917 research outputs found
Autoimmune and autoinflammatory mechanisms in uveitis
- Author
- A Amadi-Obi
- A Arida
- A Cortes
- A Fox
- A Jager
- A Peters
- A Rothova
- AC Anderson
- AD Dick
- AD Dick
- AD Dick
- AD Dick
- AD Dick
- AD Dick
- AD Dick
- AG Commodaro
- AG Commodaro
- AJ St. Leger
- AK Denniston
- AK Denniston
- AL Oberg
- Andrew D. Dick
- B Bodaghi
- B Engelhardt
- BJ Raveney
- BJ Raveney
- BJ Raveney
- BS Sheridan
- C Broderick
- C Terrada
- C-C Chan
- CC Murphy
- CEI Janssen
- Chi-Chao Chan
- CJ Calder
- CJ Chu
- CJ Chu
- D Atan
- D Atan
- D Atan
- D Atan
- D Banerjee
- D Luger
- D Perra
- DA Carter
- DA Copland
- DA Copland
- DA Copland
- DA Copland
- DA Jabs
- DC Wraith
- DF Martin
- DJ Hankey
- DJ Kilmartin
- DL Turner
- E Furusato
- EB Gouveia
- EC Kerr
- EC Kerr
- ED Mandelcorn
- EF Foxman
- EF Remmers
- EJ Wherry
- F An
- F Chen
- G Geri
- GJ Wright
- GJ Wright
- GR Wallace
- H Keino
- H Mielants
- H. Nida Sen
- HL Rosenzweig
- HL Rosenzweig
- HL Rosenzweig
- HM Cherwinski
- HN Sen
- IJ Crane
- J Bauer
- J Candia
- J Chen
- J Correale
- JA Todd
- JB Fordham
- JC Wei
- JF Bach
- JJ Kuiper
- JP Sherlock
- JT Rosenbaum
- JV Forrester
- JV Forrester
- JV Forrester
- JV Forrester
- K Gocho
- KG Anderson
- KH Sonoda
- KM Murphy
- KM Murphy
- L Jostins
- L Mao
- Lai Wei
- Lindsay B. Nicholson
- LK Grange
- LK Mackay
- LM Wakim
- LM Wakim
- LP Schewitz
- LV Rizzo
- M Chen
- M Cordero-Coma
- M Deckert
- M Greter
- M Khairallah
- M Pepper
- MC Jenmalm
- MG Netea
- MJ Mattapallil
- MJ Robertson
- MS Suttorp-Schulten
- N Hashida
- N Mizuki
- N Taylor
- N Yosef
- NA Rao
- O Tomkins-Netzer
- P Kivisäkk
- P Yang
- P Zamiri
- PA Kurz
- PB Medawar
- PP Sfikakis
- R Banchereau
- R Gold
- R Plumlee Courtney
- R Ramesh
- R Shechter
- R Zhang
- R Zhou
- RB Nussenblatt
- RB Nussenblatt
- RB Nussenblatt
- RB Nussenblatt
- RB Nussenblatt
- Richard W. Lee
- RJ Snelgrove
- RK Agarwal
- RM Hoek
- Robert B. Nussenblatt
- RP Nair
- RR Caspi
- RR Caspi
- RR Caspi
- RR Caspi
- RW Darrell
- RW Lee
- RW Lee
- RW Lee
- RW Read
- RW Read
- S Horie
- S Hou
- S Hou
- S Jawad
- S Ohno
- S Ooka
- S Preston
- S Sugita
- S Sugita
- S Sugita
- S Sugita
- S Yeh
- S Zhang
- SA Ramsey
- SB Su
- SC Bendall
- SC Teoh
- SJ Morrison
- SL Masters
- SM Islam
- SM Sharma
- SM Whitcup
- SR Boyd
- SR Taylor
- SR Thurau
- SR Thurau
- SW McPherson
- T Lambe
- T Yoshimura
- TA Manolio
- TM Martin
- U Kaufmann
- VL Calder
- W Chi
- W Chi
- WF Hickey
- WW Soon
- Y Fei
- Y Kirino
- Y Okunuki
- Y Peng
- Y Usui
- YH Lee
- Z Li
- Z Tu
- Publication venue
- Publication date
- 01/01/2014
- Field of study
The eye, as currently viewed, is neither immunologically ignorant nor sequestered from the systemic environment. The eye utilises distinct immunoregulatory mechanisms to preserve tissue and cellular function in the face of immune-mediated insult; clinically, inflammation following such an insult is termed uveitis. The intra-ocular inflammation in uveitis may be clinically obvious as a result of infection (e.g. toxoplasma, herpes), but in the main infection, if any, remains covert. We now recognise that healthy tissues including the retina have regulatory mechanisms imparted by control of myeloid cells through receptors (e.g. CD200R) and soluble inhibitory factors (e.g. alpha-MSH), regulation of the blood retinal barrier, and active immune surveillance. Once homoeostasis has been disrupted and inflammation ensues, the mechanisms to regulate inflammation, including T cell apoptosis, generation of Treg cells, and myeloid cell suppression in situ, are less successful. Why inflammation becomes persistent remains unknown, but extrapolating from animal models, possibilities include differential trafficking of T cells from the retina, residency of CD8(+) T cells, and alterations of myeloid cell phenotype and function. Translating lessons learned from animal models to humans has been helped by system biology approaches and informatics, which suggest that diseased animals and people share similar changes in T cell phenotypes and monocyte function to date. Together the data infer a possible cryptic infectious drive in uveitis that unlocks and drives persistent autoimmune responses, or promotes further innate immune responses. Thus there may be many mechanisms in common with those observed in autoinflammatory disorders
Diagnostic techniques for inflammatory eye disease: past, present and future: a review
- Author
- A Galor
- A Kijlstra
- A Kijlstra
- A Radwan
- A Rothova
- AA Akçakaya
- AC Hogan
- AD Dick
- AM Abu El-Asrar
- Andrew D Dick
- B Bodaghi
- B Wensing
- BC Ang
- CC Chan
- CC Murphy
- CD Quentin
- Centers for Disease Control and Prevention
- CJ Chu
- CJ Helm
- CM Deuter
- CM Eandi
