3,194 research outputs found
Galaxy Clusters in the Line of Sight to Background Quasars: I. Survey Design and Incidence of MgII Absorbers at Cluster Redshifts
We describe the first optical survey of absorption systems associated with
galaxy clusters at z= 0.3-0.9. We have cross-correlated SDSS DR3 quasars with
high-redshift cluster/group candidates from the Red-Sequence Cluster Survey. We
have found 442 quasar-cluster pairs for which the MgII doublet might be
detected at a transverse (physical) distance d<2 Mpc from the cluster centers.
To investigate the incidence (dN/dz) and equivalent-width distribution n(W) of
MgII systems at cluster redshifts, two statistical samples were drawn out of
these pairs: one made of high-resolution spectroscopic quasar observations (46
pairs), and one made of quasars used in MgII searches found in the literature
(375 pairs). The results are: (1) the population of strong MgII systems
(W_0>2.0 Ang.) near cluster redshifts shows a significant (>3 sigma)
overabundance (up to a factor of 15) when compared with the 'field' population;
(2) the overabundance is more evident at smaller distances (d<1 Mpc) than
larger distances (d<2 Mpc) from the cluster center; and, (3) the population of
weak MgII systems (W_0<0.3 Ang.) near cluster redshifts conform to the field
statistics. Unlike in the field, this dichotomy makes n(W) in clusters appear
flat and well fitted by a power-law in the entire W-range. A sub-sample of the
most massive clusters yields a stronger and still significant signal. Since
either the absorber number density or filling-factor/cross-section affects the
absorber statistics, an interesting possibility is that we have detected the
signature of truncated halos due to environmental effects. Thus, we argue that
the excess of strong systems is due to a population of absorbers in an
overdense galaxy environment, and the lack of weak systems to a different
population, that got destroyed in the cluster environment. (Abridged)Comment: Accepted for publication in the Astrophysical Journa
Radio source calibration for the VSA and other CMB instruments at around 30 GHz
Accurate calibration of data is essential for the current generation of CMB
experiments. Using data from the Very Small Array (VSA), we describe procedures
which will lead to an accuracy of 1 percent or better for experiments such as
the VSA and CBI. Particular attention is paid to the stability of the receiver
systems, the quality of the site and frequent observations of reference
sources. At 30 GHz the careful correction for atmospheric emission and
absorption is shown to be essential for achieving 1 percent precision. The
sources for which a 1 percent relative flux density calibration was achieved
included Cas A, Cyg A, Tau A and NGC7027 and the planets Venus, Jupiter and
Saturn. A flux density, or brightness temperature in the case of the planets,
was derived at 33 GHz relative to Jupiter which was adopted as the fundamental
calibrator. A spectral index at ~30 GHz is given for each. Cas A,Tau A, NGC7027
and Venus were examined for variability. Cas A was found to be decreasing at
percent per year over the period March 2001 to August 2004.
In the same period Tau A was decreasing at percent per year. A
survey of the published data showed that the planetary nebula NGC7027 decreased
at percent per year over the period 1967 to 2003. Venus showed
an insignificant ( percent) variation with Venusian illumination.
The integrated polarization of Tau A at 33 GHz was found to be
percent at pa .}Comment: 13 pages, 15 figures, submitted to MNRA
Bi-allelic variants in RNF170 are associated with hereditary spastic paraplegia.
Alterations of Ca2+ homeostasis have been implicated in a wide range of neurodegenerative diseases. Ca2+ efflux from the endoplasmic reticulum into the cytoplasm is controlled by binding of inositol 1,4,5-trisphosphate to its receptor. Activated inositol 1,4,5-trisphosphate receptors are then rapidly degraded by the endoplasmic reticulum-associated degradation pathway. Mutations in genes encoding the neuronal isoform of the inositol 1,4,5-trisphosphate receptor (ITPR1) and genes involved in inositol 1,4,5-trisphosphate receptor degradation (ERLIN1, ERLIN2) are known to cause hereditary spastic paraplegia (HSP) and cerebellar ataxia. We provide evidence that mutations in the ubiquitin E3 ligase gene RNF170, which targets inositol 1,4,5-trisphosphate receptors for degradation, are the likely cause of autosomal recessive HSP in four unrelated families and functionally evaluate the consequences of mutations in patient fibroblasts, mutant SH-SY5Y cells and by gene knockdown in zebrafish. Our findings highlight inositol 1,4,5-trisphosphate signaling as a candidate key pathway for hereditary spastic paraplegias and cerebellar ataxias and thus prioritize this pathway for therapeutic interventions
MAGIC upper limits on the very high energy emission from GRBs
The fast repositioning system of the MAGIC Telescope has allowed during its
first data cycle, between 2005 and the beginning of year 2006, observing nine
different GRBs as possible sources of very high energy gammas. These
observations were triggered by alerts from Swift, HETE-II, and Integral; they
started as fast as possible after the alerts and lasted for several minutes,
with an energy threshold varying between 80 and 200 GeV, depending upon the
