La cerámica de Coscopunta, un sitio del Periodo Intermedio Tardío en la provincia de Carhuaz, Callejón de Huaylas, Perú

Este artículo ofrece la descripción de un gran grupo de vasijas completas o casi completas fechadas en el Periodo Intermedio Tardío que fueron descubiertas por un agricultor en 1979 en la aldea de Coscopunta, cerca del pueblo de Anta, provincia de Carhuaz, Ancash. Esta cerámica tiene un alto grado de variabilidad pero una baja calidad en su producción. Aunque este estilo comparte elementos con otros estilos de la misma época en la zona, como Aquilpo, Chakwas y Pójoc, es fácil distinguirlo. Esta observación refuerza la impresión de que en la sierra de Ancash, durante el Periodo Intermedio Tardío, se produjo cerámica local en muchos lugares y que esta cerámica no servía de vehículo para representar unidades políticas o étnicas. Al mismo tiempo, el análisis de la cerámica de Coscopunta ofrece evidencia para contactos directos entre las comunidades de la Cordillera Negra, e inclusive con grupos más al oeste en la costa norte. Finalmente, se plantea la hipótesis que el grupo de cerámica completa y otros materiales descritos en este ensayo podrían haber sido enterrados como ofrendas a un huanca ubicado en un campo de cultivo en Coscopunta.Cet article décrit un ensemble important de céramiques entières ou presque entières datant de l’Intermédaire Récent, découvertes en 1979 par un agriculteur dans le village de Coscopunta, près de Anta, province de Carhuaz, Ancash. Cette céramique est très variée, mais de facture médiocre. Bien que certains éléments de ce style soient comparables à d’autres styles de la même époque dans la région, comme Aquilpo, Chakwas y Pójoc, il est facile de les différentier. Cette observation renforce l’impression que dans la sierra de Ancash, au cours de l’Intermédiaire récent, de la céramique ait été produite localement dans de nombreux endroits et que cette céramique n’ait pas servi de véhicule de representation des unités politiques ou ethniques. En même temps, l’analyse de la céramique de Coscopunta permet de prouver l’existence de liens directs entre les communautés de la Cordillère noire, et même avec des groupes plus à l’ouest sur la côte nord. Finalement les auteurs proposent que l’ensemble des céramiques entières et d’autres matériels décrits dans cet article aient été entérrés comme offrande à un huanca situé dans une parcelle de culture à Coscopunta.This essay describes a large group of complete or nearly complete Late Intermediate Period pottery vessels uncovered by a farmer in 1979 at the site of Coscopunta, near the town of the Anta, Carhuaz Province, Ancash. The assemblage, consisting mainly of jars and bowls, shows a considerable diversity in its style and low quality in its production. While the pottery style shares features known previously from the Callejón de Huaylas and Conchucos, it is easily destinguishable from these other styles (e.g. Aquilpo, Chakwas, Pójoc). This reinforces the impression that ceramics during the Late Intermediate Period were locally produced in the northern highlands and did not serve as emblems of large political or ethnic units. At the same time, the ceramic assemblage from Coscopunta offers evidence of direct contact between different communities in the Cordillera Negra, as well as with groups living on the Pacific coast. Finally, it is hypothesized that the group of pottery and other materials discussed in this article may have been deposited as offerings to a huanca located in the middle of an agricultural field at Coscopunta

Northeast Conference on Andean Archaeology and Ethnohistory (NCAAE) Statement on Sexual harassment and Community Values

This is a statement on sexual harassment and community values signed by eight members of the Northeast Conference on Andean Archaeology and Ethnohistory (NCAAE)https://digitalcommons.library.umaine.edu/andean_past_special/1008/thumbnail.jp

Effects of partner proteins on BCA2 RING ligase activity

Abstract Background BCA2 is an E3 ligase linked with hormone responsive breast cancers. We have demonstrated previously that the RING E3 ligase BCA2 has autoubiquitination activity and is a very unstable protein. Previously, only Rab7, tetherin, ubiquitin and UBC9 were known to directly interact with BCA2. Methods Here, additional BCA2 binding proteins were found using yeast two-hybrid and bacterial-II-hybrid screening techniques with Human breast and HeLa cDNA libraries. Co-expression of these proteins was analyzed through IHC of TMAs. Investigation of the molecular interactions and effects were examined through a series of in vivo and in vitro assays. Results Ten unique BCA2 interacting proteins were identified, two of which were hHR23a and 14-3-3sigma. Both hHR23a and 14-3-3sigma are co-expressed with BCA2 in breast cancer cell lines and patient breast tumors (n = 105). hHR23a and BCA2 expression was significantly correlated (P = \u3c 0.0001 and P = 0.0113) in both nucleus and cytoplasm. BCA2 expression showed a statistically significant correlation with tumor grade. High cytoplasmic hHR23a trended towards negative nodal status. Binding to BCA2 by hHR23a and 14-3-3sigma was confirmed in vitro using tagged partner proteins and BCA2. hHR23a and 14-3-3sigma effect the autoubiquitination and auto-degradation activity of BCA2. Ubiquitination of hHR23a-bound BCA2 was found to be dramatically lower than that of free BCA2, suggesting that hHR23a promotes the stabilization of BCA2 by inactivating its autoubiquitination activity, without degradation of hHR23a. On the other hand, phosphorylated BCA2 protein is stabilized by interaction with 14-3-3sigma both with and without proteasome inhibitor MG-132 suggesting that BCA2 is regulated by multiple degradation pathways. Conclusions The interaction between BCA2 and hHR23a in breast cancer cells stabilizes BCA2. High expression of BCA2 is correlated with grade in breast cancer, suggesting regulation of this E3 ligase is important to cancer progression

