One-Step, Three-Factor Passthought Authentication With Custom-Fit, In-Ear EEG

In-ear EEG offers a promising path toward usable, discreet brain-computer interfaces (BCIs) for both healthy individuals and persons with disabilities. To test the promise of this modality, we produced a brain-based authentication system using custom-fit EEG earpieces. In a sample of N = 7 participants, we demonstrated that our system has high accuracy, higher than prior work using non-custom earpieces. We demonstrated that both inherence and knowledge factors contribute to authentication accuracy, and performed a simulated attack to show our system's robustness against impersonation. From an authentication standpoint, our system provides three factors of authentication in a single step. From a usability standpoint, our system does not require a cumbersome, head-worn device

Broad targeting of resistance to apoptosis in cancer

Apoptosis or programmed cell death is natural way of removing aged cells from the body. Most of the anti-cancer therapies trigger apoptosis induction and related cell death networks to eliminate malignant cells. However, in cancer, de-regulated apoptotic signaling, particularly the activation of an anti-apoptotic systems, allows cancer cells to escape this program leading to uncontrolled proliferation resulting in tumor survival, therapeutic resistance and recurrence of cancer. This resistance is a complicated phenomenon that emanates from the interactions of various molecules and signaling pathways. In this comprehensive review we discuss the various factors contributing to apoptosis resistance in cancers. The key resistance targets that are discussed include (1) Bcl-2 and Mcl-1 proteins; (2) autophagy processes; (3) necrosis and necroptosis; (4) heat shock protein signaling; (5) the proteasome pathway; (6) epigenetic mechanisms; and (7) aberrant nuclear export signaling. The shortcomings of current therapeutic modalities are highlighted and a broad spectrum strategy using approaches including (a) gossypol; (b) epigallocatechin-3-gallate; (c) UMI-77 (d) triptolide and (e) selinexor that can be used to overcome cell death resistance is presented. This review provides a roadmap for the design of successful anti-cancer strategies that overcome resistance to apoptosis for better therapeutic outcome in patients with cancer

Fashioning readers: canon, criticism and pedagogy in the emergence of modern Oriya literature

Through a brief history of a widely published canon debate in nineteenth century Orissa, this article describes how anxieties about the quality of ‘traditional’ Oriya literature served as a site for imagining a cohesive Oriya public who would become the consumers and beneficiaries of a new, modernized Oriya-language canon. A public controversy about the status of Oriya literature was initiated in the 1890s with the publication of a serialized critique of the works of Upendra Bhanja, a very popular pre-colonial Oriya poet. The critic argued that Bhanja’s writing was not true poetry, that it did not speak to the contemporary era, and that it featured embarrassingly detailed discussions of obscene material. By unpacking the terms of this criticism and Oriya responses to it, I reveal how at the heart of these discussions were concerns about community building that presupposed a new kind of readership of literature in the Oriya language. Ultimately, this article offers a longer, regional history to the emerging concern of post-colonial scholarship with relationships between publication histories, readerships, and broader ideas of community – local, Indian, and global