zenith angle of the burst. No evidence for gamma signals was found, and upper
limits for the flux were derived for all events, using the standard analysis
chain of MAGIC. For the bursts with measured redshift, the upper limits are
compatible with a power law extrapolation, when the intrinsic fluxes are
evaluated taking into account the attenuation due to the scattering in the
Metagalactic Radiation Field (MRF).Comment: 25 pages, 9 figures, final version accepted by ApJ. Changet title to
"MAGIC upped limits on the VERY high energy emission from GRBs", re-organized
chapter with description of observation, removed non necessaries figures,
added plot of effective area depending on zenith angle, added an appendix
explaining the upper limit calculation, added some reference
Evidence for TeV gamma ray emission from Cassiopeia A
232 hours of data were accumulated from 1997 to 1999, using the HEGRA
Stereoscopic Cherenkov Telescope System to observe the supernova remnant
Cassiopeia A. TeV gamma ray emission was detected at the 5 sigma level, and a
flux of (5.8 +- 1.2(stat) +- 1.2(syst)) 10^(-9) ph m^(-2) s^(-1) above 1 TeV
was derived. The spectral distribution is consistent with a power law with a
differential spectral index of -2.5 +- 0.4(stat) +- 0.1(syst) between 1 and 10
TeV. As this is the first report of the detection of a TeV gamma ray source on
the "centi-Crab" scale, we present the analysis in some detail. Implications
for the acceleration of cosmic rays depend on the details of the source
modeling. We discuss some important aspects in this paper.Comment: 9 pages, 6 figures, accepted for publication in Astronomy &
Astrophysic
Effects of Inhibiting CoQ10 Biosynthesis with 4-nitrobenzoate in Human Fibroblasts
Coenzyme Q10 (CoQ10) is a potent lipophilic antioxidant in cell membranes and a carrier of electrons in the mitochondrial respiratory chain. We previously characterized the effects of varying severities of CoQ10 deficiency on ROS production and mitochondrial bioenergetics in cells harboring genetic defects of CoQ10 biosynthesis. We observed a unimodal distribution of ROS production with CoQ10 deficiency: cells with <20% of CoQ10 and 50–70% of CoQ10 did not generate excess ROS while cells with 30–45% of CoQ10 showed increased ROS production and lipid peroxidation. Because our previous studies were limited to a small number of mutant cell lines with heterogeneous molecular defects, here, we treated 5 control and 2 mildly CoQ10 deficient fibroblasts with varying doses of 4-nitrobenzoate (4-NB), an analog of 4-hydroxybenzoate (4-HB) and inhibitor of 4-para-hydroxybenzoate:polyprenyl transferase (COQ2) to induce a range of CoQ10 deficiencies. Our results support the concept that the degree of CoQ10 deficiency in cells dictates the extent of ATP synthesis defects and ROS production and that 40–50% residual CoQ10 produces maximal oxidative stress and cell death
Charge separation relative to the reaction plane in Pb-Pb collisions at TeV
Measurements of charge dependent azimuthal correlations with the ALICE
detector at the LHC are reported for Pb-Pb collisions at TeV. Two- and three-particle charge-dependent azimuthal correlations in
the pseudo-rapidity range are presented as a function of the
collision centrality, particle separation in pseudo-rapidity, and transverse
momentum. A clear signal compatible with a charge-dependent separation relative
to the reaction plane is observed, which shows little or no collision energy
dependence when compared to measurements at RHIC energies. This provides a new
insight for understanding the nature of the charge dependent azimuthal
correlations observed at RHIC and LHC energies.Comment: 12 pages, 3 captioned figures, authors from page 2 to 6, published
version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/286
Measurements of fiducial and differential cross sections for Higgs boson production in the diphoton decay channel at s√=8 TeV with ATLAS
Measurements of fiducial and differential cross sections are presented for Higgs boson production in proton-proton collisions at a centre-of-mass energy of s√=8 TeV. The analysis is performed in the H → γγ decay channel using 20.3 fb−1 of data recorded by the ATLAS experiment at the CERN Large Hadron Collider. The signal is extracted using a fit to the diphoton invariant mass spectrum assuming that the width of the resonance is much smaller than the experimental resolution. The signal yields are corrected for the effects of detector inefficiency and resolution. The pp → H → γγ fiducial cross section is measured to be 43.2 ±9.4(stat.) − 2.9 + 3.2 (syst.) ±1.2(lumi)fb for a Higgs boson of mass 125.4GeV decaying to two isolated photons that have transverse momentum greater than 35% and 25% of the diphoton invariant mass and each with absolute pseudorapidity less than 2.37. Four additional fiducial cross sections and two cross-section limits are presented in phase space regions that test the theoretical modelling of different Higgs boson production mechanisms, or are sensitive to physics beyond the Standard Model. Differential cross sections are also presented, as a function of variables related to the diphoton kinematics and the jet activity produced in the Higgs boson events. The observed spectra are statistically limited but broadly in line with the theoretical expectations
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