Writing and Its Mis/Fortunes: How I write Where I Write

Panel: Writing and Its Mis/Fortunes: How I Write Where I Writ

Take a sip of TEI and relax: a proposition for an end-to-end workflow to enrich and publish data created with automatic text recognition

International audienc

Aplikasi Lima Kunci Keamanan Pangan dalam Pemilihan Pangan Jajanan Anak Sekolah (PJAS) oleh Murid SD Inpres Bertingkat Kelapa Lima II Kota Kupang

Street Food provides an important contribution to the fulfillment of children's energy while in school, but street food is very risky for biological, physical, and chemical contamination. These problems caused by several factors, namely the knowledge, attitudes, and actions of the makers, sellers, and buyers, about the importance of food security. Therefore, one of the efforts made by the government to overcome food insecurity is by educating five keys of food safety measures for the school community, students, and vendors of Pupils street food. This study is descriptive research that aims to know the knowledge and attitudes of the pupils in choosing food and vendors in processing street food at SD Inpres Bertingkat Kelapa Lima II Kota Kupang dealing with the five food security keys. The samples in this study were 52 students and 4 food vendors. The results showed that the knowledge of 52 student respondents, specifically 35 (67.3%) students had good knowledge, 14 (26.9%) students had sufficient knowledge, and 3 (5.8%) students had less knowledge. The attitude of 52 Respondents were categorized as Positive (100%). The respondent's actions based on triangulation revealed that the most of respondents still had actions that were not in accordance with the 5 keys food safety measures in the Selection of Snacks for Students

TRAPPC11 and GOSR2 mutations associate with hypoglycosylation of α-dystroglycan and muscular dystrophy

Abstract Background Transport protein particle (TRAPP) is a supramolecular protein complex that functions in localizing proteins to the Golgi compartment. The TRAPPC11 subunit has been implicated in muscle disease by virtue of homozygous and compound heterozygous deleterious mutations being identified in individuals with limb girdle muscular dystrophy and congenital muscular dystrophy. It remains unclear how this protein leads to muscle disease. Furthermore, a role for this protein, or any other membrane trafficking protein, in the etiology of the dystroglycanopathy group of muscular dystrophies has yet to be found. Here, using a multidisciplinary approach including genetics, immunofluorescence, western blotting, and live cell analysis, we implicate both TRAPPC11 and another membrane trafficking protein, GOSR2, in α-dystroglycan hypoglycosylation. Case presentation Subject 1 presented with severe epileptic episodes and subsequent developmental deterioration. Upon clinical evaluation she was found to have brain, eye, and liver abnormalities. Her serum aminotransferases and creatine kinase were abnormally high. Subjects 2 and 3 are siblings from a family unrelated to subject 1. Both siblings displayed hypotonia, muscle weakness, low muscle bulk, and elevated creatine kinase levels. Subject 3 also developed a seizure disorder. Muscle biopsies from subjects 1 and 3 were severely dystrophic with abnormal immunofluorescence and western blotting indicative of α-dystroglycan hypoglycosylation. Compound heterozygous mutations in TRAPPC11 were identified in subject 1: c.851A>C and c.965+5G>T. Cellular biological analyses on fibroblasts confirmed abnormal membrane trafficking. Subject 3 was found to have compound heterozygous mutations in GOSR2: c.430G>T and c.2T>G. Cellular biological analyses on fibroblasts from subject 3 using two different model cargo proteins did not reveal defects in protein transport. No mutations were found in any of the genes currently known to cause dystroglycanopathy in either individual. Conclusion Recessive mutations in TRAPPC11 and GOSR2 are associated with congenital muscular dystrophy and hypoglycosylation of α-dystroglycan. This is the first report linking membrane trafficking proteins to dystroglycanopathy and suggests that these genes should be considered in the diagnostic evaluation of patients with congenital muscular dystrophy and dystroglycanopathy

PENGEMBANGAN AGRIBISNIS KEDELAI

viii,; 99 hlm,; 21 c

Littérature-monde en français et littérature africaine francophone

Le 16 mars 2007, Le Monde des livres publiait un manifeste signé par 44 écrivains appelant à une « littérature-monde en français ». Quelques mois plus tard, un ouvrage collectif, Pour une littérature-monde, sous la direction de Michel Le Bris et de Jean Rouaud, réunissait plus d’une vingtaine de textes dont la majorité écrite par des auteurs de l’Afrique noire, des Antilles et du Maghreb. Pour Michel Le Bris, chef de file du manifeste des 44, la France entame un tournant historique dans sa vi..