162 research outputs found
Effect of intracellular lipid accumulation in a new model of non-alcoholic fatty liver disease
- Author
- A Basu
- A Canbay
- A Canbay
- A Wieckowska
- B Brenner
- Claudio Tiribelli
- F Marra
- G Gribilas
- GJ Quinlan
- H Nakabayashi
- H Nakabayashi
- J Araya
- J George
- JE O'Connor
- LP Bechmann
- M Trauner
- M Vinciguerra
- MC Garcia
- MK McMillian
- N Chavez-Tapia
- N Nieto
- Natalia Rosso
- NC Chavez-Tapia
- Norberto C Chavez-Tapia
- OA Gressner
- P Greenspan
- PK Smith
- R Brodersen
- S Bellentani
- S Joshi-Barve
- S March
- SH Ibrahim
- SL Friedman
- SS Zhan
- T Matsuguchi
- T Mosmann
- TH Nguyen
- U Prabhakar
- V Sottile
- WO Carter
- Publication venue
- BioMed Central
- Publication date
- 01/01/2012
- Field of study
<p>Abstract</p> <p>Background</p> <p><it>In vitro </it>exposure of liver cells to high concentrations of free fatty acids (FFA) results in fat overload which promotes inflammatory and fibrogenic response similar to those observed in patients with Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH). Since the mechanisms of this event have not been fully characterized, we aimed to analyze the fibrogenic stimuli in a new <it>in vitro </it>model of NASH.</p> <p>Methods</p> <p>HuH7 cells were cultured for 24 h in an enriched medium containing bovine serum albumin and increasing concentrations of palmitic and oleic acid at a molar ratio of 1:2 (palmitic and oleic acid, respectively). Cytotoxic effect, apoptosis, oxidative stress, and production of inflammatory and fibrogenic cytokines were measured.</p> <p>Results</p> <p>FFA induces a significant increment in the intracellular content of lipid droplets. The gene expression of interleukin-6, interleukin-8 and tumor necrosis factor alpha was significantly increased. The protein level of interleukin-8 was also increased. Intracellular lipid accumulation was associated to a significant up-regulation in the gene expression of transforming growth factor beta 1, alpha 2 macroglobulin, vascular endothelial growth factor A, connective tissue growth factor, insulin-like growth factor 2, thrombospondin 1. Flow cytometry analysis demonstrated a significant increment of early apoptosis and production of reactive oxygen species.</p> <p>Conclusions</p> <p>The exposure of hepatocytes to fatty acids elicits inflammation, increase of oxidative stress, apoptosis and production of fibrogenic cytokines. These data support a primary role of FFA in the pathogenesis of NAFLD and NASH.</p
PROPOSAL OF A CLINICAL CARE PATHWAY FOR THE MANAGEMENT OF ACUTE UPPER GASTROINTESTINAL BLEEDING
- Author
- Abe N
- Al-Sabah S
- Aljebreen AM
- Bai Y
- Baradarian R
- Barkun AN
- Barkun AN
- Bernard B
- Bernardo WM
- Bittencourt PL
- Blatchford O
- Blatchford O
- Cappell MS
- Carbonell N
- Chavez-Tapia NC
- Chiu P
- Cooper GS
- Costa Junior AB
- de Franchis R
- DechĂȘne A
- Ermelindo Della LIBERA
- Fauze MALUF-FILHO
- FernĂĄndez J
- Ferreira R
