Effect of Altitude and Duration of Stay on Pulmonary Function in Healthy Indian Males

The study was carried out with the objective to investigate the effect of varying altitude and duration of exposure on blood pressure, heart rate and lung function parameters in healthy Indian soldiers after adopting proper acclimatization schedule. For this purpose 17 soldiers of Indian Army, weight and height matched, were studied after obtaining written consent. Recording of Blood pressure (systolic and diastolic), heart rate and lung function variables (FVC, FEV1, FEV1/FVC%, MVV, FEF25-75%, MEF 25%, MEF 50%, MEF 75%, PEF) were measured at basal (290m), 800m, 3200m (day 10 and day 20) and upon de-induction. Our results demonstrate that with increasing altitude FVC declined, FEV1 did not change and due to these changes FEV1/FVC% increased. Expiratory flow rates including MEF 25%, MEF50% MEF 75%, PEF and mean expiratory flow rate (FEF25-75%) increased upon induction to high altitude. This increase may be due to reduction in air density causing less air resistance which accelerates lung emptying. Though the increase upon induction in all the values was transient and returned to baseline values after de-induction. MVV reflecting respiratory muscle function increased significantly upon induction to altitude in our study and returned to basal values upon de-induction. Understanding respiratory system in mountainous regions and its further correlation with other systems pertaining to acclimatization could help in laying step in unveiling mechanism of human high altitude adaptation

Zmiany w stężeniu greliny, CCK, GLP-1 i ekspresji receptorów aktywowanych przez proliferatory peroksysomów w szczurzym modelu anoreksji wywołanej przez hipoksję

  Introduction: A high-altitude environment causes appetite loss in unacclimatised humans, leading to weight reduction. Ghrelin, cholecystokinin (CCK), and glucagon like peptide-1 (GLP-1), are gut hormones involved in the regulation of food intake and energy metabolism. The liver is an important site of metabolic regulation, and together with the gut it plays a role in food intake regulation. This study intends to study the timedependent changes occurring in plasma gut hormones, PPARα, PPARδ, and PGC1α, in the stomach and liver during hypoxia. Material and methods: Male Sprague Dawley rats were exposed to hypobaric hypoxia in a decompression chamber at 7620 m for different durations up to seven days. Results: Hypoxia increased circulating ghrelin from the third day onwards while CCK and GLP-1 decreased immediately. An increase in ghrelin, ghrelin receptor protein levels, and GOAT mRNA levels in the stomach was observed. Stomach cholecystokinin receptor (CCKAR), PPARα, and PPARδ decreased. Liver CCKAR decreased during the first day of hypoxia and returned to normal levels from the third day onwards. PPARα and PGC1α expression increased while PPARδ protein levels reduced in the liver on third day. Conclusion: Hypoxia alters the expression of ghrelin and ghrelin receptor in the stomach, CCKAR in the liver, and PPAR and its cofactors, which might be possible role players in the contribution of gut and liver to anorexia at high altitude. (Endokrynol Pol 2015; 66 (4): 334–341)    Wstęp: Przebywanie na dużej wysokości powoduje utratę apetytu u osób do tego nieprzystosowanych i prowadzi do redukcji masy ciała. Grelina, cholecystokinina (CCK) i peptyd glukagonopodobny 1 (GLP-1) są hormonami przewodu pokarmowego biorącymi udział w regulacji przyjmowania pokarmu i metabolizmu energii. Wątroba stanowi ważne miejsce regulacji metabolicznej i razem z jelitem spełnia istotną funkcję w regulacji przyjmowania pokarmu. Niniejsze badanie miało na celu ocenę zmian zależnych od czasu w stężeniu hormonów przewodu pokarmowego oraz ekspresji PPARα, PPARδ oraz PGC1α w żołądku i wątrobie występujących podczas hipoksji. Materiał i metody: Szczury Sprague Dawley płci męskiej poddano działaniu hipoksji hipobarycznej w komorze dekompresyjnej na wysokości 7620 m. Pobyty w komorze różniły się czasem trwania, do maksymalnie 7 dni. Wyniki: Hipoksja podwyższała stężenie krążącej greliny od trzeciego dnia pobytu z komorze do końca jego trwania, podczas gdy stężenia CCK i GLP-1 uległy natychmiastowemu obniżeniu. Zaobserwowano podwyższenie stężenie greliny, białka receptora greliny i GOAT mRNA w żołądku. W żołądku ekspresja receptorów cholecystokininy (CCKAR), PPARα i PPARδ uległy obniżeniu. stężenie wątrobowego CCKAR uległ obniżeniu pierwszego dnia wystąpienia hipoksji, powrócił do prawidłowego stężenia trzeciego dnia i pozostał prawidłowy do końca pobytu w komorze. Ekspresje PPARα i PGC1α wzrosły, podczas gdy stężenie białka PPARδ uległo obniżeniu w wątrobie. Wnioski: Hipoksja zmienia ekspresję greliny oraz receptora greliny w żołądku, CCKAR w wątrobie i PPAR oraz jego kofaktory, które mogą odgrywać rolę w przyczynianiu się jelit i wątroby do anoreksji przy przebywaniu na dużej wysokości. (Endokrynol Pol 2015; 66 (4): 334–341)

