJ Dixon
- SJ Dixon
- SJ Dixon
- SJ Gardai
- SJ Martin
- SJ Riedl
- SJ Wang
- SJ Yu
- SK Dasari
- SL Petersen
- SL Thompson
- SL Wong
- SM Frisch
- SM Harding
- SM Kallenberger
- SM Kavuri
- SM Man
- SM Man
- SM Man
- Sonia Melino
- SR Clark
- SR Woo
- Stephen W.G. Tait
- Stuart A. Aaronson
- Stuart A. Lipton
- SW Tait
- SW Tait
- SW Tait
- SW Yu
- SW Yu
- T Bergsbaken
- T Eggert
- T Eisenberg
- T Kamijo
- T Kirkegaard
- T Kirkegaard
- T Konig
- T Kuriakose
- T Kurz
- T Kurz
- T Kurz
- T Kuwana
- T Li
- T Lindsten
- T Mizuta
- T Moldoveanu
- T Moldoveanu
- T Motte Rouge de La
- T Nakagawa
- T Panaretakis
- T Panaretakis
- T Piyush
- T Raveh
- T Saleh
- T Shibue
- T Vanden Berghe
- T Vanden Berghe
- T Vanden Berghe
- T Vanden Berghe
- T Vanden Berghe
- T Varanita
- T Vervliet
- T Xu
- T Xu
- T Zhang
- TA Fuchs
- TB Kang
- TC Cheng
- Ted M. Dawson
- Theocharis Panaretakis
- Thomas Kaufmann
- Thomas Rudel
- TJ Daish
- TJ Sargeant
- TK Chang
- TL Haas
- TM Fu
- TM Ng
- Tom Luedde
- Tom Vanden Berghe
- TP Garner
- TS Luongo
- TS Luongo
- TT Cung
- TT Renault
- TV Denisenko
- TV Lee
- TW Kang
- U Fischer
- Ute M. Moll
- V Brinkmann
- V Brinkmann
- V Giorgio
- V Giorgio
- V Giorgio
- V Hornung
- V Izzo
- V Kondylis
- V Labi
- V Papayannopoulos
- V Purvanov
- V Sica
- V Turk
- V Turk
- VA Rathinam
- Valina L. Dawson
- VE Kagan
- VI Maltez
- Vincenzo De Laurenzi
- Vincenzo DâAngiolella
- Vishva M. Dixit
- VL Dawson
- VS Marsden
- VS Viswanathan
- W Chen
- W He
- W Hou
- W Lu
- W Zhou
- Wafik S. El-Deiry
- Walter Malorni
- WC Yeh
- WD Cook
- Will Wood
- William J. Kaiser
- WJ Kaiser
- WJ Kaiser
- WJ Kaiser
- WJ Kaiser
- WP Roos
- WS Hambright
- WS Yang
- WS Yang
- WS Yang
- WS Yang
- WT He
- X Chen
- X Chen
- X Hu
- X Jiang
- X Li
- X Liu
- X Liu
- X Luo
- X Qu
- X Song
- X Sun
- X Sun
- X Sun
- X Sun
- X Wang
- X Wang
- X Zhang
- XM Yin
- XM Yin
- XM Zhao
- XN Wu
- Y Aachoui
- Y Aachoui
- Y Dondelinger
- Y Dondelinger
- Y Dondelinger
- Y Dondelinger
- Y Dondelinger
- Y Fernandez-Marrero
- Y Fuchs
- Y Fuchs
- Y Ishizaki
- Y Ito
- Y Lee
- Y Li
- Y Li
- Y Liu
- Y Liu
- Y Luo
- Y Ma
- Y Ma
- Y Morizane
- Y Ou
- Y Pang
- Y Rong
- Y Shlyakhtina
- Y Subburaj
- Y Suzuki
- Y Tsujimoto
- Y Wang
- Y Wang
- Y Wang
- Y Wang
- Y Xie
- Y Xie
- Y Xie
- Y Zaltsman
- Y Zermati
- Y Zhang
- Y Zheng
- Y Zhu
- Y Zhu
- YB Chen
- YC Hou
- YH Liao
- YI Nakajima
- Ying Wang
- YN Gong
- Yoshihide Tsujimoto
- YS Cho
- Yufang Shi
- Z Cai
- Z Cai
- Z Wang
- Z Wang
- Z Xu
- Z You
- Z Zhang
- Z Zhong
- Zahra Zakeri
- ZG Liu
- ZN Oltvai
- ZT Schafer
- ZX Chen
- ZX Chen
- Publication venue
- Cell Death Differ
- Publication date
- 01/01/2018
- Field of study
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field
SDSS-III: Massive Spectroscopic Surveys of the Distant Universe, the Milky Way Galaxy, and Extra-Solar Planetary Systems
- Author
- Abazajian
- Abazajian
- Adam D. Myers
- Adam S. Bolton
- Adrian M. Price-Whelan
- Aihara
- Alaina Shelden
- Albrecht
- Alexander S. Szalay
- Allende Prieto
- Allende Prieto
- Ana Elia GarcĂa PĂ©rez
- Andreas A. Berlind
- Andreu Font-Ribera
- Andrew Gould
- Angelo Fausti Neto
- Aniruddha R. Thakar
- Anne Ealet
- Annie C. Robin
- AnĆŸe Slosar
- Ariel G. SĂĄnchez
- Armitage
- Ashley J. Ross
- Audrey E. Simmons
- B. Scott Gaudi
- Bailer-Jones
- Basilio Santiago
- Batalha
- Beatriz H. F. Ramos
- Beers
- Bell
- Belokurov
- Ben Breslauer
- Benjamin A. Weaver
- Benjamin M. Tofflemire
- Bharadwaj
- Blake
- Bo Ma
- Bo Zhao
- Bolton
- Bolton
- Bolton
- Bovy
- Bovy
- Brian L. Lee
- Brian Yanny
- Brice MĂ©nard
- Britt Lundgren
- Brown
- Bruce A. Gillespie
- Bruno FemenĂa CastellĂĄ
- Bruno Rossetto
- Bullock
- Bullock
- C. S. Kochanek
- Cameron K. McBride
- Carlos Allende Prieto
- Casey T. Bosman
- Castelli
- Cathy Jordan
- Celine Reyle
- Christophe Pichon
- Christophe YĂšche
- Christy A. Tremonti
- Claude Mack
- Claudia Maraston
- Conor Sayres
- Constance M. Rockosi
- Craig P. Loomis
- Cristina Chiappini
- Dan Burger
- Daniel C. Long
- Daniel J. Eisenstein
- Daniel J. Oravetz
- Daniel Margala
- Daniel Thomas
- David A. Wake
- David H. Weinberg
- David J. Schlegel
- David Kirkby
- David L. Nidever
- David W. Harris
- David W. Hogg
- Demitri Muna
- Dmitry Bizyaev
- Donald G. York
- Donald P. Schneider
- Dustin Lang
- Duy Cuong Nguyen
- Eduardo Balbinot
- Edward M. Edmondson
- Eisenstein
- Eisenstein
- Eisenstein
- Eisenstein
- Eisenstein
- Elena Malanushenko
- Emmanuel Rollinde
- Eric Agol
- Eric B. Ford
- Erick Young
- Erin Sheldon
- Erskine
- Eva K. Grebel
- Eyal Kazin
- Fabrycky
- Fan
- Fergal Mullally
- Fernando de Simoni
- Ford
- Francisco Prada
- Frederick R. Hearty
- Frieman
- Fulbright
- G. Gilmore
- G. R. Knapp
- Gail Zasowski
- Garrett L. Ebelke
- Gates
- Ge
- Ge
- Ge
- George H. Rieke
- Gordon T. Richards
- Greg Fitzgerald