- Frank Shigueo NAKAO
- Garcia-Tsao G
- GarcĂa-PagĂĄn JC
- Gisbert JP
- Gonzalez R
- Gustavo Andrade de PAULO
- Hsu YC
- Huang ES
- Hwang JH
- Hwang JH
- Ioannou G
- Katschinski B
- Laine L
- Laine L
- Lee TY
- Lim LG
- Lo GH
- Matheus Cavalcante FRANCO
- Mishra SR
- Neumann I
- Pang SH
- Pfau PR
- Rockall TA
- Rodrigo RODRIGUES
- Rotter T
- Schilling D
- Souza CDC
- Srirajaskanthan R
- Sulz MC
- Wong TC
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Predicting risk factors for rebleeding, infections, mortality following peptic ulcer bleeding in patients with cirrhosis and the impact of antibiotics prophylaxis at different clinical stages of the disease
- Author
- A Lanas
- A Rimola
- B Gao
- CH Hung
- Cheng-Kun Wu
- Chien-Ning Hsu
- Chih-Ming Liang
- Chung-Huang Kuo
- Chung-Mou Kuo
- CK Wu
- D Thabut
- DS Sanders
- E Haglind
- G DâAmico
- G Garcia-Tsao
- G Soriano
- H Rosa
- HW Xu
- J FernĂĄndez
- J Goulis
- J Goulis
- JA Forrest
- JJ Sung
- LS Lu
- Lung-Sheng Lu
- M Borzio
- M Rudler
- MG Foreman
- Ming-Te Kuo
- NC Chavez-Tapia
- PG Venkatesh
- PJ Shorvon
- R Marmo
- RJ Wyke
- RS OâShea
- S Kondo
- S Vivas
- Seng-Kee Chuah
- Shih-Cheng Yang
- TA Rockall
- V Arvaniti
- Wei-Chen Tai
- YC Hsu
- YC Hsu
- Yuan-Hung Kuo
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Anatomy of the sign-problem in heavy-dense QCD
- Author
- Adam E Romero
- Aranda C Padilla
- Arjanovic MM
- Armadans R Caminal
- Astigarraga ME Pozo
- Barajas CA Chavez
- Bechtle P
- Beck HP
- Becker K
- Becker M
- Beckingham M
- Becot C
- Beddall A
- Beddall AJ
- Bednyakov VA
- Bedognetti M
- Bee CP
- Beemster LJ
- Beermann TA
- Begel M
- Behr JK
- Belanger-Champagne C
- Bell AS
- Bella G
- Bellagamba L
- Bellerive A
- Bellomo M
- Belotskiy K
- Beltramello O
- Belyaev NL
- Benary O
- Benchekroun D
- Bender M
- Bendtz K
- Benekos N
- Benhammou Y
- Benitez J
- Benjamin DP
- Bensinger JR
- Bentvelsen S
- Beresford L
- Beretta M
- Berge D
- Berger N
- Berghaus F
- Beringer J
- Berlendis S
- Berlingen J Montejo
- Bernard NR
- Bernius C
- Bernlochner FU
- Berry T
- Berta P
- Bertella C
- Bertoli G
- Bertolucci F
- Bertram IA
- Bertsche C
- Bertsche D
- Besjes GJ
- Bessner M
- Besson N
- Betancourt C
- Bethke S
- Bevan AJ
- Bhimji W
- Bianchi RM
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- Biebel O
- Biedermann D
- Bielski R
- Biesuz NV
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- Bilokon H
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- Blanco JE
- Blazek T
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- Blunier S
- Bobbink GJ
- Bobrovnikov VS
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- Zurzolo G
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
QCD at finite densities of heavy quarks is investigated
using the density-of-states method. The phase factor
expectation value of the quark determinant is calculated to
unprecedented precision as a function of the chemical potential.
