Recuperación de un sector urbano en la Ciudad de Buenos Aires: el caso de la ex AU3 : Intereses en disputa

La Ciudad sufrió en los últimos años cambios en su configuración socio-espacial así como en las formas de apropiación que reflejan los conflictos de clase e intereses de los actores que intervienen en el territorio. Esta construcción del espacio urbano supone una lucha de intereses entre los agentes que intervienen en él, profundizando las desigualdades y las controversias existentes en cada grupo social. El hábitat resultante se presenta desigual y segregador, siendo la demanda por el suelo urbano el epicentro de lucha de intereses de los diferentes sectores sociales. La selección del sector de la Traza de la Ex Autopista AU3 como caso de estudio, responde a la presencia de un área fragmentada y heterogénea a intervenir a través de políticas de gestión urbana sustentadas en la participación ciudadana. Este espacio físico compartido por los diferentes actores sociales (propietarios, ocupantes de inmuebles y Estado), generó una degradación socio-ambiental que aún hoy se verifica. Por ello, se torna necesario incorporar nuevos modelos a la gestión del gobierno local que dejen atrás viejas prácticas de orden jerárquico y concentrador de poder en torno a la toma de decisiones sobre lo público, para dar paso a un modelo de mayor gobernabilidad y gobernanza.Facultad de Humanidades y Ciencias de la Educació

A Response to Léa Drieu et al., 2020, "Is It Possible to Identify Ancient Wine Production Using Biomolecular Approaches?" (STAR: Science & Technology of Archaeological Research, DOI:10.1080/20548923.2020.1738728)

Comparable to Drieu et al.'s viewpoint, we argue that it is possible to identify ancient Eurasian grape wine by current biomolecular methods, but only in conjunction with the relevant archaeological, archaeobotanical, and other natural and social scientific data. Additionally, we advocate an inductive-deductive working hypothesis model, which is appropriate for the 'historical science' of archaeology. We focus on two key deficiencies of Drieu et al.'s argumentation: (1) the assumption that Guasch-Jané et al. (2004) extracted their ancient samples with potassium hydroxide before testing for tartaric acid/tartrate, and (2) the supposition that 5000-year-old yeast DNA would not be preserved in the hot climate of Egypt but rather represents modern contamination

The AMMA mulid network for aerosol characterization in West Africa

Three ground based portable low power consumption microlidars (MULID) have been built and deployed at three remote sites in Banizoumbou (Niger), Cinzana (Mali) and M'Bour (Senegal) in the framework of the African Monsoon Multidisciplinary Analyses (AMMA) project for the characterization of aerosols optical properties. A description of the instrument and a discussion of the data inversion method, including a careful analysis of measurement uncertainties (systematic and statistical errors) are presented. Some case studies of typical lidar profiles observed over the Banizoumbou site during 2006 are shown and discussed with respect to the AERONET 7-day back-trajectories and the biomass burning emissions from the Combustion Emission database for the AMMA campaign

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.

Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that identified genes at eGFR loci are enriched for expression in kidney tissues and in pathways relevant for kidney development and transmembrane transporter activity, kidney structure, and regulation of glucose metabolism. Chromatin state mapping and DNase I hypersensitivity analyses across adult tissues demonstrate preferential mapping of associated variants to regulatory regions in kidney but not extra-renal tissues. These findings suggest that genetic determinants of eGFR are mediated largely through direct effects within the kidney and highlight important cell types and biological pathways

Recuperación de un sector urbano en la Ciudad de Buenos Aires : El caso de la Ex AU3. Intereses en disputa

La Ciudad sufrió en los últimos años cambios en su configuración socio-espacial así como en las formas de apropiación que reflejan los conflictos de clase e intereses de los actores que intervienen en el territorio. Esta construcción del espacio urbano supone una lucha de intereses entre los agentes que intervienen en él, profundizando las desigualdades y las controversias existentes en cada grupo social. El hábitat resultante se presenta desigual y segregador, siendo la demanda por el suelo urbano el epicentro de lucha de intereses de los diferentes sectores sociales. La selección del sector de la Traza de la Ex Autopista AU3 como caso de estudio, responde a la presencia de un área fragmentada y heterogénea a intervenir a través de políticas de gestión urbana sustentadas en la participación ciudadana. Este espacio físico compartido por los diferentes actores sociales (propietarios, ocupantes de inmuebles y Estado), generó una degradación socio-ambiental que aún hoy se verifica. Por ello, se torna necesario incorporar nuevos modelos a la gestión del gobierno local que dejen atrás viejas prácticas de orden jerárquico y concentrador de poder en torno a la toma de decisiones sobre lo público, para dar paso a un modelo de mayor gobernabilidad y gobernanz

Gestión Social de vacíos urbanos en la Ciudad Autónoma de Buenos Aires. Un caso de estudio

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Oligonucleotide therapies for disorders of the nervous system

Oligonucleotide therapies are currently experiencing a resurgence driven by advances in backbone chemistry and discoveries of novel therapeutic pathways that can be uniquely and efficiently modulated by the oligonucleotide drugs. A quarter of a century has passed since oligonucleotides were first applied in living mammalian brain to modulate gene expression. Despite challenges in delivery to the brain, multiple oligonucleotide-based compounds are now being developed for treatment of human brain disorders by direct delivery inside the blood brain barrier (BBB). Notably, the first new central nervous system (CNS)-targeted oligonucleotide-based drug (nusinersen/Spinraza) was approved by US Food and Drug Administration (FDA) in late 2016 and several other compounds are in advanced clinical trials. Human testing of brain-targeted oligonucleotides has highlighted unusual pharmacokinetic and pharmacodynamic properties of these compounds, including complex active uptake mechanisms, low systemic exposure, extremely long half-lives, accumulation and gradual release from subcellular depots. Further work on oligonucleotide uptake, development of formulations for delivery across the BBB and relevant disease biology studies are required for further optimization of the oligonucleotide drug development process for brain applications