- Grether
- Grillmair
- Grillmair
- Guinevere Kauffmann
- Gunn
- Gunn
- Gustavo F. Porto de Mello
- Hans-Walter Rix
- Harris
- Heather Campbell
- Heather L. Morrison
- Helio J. Rocha-Pinto
- Hiroaki Aihara
- Hitoshi Murayama
- Howard J. Brewington
- Hubert Lampeitl
- I. Neill Reid
- Ian D. McGreer
- Ibata
- Idit Zehavi
- Inese I. Ivans
- Isabelle PĂąris
- IveziÄ
- IveziÄ
- J. Brinkmann
- J. Richard Gott
- Jacob M. Eiting
- James A. Arns
- James E. Gunn
- James E. Lawler
- James R. A. Davenport
- James Rich
- Janice Dean
- Janine Pforr
- Jarron M. Leisenring
- Jean-Christophe Hamilton
- Jean-Marc Le Goff
- Jean-Paul Kneib
- Jennifer A. Johnson
- Jennifer Simmerer
- Jeremy L. Tinker
- Ji Wang
- Jian Ge
- Jian Liu
- Jo Bovy
- Joel R. Brownstein
- Johan Comparat
- John C. Wilson
- John D. Silverman
- John J. Bochanski
- John K. Parejko
- John P. Wisniewski
- Joleen K. Carlberg
- Jon A. Holtzman
- Jonay I. GonzĂĄlez HernĂĄndez
- Jordi Miralda-Escudé
- Joseph F. Hennawi
- Joshua Pepper
- Juna A. Kollmeier
- JuriÄ
- JuriÄ
- Kaike Pan
- Karen L. Masters
- Katharine J. Schlesinger
- Katia Cunha
- Kazin
- Keivan G. Stassun
- Kirkpatrick
- Klaus Honscheid
- Kollmeier
- Koopmans
- Koopmans
- Kris Sellgren
- Kyle Dawson
- Lanz
- Lars Koesterke
- Larson
- Lasker
- Lee
- Lee
- Lee
- Lee
- Lee
- Leticia Dutra Ferreira
- Liang Chang
- Licia Verde
- Liddle
- Linhua Jiang
- Luan Ghezzi
- Luiz N. da Costa
- LĂ©o Girardi
- M. F. Skrutskie
- M. Jordan Raddick
- Madrid
- Madrid
- Majewski
- Majewski
- Majewski
- Maraston
- Marcia J. Rieke
- Marcio A. G. Maia
- Marcy
- Mariana Vargas Magaña
- Marina Cortes
- Mark A. Klaene
- Mark H. Stockett
- Martin
- Martin Makler
- Martin Paegert
- Martin White
- Masayuki Tanaka
- Massimiliano Esposito
- Matthew D. Olmstead
- Matthew M. Pieri
- Matthew Shetrone
- Matthias Steinmetz
- Michael A. Carr
- Michael A. Strauss
- Michael L. Evans
- Michael R. Blanton
- Morrison
- Nagasawa
- Naohisa Inada
- Naoki Yasuda
- Natalia Connolly
- Natalie A. Roe
- Nathalie Palanque-Delabrouille
- Nathan De Lee
- Newberg
- Nicholas MacDonald
- Nicholas P. Ross
- Nicolas G. Busca
- Nicole P. Vogt
- Nikhil Padmanabhan
- Norman
- Odenkirchen
- Olga Mena Requejo
- Oliver Steele
- Orban
- Parul Pandey
- Patrick McDonald
- Patrick Petitjean
- Paul Harding
- Paul Maseman
- Paulo Pellegrini
- Peng Jiang
- Perlmutter
- Peter J. Brown
- Peter M. Frinchaboy
- Phillip A. Cargile
- Rachel Mandelbaum
- Reid
- Reid
- Ricardo L. C. Ogando
- Ricardo Schiavon
- Richard G. Kron
- Richard G. McMahon
- Richards
- Richards
- Riess
- Rita Tojeiro
- Robert Barkhouser
- Robert C. Nichol
- Robert H. Lupton
- Robert Pfaffenberger
- Robert W. OâConnell
- Ross
- Rupert A. C. Croft
- Sara Lucatello
- Sarah J. Schmidt
- Saurav Dhital
- Schlaufman
- Schlegel
- Schneider
- Scott F. Anderson
- Scott W. Fleming
- Seo
- Seo
- Seo
- Shirley Ho
- Simon D. M. White
- Skrutskie
- Slosar
- Slosar
- Smolinski
- Stefanie Phleps
- Steinmetz
- Stephanie A. Snedden
- Stephanie Escoffier
- Stephen Bailey
- Stephen Smee
- Steven J. Bickerton
- Steven R. Majewski
- Stoughton
- Strauss
- Sunyaev
- Suvrath Mahadevan
- Suzanne L. Hawley
- Takahashi
- Takahashi
- Thirupathi Sivarani
- Timothy C. Beers
- Todd Stollberg
- Tracy Naugle
- van Eyken
- Verne V. Smith
- Viktor Malanushenko
- W. Michael Wood-Vasey
- W. N. Brandt
- Wang
- Wendell P. Jordan
- White
- White
- White
- Will J. Percival
- William C. Carithers
- Wilson
- Wright
- Wright
- Wu
- Xiaohui Fan
- Xiaoke Wan
- Yanmei Chen
- Yanny
- Yanny
- Yanny
- Yen-Ting Lin
- Yiping Shu
- York
- Young Sun Lee
- Zacharias
- Zacharias
- Zel'dovich
- Zhibo Ma
- Zwitter
- Ăric Aubourg
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2011
- Field of study
Building on the legacy of the Sloan Digital Sky Survey (SDSS-I and II),
SDSS-III is a program of four spectroscopic surveys on three scientific themes:
dark energy and cosmological parameters, the history and structure of the Milky
Way, and the population of giant planets around other stars. In keeping with
SDSS tradition, SDSS-III will provide regular public releases of all its data,
beginning with SDSS DR8 (which occurred in Jan 2011). This paper presents an
overview of the four SDSS-III surveys. BOSS will measure redshifts of 1.5
million massive galaxies and Lya forest spectra of 150,000 quasars, using the
BAO feature of large scale structure to obtain percent-level determinations of
the distance scale and Hubble expansion rate at z<0.7 and at z~2.5. SEGUE-2,
which is now completed, measured medium-resolution (R=1800) optical spectra of
118,000 stars in a variety of target categories, probing chemical evolution,
stellar kinematics and substructure, and the mass profile of the dark matter
halo from the solar neighborhood to distances of 100 kpc. APOGEE will obtain