Influence of Altitude on Pulmonary Function

Variation in lung function at high altitude (HA) impacts the working capacity of individuals and may predispose body towards hypoxia induced illness. So, we investigated the changes in pulmonary function of healthy human male volunteers belonging to two different ethnicities i.e. Indian and Kyrgyz. Twenty, age and BMI matched, volunteers (Indian=10 and Kyrgyz=10) were recruited for the study. Measurement for pulmonary functions (FVC, FEV1, FEV1/FVC ratio, PEF, FEF 25-75%, MEF 25%, MEF 50%, MEF 75%, MVV) were performed on each individual at basal (800 m) and high altitude (4,111 m) on day 3,7,14 and 21. Results indicate that Kyrgyz has comparatively higher FVC, FEV1, PEF and MVV values and lower FEV1/FVC ratio upon altitude induction than those of Indian counterparts. Mid expiratory flow FEF25-75% was significantly increased in Kyrgyz upon altitude induction indicate more proficient lung emptying while only moderate increase at day 7 in Indian. MEF25% was significantly increased in Kyrgyz, while no change is observed in Indians at high altitude which indicates that 75% of lung emptying through small airways is better in Kyrgyz. MEF 50% and MEF 75% increased with altitude in both groups. For MVV, the maximum increase was ~17% in Indian at HA14 (p<0.01) and in Kyrgyz ~33% (p<0.001) at HA14 as compared to basal. Difference in lung function response observed, indicates that Kyrgyz has better pulmonary dynamics during altitude exposure as compared to Indian counterparts. The varied result observed may be due to different ethnic origin of the groups

Development of a water-based cooling system for the Muon Chamber detector system of the CBM experiment

A water-based cooling system is being investigated to meet the cooling requirement of the Gas Electron Multiplier (GEM) based Muon Chamber (MuCh) detector system of the Compressed Baryonic Matter (CBM) experiment at GSI, Germany. The system is based on circulating cold water through the channels inside an aluminium plate. The aluminium plate is attached to a GEM chamber. A feasibility study is conducted on one small and two real-size prototype cooling plates. A microcontroller based unit has been built and integrated into the system to achieve automatic control and monitoring of temperature on plate surface. The real-size prototypes have been used in a test beam experiment at the CERN SPS (Super Proton Synchrotron) with the lead beam on a lead target. A setup using three prototype modules has been prepared in the lab for testing in a simulated real life environment. This paper discusses the working principle, mechanical design, fabrication, and test results of the cooling prototypes in detail.Comment: 8 pages, 12 figures, 2 table

Challenges in QCD matter physics - The Compressed Baryonic Matter experiment at FAIR

Substantial experimental and theoretical efforts worldwide are devoted to explore the phase diagram of strongly interacting matter. At LHC and top RHIC energies, QCD matter is studied at very high temperatures and nearly vanishing net-baryon densities. There is evidence that a Quark-Gluon-Plasma (QGP) was created at experiments at RHIC and LHC. The transition from the QGP back to the hadron gas is found to be a smooth cross over. For larger net-baryon densities and lower temperatures, it is expected that the QCD phase diagram exhibits a rich structure, such as a first-order phase transition between hadronic and partonic matter which terminates in a critical point, or exotic phases like quarkyonic matter. The discovery of these landmarks would be a breakthrough in our understanding of the strong interaction and is therefore in the focus of various high-energy heavy-ion research programs. The Compressed Baryonic Matter (CBM) experiment at FAIR will play a unique role in the exploration of the QCD phase diagram in the region of high net-baryon densities, because it is designed to run at unprecedented interaction rates. High-rate operation is the key prerequisite for high-precision measurements of multi-differential observables and of rare diagnostic probes which are sensitive to the dense phase of the nuclear fireball. The goal of the CBM experiment at SIS100 (sqrt(s_NN) = 2.7 - 4.9 GeV) is to discover fundamental properties of QCD matter: the phase structure at large baryon-chemical potentials (mu_B > 500 MeV), effects of chiral symmetry, and the equation-of-state at high density as it is expected to occur in the core of neutron stars. In this article, we review the motivation for and the physics programme of CBM, including activities before the start of data taking in 2022, in the context of the worldwide efforts to explore high-density QCD matter.Comment: 15 pages, 11 figures. Published in European Physical Journal

Penilaian Kinerja Keuangan Koperasi di Kabupaten Pelalawan

This paper describe development and financial performance of cooperative in District Pelalawan among 2007 - 2008. Studies on primary and secondary cooperative in 12 sub-districts. Method in this stady use performance measuring of productivity, efficiency, growth, liquidity, and solvability of cooperative. Productivity of cooperative in Pelalawan was highly but efficiency still low. Profit and income were highly, even liquidity of cooperative very high, and solvability was good

Juxtaposing BTE and ATE – on the role of the European insurance industry in funding civil litigation

