Design by social entrepreneurs:The analysis of four Chilean social entrepreneurs

Social entrepreneurship is the application of the mindset, process, tools and techniques of business entrepreneurship to the pursuit of a social and or environmental mission. However, issues such as lack of resources and knowledge affect the performance of these organisations. On the other hand, design is used by organisations to increase their competitive advantages and in social innovation to develop solutions to pressing social issues using the principles of sustainability. Nevertheless, despite the wide range of studies regarding the benefits of design for organisations and social innovation, there is no evidence of studies regarding the use of design by social entrepreneurs. This thesis studies how four Chilean social entrepreneurs use design through their social entrepreneurship processes. For this purpose, a Narrative Research was conducted in a business incubator in which these entrepreneurs were participating in a programme called Open Gate. Data collection methods such as semi-structured interviews with members of the staff and social entrepreneurs were used. The data collected were analysed using a model developed for this study called Social Entrepreneurship and Design Framework. This multidimensional framework enabled the analysis of the main issues that social entrepreneurs encounter against the social entrepreneurship process and different levels of design use. It was concluded that these entrepreneurs encountered six main issues in their processes: research, community engagement, development, co-creation, positioning and strategies. Consequently, six design drivers were described that show how design was used in the issues found. Buchanan’s four orders of design model were adopted to classify the design practices used by the entrepreneurs. This analysis shows that design practices such as graphic, product, interaction and experience design as well as illustrations were mostly conducted by designers, both, external or internal to the social enterprise. Facilitation activities, processes of engagement and strategies were conducted by social entrepreneurs (non-designers)

MANY Project Toolkit for Community Engagement in Complex Projects:Lessons from a 5G Digital Infrastructure Project

This toolkit shares social science research insights from the MANY (Mobile Access North Yorkshire) project: working to put 5G connectivity infrastructures in place for very rural communities. The toolkit is designed to guide project managers and those in roles seeking to directly engage with communities in difficult and sometimes controversial projects. The toolkit is divided into three elements - themes (foundational elements for community engagement), principles (what community engagement is trying to achieve) and methods (how to achieve it). You can see how the Themes, Principles and Methods all fit together, ‘in a nutshell’, in the Toolkit Matrix (page 35) and how the methods are underpinned by the principles and themes. The toolkit is designed to help you use community engagement insights (themes, principles and methods) to shape your project, deliver real value, and put your own action plan in place

Talking about food:reflecting on transitions of practice in people with lived experience of food poverty

In this paper, we deploy a practice theory lens to explore how co-design activities have enabled individuals to transition to new and different advocacy, inquiry and engagement practices. The co-design project we describe sought to bring about change in a national network of organisations addressing food poverty in the UK. The aim of the project was to collaborate with young people and adults from different communities of the North of England to co-design tools for gathering stories and enabling advocacy relating to food insecurity. We use a practice theory lens to describe the relationships between co-design activities and transitions in practices of a single participant. The findings show the value of exploring and sharing meanings, practical experimentation and facilitating transitions within participant’s practice. We argue that practice theory provides an analytical framework to understand the impacts of co-design and social design by interpreting the transitioning practices in participants

Analytical applications of single particle inductively coupled plasma mass spectrometry: a comprehensive and critical review

Single particle inductively coupled plasma mass spectrometry (SP-ICP-MS) refers to the use of ICP-MS as a particle counting technique. When ICP-MS measurements are performed at very high data acquisition frequencies, information about (nano)particles containing specific elements and their dissolved forms can be obtained (element mass per particle, size and number and mass concentrations). As a result of its outstanding performance, SP-ICP-MS has become a relevant technique for the analysis of complex samples containing inorganic nanoparticles. This review discusses the maturity level achieved by the technique through the methods developed for the detection, characterisation and quantification of engineered and natural (nano)particles. The application of these methods in different analytical scenarios is comprehensively reviewed and critically discussed, with special attention to their current technical and metrological limitations. The emergent applications of SP-ICP-MS in the field of nanoparticle-tagged immunoassay and hybridization methods are also reviewed

Litsea glaucescens Kuth possesses bactericidal activity against Listeria monocytogenes