high-resolution (R~30,000), high signal-to-noise (S/N>100 per resolution
element), H-band (1.51-1.70 micron) spectra of 10^5 evolved, late-type stars,
measuring separate abundances for ~15 elements per star and creating the first
high-precision spectroscopic survey of all Galactic stellar populations (bulge,
bar, disks, halo) with a uniform set of stellar tracers and spectral
diagnostics. MARVELS will monitor radial velocities of more than 8000 FGK stars
with the sensitivity and cadence (10-40 m/s, ~24 visits per star) needed to
detect giant planets with periods up to two years, providing an unprecedented
data set for understanding the formation and dynamical evolution of giant
planet systems. (Abridged)Comment: Revised to version published in The Astronomical Journa
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
- Author
- Aahlin EK
- Aamer A
- Aaniana K
- Ababneh A
- Abaliksta T
- Abantanga F
- Abantanga F
- Abbas A
- Abbas M
- Abbasy J
- Abbo O
- Abbo O
- Abbott T
- Abbouch M
- Abd El Galeel A
- Abd El Hameed OS
- Abd El Hamid N
- Abd El Salam Y
- Abd El Slam M
- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elmawla M
- Abd-Elrasoul Y
- Abdallah E
- Abdallah E
- Abdel-Aty A
- Abdel-Hameed N
- Abdel-Kader SM
- Abdel-Wahab NYE
- Abdelaal A
- Abdelaty M
- Abdelazeam AR
- Abdelazim G
- Abdelaziz MA
- Abdelbadeai K
- Abdelfatah A
- AbdelFattah I
- Abdelgelil A
- Abdelghany S
- Abdelhady S
- Abdelhamed R
- Abdelhamid A
- Abdelhaq A
- Abdelkader M
- Abdelkader M
- Abdelkader O
- Abdelkareem A
- Abdelkhalek M
- Abdelmageed E
- Abdelmotaleb I
- Abdelraheim M
- Abdelraouf AM
- Abdelrouf DM
- Abdelshafy M
- Abdelshakour M
- Abdrabou AK
- Abdul-Latif S
- Abdulaziz H
- Abdulaziz M
- Abdulbagi O
- Abdulgawad M
- Abdulhakeem EM
- Abdullah AAN
- Abdullah MA
- Abdullah N
- Abdullah NAN
- Abdullah NAN
- Abdullahi L
- Abdurrazzaaq A
- Abebe NS
- Abebe NS
- Abem OE
- Aber A
- Abington E
- Abiola O
- Aboarab A
- Aboelella M
- Aboelmagd O
- Aboelsoud MR
- Aboraya M
- Aboraya M
- Abouelnasr A
- Aboul-Naga MS
- Abouzahra A
- Abouzaid A
- Abozaid M
- Abozeid K
- Abozyed MAF
- Abu Qumbos A
- Abu-toyour M
- Abubakr M
- Abudeeb H
- Abuowda Y
- Abuqwaider E
- Abusalem L
- Abuseif M
- Abushamleh S
- Acharya P
- Ackom E
- Acquah E
- Adam A
- Adam N
- Adams R
- Adamu A
- Adawi I
- Adawi M
- Adebanjo A
- Adebanjo A
- Adebola O
- Adedeji A
- Adekoya A
- Adel A
- Adel A
- Adel BE
- Adel I
- Adella FJ
- Adelshone A
- Ademuyiwa A
- Ademuyiwa A
- Ademuyiwa AO
- Ademuyiwa AO
- Ademuyiwa AO
- Ademuyiwa AO
- Adenekan B
- Adeniran J
- Adeniran J
- Adeniyi A
- Adeniyi A
- Adesanya O
- Adesanya O
- Adesina A
- Adesina A
- Adesuyi A
- Adeyeye A
- Adeyeye A
- Adeyeye A
- Adham W
- Adhitama N
- Adil M
- Adisa AO
- Adisa AO
- Adu-Aryee N
- Afana S
- Afandy A
- Afifi AM
- Afzal M
- Agalianos C
- Agalianos C
- Agarwal A
- Agarwal A
- Agarwal A
- Agbedinu K
- Agius M
- Aglan A
- Aguado Suarez N
- Aguilar-Jimenez J
- Aguilera M
- Aguilera ML
- Aguilera ML
- Aguilera ML
- Aguilera O
- Aguilera-Arevalo M-L
- Ahlonsou G
- Ahlqvist S
- Ahlqvist S
- Ahlqvist S
- Ahmed A
- Ahmed A
- Ahmed A
- Ahmed EA
- Ahmed H
- Ahmed H
- Ahmed H
- Ahmed LAM
- Ahmed S
- Ahmed S
- Ahmed SM
- Ahounou EYS
- Aigrain Y
- Aiyaman C
- Ajah J
- Ajai O
- Ajao A
- Ajao AE
- Ajiboye A
- Akatibo E
- Akeel N
- Akhtar M
- Akoto E
- Akpenyi O
- Al Amin S
- Al Attar SM
- Al Awwad S
- Al Barrawi FE
- Al Bastawis F
- Al Meligy A
- Al Rafati AAR
- Al Raouf EA
- Al Saied G
- Al Subaie N
- Al-Aarag AA-R
- Al-Azraqi IAA
- Al-Bahrani A
- Al-Buhaisi A
- Al-Dakka E
- Al-Faifi JJ
- Al-faqawi M
- Al-farram H
- Al-Hameedi HII
- Al-Hasani RKMJ
- Al-khatib A
- Al-Mallah A
- Al-Marakby D
- Al-Mousa M
- Al-Nahrawi S
- Al-Obaedi O
- Al-saqqa S
- Al-Saqqa SW
- Al-Saqqa SW
- Al-shammari A
- Al-Slaibi I
- Al-taher T
- Alaael-Dein S
- Alada M
- Alahmady O
- Alakaloko F
- Alakaloko F
- Alaloul E
- Alamin S
- Alamoudi M
- Alamoudi U
- Albeladi B
- Albiety A
- Alcca Ticona W
- Aldalaq A
- Aldhafeeri S
- Aledrisy M
- Alejos Bermudez YE
- Alexander P
- Alexander P
- Alexander P
- Alexandre C
- Alfarsi MA
- Alghamdi A
- Alghamdi B
- Alghamdi M
- Alghamdi MSA
- Algohary O
- Alhabli I
- Alhady K
- Alhammali T
- Alhassan B
- Alhazmi W
- Alhendy M
- Alherz M
- Ali A
- Ali A
- Ali A
- Ali CDM
- Ali E
- Ali FM
- Ali H
- Ali S
- Ali SAWEW
- Ali SS
- Ali THA
- Ali W
- Alihonou T
- Alimi Q
- Alis H
- Aliyu H
- Aliyu M
- Aliyu S
- Aljboor K
- Aljiffry M
- Aljiffry M
- Aljohani E
- Aljohani E
- Aljohani S
- Alkaaki A
- Alkammash A
- Alkelani M
- Alkhabbaz D
- Alkhouri M
- Allam M
- Allam M
- Allam Y
- Allegri A
- Allegri A
- Allen JLY
- Allott R
- Almallah A
- Almoflihi A
- Almuallem S
- Almy J
- Alnaby MH
- Alnawam E
- Alnuqaydan SA
- Alnusairat A
- Alomar IN
- Alqahtani E
- Alqahtani S
- Alrahawy M
- Alrajraji M
- Alrifaie A
- AlRowais M
