Contribution of Decision Support System in Enhancing Productivity and Profitability of the Firm

The business paradigms are changing amidst changing business environment. There are newer technologies at disposal, rising customer awareness and their expectations from the need to attain efficiency and effectiveness in business processes for survival and competitive advantage. This paper provides insights on the significance of business decision making and present state of organizations that are striving to achieve optimal utilization of limited business resources. The paper highlights the nature of linear programming model and its importance in effective business decision making. The business impact of model is illustrated in the case using the linear programming model and transportation method through excel solver in computer manufacturing firms to help in deciding optimum quantity to produce within limited resources and how the computers manufactured can be distributed to market places at minimal cost. The paper elicits the effectiveness of the linear programming model to realize good decision making in business by meeting the business objectives through optimal utilization of resources. It concludes that model driven decision support system enhances the productivity and profitability of the firm in a constrained environment and is a highly effective model for solving business problems

Performance Enhancement of DS-CDMA System using Extended BPSK Modulation Scheme

In a last few decades there has been tremendous growth and a drastic rise in wireless communication technologies. The major issue that the world is facing today with the advent of so many sophisticated wireless communication devices is efficient utilization of the spectrum. Spectrum efficiency comes together with a tradeoff factor of energy consumption. Thus, the need of the hour is an energy and bandwidth efficient technique. DS-CDMA is one of the competitive and most investigated technique in wireless communication which caters the large demand at the same time with limited bandwidth. Existing modulation techniques does not promise to provide better performance in case of higher noise. Therefore, one looks for a better BER stipulated modulation format to improve and enhance the performance of the system. This article revisits conventional Binary phase shift keying method and compares its performance in terms of BER with a special Extended Binary Phase Shift Keying (EBPSK) modulation format for a DS- CDMA system. EBPSK scheme is flexible and simple which is easily integrated in a network and assures improved and enhanced performance

Localization of Compact Binary Sources with Second Generation Gravitational-wave Interferometer Networks

GW170817 began gravitational-wave multimessenger astronomy. However, GW170817 will not be representative of detections in the coming years -- typical gravitational-wave sources will be closer the detection horizon, have larger localization regions, and (when present) will have correspondingly weaker electromagnetic emission. In its design state, the gravitational-wave detector network in the mid-2020s will consist of up to five similar-sensitivity second-generation interferometers. The instantaneous sky-coverage by the full network is nearly isotropic, in contrast to the configuration during the first \change{three} observing runs. Along with the coverage of the sky, there are also commensurate increases in the average horizon for a given binary mass. We present a realistic set of localizations for binary neutron stars and neutron star--black hole binaries, incorporating intra-network duty cycles and selection effects on the astrophysical distributions. Based on the assumption of an $80\%$ duty cycle, and that two instruments observe a signal above the detection threshold, we anticipate a median of $28$ sq.\ deg.\ for binary neutron stars, and $50$--$120$ sq.\ deg.\ for neutron star--black hole (depending on the population assumed). These distributions have a wide spread, and the best localizations, even for networks with fewer instruments, will have localizations of $1$--$10$ sq.\ deg.\ range. The full five instrument network reduces localization regions to a few tens of degrees at worst.Comment: 20 pages, 8 figures, 3 tables, accepted in Ap

A rapid systematic scoping review of research on the impacts of water contaminated by chemicals on very young children

Low-income countries are struggling with the health impacts of both surface and groundwater chemical contamination. Although the impact of biological contaminants on children's health is acknowledged, the long-term effects of these and emerging contaminants on young children may be underestimated. To map the existing evidence on health impacts of water contaminated with chemicals on young children (<5 years), we conducted a scoping review to select and organize relevant literature. Of the 98 studies in the review, 24 revealed that the hazard ratio of arsenic, nitrates, cadmium, and fluoride (all of which are on the World Health Organisation's list of 10 chemicals of public health concern) was higher in very young children than in older age groups. Anthropogenic activities (textile manufacturing, waste disposal, and intensified agriculture) are leading contributors to the release of chemicals to groundwater used for drinking. Three major pathways for chemical contamination exposure in young children were confirmed: maternal transmission during pregnancy and breastfeeding, and early school years. Children exhibited acute and chronic disruptions to their neurological, skeletal, reproductive, and endocrine systems, as well as cumulative carcinogenic risks, amongst other life-altering consequences. The lack of research on emerging contaminants' effects on young children in low-income countries is worrisome, as their increased use may compound the issues caused by the existing problem of "legacy chemicals." Precautionary principle should regulate the operation of industries producing these chemicals in a robust manner. Evidence from major producers and exporters in high-income countries is sufficient to warrant action, even without waiting for direct harm to be observed in low-income countries. Literature recommends prioritising prevention of contamination over demand side treatment or finding alternative water sources, especially in water-scarce areas affected by climate change. Local and transnational efforts are required to enforce safer industry practices and prevent further water quality deterioration in low-income countries

Agricultural production and food security implications of Covid-19 disruption on small-scale farmer households: Lessons from Kenya

