85 research outputs found
Suzaku Observations of Luminous Quasars: Revealing the Nature of High-Energy Blazar Emission in Quiescent States
We present the results from the Suzaku X-ray observations of five
flat-spectrum radio quasars (FSRQs), namely PKS0208-512, Q0827+243,
PKS1127-145, PKS1510-089 and 3C 454.3. All these sources were additionally
monitored simultaneously or quasi-simultaneously by the Fermi satellite in
gamma-rays and the Swift UVOT in the UV and optical bands, respectively. We
constructed their broad-band spectra covering the frequency range from 10^14 Hz
up to 10^25 Hz, and those reveal the nature of high-energy emission of luminous
blazars in their low-activity states. The analyzed X-ray spectra are well
fitted by a power-law model with photoelectric absorption. In the case of
PKS0208-512, PKS1127-145, and 3C 454.3, the X-ray continuum showed indication
of hard-ening at low-energies. Moreover, when compared with the previous X-ray
observations, we see a significantly increasing contribution of low-energy
photons to the total X-ray fluxes when the sources are getting fainter. The
same behavior can be noted in the Suzaku data alone. A likely explanation
involves a variable, flat-spectrum component produced via inverse-Compton (IC)
emission, plus an additional, possibly steady soft X-ray component prominent
when the source gets fainter. This soft X-ray excess is represented either by a
steep powerlaw (photon indices Gamma ~ 3 - 5) or a blackbody-type emission with
temperatures kT ~ 0.1-0.2 keV. We model the broad-band spectra spectra of the
five observed FSRQs using synchrotron self-Compton (SSC) and/or
external-Compton radiation (ECR) models. Our modeling suggests that the
difference between the low and high-activity states in luminous blazars is due
to the different total kinetic power of the jet, most likely related to varying
bulk Lorentz factor of the outflow within the blazar emission zone.Comment: 36 pages, 8 figures, 11 tables. Accepted for publication in the
Astrophysical Journal
Association of plasma and cortical beta-amyloid is modulated by APOE ε4 status.
Background: APOE ε4’s role as a modulator of the relationship between soluble plasma beta-amyloid (Aβ) and fibrillar brain Aβ measured by Pittsburgh Compound-B positron emission tomography ([11C]PiB PET) has not been assessed. Methods: Ninety-six Alzheimer’s Disease Neuroimaging Initiative participants with [11C]PiB scans and plasma Aβ1-40 and Aβ1-42 measurements at time of scan were included. Regional and voxel-wise analyses of [11C]PiB data were used to determine the influence of APOE ε4 on association of plasma Aβ1-40, Aβ1-42, and Aβ1-40/Aβ1-42 with [11C]PiB uptake. Results: In APOE ε4− but not ε4+ participants, positive relationships between plasma Aβ1-40/Aβ1-42 and [11C]PiB uptake were observed. Modeling the interaction of APOE and plasma Aβ1-40/Aβ1-42 improved the explained variance in [11C]PiB binding compared to using APOE and plasma Aβ1-40/Aβ1-42 as separate terms. Conclusions: The results suggest that plasma Aβ is a potential Alzheimer’s disease biomarker and highlight the importance of genetic variation in interpretation of plasma Aβ levels
Fighting Conflict: Violent Splits or Healthy Divides?
In this study, we develop a theory to understand how groups with strong divisions may, paradoxically, help members to cope with conflict and injustice. We test our theoretical predictions using a survey methodology and the data from 72 work groups across different industries. Consistent with our hypotheses, we found that group faultlines weakened the positive relationships between injustice and psychological health
Fermi/LAT discovery of gamma-ray emission from the flat-spectrum radio quasar PKS 1454-354
We report the discovery by the Large Area Telescope (LAT) onboard the Fermi
Gamma-ray Space Telescope of high-energy gamma-ray (GeV) emission from the
flat-spectrum radio quasar PKS 1454-354 (z=1.424). On 4 September 2008 the
source rose to a peak flux of (3.5 +/- 0.7)x 10^-6 ph cm^-2 s^-1 (E > 100 MeV)
on a time scale of hours and then slowly dropped over the following two days.
No significant spectral changes occurred during the flare. Fermi/LAT
observations also showed that PKS 1454-354 is the most probable counterpart of
the unidentified EGRET source 3EG J1500-3509. Multiwavelength measurements
performed during the following days (7 September with Swift; 6-7 September with
the ground-based optical telescope ATOM; 13 September with the Australia
Telescope Compact Array) resulted in radio, optical, UV and X-ray fluxes
greater than archival data, confirming the activity of PKS 1454-354.Comment: 8 pages, 5 figures, 2 tables. Accepted for publication on ApJ Main
Journa
Nothing Lasts Forever: Environmental Discourses on the Collapse of Past Societies
The study of the collapse of past societies raises many questions for the theory and practice of archaeology. Interest in collapse extends as well into the natural sciences and environmental and sustainability policy. Despite a range of approaches to collapse, the predominant paradigm is environmental collapse, which I argue obscures recognition of the dynamic role of social processes that lie at the heart of human communities. These environmental discourses, together with confusion over terminology and the concepts of collapse, have created widespread aporia about collapse and resulted in the creation of mixed messages about complex historical and social processes
Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study
Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research
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