- Alsaggaf M
- Alsaggaf MU
- Alsaggaf MU
- Alser OH
- Alshareef R
- Altaf A
- Altaf A
- Altamimi A
- Altamimi A
- Altamimi A
- Altamimi A
- Altamini A
- Altarayra M
- Althwainy A
- Altibi A
- Altinel Y
- Altinel Y
- Altoe F
- Altwigry AM
- Altwijri A
- Alvarado Jaramillo R
- Alvarez Barreda LM
- Alvi AR
- Alwafai MG
- Aly AK
- Aly MYM
- Alyacoubi S
- Alyahya R
- Alyami R
- Alyami R
- AlYoussef I
- Alzahrani A
- Alzahrani M
- Alzahrani M
- Alzayat T
- Aman NF
- Amandito R
- Amandito R
- Amandito R
- Amandito R
- Ambrona-Zafra D
- Ambrozeviciute V
- Ameen M
- Amer MA
- Amin HAA
- Amin J
- Amin J
- Amjad M
- Ammar M
- Ammar MS
- Amoah M
- Amoako J
- Amoako PT
- Amoako-Boateng M
- Amole I
- Amreia M
- Amreia M
- Anandkumar D
- Anderson D
- Anderson F
- Anderson R
- Anderson-Knight H
- Andersson L
- Andika FFA
- Andreotti D
- Andres Garcia-Marin J
- Andress C
- Andriola V
- Ang YL
- Angelieri D
- Anis E
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Antar S
- Antezana D
- Anthoulakis C
- Anthoulakis C
- Antoniozzi A
- Anwar AW
- Anwar N
- Anwer W
- Anyanwu L-J
- Anyanwu L-J
- Aonzo P
- Appeadu-Mensah W
- Appiah EK
- Aql S
- Aquilino F
- Arachchi PP
- Arachchige LAJJ
- Arafa O
- Arafa S
- Arango MCM
- Arango MCM
- Aranzabal Durand SY
- Araujo R
- Arcudi C
- Ardley R
- Arenas A
- Arevalo Azmitia JR
- Arias Pacheco RD
- Arman S
- Arman S
- Armando ChunguiBravo J
- Armellini A
- Arnaud A
- Arnaud AP
- Arnaud AP
- Arnaud AP
- Arroyo Basto CA
- Arshad MM
- Arslan E
- Arsyad HM
- Arthur T
- Arulampalam T
- Aruldas N
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- Asar YH
- Asare-Bediako K
- Asele FA
- Ashour A
- Ashour A
- Ashour K
- Ashraf SF
- Ashtari M
- Ashton A
- Asi F
- Asilah SMD
- Assal A
- Assouto PA
- Asturia S
- Asumah H
- Ata A
- Ata AAA
- Ata AY
- Atiyeh A
- Atkins ET
- Atkinson K
- Atobatele K
- Attallah NA
- Attard M
- Attia A
- Attia AM
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- Aung KP
- Austraite A
- Aviles S
- Avoka A
- Awad I
- Awad SA
- Awadallah S
- Awuku-Asabre J
- Ayad S
- Ayandipo O
- Ayandipo OO
- Aydin MC
- Ayyar S
- Aziz DNA
- Aziz MRA
- Aziz NA
- Azizeldine MG
- Azmitia Mendizabal CA
- Azodo IA
- Azzie G
- Azzie G
- Azzis O
- Baba S
- Bachri H
- Badawy M
- Badenjki MA
- Badicel M
- Badr A
- Badr MFM
- Badwi NM
- Badwi NM
- Badwy A
- Bahar S
- Baheeg M
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- Baillie K
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- Bakhaidar M
- Baki BE
- Bakr A
- Bakry HM
- Bala M
- Balalis D
- Baldacchino M
- Balducci G
- Balila RMH
- Balkan AZA
- Ballouhey Q
- Balmaceda R
- Balmaceda R
- Balmaceda R
- Balogun F
- Baltrunas R
- Baluch F
- Bamford R
- Bamicha A
- Bamicha A
- Banaitis VJ
- Bandi A
- Bandoh D
- Bani-Sadar A
- Banipal GS
- Baraka H
- Barakat SAE
- Barendegere V
- Barker T
- Barkolias C
- Barmayehvar B
- Barnabas GN
- Barnacle J
- Barneo L
- Barrionuevo Ojeda RR
- Barrios E
- Barrios E
- Barros De Castro Segundo LC
- Barroso de Lima CV
- Barry J
- Basilico S
- Basir ERM
- Bassem M
- Bassit KA
- Basso SMM
- Basson S
- Batt J
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- Beasley W
- Beaton C
- Bedada AG
- Bediako-Bowan A
- Behar N
- Beisa V
- Beisa V
- Bekhet AH
- Bekhet NM
- Beleno AEM
- Belkouchi A
- Belli A
- Bello B
- Benammi S
- Benevento A
- Benevento A
- Benger M
- Bennai RM
- Benons N
- Bentounsi Z
- Benyaiche C
- Berti S
- Bertuello I
- Beuran M
- Beuran M
- Beyene R
- Bezerra Morais PA
- Bezzina M
- Bhang A
- Bhangu A
- Bhangu A
- Bhargava A
- Bharj IS
- Bhat S
- Bhatnagar A
- Bhattacharya S
- Bhopal KF
- Bhopal KF
- Bianco F
- Bigaran A
- Billy M
- Bin Adnan A
- Bin Hasnan M
- Bin Ismail MJ
- Bin Mahamood A
- Birindelli A
- Birring A
- Bisset C
- Bjorklund I
- Bjorklund I
- Blacker S
- Blackwell J
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- Blanco-Colino R
- Blencowe N
- Blencowe N
- Bliksoen M
- Blower E
- Bluelle R
- Blundell R
- Boakye-Yiadom K
- Boal M
- Bocchetti T
- Boddy A
- Bode C
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- Bondin J
- Bondurri A
- Bondurri A
- Boni S
- Bonnard A
- Bonney W
- Borda Luque G
- Borda-Luque G
- Borda-Luque G
- Borg E
- Borg E
- Borg E
- Borin E
- Bortolasi L
- Bortolasi L
- Boshnaq M
- Botes S
- Bottini C
- Botto N
- Bouali O
- Bougard H
- Boukhal K
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- Bowman C
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- Bradulskis S
- Bradulskis S
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- Bratu MR
- Bratu R-M
- Braungart S
- Bray LD
- Breaud J
- Breistrand M
- Breitenstein S
- Breslin R
- Brincat SD
- Broch A
- Brogden T
- Brown D
- Brown E
- Brown J
- Brown J
- Browning DRL
- Brunoni B
- Bsisu I
- Bucci L
- Bugaev N
- Bugeja R
- Buisson P
- Bukari M
- Bunting D
- Burger S
- Burmistrovas A