- DA Jabs
- DC Gritz
- DJ Kilmartin
- DJ Kilmartin
- DK Sen
- DR Lucey
- DV Vasconcelos-Santos
- E Bloch-Michel
- E Dussaix
- EB Suhler
- ET Cunningham Jr
- F Forooghian
- F Willermain
- FR Imrie
- G Gorochov
- GN Holland
- GN Holland
- GS Baarsma
- H Chams
- H Dabil
- H Direskeneli
- H Talabani
- H Yasuoka
- HJ Turunen
- HN Sen
- I Lahmar
- IR Hill
- IS Barequet
- J Li
- J Suzuki
- JD De Groot-Mijnes
- JD de Groot-Mijnes
- JD Isaacs
- JE Marr
- JE Thorne
- JL Davis
- JV Iyer
- K Hoebe
- K Kimura
- K Ohta
- KJ Zamecki
- L Intzedy
- L Lim
- LA Wolf
- M Accorinti
- M Ang
- M Ang
- MD de Smet
- MF Tosi
- MP White
- MS Suttorp-Schulten
- MT Kuo
- MV Larsen
- N Cassoux
- N Cassoux
- ND Dore
- NJ Cutrufello
- O Villard
- P Kunavisarut
- P LeHoang
- P Mahendradas
- PC Ruokonen
- PI Murray
- PP Sfikakis
- QD Nguyen
- R Clark
- R Diel
- R McCoy
- R Witmer
- RA Zaldivar
- RB Nussenblatt
- RB Nussenblatt
- RO Kaçmaz
- S Baltatzis
- S Fekrat
- S Gangaputra
- S Hirose
- S Kaleemunnisha
- S Nayak
- S Ohno
- S Pasadhika
- S Yamamoto
- SB Teoh
- SC Park
- SC Teoh
- SC Teoh
- SE Coupland
- SE Coupland
- SE Coupland
- SM Whitcup
- SP Chee
- SR Rathinam
- SS Pujari
- Stephen C Teoh
- T Ghose
- T Larson
- T Mori
- TE Feltkamp
- V Gupta
- Y Kobashi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2013
- Field of study
Investigations used to aid diagnosis and prognosticate outcomes in ocular inflammatory disorders are based on techniques that have evolved over the last two centuries have dramatically evolved with the advances in molecular biological and imaging technology. Our improved understanding of basic biological processes of infective drives of innate immunity bridging the engagement of adaptive immunity have formed techniques to tailor and develop assays, and deliver targeted treatment options. Diagnostic techniques are paramount to distinguish infective from non-infective intraocular inflammatory disease, particularly in atypical cases. The advances have enabled our ability to multiplex assay small amount of specimen quantities of intraocular samples including aqueous, vitreous or small tissue samples. Nevertheless to achieve diagnosis, techniques often require a range of assays from traditional hypersensitivity reactions and microbe specific immunoglobulin analysis to modern molecular techniques and cytokine analysis. Such approaches capitalise on the advantages of each technique, thereby improving the sensitivity and specificity of diagnoses. This review article highlights the development of laboratory diagnostic techniques for intraocular inflammatory disorders now readily available to assist in accurate identification of infective agents and appropriation of appropriate therapies as well as formulating patient stratification alongside clinical diagnoses into disease groups for clinical trials
Serum Islet Cell Autoantibodies During Interferon α Treatment in Patients With HCV-Genotype 4 Chronic Hepatitis
- Author
- Abdel-Aziz F
- Ahmed A
- Ahmed El-Shaarawy
- Alter HJ
- Alter MJ
- Batstra MR
- Betterle C
- Carlo Selmi
- Dusheiko G
- el-Zayadi A
- Fabris P
- Fattovich G
- Fattovich G
- Fried MW
- Gamal Badra
- Gerber MA
- Hieronimus S
- Hoofnagle JH
- Imam Waked
- Kiehne K
- Koshy A
- Koshy A
- Lauer GM
- Legrand-Abravanel F
- Liang TJ
- Mahmoud Lotfy
- Manns MP
- Marcellin P
- Mason AL
- McOmish F
- Nguyen MH
- Ray SC
- Saleh M. Saleh
- Shepard CW
- Teoh NC
- Wasmuth HE
- Wesche B
- Zeuzem S
- Publication venue
- Hindawi Publishing Corporation
- Publication date
- 01/01/2006
- Field of study
Chronic hepatitis C virus (HCV) infection is a leading cause of end-stage liver disease worldwide and HCV genotype 4 (HCV4) is predominant in African and Middle Eastern countries. It is well established that interferon-α (IFNa) treatment for HCV may trigger serum autoantibodies against pancreatic islet cells (ICA) in a subgroup of patients. Available data on the incidence of ICA during IFNa therapy for chronic HCV4 infection are not conclusive. We investigated the appearance of ICA in 40 naïve Egyptian patients (38 males, 32 ± 6 years) with histologically defined chronic HCV4 infection undergoing IFNa treatment at a dose of 9-million U/week for 24 weeks. Serum samples were collected at baseline and following IFNa therapy and ICA were detected using indirect immunofluorescence. Baseline evaluation indicated that 2/40 (5%) patients had detectable serum ICA. After the completion of the treatment scheme, 12/38 (32%) previously ICA negative patients became ICA positive; however, no patient developed impaired glucose tolerance (IGT) or diabetes during follow-up. In conclusion, we submit that IFNa treatment for chronic hepatitis C (CHC) may induce serum ICA in one-third of Egyptian patients with HCV4. These autoantibodies, however, do not lead to alterations in glucose metabolism