Background Litsea glaucencens Kuth is an aromatic plant used for food seasoning food and in Mexican traditional medicine. Among, L. glaucencens leaves properties, it has proven antibacterial activity which can be used against opportunistic pathogens like Listeria monocytogenes, a foodborne bacteria that is the causal agent of listeriosis, a disease that can be fatal in susceptible individuals. The aim of this work was to investigate the antibacterial activity of L. glaucescens Kuth leaf extracts against L. monocytogenes and to identify its bioactive components. Material and Methods L. glaucences leaves were macerated with four solvents of different polarity (n-hexane, dichloromethane, ethyl acetate, and methanol). To determine the capacity to inhibit bacterial proliferation in vitro, agar diffusion and microdilution methods were used. Next, we determined the minimal bactericidal concentration (MBC). Finally, we determined the ratio of MBC/MIC. Metabolites present in the active methanolic extract from L. glaucescens Kuth (LgMeOH) were purified by normal-phase open column chromatography. The structure of the antibacterial metabolite was determined using nuclear magnetic resonance (1H, 13C, COSY, HSQC) and by comparison with known compounds. Results The LgMeOH extract was used to purify the compound responsible for the observed antimicrobial activity. This compound was identified as 5,7-dihydroxyflavanone (pinocembrin) by analysis of its spectroscopic data and comparison with those described. The MIC and MBC values obtained for pinocembrin were 0.68 mg/mL, and the ratio MBC/MIC for both LgMeOH and pinocembrin was one, which indicates bactericidal activity. Conclusion L. glaucences Kuth leaves and its metabolite pinocembrin can be used to treat listeriosis due the bactericidal activity against L. monocytogenes

Measurement of the cross-section and charge asymmetry of WW bosons produced in proton-proton collisions at s=8\sqrt{s}=8 TeV with the ATLAS detector

This paper presents measurements of the $W^+ \rightarrow \mu^+\nu$ and $W^- \rightarrow \mu^-\nu$ cross-sections and the associated charge asymmetry as a function of the absolute pseudorapidity of the decay muon. The data were collected in proton--proton collisions at a centre-of-mass energy of 8 TeV with the ATLAS experiment at the LHC and correspond to a total integrated luminosity of 20.2~\mbox{fb^{-1}}. The precision of the cross-section measurements varies between 0.8% to 1.5% as a function of the pseudorapidity, excluding the 1.9% uncertainty on the integrated luminosity. The charge asymmetry is measured with an uncertainty between 0.002 and 0.003. The results are compared with predictions based on next-to-next-to-leading-order calculations with various parton distribution functions and have the sensitivity to discriminate between them.Comment: 38 pages in total, author list starting page 22, 5 figures, 4 tables, submitted to EPJC. All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2017-13

Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector

Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente

Search for chargino-neutralino production with mass splittings near the electroweak scale in three-lepton final states in √s=13 TeV pp collisions with the ATLAS detector

A search for supersymmetry through the pair production of electroweakinos with mass splittings near the electroweak scale and decaying via on-shell W and Z bosons is presented for a three-lepton final state. The analyzed proton-proton collision data taken at a center-of-mass energy of √s=13  TeV were collected between 2015 and 2018 by the ATLAS experiment at the Large Hadron Collider, corresponding to an integrated luminosity of 139  fb−1. A search, emulating the recursive jigsaw reconstruction technique with easily reproducible laboratory-frame variables, is performed. The two excesses observed in the 2015–2016 data recursive jigsaw analysis in the low-mass three-lepton phase space are reproduced. Results with the full data set are in agreement with the Standard Model expectations. They are interpreted to set exclusion limits at the 95% confidence level on simplified models of chargino-neutralino pair production for masses up to 345 GeV

Impact of COVID-19 Pandemic on TAVR Activity: A Worldwide Registry

Background: The COVID-19 pandemic had a considerable impact on the provision of structural heart intervention worldwide. Our objectives were: 1) to assess the impact of the COVID-19 pandemic on transcatheter aortic valve replacement (TAVR) activity globally; and 2) to determine the differences in the impact according to geographic region and the demographic, development, and economic status of diverse international health care systems. Methods: We developed a multinational registry of global TAVR activity and invited individual TAVR sites to submit TAVR implant data before and during the COVID-19 pandemic. Specifically, the number of TAVR procedures performed monthly from January 2019 to December 2021 was collected. The adaptive measures to maintain TAVR activity by each site were recorded, as was a variety of indices relating to type of health care system and national economic indices. The primary subject of interest was the impact on TAVR activity during each of the pandemic waves (2020 and 2021) compared with the same period pre–COVID-19 (2019). Results: Data were received from 130 centers from 61 countries, with 14 subcontinents and 5 continents participating in the study. Overall, TAVR activity increased by 16.7% (2,337 procedures) between 2018 and 2019 (ie, before the pandemic), but between 2019 and 2020 (ie, first year of the pandemic), there was no significant growth (–0.1%; –10 procedures). In contrast, activity again increased by 18.9% (3,085 procedures) between 2020 and 2021 (ie, second year of the pandemic). During the first pandemic wave, there was a reduction of 18.9% (945 procedures) in TAVR activity among participating sites, while during the second and third waves, there was an increase of 6.7% (489 procedures) and 15.9% (1,042 procedures), respectively. Further analysis and results of this study are ongoing and will be available at the time of the congress. Conclusion: The COVID-19 pandemic initially led to a reduction in the number of patients undergoing TAVR worldwide, although health care systems subsequently adapted, and the number of TAVR recipients continued to grow in subsequent COVID-19 pandemic waves. Categories: STRUCTURAL: Valvular Disease: Aorti