- Burns H
- Bustangi N
- Butt MT
- Cabala Chiong JA
- Cabala Chiong JA
- Cacurri A
- Cadogan DD
- Cahill R
- Cakaloglu HC
- Caliman C
- Callan R
- Camacho R
- Cameron B
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- Camilleri-Brennan J
- Camilleri-Brennan J
- Camilleri-Brennan JF
- Camilo Correa J
- Campagnaro T
- Canta Calua A
- Capito C
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- Careta MC
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- Carmela Lapitan M
- Carmona JM
- Carpio J
- Carrasco N
- Carreira J-A
- Carreiro De Freitas AV
- Cassar K
- Castro Mollo M
- Catani M
- Cautiero R
- Caydiid H
- Cecilia T
- Celik S
- Cengiz TB
- Cengiz Y
- Cengiz Y
- Cengiz Y
- Cengiz Y
- Ceriani C
- Cevik M
- Chabok A
- Chachulski W
- Chai C-A
- Chai FY
- Chambers A
- Chambers A
- Chan E
- Chan L
- Chan T-YK
- Chan XW
- Chan Z
- Chandrakumar C
- Chang K
- Chang KY-C
- Chapman A
- Chapman SJ
- Charles A
- Cheah AEZ
- Chen CY
- Chen KY
- Chen T-L
- Chenn R
- Cheong YJ
- Chetta N
- Cheung YHE
- Chew LS
- Chhabra S
- Chibuye C
- Chidambaram S
- Chiesa D
- Chilton G
- Chin PX
- Chin YR
- Chiu S
- Chiu S
- Chiu SMY
- Choi J
- Choi P
- Chong BFHK
- Chong CL
- Chong CL
- Chong CL
- Chong CS
- Chong H-Y
- Chong HY
- Choudhry A
- Chow CYN
- Chowdhury A
- Chowdhury D
- Chu K
- Chun A
- Chun T
- Chung KJ
- Chung S
- Ciccioli E
- Cirocchi R
- Ciubotaru C
- Claire R
- Clarissa A
- Clark DJ
- Clark T
- Clegg-Lampety J-N
- Clegg-Lamptey J-N
- Clement KD
- Clements JM
- Clerico G
- Clifford C
- Cloro LM
- Coasaca Huaraya R
- Coccolini F
- Coccolini F
- Coccolini F
- Coccolini F
- Cocker DM
- Cocorullo G
- Cohen DM
- Cohen F
- Cole S
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- Coletti M
- Colombani J-F
- Cona C
- Conci S
- Confalonieri G
- Conlon KC
- Connor K
- Connor K
- Contreras Merida SM
- Contreras Urquizu M
- Contreras Vergara AL
- Contreras E
- Coomber R
- Coompson CL
- Corbellini C
- Corbellino M
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- Coronel J
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- Corro-Diaz S
- Costa C
- Costa-Maia J
- Costa-Maia J
- Costas-Chavarri A
- Costas-Chavarri A
- Courboin E
- Court E
- Cox D
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- Cragg J
- Craus-Miguel A
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- Cruz H
- Cucumazzo S
- Cullen F
- Curletti G
- Currow C
- Currow C
- D'aguzan N
- D'Amours S
- D'amours SK
- D'cruz R
- D'Souza MS
- D'Souza R
- Da Silva LA
- Dabboor M
- Dabbour K
- Dabessa D
- Dablouk M
- Dablouk MO
- Dagoe E
- Dahy A
- Dainius E
- Dakubo J
- Dal Canto M
- Dalli J
- Dally C
- Dambrauskas Z
- Dambrauskas Z
- Dan I
- Danelli P
- Daniels I
- Daniyan M
- Danys D
- Dao W
- Daqeeq A
- Dar M
- Dar W
- Dardenne S
- Darweesh M
- Darwish AKZ
- Das A
- Das K
- Das S
- Dasari M
- Dashnyam E
- Dassah V
- Datta U
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- De Franciscis S
- De Luca E
- De Marco P
- De Sousa AV
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- Dean R
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- Debrah S
- Deckelbaum DL
- Decker E
- Dedekind B
- Dedey F
- Deichsel F
- Del Basso C
- del Pilar Paucar A
- Delforge X
- Dell A
- Dempster E
- Denakpo M
- Denewar A
- Depalma N
- Deputy M
- Der Y
- Dervenis C
- Despotidis V
- Desta S
- Deutschmann P
- Devadasar GH
- Dharamshi HA
- Dhillon D
- Di Franco F
- Di Martino N
- Di Saverio S
- Di Saverio S
- Diab A
- Diaconescu B
- Diaconescu I-B
- Dias S
- Diaz Vico T
- Diaz-Jover P
- Diaz-Zorrilla C
- Dick L
- Dickfos M
- Dickson L
- Dijan E
- Dimech T
- Din F
- Dindyal S
- Dindyal S
- Dione Parreno-Sacdalan M
- Dissanayake T
- Djivoh F
- Domini E
- Domini E
- Donnelly P
- Donoghue D
- Dorani RMNR
- Dorisme A
- dos Santos DV
- Dossou F
- Doughan S
- Doughty J
- Dousset B
- Dragatas D
- Drake TM
- Drake TM
- Drake TM
- Driscoll A
- Drungilas M
- Du Plessis D
- du Plooy F
- Du Toit F
- Duane T
- Dubois A
- Duffy L
- Duhoranenayo D
- Duinhouwer L
- Dulskas A
- Dwydar A
- Ebdewi H
- Ebidy M
- Ebidy MM
- Ebrahim OS
- Eduard P
- Edwards J
- Edye M
- Eid MM
- Eisner L
- Ekow M
- El Ashal G
- El Dahab AA
- El Deen KN
- El Gendy A
- El Gendy NH
- El Halawany M
- El Jamassi A
- El Kashash A
- El Kholy A
- El Magd AA
- El Mesery S
- El Sayed GS
- El Sayed IM
- El Shoura Y
- El-badawy HA
- El-Dien KS
- El-Dien KS
- El-Din RA
- El-Din SA
- El-Gizawy E
- El-Hamouly AS
- El-Kashef H
- El-Latif NK
- El-Ma'doul AS
- El-Rabaa S
- El-Sagheer N
- El-Sawy A
- El-Sehily A
- El-Shahat NS
- El-Sheemy H
- El-Taher E
- Elabdin HZ
- Elashmawy M
- Elashry R
- Elazab A
- Elazayem AA
- Elazoul M
- Elbanby E
- Elbanby ES
- Elbatahgy A
- Elbe P
- Elbermawy M
- Elbisomy KH
- Eldafrawy M
- Eldamaty L
- Eldeeb AZ
- Eldeen EA
- Eldin MAB
- EldosoukyMohammed A
- Elebute O
- Elebute O
- Elena G