Search for direct pair production of the top squark in all-hadronic final states in proton-proton collisions at s√=8 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
- Aben R
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Abreu R
- Abulaiti Y
- Acharya BS
- Adamczyk L
- Adams DL
- Adelman J
- Adomeit S
- Adye T
- Agatonovic-Jovin T
- Aguilar-Saavedra JA
- Agustoni M
- Ahlen SP
- Ahmadov F
- Aielli G
- Akerstedt H
- Akesson TPA
- Akimoto G
- Akimov AV
- Alberghi GL
- Albert J
- Albrand S
- Alconada Verzini MJ
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Alimonti G
- Alio L
- Alison J
- Allbrooke BMM
- Allison LJ
- Allport PP
- Almond J
- Aloisio A
- Alonso A
- Alonso F
- Alpigiani C
- Altheimer A
- Alviggi MG
- Amako K
- Amaral Coutinho Y
- Amelung C
- Amidei D
- Amor Dos Santos SP
- Amorim A
- Amoroso S
- Amram N
- Amundsen G
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders G
- Anderson KJ
- Andreazza A
- Andrei V
- Anduaga XS
- Angelidakis S
- Angelozzi I
- Anger P
- Angerami A
- Anghinolfi F
- Anh TV
- Anisenkov AV
- Anjos N
- Annovi A
- Antonaki A
- Antonelli M
- Antonov A
- Antos J
- Anulli F
- Aoki M
- Apolle R
- Arabidze G
- Aracena I
- Arai Y
- Araque JP
- Arce ATH
- Arguin J-F
- Argyropoulos S
- Arik M
- Armbruster AJ
- Arnaez O
- Arnal V
- Arnold H
- Arratia M
- Arslan O
- Artamonov A
- Artoni G
- Asai S
- Asbah N
- Ashkenazi A
- Asman B
- Asquith L
- Assamagan K
- Astalos R
- Atkinson M
- Atlay NB
- Auerbach B
- Augsten K
- Aurousseau M
- Avolio G
- Azuelos G
- Azuma Y
- Baak MA
- Baas A
- Bacci C
- Bachacou H
- Bachas K
- Backes M
- Backhaus M
- Badescu E
- Bagiacchi P
- Bagnaia P
- Bai Y
- Bain T
- Baines JT
- Baker OK
- Balek P
- Balli F
- Banas E
- Banerjee S
- Bannoura AAE
- Bansal V
- Bansil HS
- Barajas CAC
- Barak L
- Baranov SP
- Barberio EL
- Barberis D
- Barbero M
- Barillari T
- Barisonzi M
- Barklow T
- Barlow N
- Barnett BM
- Barnett RM
- Barnovska Z
- Baroncelli A
- Barone G
- Barr AJ
- Barreiro F
- Barrera CO
- Bartoldus R
- Barton AE
- Bartos P
- Bartsch V
- Bassalat A
- Basye A
- Bates RL
- Batkova L
- Batley JR
- Battaglia M
- Battistin M
- Bauer F
- Bawa HS
- Beau T
- Beauchemin PH
- Beccherle R
- Bechtle P
- Beck HP
- Becker K
- Becker S
- Beckingham M
- Becot C
- Beddall A
- Beddall AJ
- Bedikian S
- Bednyakov VA
- Bee CP
- Beemster LJ
- Beermann TA
- Begel M
- Behr K
- Belanger-Champagne C
- Belenguer MJ
- Bell PJ
- Bell WH
- Bella G
- Bella LA
- Bellagamba L
- Bellerive A
- Bellomo M
- Belotskiy K
- Beltramello O
- Benary O
- Benchekroun D
- Bendtz K
- Benekos N
- Benhammou Y
- Benjamin DP
- Bensinger JR
- Benslama K
- Bentvelsen S
- Berge D
- Berger N
- Berghaus F
- Beringer J
- Bernard C
- Bernat P
- Bernius C
- Bernlochner FU
- Berry T
- Berta P
- Bertella C
- Bertoli G
- Bertolucci F
- Bertsche D
- Besana MI
- Besjes GJ
- Bessidskaia O
- Bessner MF
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- Boldea V
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- Borisov A
- Borissov G
- Borri M
- Borroni S
- Bortfeldt J
- Bortolotto V
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- Boscherini D
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- Boudreau J
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- Bouhova-Thacker EV
- Boumediene D
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- Boveia A
- Boyd J
- Boyko IR
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- Brandt A
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- Caminal Armadans R
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- Canale V
- Canepa A
- Cantero J
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- Carrillo-Montoya GD
- Carter JR
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- Casadei D
- Casado MP
- Casolino M
- Castaneda-Miranda E
- Castanheira MTD
- Castelli A
- Castillo Gimenez V
- Castillo IS
- Castillo LRF
- Castro NF
- Catastini P
- Catinaccio A
- Catmore JR
- Cattai A
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- Cetin SA
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- Chalupkova I
- Chang P
- Chapleau B
- Chapman JD
- Charfeddine D
- Charlton DG
- Chau CC
- Cheatham S
- Chegwidden A
- Chekanov S
- Chekulaev SV
- Chelkov GA
- Chelstowska MA
- Chen C
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- Chen K
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- Chen S
- Chen X
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- Cheng HC
- Cheng Y
- Cheplakov A
- Cherkaoui El Moursli R
- Chernyatin V
- Cheu E
- Chevalier L
- Chiarella V
- Chiefari G
- Childers JT
- Chilingarov A
- Chiodini G