Results are validated using those from a reweighting
approach where the latter can produce a significant signalto-noise
ratio. We confirm the particleâhole symmetry at low
temperatures, find a strong sign problem at intermediate values
of the chemical potential, and an inverse Silver Blaze
feature for chemical potentials close to the onset value: here,
the phase-quenched theory underestimates the density of the
full theory
Search for High-Mass Resonances Decaying to ÏÎœ in pp Collisions at âs=13 TeV with the ATLAS Detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdinov O
- Abeloos B
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- Aleksandrov IN
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- Yildirim E
- Yildiz H Duran
- Yorita K
- Yoshihara K
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- Young CJS
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- Yuen SPY
- Yusuff I
- Zabinski B
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- Zakharchuk N
- Zalieckas J
- Zambito S
- Zanzi D
- Zeitnitz C
- Zemaityte G
- Zeng JC
- Zeng Q
- Zenin O
- Zenis T
- Zerwas D
- Zgubic M
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- Zhang Z
- Zhao X
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zhou B
- Zhou C
- Zhou L
- Zhou M
- Zhou M
- Zhou N
- Zhou Y
- Zhu CG
- Zhu H
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zhulanov V
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann S
- Zinonos Z
- Zinser M
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zu Theenhausen H Meyer
- zur Nedden M
- Zwalinski L
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2018
- Field of study
A search for high-mass resonances decaying to ÏÎœ using proton-proton collisions at âs=13 TeV produced by the Large Hadron Collider is presented. Only Ï-lepton decays with hadrons in the final state are considered. The data were recorded with the ATLAS detector and correspond to an integrated luminosity of 36.1 fbâ1. No statistically significant excess above the standard model expectation is observed; model-independent upper limits are set on the visible ÏÎœ production cross section. Heavy WâČ bosons with masses less than 3.7 TeV in the sequential standard model and masses less than 2.2â3.8 TeV depending on the coupling in the nonuniversal G(221) model are excluded at the 95% credibility level
Search for the direct production of charginos and neutralinos in final states with tau leptons in âs=13 TeV collisions with the ATLAS detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdinov O
- Abeloos B
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abreu R
- Abulaiti Y
- Acharya BS
- Adachi S
- Adamczyk L
- Adelman J
- Adersberger M
- Adye T
- Affolder AA
- Afik Y
- Agatonovic-Jovin T
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahlen SP
- Ahmadov F
- Aielli G
- Akatsuka S
- Akerstedt H
- Akesson TPA
- Akilli E
- Akimov AV
- Albergh GL
- Albert J
- Albicocco P
- Alconada Verzini MJ
- Alderweireldt SC
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexopoulos T
- Alhroob M
- Ali B
- Aliev M
- Alimonti G
- Alison J
- Alkire SP
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso A
- Alonso F
- Alpigiani C
- Alshehri AA
- Alstaty MI
- Alvarez Piqueras D
- Alviggi MG
- Amadio BT
- Amelung C
- Amidei D
- Amoroso S
- Amundsen G
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders JK
- Anderson KJ
- Andreazza A
- Andrei V
- Angelidakis S
- Angelozzi I
- Angerami A
- Anisenkov AV
- Anjos N
- Annovi A
- Antel C
- Antonelli M
- Antonov A
- Antrim DJ
- Anulli F
- Aoki M
- Arabidze G
- Arai Y
- Araque JP
- Arce ATH
- Ardell RE
- Arduh FA
- Arguin J-F
- Argyropoulos S
- Arik M
- Armadans R Caminal
- Armbruster AJ
- Armitage LJ
- Arnaez O
- Arnold H
- Arratia M
- Arslan O
- Artamonov A
- Artoni G
- Artz S
- Asai S
- Asbah N
- Ashkenazi A
- Asquith L
- Assamagan K
- Astalos R
- Astigarraga ME Pozo
- Atkinson M
- Atlay NB
- Augsten K
- Avolio G
- Axen B
- Ayoub MK
- Azuelos G
- Baas AE
- Baca MJ
- Bachacou H
- Bachas K
- Backes M
- Bagnaia P
- Bahmani M
- Bahrasemani H
- Baines JT
- Bajic M
- Baker OK
- Baldin EM
- Balek P
- Balli F
- Balunas WK
- Banas E
- Bandyopadhyay A
- Banerjee Sw
- Bannoura AAE
- Barajas CA Chavez
- Barak L
- Barberio EL
- Barberis D
- Barbero M
- Barillari T
- Barisits M-S
- Barkeloo JT
- Barklow T
- Barlow N
- Barnes SL
- Barnett BM
- Barnett RM
- Barnovska-Blenessy Z
- Baroncelli A
- Barone G
- Barr AJ
- Barranco Navarro L
- Barreiro F
- Bartoldus R
- Barton AE
- Bartos P
- Basalaev A
- Bassalat A
- Bates RL
- Batista SJ
- Batley JR
- Battaglia M
- Bauce M
- Bauer F
- Bawa HS
- Beacham JB
- Beattie MD
- Beau T
- Beauchemin PH
- Bechtle P
- Beck HC