- Elfarargy A
- Elfeki H
- Elfeki H
- Elfiky M
- Elfil M
- Elfouly N
- Elfouly N
- Elfouly Y
- Elfouly Y
- Elgebaly A
- Elgendy AH
- Elgendy FI
- Elgheriany M
- Elhadad A
- Elhadary NM
- Elhadry S
- Elhalawany E
- Elhamouly S
- Elhelbawy MS
- Elhendawy A
- Elhendawy AOA
- Elhoseny G
- Elhusseiny AAE
- Elizabeth Lopez C
- Elkadsh I
- Elkady F
- Elkelany A
- Elkelany A
- Elkelany A
- Elkelany A
- Elkhadrawi M
- Elkhalek EA
- Elkholy A
- Elkholy SS
- Elkolaly SS
- Elkorashy AM
- Ellison Q
- Elmashala A
- Elmasry M
- Elmelegy R
- Elmihy S
- Elnagar A
- Elnajjar MA
- Elnemr AE
- Elrazek AA
- Elsabbagh N
- Elsameea AA
- Elsawahly DME
- Elsawy A
- Elsayed M
- Elsayed M
- Elsayed N
- Elsayed NAR
- Elsayed ZM
- Elsebaaye AO
- Elsehimy M
- Elsemelawy R
- Elshaar M
- Elshaer K
- Elshaer M
- Elshaer M
- Elshafay AE
- Elshami M
- Elshanwany S
- Elsharkawy AA
- Elsheikh S
- Elsherbiney S
- Elsherbiny AS
- Elsherif FA
- Elshobary M
- Elsiddig M
- Elsobky S
- Elsorogy DEAA
- Elwaey A
- Elwakil H
- Elwan A
- Elwan A
- Elwy E
- Elzahed N
- Elzayat I
- Elzayat M
- Elzayyat I
- Elzowawi F
- Emadeldin D
- Emadeldin H
- Emara E
- Emile S
- Eng C
- English W
- Esam A
- Escalante Salas MDC
- Espin-Basany E
- Espinoza F
- Essam A
- Essam AA
- Essam M
- Essoun S
- Esteban E
- Estee MM
- Estupinian S
- Etchill E
- Etchill E
- Etienne S
- Etman M
- Etwire V
- Evajelista CV
- Evans D
- Evans E
- Eysa A
- Eyssartier E
- Ezzat E
- Ezzat T
- Faboya O
- Faccincani R
- Fadel A
- Fahiem A
- Fahim M
- Fahmy MAB
- Fahy C
- Fairfield C
- Fairfield C
- Fairfield C
- Fairfield C
- Fakher R
- Falaschi F
- Falco N
- Falzon M
- Farag A
- Farag S
- Farah A
- Farahat MM
- Faraz A
- Fares M
- Farhad M
- Farhan-Alanie MMH
- Farhangmehr N
- Farinella E
- Farmakis K
- Farooq T
- Farouk SAM
- Farquharson A
- Farrugia A
- Farrugia A
- Faruq A
- Fathy AM
- Fattah AA
- Fatuga A
- Faturoti O
- Faturoti O
- Faure A
- Fautz T
- Favero A
- Fawzy A
- Feidantsis T
- Felipe CO
- Fergany A
- Fergusson SJ
- Fergusson SJ
- Fergusson SJ
- Fergusson SJ
- Fermani C
- Fermani CG
- Fernandes C
- Fernandez C
- Fernandez-Bueno F
- Fernandez-Vega L
- Ferousis C
- Ferrero E
- Fievet L
- Filatau A
- Findlay-Cooper K
- Firdouse M
- Firdouse M
- Firdouse M
- Firwana A
- Fitsum A
- Fitzgerald JE
- Fitzgerald JE
- Florez Farfan ES
- Foco M
- Fok CYJ
- Fontana T
- Foo CC
- Forlin L
- Forno W
- Fouad A
- Fouad D
- Fouad D
- Fourcade L
- Fowler AJ
- Fozard T
- Fozard T
- Frade F
- Fraga GP
- Francisco Roxas M
- Franco H
- Francois P
- Francois-Coridon H
- Francone E
- Freitas AV
- Frey D
- Frisk B
- Fuentes-Rivera L
- Fujii F
- Furqan MM
- Gaafar S
- Gaarder T
- Gad A
- Gad MO
- Gadelkarim M
- Gadhvi V
- Gado A
- Gaignard E
- Gaignard E
- Gaizauskas V
- Gala T
- Gala T
- Galiqi G
- Galleano R
- Gallo G
- Galloway S
- Galvez CP
- Gamal D
- Gamal E
- Gamal H
- Gamal S
- Gamaly E
- Gamil D
- Gan C
- Gan YY
- Gani MA
- Garaycochea O
- Garcia Bernardo C
- Garcia Florez LJ
- Garcia Septiem J
- Garcia Torres CP
- Garcia-Florez L
- Garland A
- Gash K
- Gash K
- Gash K
- Gastaldi P
- Gasteratos K
- Gaujoux S
- Gavagna L
- Gbessi DG
- Gemeah M
- Gemenetzis G
- Gemenetzis G
- George R
- Germanos S
- Germanos S
- Gerosa A
- Gerosa A
- Geuoshy A
- Ghaben A
- Ghandora N
- Ghanem A
- Ghanem E
- Ghanem S
- Ghanem S
- Ghannam M
- Gharib A
- Gharib A
- Ghazy AA
- Gheith A
- Ghetia M
- Ghetia M
- Ghonaim MA
- Ghoneem M
- Ghoneim O
- Giacci L
- Giardino FR
- Giavarini L
- Giglio MC
- Gilbert R
- Gilbert RW
- Giles J
- Gillespie M
- Gimzewska M
- Giraldo RSR
- Giuliani S
- Giuliani S
- Giuriato TF
- Gkiokas G
- Glasbey J
- Glasbey J
- Glasbey JC
- GlobalSurg Collaborative
- Glover TE
- Glover-Addy H
- Glynn M
- Gobin N
- Gobin N
- Goh CC
- Goh CC
- Goh W
- Gohar ME-SAM
- Gokani S
- Goldin E
- Golding D
- Gomaa A
- Gomah M
- Gonzales Montejo MS
- Gonzales Stuva JP
- Gonzalez M
- Goodstein M
- Gosling S
- Gosling SG
- Gouda A
- Gould L
- Gouldthorpe C
- Gouvas N
- Gouws J
- Graffeille V
- Graffieille V
- Gran M
- Grandinetti PP
- Grant A
- Grasset E
- Grasset E
- Grassi V
- Gratton R
- Gravante G
- Gravante G
- Gray D
- Grech N
- Green N
- Grella MG
- Gribauskaite J
- Griffiths E
- Griffiths E
- Griffiths M
- Grima T
- Grisin E
- Grizhja B
- Grobler DC
- Grosos C
- Grossart C
- Gubeli A
- Gudal A
- Gudal A
- Gudal A
- Gudlaugsdottir K
- Guevara Torres S
- Guevara R
- Guglielmo V
- Gui D
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- Zerihun AB
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- Zilinskiene R
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- Zulkifli A
- Zumbuhl L
- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
AI is a viable alternative to high throughput screening: a 318-target study
- Author
- Abaffy Tatjana
- Abraham Elena Theres
- AbrahaÌo JoÌnatas Santos
- Abramyan Tigran M.