- Chisholm AS
- Chislett RT
- Chitan A
- Chizhov MV
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- Chow BKB
- Chromek-Burckhart D
- Chu ML
- Chudoba J
- Chwastowski JJ
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- Collaboration ATLAS
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- Compostella G
- Conde Muino P
- Coniavitis E
- Conidi MC
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- Connelly IA
- Consonni SM
- Consorti V
- Constantinescu S
- Conta C
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- Conventi F
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- Cooper BD
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- Cornelissen T
- Corradi M
- Correia AMH
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- Cortes-Gonzalez A
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- Costa MJ
- Costanzo D
- Cote D
- Cottin G
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- Cree G
- Crepe-Renaudin S
- Crescioli F
- Cribbs WA
- Cristinziani M
- Croft V
- Crosetti G
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- Cummings J
- Curatolo M
- Cuthbert C
- Czirr H
- Czodrowski P
- Czyczula Z
- D'Auria S
- D'Onofrio M
- da Costa JBG
- Da Costa JGPF
- Da Cunha Sargedas De Sousa MJ
- Da Via C
- Dabrowski W
- Dafinca A
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- Dallaire F
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- Dam M
- Damazio DO
- Daniells AC
- Dao V
- Darbo G
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- Daya-Ishmukhametova RK
- de Asmundis R
- De Bruin PHS
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- de Jong P
- De la Torre H
- de Lima DEF
- De Lorenzi F
- De Mendizabal JB
- De Nooij L
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- De Regie JBDV
- de Renstrom PAB
- De Salvo A
- De Sanctis U
- De Santo A
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- Dearnaley WJ
- Debbe R
- Debenedetti C
- Dechenaux B
- Dedovich DV
- Deigaard I
- Del Peso J
- Del Prete T
- Deliot F
- Delitzsch CM
- Deliyergiyev M
- Dell'Acqua A
- Dell'Asta L
- Dell'Orso M
- Della Pietra M
- della Porta GZ
- della Volpe D
- Delmastro M
- Delsart PA
- Deluca C
- Demers S
- Demichev M
- Demilly A
- Denisov SP
- Derendarz D
- Derkaoui JE
- Derue F
- Dervan P
- Desch K
- Deterre C
- Deviveiros PO
- Dewhurst A
- Dhaliwal S
- Di Ciaccio A
- Di Ciaccio L
- Di Domenico A
- Di Donato C
- Di Girolamo A
- Di Girolamo B
- Di Mattia A
- Di Micco B
- Di Nardo R
- Di Simone A
- Di Sipio R
- Di Valentino D
- Dias FA
- Diaz MA
- Diehl EB
- Dietrich J
- Dietzsch TA
- Diglio S
- Dimitrievska A
- Dingfelder J
- Dionisi C
- Dita P
- Dita S
- Dittus F
- Djama F
- Djobava T
- do Vale MAB
- Do Valle Wemans A
- Doan TKO
- Dobos D
- Doglioni C
- Doherty T
- Dohmae T
- Dolejsi J
- Dolezal Z
- Dolgoshein BA
- Donadelli M
- Donati S
- Dondero P
- Donini J
- Donszelmann TC
- Dopke J
- Doria A
- Dova MT
- Doyle AT
- Dris M
- Dubbert J
- Dube S
- Dubreuil E
- Duchovni E
- Duckeck G
- Ducu OA
- Duda D
- Dudarev A
- Dudziak F
- Duehrssen M
- Dueren M
- Duflot L
- Duguid L
- Dunford M
- Durglishvili A
- Dwuznik M
- Dyndal M
- Ebke J
- Edson W
- Edwards NC
- Ehrenfeld W
- Eifert T
- Eigen G
- Einsweiler K
- Ekelof T
- El Kacimi M
- Ellert M
- Elles S
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- Zanzi D
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- Zeman M
- Zemla A
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- Zhemchugov A
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- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann R
- Zimmermann S
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- Zobernig G
- Zoccoli A
- zur Nedden M
- Zurzolo G
- Zutshi V
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
The results of a search for direct pair production of the scalar partner to the top quark using an integrated luminosity of 20.1fb−1 of proton–proton collision data at √s = 8 TeV recorded with the ATLAS detector at the LHC are reported. The top squark is assumed to decay via t˜→tχ˜01 or t˜→ bχ˜±1 →bW(∗)χ˜01 , where χ˜01 (χ˜±1 ) denotes the lightest neutralino (chargino) in supersymmetric models. The search targets a fully-hadronic final state in events with four or more jets and large missing transverse momentum. No significant excess over the Standard Model background prediction is observed, and exclusion limits are reported in terms of the top squark and neutralino masses and as a function of the branching fraction of t˜ → tχ˜01 . For a branching fraction of 100%, top squark masses in the range 270–645 GeV are excluded for χ˜01 masses below 30 GeV. For a branching fraction of 50% to either t˜ → tχ˜01 or t˜ → bχ˜±1 , and assuming the χ˜±1 mass to be twice the χ˜01 mass, top squark masses in the range 250–550 GeV are excluded for χ˜01 masses below 60 GeV