- Beck HP
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- Zhemchugov A
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
A search for the direct production of charginos and neutralinos in final states with at least two hadronically decaying tau leptons is presented. The analysis uses a dataset of pp collisions corresponding to an integrated luminosity of 36.1 fbâ1, recorded with the ATLAS detector at the Large Hadron Collider at a centre-of-mass energy of 13TeV.Nosignificant deviation from the expected Standard Model background is observed. Limits are derived in scenarios of ËÏ+1 ËÏâ1 pair production and of Ëϱ1 ËÏ02 and ËÏ+1 ËÏâ1 production in simplified models where the neutralinos and charginos decay solely via intermediate left-handed staus and tau sneutrinos, and the mass of the Ë ÏL state is set to be halfway between the masses of the Ëϱ1 and the ËÏ01. Chargino masses up to 630 GeV are excluded at 95% confidence level in the scenario of direct production of ËÏ+1 ËÏâ1 for a massless ËÏ01. Common Ëϱ1 and ËÏ02 masses up to 760 GeV are excluded in the case of production of Ëϱ1 ËÏ02 and ËÏ+1 ËÏâ1 assuming a massless ËÏ01. Exclusion limits for additional benchmark scenarios with large and small mass-splitting between the Ëϱ1 and the ËÏ01 are also studied by varying the Ë ÏL mass between the masses of the Ëϱ1 and the ËÏ01
Combined measurement of differential and total cross sections in the HâŻââŻÎłÎł and the HâŻââŻZZ*âŻââŻ4â decay channels at s=13 TeV with the ATLAS detector
- Author
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- Aad G
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- Abdinov O
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- Abhayasinghe DK
- Abidi SH
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- Zhemchugov A
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- Zibell A
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- Zimine NI
- Zimmermann S
- Zinonos Z
- Zinser M
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- Zobernig G
- Zoccoli A
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- Zorbas TG
- Zou R
- Zur Nedden M
- Zwalinski L
- Ălvarez Piqueras D
- Ă kesson TPA
- Ć filigoj T
- ĆœeniĆĄ T
- ĆœivkoviÄ L
- Publication venue
- Elsevier
- Publication date
- 01/01/2018
- Field of study
A combined measurement of differential and inclusive total cross sections of Higgs boson production is performed using 36.1 fbâ1 of 13 TeV protonâproton collision data produced by the LHC and recorded by the ATLAS detector in 2015 and 2016. Cross sections are obtained from measured Hâγγ and HâZZ*(â4â event yields, which are combined taking into account detector efficiencies, resolution, acceptances and branching fractions. The total Higgs boson production cross section is measured to be 57.0â5.9 +6.0 (stat.) â3.3 +4.0 (syst.) pb, in agreement with the Standard Model prediction. Differential cross-section measurements are presented for the Higgs boson transverse momentum distribution, Higgs boson rapidity, number of jets produced together with the Higgs boson, and the transverse momentum of the leading jet. The results from the two decay channels are found to be compatible, and their combination agrees with the Standard Model predictions
Measurement of differential cross sections and W + /W â cross-section ratios for W boson production in association with jets at âs =8 TeV with the ATLAS detector
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdinov O
- Abeloos B
- Abidi SH
- AbouZeid OS
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- Yap YC
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- Yeletskikh I
- Yigitbasi E
- Yildirim E
- Yildiz H Duran
- Yorita K
- Yoshihara K
- Young C
- Young CJS
- Yu J
- Yu J
- Yuen SPY
- Yusuff I
- Zabinski B
- Zacharis G
- Zaidan R
- Zaitsev AM
- Zakharchuk N
- Zalieckas J
- Zaman A
- Zambito S
- Zanzi D
- Zeitnitz C
- Zemaityte G
- Zemla A
- Zeng JC
- Zeng Q
- Zenin O
- Zenis T
- Zerwas D
- Zhang D
- Zhang D
- Zhang F
- Zhang G
- Zhang H
- Zhang J
- Zhang L
- Zhang L
- Zhang M
- Zhang P
- Zhang R
- Zhang R
- Zhang X
- Zhang Y
- Zhang Z
- Zhao X
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zhou B
- Zhou C
- Zhou L
- Zhou M
- Zhou M
- Zhou N
- Zhou Y
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann S
- Zinonos Z
- Zinser M
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zou R
- zur Nedden M
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
