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HAMMER COURSEWARE MANAGEMENT SYSTEM (CMS) SYSTEM DEVELOPMENT AND IMPLEMENTATION
HAMMER Courseware Management System (HAMMERCMS) is the official name of the system Fluor Hanford, Inc., uses to facilitate development of, deliver, and track training presented in some electronic form (mainly, web-based training) to Hanford Site employees, subcontractors, and vendors
The rhodanese RhdA helps Azotobacter vinelandii in maintaining cellular redox balance
The tandem domain rhodanese-homology protein RhdA of Azotobacter vinelandii shows an active-site loop structure that confers structural peculiarity in the environment of its catalytic cysteine residue. The in vivo effects of the lack of RhdA were investigated using an A. vinelandii mutant strain (MV474) in which the rhdA gene was disrupted by deletion. Here, by combining analytical measurements and transcript profiles, we show that deletion of the rhdA gene generates an oxidative stress condition to which A. vinelandii responds by activating defensive mechanisms. In conditions of growth in the presence of the superoxide generator phenazine methosulfate, a stressor-dependent induction of rhdA gene expression was observed, thus highlighting that RhdA is important for A. vinelandii to sustain oxidative stress. The potential of RhdA to buffer general levels of oxidants in A. vinelandii cells via redox reactions involving its cysteine thiol is discussed.Vigoni project/081517
Women, men and coronary heart disease: a review of the qualitative literature
Aim. This paper presents a review of the qualitative literature which examines the experiences of patients with coronary heart disease. The paper also assesses whether the experiences of both female and male patients are reflected in the literature and summarizes key themes.
Background. Understanding patients' experiences of their illness is important for coronary heart disease prevention and education. Qualitative methods are particularly suited to eliciting patients' detailed understandings and perceptions of illness. As much previous research has been 'gender neutral', this review pays particular attention to gender.
Methods. Published papers from 60 qualitative studies were identified for the review through searches in MEDLINE, EMBASE, CINAHL, PREMEDLINE, PsychINFO, Social Sciences Citation Index and Web of Science using keywords related to coronary heart disease.
Findings. Early qualitative studies of patients with coronary heart disease were conducted almost exclusively with men, and tended to generalize from 'male' experience to 'human' experience. By the late 1990s this pattern had changed, with the majority of studies including women and many being conducted with solely female samples. However, many studies that include both male and female coronary heart disease patients still do not have a specific gender focus. Key themes in the literature include interpreting symptoms and seeking help, belief about coronary 'candidates' and relationships with health professionals. The influence of social roles is important: many female patients have difficulties reconciling family responsibilities and medical advice, while male patients worry about being absent from work.
Conclusions. There is a need for studies that compare the experiences of men and women. There is also an urgent need for work that takes masculinity and gender roles into account when exploring the experiences of men with coronary heart disease
Transiting Exoplanets with JWST
The era of exoplanet characterization is upon us. For a subset of exoplanets
-- the transiting planets -- physical properties can be measured, including
mass, radius, and atmosphere characteristics. Indeed, measuring the atmospheres
of a further subset of transiting planets, the hot Jupiters, is now routine
with the Spitzer Space Telescope. The James Webb Space Telescope (JWST) will
continue Spitzer's legacy with its large mirror size and precise thermal
stability. JWST is poised for the significant achievement of identifying
habitable planets around bright M through G stars--rocky planets lacking
extensive gas envelopes, with water vapor and signs of chemical disequilibrium
in their atmospheres. Favorable transiting planet systems, are, however,
anticipated to be rare and their atmosphere observations will require tens to
hundreds of hours of JWST time per planet. We review what is known about the
physical characteristics of transiting planets, summarize lessons learned from
Spitzer high-contrast exoplanet measurements, and give several examples of
potential JWST observations.Comment: 22 pages, 11 figures. In press in "Astrophysics in the Next Decade:
JWST and Concurrent Facilities, Astrophysics & Space Science Library,
Thronson, H. A., Tielens, A., Stiavelli, M., eds., Springer: Dordrecht
(2008)." The original publication will be available at
http://www.springerlink.co
Mortality among patients with non-affective functional psychoses in a metropolitan area of South-Eastern Brazil
Young and Intermediate-age Distance Indicators
Distance measurements beyond geometrical and semi-geometrical methods, rely
mainly on standard candles. As the name suggests, these objects have known
luminosities by virtue of their intrinsic proprieties and play a major role in
our understanding of modern cosmology. The main caveats associated with
standard candles are their absolute calibration, contamination of the sample
from other sources and systematic uncertainties. The absolute calibration
mainly depends on their chemical composition and age. To understand the impact
of these effects on the distance scale, it is essential to develop methods
based on different sample of standard candles. Here we review the fundamental
properties of young and intermediate-age distance indicators such as Cepheids,
Mira variables and Red Clump stars and the recent developments in their
application as distance indicators.Comment: Review article, 63 pages (28 figures), Accepted for publication in
Space Science Reviews (Chapter 3 of a special collection resulting from the
May 2016 ISSI-BJ workshop on Astronomical Distance Determination in the Space
Age
An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types
Search for a W' boson decaying to a bottom quark and a top quark in pp collisions at sqrt(s) = 7 TeV
Results are presented from a search for a W' boson using a dataset
corresponding to 5.0 inverse femtobarns of integrated luminosity collected
during 2011 by the CMS experiment at the LHC in pp collisions at sqrt(s)=7 TeV.
The W' boson is modeled as a heavy W boson, but different scenarios for the
couplings to fermions are considered, involving both left-handed and
right-handed chiral projections of the fermions, as well as an arbitrary
mixture of the two. The search is performed in the decay channel W' to t b,
leading to a final state signature with a single lepton (e, mu), missing
transverse energy, and jets, at least one of which is tagged as a b-jet. A W'
boson that couples to fermions with the same coupling constant as the W, but to
the right-handed rather than left-handed chiral projections, is excluded for
masses below 1.85 TeV at the 95% confidence level. For the first time using LHC
data, constraints on the W' gauge coupling for a set of left- and right-handed
coupling combinations have been placed. These results represent a significant
improvement over previously published limits.Comment: Submitted to Physics Letters B. Replaced with version publishe
Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in √s = 7 TeV pp collisions with the ATLAS detector
A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fb−1 of proton–proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric models and in simplified models, significantly extending previous results
Search for the standard model Higgs boson decaying into two photons in pp collisions at sqrt(s)=7 TeV
A search for a Higgs boson decaying into two photons is described. The
analysis is performed using a dataset recorded by the CMS experiment at the LHC
from pp collisions at a centre-of-mass energy of 7 TeV, which corresponds to an
integrated luminosity of 4.8 inverse femtobarns. Limits are set on the cross
section of the standard model Higgs boson decaying to two photons. The expected
exclusion limit at 95% confidence level is between 1.4 and 2.4 times the
standard model cross section in the mass range between 110 and 150 GeV. The
analysis of the data excludes, at 95% confidence level, the standard model
Higgs boson decaying into two photons in the mass range 128 to 132 GeV. The
largest excess of events above the expected standard model background is
observed for a Higgs boson mass hypothesis of 124 GeV with a local significance
of 3.1 sigma. The global significance of observing an excess with a local
significance greater than 3.1 sigma anywhere in the search range 110-150 GeV is
estimated to be 1.8 sigma. More data are required to ascertain the origin of
this excess.Comment: Submitted to Physics Letters
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