Search for pair-produced long-lived neutral particles decaying to jets in the ATLAS hadronic calorimeter in ppcollisions at √s=8TeV
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
- Aben R
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Abreu R
- Abulaiti Y
- Acharya BS
- Adamczyk L
- Adams DL
- Adelman J
- Adomeit S
- Adye T
- Agatonovic-Jovin T
- Aguilar-Saavedra JA
- Agustoni M
- Ahlen SP
- Ahmadov F
- Aielli G
- Akerstedt H
- Akesson TP
- Akimoto G
- Akimov AV
- Alberghi GL
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
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- Alimonti G
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- Allbrooke BMM
- Allison LJ
- Allport PP
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- Yilmaz M
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- Zhemchugov A
- Zhong J
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- Zhuang X
- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zurzolo G
- Zutshi V
- Zwalinski L
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2014
- Field of study
The ATLAS detector at the Large Hadron Collider at CERN is used to search for the decay of a scalar boson to a pair of long-lived particles, neutral under the Standard Model gauge group, in 20.3fb−1of data collected in proton–proton collisions at √s=8TeV. This search is sensitive to long-lived particles that decay to Standard Model particles producing jets at the outer edge of the ATLAS electromagnetic calorimeter or inside the hadronic calorimeter. No significant excess of events is observed. Limits are reported on the product of the scalar boson production cross section times branching ratio into long-lived neutral particles as a function of the proper lifetime of the particles. Limits are reported for boson masses from 100 GeVto 900 GeV, and a long-lived neutral particle mass from 10 GeVto 150 GeV
Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector
- Author
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- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
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- Zhemchugov A
- Zheng Z
- Zhong D
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- Zimine N
- Zimmermann S
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- Zivkovic L
- Zobernig G
- Zoccoli A
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- Zorbas TG
- Zou R
- Zu Theenhausen HM
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente
Loss of C2orf69 defines a fatal autoinflammatory syndrome in humans and zebrafish that evokes a glycogen-storage-associated mitochondriopathy
- Author
- Akarsu NA
- Ali NA
- Alsubhi A
- Arman-Bilir O
- Bard FA
- Bascom CC
- Bauer P
- Bertoli-Avella A
- Boisson B
- Casanova J-L
- Cepni E
- Cetinkaya A
- Ceylaner S
- Chaabouni M
- Chai G
- Chia CY
- Choo SC
- Cimen DU
- Coon JJ
- Efthymiou S
- Eyaid W
- Georgiadou D
- Gilani N
- Gleeson JG
- Gumruk F
- Gurel A
- Hasbini D
- Ho L
- Houlden H
- Isfort RJ
- Isikay S
- Kayserili H
- Keng SS
- Khotaei GT
- Laine C
- Lee C
- Liang C
- Loh AYT
- Lupski JR
- Ly TTN
- Maier M
- Maroofian R
- Mathuru AS
- Maurer-Stroh S
- Mbarek H
- Mitani T
- Nathan FM
- Ordonez N
- Pagliarini DJ
- Paul F
- Pehlivan D
- Rensvold J
- Reversade B
- Rezaei N
- Seet SH
- Seyedpour S
- Shishkova E
- Simsek-Kiper PO
- Sirota FL
- Sng D
- Sotiropoulou K
- Talim B
- Teoh TS
- Traspas RM
- Tripolszki K
- Unal S
- Wong HH
- Xue S
- Yarali N
- Yilmaz E
- Zaki MS
- Zhang S
- Publication venue
- CELL PRESS
- Publication date
- 01/07/2021
- Field of study
Summary
Human C2orf69 is an evolutionarily conserved gene whose function is unknown. Here, we report eight unrelated families from which 20 children presented with a fatal syndrome consisting of severe autoinflammation and progredient leukoencephalopathy with recurrent seizures; 12 of these subjects, whose DNA was available, segregated homozygous loss-of-function C2orf69 variants. C2ORF69 bears homology to esterase enzymes, and orthologs can be found in most eukaryotic genomes, including that of unicellular phytoplankton. We found that endogenous C2ORF69 (1) is loosely bound to mitochondria, (2) affects mitochondrial membrane potential and oxidative respiration in cultured neurons, and (3) controls the levels of the glycogen branching enzyme 1 (GBE1) consistent with a glycogen-storage-associated mitochondriopathy. We show that CRISPR-Cas9-mediated inactivation of zebrafish C2orf69 results in lethality by 8 months of age due to spontaneous epileptic seizures, which is preceded by persistent brain inflammation. Collectively, our results delineate an autoinflammatory Mendelian disorder of C2orf69 deficiency that disrupts the development/homeostasis of the immune and central nervous systems