This paper presents a measurement of the W boson production cross section and the W + /W â cross-section ratio, both in association with jets, in proton--proton collisions at s â =8 TeV with the ATLAS experiment at the Large Hadron Collider. The measurement is performed in final states containing one electron and missing transverse momentum using data corresponding to an integrated luminosity of 20.2 fb â1 . Differential cross sections for events with one or two jets are presented for a range of observables, including jet transverse momenta and rapidities, the scalar sum of transverse momenta of the visible particles and the missing transverse momentum in the event, and the transverse momentum of the W boson. For a subset of the observables, the differential cross sections of positively and negatively charged W bosons are measured separately. In the cross-section ratio of W + /W â the dominant systematic uncertainties cancel out, improving the measurement precision by up to a factor of nine. The observables and ratios selected for this paper provide valuable input for the up quark, down quark, and gluon parton distribution functions of the proto
Operation and performance of the ATLAS Tile Calorimeter in Run 1
- Author
- Aaboud M
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
- Abeloos B
- Abhayasinghe DK
- Abidi SH
- Abouelfadl 
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- Abraham NL
- Abramowicz H
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- Acharya BS
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- Adersberger M
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- Aielli G
- Akatsuka S
- Akerstedt H
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- Alberghi GL
- Albert J
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- Alconada Verzini MJ
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
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- Ali B
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- Alison J
- Alkire SP
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- Allen BW
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- Alstaty MI
- Alvarez 
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- Zwalinski L
- ZÌenisÌ T
- ZÌivkovicÌ L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
The Tile Calorimeter is the hadron calorimeter covering the central region of the ATLAS experiment at the Large Hadron Collider. Approximately 10,000 photomultipliers collect light from scintillating tiles acting as the active material sandwiched between slabs of steel absorber. This paper gives an overview of the calorimeterâs performance during the years 2008â2012 using cosmic-ray muon events and protonâproton collision data at centre-of-mass energies of 7 and 8TeV with a total integrated luminosity of nearly 30 fbâ1. The signal reconstruction methods, calibration systems as well as the detector operation status are presented. The energy and time calibration methods performed excellently, resulting in good stability of the calorimeter response under varying conditions during the LHC Run 1. Finally, the Tile Calorimeter response to isolated muons and hadrons as well as to jets from protonâproton collisions is presented. The results demonstrate excellent performance in accord with specifications mentioned in the Technical Design Report
Study of ordered hadron chains with the ATLAS detector
- Author
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- Aad G
- Abbott B
- Abdinov O
- Abeloos B
- Abidi SH
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- Zhang J
- Zhang L
- Zhang L
- Zhang M
- Zhang P
- Zhang R
- Zhang R
- Zhang X
- Zhang Y
- Zhang Z
- Zhao X
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zhou B
- Zhou C
- Zhou L
- Zhou M
- Zhou M
- Zhou N
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann S
- Zinonos Z
- Zinser M
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zou R
- Zu Theenhausen H Meyer
- zur Nedden M
- Zwalinski L
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2017
- Field of study
The analysis of the momentum difference between charged hadrons in high-energy proton-proton collisions is performed in order to study coherent particle production. The observed correlation pattern agrees with a model of a helical QCD string fragmenting into a chain of ground-state hadrons. A threshold momentum difference in the production of adjacent pairs of charged hadrons is observed, in agreement with model predictions. The presence of low-mass hadron chains also explains the emergence of charge-combination-dependent two-particle correlations commonly attributed to Bose-Einstein interference. The data sample consists of 190 ÎŒbâ1 of minimum-bias events collected with proton-proton collisions at a center-of-mass energy âs=7 TeV in the early low-luminosity data taking with the ATLAS detector at the LHC
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