One of the ways in which legal services are financed, and indeed shaped, is through private insurance arrangement. Two contrasting types of legal expenses insurance contracts (LEI) seem to dominate in Europe: before the event (BTE) and after the event (ATE) legal expenses insurance. Notwithstanding institutional differences between different legal systems, BTE and ATE insurance arrangements may be instrumental if government policy is geared towards strengthening a market-oriented system of financing access to justice for individuals and business. At the same time, emphasizing the role of a private industry as a keeper of the gates to justice raises issues of accountability and transparency, not readily reconcilable with demands of competition. Moreover, multiple actors (clients, lawyers, courts, insurers) are involved, causing behavioural dynamics which are not easily predicted or influenced. Against this background, this paper looks into BTE and ATE arrangements by analysing the particularities of BTE and ATE arrangements currently available in some European jurisdictions and by painting a picture of their respective markets and legal contexts. This allows for some reflection on the performance of BTE and ATE providers as both financiers and keepers. Two issues emerge from the analysis that are worthy of some further reflection. Firstly, there is the problematic long-term sustainability of some ATE products. Secondly, the challenges faced by policymakers that would like to nudge consumers into voluntarily taking out BTE LEI

Search for stop and higgsino production using diphoton Higgs boson decays

Results are presented of a search for a "natural" supersymmetry scenario with gauge mediated symmetry breaking. It is assumed that only the supersymmetric partners of the top-quark (stop) and the Higgs boson (higgsino) are accessible. Events are examined in which there are two photons forming a Higgs boson candidate, and at least two b-quark jets. In 19.7 inverse femtobarns of proton-proton collision data at sqrt(s) = 8 TeV, recorded in the CMS experiment, no evidence of a signal is found and lower limits at the 95% confidence level are set, excluding the stop mass below 360 to 410 GeV, depending on the higgsino mass

Severe early onset preeclampsia: short and long term clinical, psychosocial and biochemical aspects

Preeclampsia is a pregnancy specific disorder commonly defined as de novo hypertension and proteinuria after 20 weeks gestational age. It occurs in approximately 3-5% of pregnancies and it is still a major cause of both foetal and maternal morbidity and mortality worldwide1. As extensive research has not yet elucidated the aetiology of preeclampsia, there are no rational preventive or therapeutic interventions available. The only rational treatment is delivery, which benefits the mother but is not in the interest of the foetus, if remote from term. Early onset preeclampsia (<32 weeks’ gestational age) occurs in less than 1% of pregnancies. It is, however often associated with maternal morbidity as the risk of progression to severe maternal disease is inversely related with gestational age at onset2. Resulting prematurity is therefore the main cause of neonatal mortality and morbidity in patients with severe preeclampsia3. Although the discussion is ongoing, perinatal survival is suggested to be increased in patients with preterm preeclampsia by expectant, non-interventional management. This temporising treatment option to lengthen pregnancy includes the use of antihypertensive medication to control hypertension, magnesium sulphate to prevent eclampsia and corticosteroids to enhance foetal lung maturity4. With optimal maternal haemodynamic status and reassuring foetal condition this results on average in an extension of 2 weeks. Prolongation of these pregnancies is a great challenge for clinicians to balance between potential maternal risks on one the eve hand and possible foetal benefits on the other. Clinical controversies regarding prolongation of preterm preeclamptic pregnancies still exist – also taking into account that preeclampsia is the leading cause of maternal mortality in the Netherlands5 - a debate which is even more pronounced in very preterm pregnancies with questionable foetal viability6-9. Do maternal risks of prolongation of these very early pregnancies outweigh the chances of neonatal survival? Counselling of women with very early onset preeclampsia not only comprises of knowledge of the outcome of those particular pregnancies, but also knowledge of outcomes of future pregnancies of these women is of major clinical importance. This thesis opens with a review of the literature on identifiable risk factors of preeclampsia

Azimuthal anisotropy of charged jet production in root s(NN)=2.76 TeV Pb-Pb collisions

We present measurements of the azimuthal dependence of charged jet production in central and semi-central root s(NN) = 2.76 TeV Pb-Pb collisions with respect to the second harmonic event plane, quantified as nu(ch)(2) (jet). Jet finding is performed employing the anti-k(T) algorithm with a resolution parameter R = 0.2 using charged tracks from the ALICE tracking system. The contribution of the azimuthal anisotropy of the underlying event is taken into account event-by-event. The remaining (statistical) region-to-region fluctuations are removed on an ensemble basis by unfolding the jet spectra for different event plane orientations independently. Significant non-zero nu(ch)(2) (jet) is observed in semi-central collisions (30-50% centrality) for 20 <p(T)(ch) (jet) <90 GeV/c. The azimuthal dependence of the charged jet production is similar to the dependence observed for jets comprising both charged and neutral fragments, and compatible with measurements of the nu(2) of single charged particles at high p(T). Good agreement between the data and predictions from JEWEL, an event generator simulating parton shower evolution in the presence of a dense QCD medium, is found in semi-central collisions. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Peer reviewe