Measurement of Higgs boson production in the diphoton decay channel in pp collisions at center-of-mass energies of 7 and 8 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
- Aben R
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Abreu R
- Abulaiti Y
- Acharya BS
- Adam ER
- Adamczyk L
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- Adelman J
- Adomeit S
- Adye T
- Agatonovic-Jovina T
- Aguilar-Saavedra JA
- Agustoni M
- Ahlen SP
- Ahmadov F
- Aielli G
- Akerstedt H
- Akesson TP
- Akimoto G
- Akimov AV
- Alberghi GL
- Albert J
- Albrand S
- Alconada Verzini MJ
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Alimonti G
- Alio L
- Alison J
- Allbrooke BMM
- Allison LJ
- Allport PP
- Aloisio A
- Alonso A
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- Altheimer A
- Alviggi MG
- Amako K
- Amaral Coutinho Y
- Amelung C
- Amidei D
- Amor Dos Santos SP
- Amorim A
- Amoroso S
- Amram N
- Amundsen G
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
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- Anduaga XS
- Angelidakis S
- Angelozzi I
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- Anghinolfi F
- Anh TV
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- Bloch I
- Blocker C
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- Bobrovnikov VS
- Bocchetta SS
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- Boeriu OEV
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- Bogdanchikov AG
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- Borisov A
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- Brandt A
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- Braun HM
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- Bueso XP
- Bugge L
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- Wolter MW
- Wolters H
- Wong KHY
- Wosiek BK
- Wotschack J
- Woudstra MJ
- Wozniak KW
- Wright M
- Wu M
- Wu SL
- Wu X
- Wu Y
- Wulf E
- Wyatt TR
- Wynne BM
- Xella S
- Xiao M
- Xu D
- Xu L
- Yabsley B
- Yacoob S
- Yakabe R
- Yamada M
- Yamaguchi H
- Yamaguchi Y
- Yamamoto A
- Yamamoto K
- Yamamoto S
- Yamamura T
- Yamanaka T
- Yamauchi K
- Yamazaki Y
- Yan Z
- Yang H
- Yang H
- Yang UK
- Yang Y
- Yanush S
- Yao L
- Yao W-M
- Yasu Y
- Yatsenko E
- Ye J
- Ye S
- Yeletskikh I
- Yen AL
- Yildirim E
- Yildiz HD
- Yilmaz M
- Yoosoofmiya R
- Yorita K
- Yoshida R
- Yoshihara K
- Young C
- Young CJS
- Youssef S
- Yu DR
- Yu J
- Yu J
- Yu JM
- Yuan L
- Yurkewicz A
- Yusuff I
- Zabinski B
- Zaidan R
- Zaitsev AM
- Zaman A
- Zambito S
- Zanello L
- Zanzi D
- Zeitnitz C
- Zeman M
- Zemla A
- Zengel K
- Zenin O
- Zenis T
- Zerwas D
- Zhang D
- Zhang F
- Zhang H
- Zhang J
- Zhang L
- Zhang X
- Zhang Z
- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
- Zhou L
- Zhou N
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zurzolo G
- Zutshi V
- Zwalinski L
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2014
- Field of study
A measurement of the production processes of the recently discovered Higgs boson is performed in the two-photon final state using 4.5 fb[superscript −1] of proton-proton collisions data at √s=7 TeV and 20.3 fb[superscript −1] at √s=8 TeV collected by the ATLAS detector at the Large Hadron Collider. The number of observed Higgs boson decays to diphotons divided by the corresponding Standard Model prediction, called the signal strength, is found to be μ=1.17±0.27 at the value of the Higgs boson mass measured by ATLAS, m[subscript H]=125.4 GeV. The analysis is optimized to measure the signal strengths for individual Higgs boson production processes at this value of m[subscript H]. They are found to be μ[subscript ggF]=1.32±0.38, μ[subscript VBF]=0.8±0.7, μ[subscript WH]=1.0±1.6, μ[subscript ZH]=0.1[superscript +3.7 subscript −0.1], and μ[subscript t [bar over t] H] =1.6[superscript +2.7 subscript −1.8], for Higgs boson production through gluon fusion, vector-boson fusion, and in association with a W or Z boson or a top-quark pair, respectively. Compared with the previously published ATLAS analysis, the results reported here also benefit from a new energy calibration procedure for photons and the subsequent reduction of the systematic uncertainty on the diphoton mass resolution. No significant deviations from the predictions of the Standard Model are found.European Organization for Nuclear ResearchUnited States. Dept. of EnergyNational Science Foundation (U.S.)Brookhaven National Laborator
What scans we will read: imaging instrumentation trends in clinical oncology
- Author
- A Alex
- A Carpentier
- A El Kaffas
- A Haase
- A Kesner