- Agianian Bogos
- Agogo-Mawuli Percy
- Agoulnik Alexander I.
- Agrawal Rajendra K.
- Aguilera Elena
- Ahmed Mostafa
- Akk Gustav
- Akopian Tatos
- Al-Yozbaki Minnatallah
- Aldhamen Yasser Ali
- Alkan Cigdem
- Alramadhani Dina
- Alteen Matthew G.
- Alvarez GuzmaÌn
- Ammendola Serena
- Anastasio Noelle C.
- Anderson Brandon M.
- Anderson Deborah H.
- Andricopulo Adriano D.
- Angell Richard M.
- Anthis Nicholas J.
- Antonelli Lorenzo
- Apfel Athena Marie
- Arias Juan Antonio Sanchez
- Arozarena Imanol
- Arrigoni Cristina
- ArtiÌa Zoraima
- Ashkar Shireen R.
- Ashton Mark R.
- Austin Richard C.
- Ayachi Aicha Gharbi
- Azeem Syeda Maryam
- Bailey-Elkin Ben A.
- Balakrishnan Bijina
- BalanÌa-Fouce Rafael
- Ballatore Carlo
- Banerjee Sourav
- Banerji Versha
- Banjo Toshihiro
- Barghash Marim M.
- Batey Robert A.
- Battistoni Andrea
- Baumann Ulrich
- Bdira Fredj Ben
- Bedi Mel
- Ben-Johny Manu
- Bergman Bastiaan
- Bernard Denzil
- Berti Andrew
- Bharambe Nikhil
- Bishop Ozlem Tastan
- Blanchet Xavier
- Blelloch Robert
- Blumenthal Robert M.
- BognaÌr Gabriella
- Bogomolovas Julijus
- Bon Carlotta
- Boorman Jacob
- Borowska Anna
- Borriello Francesco
- Bowman Gregory R.
- Bradley Robert K.
- Bradshaw William J.
- Brady-Kalnay Susann M.
- Breton Hairol E.
- Bruning John B.
- Bruning John Burt
- Bryant-Friedrich Amanda
- Buckner Frederick S.
- Buroni Silvia
- Butler Brittany
- Byrne Lee J.
- Byun Soo Young
- Caflisch Amedeo
- Cakir Isin
- Caliandro Ileana
- Caljon Guy
- Cann Andrew B.
- Caporali Andrea
- Capuzzi Stephen J.
- Caroleo Maria Cristina
- Cathcart Ann M.
- Celano Stephanie L.
- Cerna Mark Vincent C. dela
- Chadni Somaia Haque
- Champion Matthew M.
- Chan Nei-Li
- Chapman Carly J.
- Chaton Catherine T.
- Chatterjee Arnab K.
- Chaudhuri Dipayan
- Chauhan Shefali
- Chaytow Helena
- Chen Daniel
- Chen Lifeng
- Chen Yicheng
- Chern Ting-Rong
- Chini Andrea
- Chou Tristan
- Chou Tsui-Fen
- Christensen Emily M.
- Christodoulides Myron
- Chu Shaoyou
- Chua Benjamin Soon Kai
- Chuah Janelle
- Chung Zara
- Chuong Patrick
- Ciccia Alberto
- Cildir GoÌkhan
- Cione Erika
- Clayton W. Brent
- Coles John G.
- Colomba Audrey
- Colotti Gianni
- Conn Graeme L.
- Conticello Silvestro G.
- Contreras Stephanie
- Cools Julie
- Coombe Deirdre R.
- Corson Timothy W.
- Cortopassi Gino
- Corvo Ileana
- Costoya Jose A.
- Cowen Leah E.
- Cox Bryan D.
- Cuddihy Andrew R.
- Cullinane Ryan T.
- Cunningham Kathryn A.
- Dahal Gopal
- Dallman Sydney
- Dame Remus T.
- Davtyan Aram
- De Keulenaer Gilles
- De Luise Monica
- de Oliveira Aldo Sena
- de Oliveira Saulo
- de Sousa Alessandra Mara
- de Souza Guilherme Eduardo
- Debonsi Hosana Maria
- Degterev Alexei
- DeHaan Nicholas
- Del Rio Flores Antonio
- Dempsey Garrett
- Desai Umesh R.
- Diallo Bakary Nâtji
- Dickhout Jeffrey
- Dickinson Bryan C.
- Dieck Chelsea L.
- Dirksen Dorian
- do Monte-Neto Rubens Lima
- Dolce Vincenza
- Donaldson William A.
- Douville ReneÌe N.
- Dowling David J.
- Drewry David H.
- Duggan Brendan M.
- Duncan Dustin
- Dymock Brian W.
- Dzhumaev Sergei
- DâAntuono Anna
- Ebright Richard H.
- Eckert Sam
- Edelman Benjamin L.
- Eitzen Gary
- ElSheikh Assmaa
- Englinger Bernhard
- Escaffre Olivier
- Espinoza Stefano
- Evans Jay D.
- Faller Kiterie M. E.
- Fan Erkang
- Fan Hua-Ying
- Fathallah M. Dahmani
- Feng Hui
- Ferrando Adolfo A.
- Ferraris Davide Maria
- Ferreira Jacob
- Ferreira Rafaela Salgado
- Fiermonte Giuseppe
- Finkelstein Joshua M.
- Fiorillo Annarita
- Fish Paul V.
- Foong Wuen Ee
- Foote Andrea Talbot
- Francisco Karol R.
- Frangos Zachary J.
- Fraser Cameron
- Freiberg Alexander N.
- Freywald Andrew
- Friedland Greg
- Fries Jacob
- Gadar Kavita
- Gandhi Neha S.
- Garaeva Alisa A.
- Garavaglia Silvia
- Garcia George A.
- GarciÌa-Cuesta Eva M.
- Garmendia Antonio E.
- Gasparre Giuseppe
- Gavathiotis Evripidis
- Gebauer Jan M.