Pretargeted adjuvant radioimmunotherapy with Yttrium-90-biotin in malignant glioma patients: A pilot study

In a previous study we applied a three-step avidin–biotin pretargeting approach to target 90Y-biotin to the tumour in patients with recurrent high grade glioma. The encouraging results obtained in this phase I–II study prompted us to apply the same approach in an adjuvant setting, to evaluate (i) time to relapse and (ii) overall survival. We enrolled 37 high grade glioma patients, 17 with grade III glioma and 20 with glioblastoma, in a controlled open non-randomized study. All patients received surgery and radiotherapy and were disease-free by neuroradiological examinations. Nineteen patients (treated) received adjuvant treatment with radioimmunotherapy. In the treated glioblastoma patients, median disease-free interval was 28 months (range=9–59); median survival was 33.5 months and one patient is still without evidence of disease. All 12 control glioblastoma patients died after a median survival from diagnosis of 8 months. In the treated grade III glioma patients median disease-free interval was 56 months (range=15–60) and survival cannot be calculated as only two, within this group, died. Three-step radioimmunotherapy promises to have an important role as adjuvant treatment in high grade gliomas, particularly in glioblastoma where it impedes progression, prolonging time to relapse and overall survival. A further randomized trial is justified

Measurement of the cross-section and charge asymmetry of WW bosons produced in proton-proton collisions at s=8\sqrt{s}=8 TeV with the ATLAS detector

This paper presents measurements of the $W^+ \rightarrow \mu^+\nu$ and $W^- \rightarrow \mu^-\nu$ cross-sections and the associated charge asymmetry as a function of the absolute pseudorapidity of the decay muon. The data were collected in proton--proton collisions at a centre-of-mass energy of 8 TeV with the ATLAS experiment at the LHC and correspond to a total integrated luminosity of 20.2~\mbox{fb^{-1}}. The precision of the cross-section measurements varies between 0.8% to 1.5% as a function of the pseudorapidity, excluding the 1.9% uncertainty on the integrated luminosity. The charge asymmetry is measured with an uncertainty between 0.002 and 0.003. The results are compared with predictions based on next-to-next-to-leading-order calculations with various parton distribution functions and have the sensitivity to discriminate between them.Comment: 38 pages in total, author list starting page 22, 5 figures, 4 tables, submitted to EPJC. All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2017-13

Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector

Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente

Search for chargino-neutralino production with mass splittings near the electroweak scale in three-lepton final states in √s=13 TeV pp collisions with the ATLAS detector

A search for supersymmetry through the pair production of electroweakinos with mass splittings near the electroweak scale and decaying via on-shell W and Z bosons is presented for a three-lepton final state. The analyzed proton-proton collision data taken at a center-of-mass energy of √s=13  TeV were collected between 2015 and 2018 by the ATLAS experiment at the Large Hadron Collider, corresponding to an integrated luminosity of 139  fb−1. A search, emulating the recursive jigsaw reconstruction technique with easily reproducible laboratory-frame variables, is performed. The two excesses observed in the 2015–2016 data recursive jigsaw analysis in the low-mass three-lepton phase space are reproduced. Results with the full data set are in agreement with the Standard Model expectations. They are interpreted to set exclusion limits at the 95% confidence level on simplified models of chargino-neutralino pair production for masses up to 345 GeV

The role of neutralizing antibodies in prevention of HIV-1 infection: what can we learn from the mother-to-child transmission context?

International audienceIn most viral infections, protection through existing vaccines is linked to the presence of vaccine-induced neutralizing antibodies (NAbs). However, more than 30 years after the identification of AIDS, the design of an immunogen able to induce antibodies that would neutralize the highly diverse HIV-1 variants remains one of the most puzzling challenges of the human microbiology. The role of antibodies in protection against HIV-1 can be studied in a natural situation that is the mother-to-child transmission (MTCT) context. Indeed, at least at the end of pregnancy, maternal antibodies of the IgG class are passively transferred to the fetus protecting the neonate from new infections during the first weeks or months of life. During the last few years, strong data, presented in this review, have suggested that some NAbs might confer protection toward neonatal HIV-1 infection. In cases of transmission, it has been shown that the viral population that is transmitted from the mother to the infant is usually homogeneous, genetically restricted and resistant to the maternal HIV-1-specific antibodies. Although the breath of neutralization was not associated with protection, it has not been excluded that NAbs toward specific HIV-1 strains might be associated with a lower rate of MTCT. A better identification of the antibody specificities that could mediate protection toward MTCT of HIV-1 would provide important insights into the antibody responses that would be useful for vaccine development. The most convincing data suggesting that NAbs migh confer protection against HIV-1 infection have been obtained by experiments of passive immunization of newborn macaques with the first generation of human monoclonal broadly neutralizing antibodies (HuMoNAbs). However, these studies, which included only a few selected subtype B challenge viruses, provide data limited to protection against a very restricted number of isolates and therefore have limitations in addressing the hypervariability of HIV-1. The recent identification of highly potent second-generation cross-clade HuMoNAbs provides a new opportunity to evaluate the efficacy of passive immunization to prevent MTCT of HIV-1