- A Pépin
- A Rajkomar
- A Rezaei
- A Rix
- A Stenzl
- A Vija
- A Vourtsis
- AA Lammertsma
- AL Vahrmeijer
- ALB de Barros
- AR Padhani
- AS Lundervold
- B Theek
- B Zhu
- BF Hutton
- BF Hutton
- BJ Tromberg
- BW Pogue
- BW Wessels
- C Blatter
- C Chi
- C Errico
- C Li
- C Lois
- C Zhang
- C-L Chen
- CB Hruska
- CES Hoogstins
- CH McCollough
- CJ Liu
- CK Kuhl
- CL Dumoulin
- CM Rank
- CM Rank
- CN De Cecco
- CS Levin
- CS Reiner
- D Bovenkamp
- D Ma
- DH Turnbull
- DK Sodickson
- DL Bailey
- DL Bailey
- DW Townsend
- E Goshen
- E Maloney
- E Meyer
- EJ Hoffman
- EJ Hoffman
- EJ Hoffman
- EJ Limkin
- EJ Teoh
- F Bloch
- F Büther
- FA Breuer
- FU Chowdhury
- G Antoch
- G Dimcevski
- G Diot
- G Hatzung
- G Loudos
- G Sadigh
- G Tedesco
- G Zaharchuk
- G-Y Wu
- GK Azad
- GL Brownell
- GM Palmer
- H Beaumont
- H Li
- H Stepp
- H Zaidi
- H(H) Sung-Cheng
- HN Wagner
- I Buvat
- I Häggström
- IAS Elhelf
- II Rabi
- IO Lawal
- IR Duffy
- J Cal-Gonzalez
- J Czernin
- J Dickson
- J Hennig
- J Maier
- J Nuyts
- J Nuyts
- J Provost
- J Schwaab
- J Shi
- J-H Choi
- J-M Beauregard
- JC Mazziotta
- JH Turner
- JJW Lagendijk
- JK Willmann
- JM Wolterink
- JN Rydberg
- JR Ballinger
- K Brechtel
- K Erlandsson
- K Erlandsson
- K Gono
- K Jia
- K Nie
- K Schäfers
- K Tanha
- K Tharp
- K Wang
- KM Meiburger
- KP Pruessmann
- L Abou-Elkacem
- L Antonelli
- L Bodei
- L Ding
- LL Geyer
- LV Wang
- M Claudon
- M Dawood
- M Friedrich-Rust
- M Genovese
- M Klauß
- M Ljungberg
- M Ljungberg
- M Ljungberg
- M Lustig
- M Occhipinti
- M Potter
- M Smeenge
- M Soret
- M Tanter
- M Uhrig
- M Wu
- MA Griswold
- MD Aldridge
- ME Casey
- MHM Schwarzbach
- MJ Willemink
- MJ Willemink
- ML Welch
- MM Lell
- MM Lell
- MN Asiedu
- MS Hofman
- MT Erkkilä
- MT Madsen
- MY Berezin
- N Cho
- N Hijnen
- N McGranahan
- N Onda
- O Israel
- P Debie
- P Lambin
- P Mansfield
- P Sidhu
- PB Roemer
- PC Lauterbur
- PCM van Zijl
- PE Kinahan
- PH Pretorius
- PJ Basser
- PJ Phillips
- PJ Slomka
- PJA Frinking
- PN Burns
- PS Choudhury
- Q Fang
- Q Huang
- R Damadian
- R Guo
- R Manber
- R Muthupillai
- R Richards-Kortum
- R Smith-Bindman
- RA Leitgeb
- RA Leitgeb
- RG Abramson
- RH Patt
- RJ Eckersley
- RJ Hicks
- RJ Hicks
- RL Wahl
- RP Baum
- RS Benjamin
- S Dencks
- S Huang
- S Li
- S Surti
- S Wojcinski
- S-C Huang
- S-C Huang
- SA Nehmeh
- SC Baetke
- SD Wolff
- SR Cherry
- SR Cherry
- SS Gambhir
- ST Mahmood
- SW Lee
- SW Smith
- T Beyer
- T Beyer
- T Durduran
- T Henzler
- T Heußer
- T Ichihara
- T Jones
- T Langbein
- T Opacic
- T Tirkes
- TA Hope
- U Katscher
- V Ntziachristos
- V Paefgen
- W Drexler
- W Drexler
- W Wuest
- WA Kalender
- WA Kalender
- WM Thaiss
- WT Dixon
- X Huang
- Y Berker
- Y Chen
- Y Wang
- Y Zhang
- Z Keidar
- Z Obermeyer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
Oncological diseases account for a significant portion of the burden on public healthcare systems with associated
costs driven primarily by complex and long-lasting therapies. Through the visualization of patient-specific
morphology and functional-molecular pathways, cancerous tissue can be detected and characterized non-
invasively, so as to provide referring oncologists with essential information to support therapy management
decisions. Following the onset of stand-alone anatomical and functional imaging, we witness a push towards
integrating molecular image information through various methods, including anato-metabolic imaging (e.g., PET/
CT), advanced MRI, optical or ultrasound imaging.
This perspective paper highlights a number of key technological and methodological advances in imaging
instrumentation related to anatomical, functional, molecular medicine and hybrid imaging, that is understood as
the hardware-based combination of complementary anatomical and molecular imaging. These include novel
detector technologies for ionizing radiation used in CT and nuclear medicine imaging, and novel system
developments in MRI and optical as well as opto-acoustic imaging. We will also highlight new data processing
methods for improved non-invasive tissue characterization. Following a general introduction to the role of imaging
in oncology patient management we introduce imaging methods with well-defined clinical applications and
potential for clinical translation. For each modality, we report first on the status quo and point to perceived
technological and methodological advances in a subsequent status go section. Considering the breadth and
dynamics of these developments, this perspective ends with a critical reflection on where the authors, with the
majority of them being imaging experts with a background in physics and engineering, believe imaging methods
will be in a few years from now.