- Geden Sandra E.
- Geisbrecht Brian V.
- Gelardi Edoardo Luigi Maria
- Gerwick William H.
- Ghilarducci Kim
- Ghosh Agnidipta
- Giardini Miriam A.
- Gierse Robin Matthias
- Giesler Kyle
- Gillingwater Thomas H.
- Gingras Alexandre R.
- Giorgis Marta
- Girolimetti Giulia
- Glubb Dylan M.
- Glukhov Evgenia
- Gniewek Pawel
- Goldenberg Joshua M.
- Gong Bin
- Gorgoglione Ruggiero
- Granneman James G.
- Greene Geoffrey L.
- Greig Iain R.
- Gruber Joshua J.
- Guido Rafael V. C.
- Gumede Njabulo Joyfull
- Gunasekharan Vignesh
- Gupta Tushita
- Gupta Yogesh K.
- Gustincich Stefano
- Haas Arthur L.
- Hahn William C.
- Haikarainen Teemu
- Hammock Bruce D.
- Hannink Mark
- Hansen Kasper B.
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- Wang Jun
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- Wang Zhenghe
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- Wazir Sarah
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- Welsbie Derek S.
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- White Andrew
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- Wilson Mark A.
- Windisch Marc P.
- Wong Keith S.
- Woods Virgil A.
- Worley Brad
- Wu Pengpeng
- Wu Xiaoyang
- Wulff Heike
- Xiang Fei
- Xu Hongyang
- Xu Jiake
- Xu Jingyi
- Xu Sophia Q.
- Xu Xin
- Yan Riqiang
- Yang Chao-Yie
- Yen Yun
- Young Matthew A.
- Yu Fang
- Yu Xinfang
- Yuan Haynes
- Yuan Xinrui
- Zahler Stefan
- Zeina Christina M.
- Zelinskaya Natalia
- Zhang Dingqiang
- Zhang Gang
- Zhang Wenjun
- Zhang Xu
- Zhang Yan Jessie
- Zhang Zhiguo
- Zhao Jinshi
- Zhou Han
- Zhou Hui
- Zhou Jia
- Zhou Pei
- Zhou Shan
- Zhu Jiaqi
- Zhu Siran
- Zhu Yini
- Zhuo Ling
- Zochodne Douglas William
- Publication venue
- Publication date
- 01/01/2024
- Field of study
: High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNetÂź convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, high-quality X-ray crystal structures, or manual cherry-picking of compounds. We show that the molecules selected by the AtomNetÂź model are novel drug-like scaffolds rather than minor modifications to known bioactive compounds. Our empirical results suggest that computational methods can substantially replace HTS as the first step of small-molecule drug discovery
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
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- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
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- Andrews Stephanie
- Andriese Tim
- Anthouard VĂ©ronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
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- Arellano Andre
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- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
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- Asakawa Shuichi
- Asakawa Teruyo
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- Eugene Craig S.
- Evans Gareth
- Evans John
- Evans Katie
- Evans Richard
- Eveleth Gerald
- Eyras Eduardo
- Fan Hongyuan
- Fan Keke
- Fang Jianqiu
- Farina Abderrahim
- Faro Susan
- Faulkner Louisa
- Fawcett Joseph J.
- Fechtel Kim
- Fellingham Charlotte
- Felming Claire
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- Fernando Pushpa Ranjani
- Ferriera Pat
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- Finley Maria C.
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- Fischer Heather
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- Flanagan J.
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- Flint Mark
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- Fonknechten NĂșrua
- Footman Simon
- Forbes Lisa D.
- Ford Amanda F.
- Foster Myre J.
- Fotopulos Dea
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- Fowler John
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- Fujiyama Asao
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- Fuller Liam
- Fuller Sharin
- Fullerton Kathryn
- Fulton Lucinda A.
- Fulton Robert S.
- Furey Terrence S.
- Furuhashi Mie
- Förste Silke
- Gabisi Abdul M.
- Gage Diane
- Gaige Tony
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- Garcia Ricardo M, III
- Garcia-Martinez Antonio
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- Gardner Alison
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- Gardyna Steph
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- Garner Toni T.
- Garnes Jeffrey A.
- Garnett Jane
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- Gatland Leigh
- Gatland Lindsay
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- Gonzalez Guillermo B.
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- Grady Michelle L.
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- Griffiths Coline
- Griffiths Ed
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- Han Guiqing
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- Hancock Julie
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- Harding Adam
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- Heyen Joshua
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- Hillyard Guy
- Hines Sandra
- Hinkins Russell
- Hinrichs Angela S.
- Hitchens Matthew Edward
- Ho Issac
- Ho Sara-Jane
- Hodgson Anne V.
- Hodgson David
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- Iliev Ilian
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- Imo Kelvin C.
- Inacio Nicole
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- Ishibashi Akiko
- Ishikawa Sabine K.
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- Krawczyk Marie-Claude
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- Kremmidiotis Gabriel
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- Kruchowski Scott S.
- Kube Michael
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- MacLean Christine
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- Marra Marco
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- Nwokenkwo Stanley
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- O\u27Donovan Daniel
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- Tochigi Miwako
- Togashi Naoko
- Tomizawa Iori
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- Wyatt Julia
- Wycoff-Montenegro Melissa
- Wylie Kris
- Wyman Dudley
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- Xi Yan
- Xi Yingying
- Xie Fei
- Xie Gary
- Xie Jane
- Xiong Hui
- Xiong Yuqing
- Xu Alex
- Xu Jing
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- Xu Shuhua
- Xu Wei
- Xu Xinlai
- Xu Yan
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- Xu Zhihong
- Xu Zuyuan
- Xuan Yali
- Xuan Zhenyu
- Xue Rui
- Yada Tetsushi
- Yadav Shailendra
- Yakub Syed
- Yamamoto Lynn
- Yamamoto Noriko
- Yamamoto Yuko
- Yamashita Yasue
- Yamazaki Satoru
- Yang Hao
- Yang Huanming
- Yang Huanming
- Yang Joan
- Yang Shiaw-Pyng
- Yang Shudong
- Yang Xiaonan
- Yang Xiaonan
- Yang Xiaoping
- Yang Yongkui
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- Yao Zhijian
- Yao Zhijian
- Yaspo Marie-Laure
- Ye Chen
- Yeager Shane
- Yeh Mimi
- Yen Jennifer
- Yeshitela Rahel Retta
- Yoakum Martin
- Yokobata Kathy
- Yokoyama Jennifer
- Yonezawa Miho
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- Yoon Vivienne
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- You Bo
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- Younger Ruth
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- Yu Jun
- Yu Jun
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- Yuan Ye
- Yuan Yida
- Yue Shujie
- Yumae Brian
- Yun Rui
- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
- Zhang Bo
- Zhang Caimin
- Zhang Fengmei
- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers âŒ99% of the euchromatic genome and is accurate to an error rate of âŒ1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
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