Overall, methodological and technological medical imaging advances are geared towards increased image contrast,
the derivation of reproducible quantitative parameters, an increase in volume sensitivity and a reduction in overall
examination time. To ensure full translation to the clinic, this progress in technologies and instrumentation is
complemented by progress in relevant acquisition and image-processing protocols and improved data analysis. To
this end, we should accept diagnostic images as “data”, and – through the wider adoption of advanced analysis,
including machine learning approaches and a “big data” concept – move to the next stage of non-invasive tumor
phenotyping. The scans we will be reading in 10 years from now will likely be composed of highly diverse multi-
dimensional data from multiple sources, which mandate the use of advanced and interactive visualization and
analysis platforms powered by Artificial Intelligence (AI) for real-time data handling by cross-specialty clinical experts
with a domain knowledge that will need to go beyond that of plain imaging
Search for scalar diphoton resonances in the mass range 65-600 GeV with the ATLAS detector in pp collision data at √s = 8 TeV
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
- Aben R
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
- Abreu H
- Abreu R
- Abulaiti Y
- Acharya BS
- Adam ER
- Adamczyk L
- Adams DL
- Adelman J
- Adomeit S
- Adye T
- Agatonovic-Jovin T
- Aguilar-Saavedra JA
- Agustoni M
- Ahlen SP
- Ahmadov F
- Aielli G
- Akerstedt H
- Akesson TPA
- Akimoto G
- Akimov AV
- Alberghi GL
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Alimonti G
- Alio L
- Alison J
- Allbrooke BMM
- Allison LJ
- Allport PP
- Almond J
- Aloisio A
- Alonso A
- Alonso F
- Alpigiani C
- Altheimer A
- Alviggi MG
- Amako K
- Amelung C
- Amidei D
- Amorim A
- Amoroso S
- Amram N
- Amundsen G
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders G
- Anderson KJ
- Andreazza A
- Andrei V
- Anduaga XS
- Angelidakis S
- Angelozzi I
- Anger P
- Angerami A
- Anghinolfi F
- Anh TV
- Anisenkov AV
- Anjos N
- Annovi A
- Antonaki A
- Antonelli M
- Antonov A
- Antos J
- Anulli F
- Aoki M
- Apolle R
- Arabidze G
- Aracena I
- Arai Y
- Aranda CP
- Araque JP
- Arce ATH
- Arguin J-F
- Argyropoulos S
- Arik M
- Armadans RC
- Armbruster AJ
- Arnaez O
- Arnal V
- Arnold H
- Arratia M
- Arslan O
- Artamonov A
- Artoni G
- Asai S
- Asbah N
- Ashkenazi A
- Asman B
- Asquith L
- Assamagan K
- Astalos R
- Atkinson M
- Atlay NB
- Auerbach B
- Augsten K
- Aurousseau M
- Avolio G
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- Azuma Y
- Baak MA
- Baas A
- Bacci C
- Bachacou H
- Bachas K
- Backes M
- Backhaus M
- Badescu E
- Bagiacchi P
- Bagnaia P
- Bai Y
- Bain T
- Baines JT
- Baker OK
- Balek P
- Balli F
- Banas E
- Banerjee S
- Bannoura AAE
- Bansal V
- Bansil HS
- Barajas CAC
- Barak L
- Baranov SP
- Barberio EL
- Barberis D
- Barbero M
- Barillari T
- Barisonzi M
- Barklow T
- Barlow N
- Barnett BM
- Barnett RM
- Barnovska Z
- Baroncelli A
- Barone G
- Barr AJ
- Barreiro F
- Barrera CO
- Bartoldus R
- Barton AE
- Bartos P
- Bartsch V
- Bassalat A
- Basye A
- Bates RL
- Batley JR
- Battaglia M
- Battistin M
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- da Costa JBG
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- Yen AL
- Yildirim E
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- Yilmaz M
- Yoosoofmiya R
- Yorita K
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- Yoshihara K
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- Youssef S
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- Yurkewicz A
- Yusuff I
- Zabinski B
- Zaidan R
- Zaitsev AM
- Zaman A
- Zambito S
- Zanello L
- Zanzi D
- Zeitnitz C
- Zeman M
- Zemla A
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- Zenin O
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- Zerwas D
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- Zhao Z
- Zhemchugov A
- Zhong J
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- Zhu CG
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- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann R
- Zimmermann S
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- Zinonos Z
- Ziolkowski M
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zurzolo G
- Zutshi V
- Zwalinski L
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2014
- Field of study
A search for scalar particles decaying via narrow resonances into two photons in the mass range 65–600 GeV is performed using 20.3 fb−¹ of √s=8 TeV pp collision data collected with the ATLAS detector at the Large Hadron Collider. The recently discovered Higgs boson is treated as a background. No significant evidence for an additional signal is observed. The results are presented as limits at the 95% confidence level on the production cross section of a scalar boson times branching ratio into two photons, in a fiducial volume where the reconstruction efficiency is approximately independent of the event topology. The upper limits set extend over a considerably wider mass range than previous searches
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