A range of studies have highlighted the negative impacts of Covid-19 disruptions on incomes, food and nutrition security among rural agricultural communities in developing countries. However, knowledge of how such disruptions affect different categories of small-scale farmers in Sub-Sahara Africa is lacking. We used a mixed-method approach to collect data and determine the impacts of Covid-19 on farm input use, agricultural production, access to agricultural information services, and food security among small-scale farmers from Makueni, Nakuru, Siaya, Kakamega, and Bungoma counties in Kenya. A FAO-adapted farm household typology was developed with farm type 3 (wealthiest), farm type 2 (resource-constrained) and farm type 1 (most resource-constrained) farmer categories. Covid-19 related disruptions led to decreased use of improved seeds, fertilizers and access to extension services across the three farmer categories. Farm type 3 farmers recorded the lowest Covid-19 disruption driven reduction in the use of improved seeds and fertilizers, compared to farm type 2 and 1. Contrariwise, farmers increased manure application rates by 33%, with manure-associated expenditure rising by 129% across all counties. Average crop incomes decreased in three of the five study counties, i.e., Kakamega, Nakuru and Siaya, with the strongest decrease observed among farmers in type 1 and 2 households. A lower proportion of type 3 farmers were worried about not having enough food (43% of farmers) compared to type 1 (70%) and type 2 farmers (71%) across Counties. The sale of household assets and livestock commonly used as measures for household wealth implies that such disruptions leave vulnerable farmers poorer and hungrier. The findings propose that policy strategies are needed to recognize heterogenous Covid-19 effects and provide targeted interventions for household types most vulnerable to future disruptions of the agrifood system

Comparative analysis of the responses to water stress in eggplant (Solanum melongena) cultivars

[EN] Little information is available on the physiological and biochemical responses to water stress in eggplant (Solanum melongena). We valuated four genetically diverse eggplant varieties (MEL3-MEL6) under control and water stress conditions. Measurements were taken for plant growth, tissue water content, levels of chlorophylls a and b, carotenoids, roline, malondialdehyde, total phenolics, total flavonoids, superoxide dismutase (SOD), catalase (CAT), ascorbate peroxidase APX), and glutathione reductase (GR) activities. For most traits, the water stress treatment had a greater contribution than the variety effect to the total sums of squares in an ANOVA analysis, except for total flavonoids, SOD, APX, and GR. The water stress treatment had a strong effect on plant growth and tissue water content. In general, water tress reduced the three photosynthetic pigments, increased proline, malondialdehyde, total phenolics, and total flavonoids, although some varietal differences were ob- served. Different patterns were also detected in the activities of the four enzymes evaluated, but few differences were observed for individual varieties between the control and water stress treatments. Many significant phe- notypic orrelations were observed among the traits studied, but only eight environmental correlations were detected. A PCA analysis distinctly separated individuals according to the treatment, and revealed a clearer separation of varieties under water stress than under control conditions, pointing to varietal differences in the responses to stress. Our results suggest that proline could be used as a marker for drought stress tolerance in this species. The information obtained provides new insight on the physiological and biochemical responses of eggplant to drought stressAuthors are grateful to the European Union's Horizon 2020 Research and Innovation Programme under grant agreement No 677379 (G2P-SOL project: Linking genetic resources, genomes and phenotypes of Solanaceous crops), to Ministerio de Economfa, Industria y Competitividad and Fondo Europeo de Desarrollo Regional (grant AGL2015-64755-R from MINECO/FEDER), to Ministerio de Ciencia, Innovation y Universidades, Agencia Estatal de Investigation and Fondo Europeo de Desarrollo Regional (grant RTI-2018-094592-B-100 from MCIU/AEI/FEDER, UE), to the Generalitat Valenciana and Fondo Social Europeo (Ayuda a Grupos Emergentes; GV/2019/033), to the Vicerrectorado de Investigacien, Innovation y Transferencia de la Universitat Politecnica de Valencia (Ayuda a Primeros Proyectos de Investigation; PAID-06-18), and to the initiative "Adapting Agriculture to Climate Change: Collecting, Protecting and Preparing Crop Wild Relatives", which is supported by the Government of Norway. This latter project is managed by the Global Crop Diversity Trust with the Millennium Seed Bank of the Royal Botanic Gardens, Kew and implemented in partnership with national and international gene banks and plant breeding institutes around the world. For further information see the project website: http://www.cwrdiversity.org/. Mariola Plazas is grateful to Generalitat Valenciana and Fondo Social Europeo for a post-doctoral contract (APOSTD/2018/014). The contribution of Huu Trong Nguyen to this paper has been developed as a result of a mobility stay funded by Erasmus + KA1 Erasmus Mundus Joint Master Degrees Programme of the European Commission under the PLANT HEALTH project.Plazas, M.; Nguyen, HT.; González-Orenga, S.; Fita, A.; Vicente, O.; Prohens Tomás, J.; Boscaiu, M. (2019). Comparative analysis of the responses to water stress in eggplant (Solanum melongena) cultivars. Plant Physiology and Biochemistry. 143:72-82. https://doi.org/10.1016/j.plaphy.2019.08.031S728214

Recent progress in development of dressings used for diabetic wounds with special emphasis on scaffolds

Diabetic wound (DW) is a secondary application of uncontrolled diabetes and affects about 42.2% of diabetics. If the disease is left untreated/uncontrolled, then it may further lead to amputation of organs. In recent years, huge research has been done in the area of wound dressing to have a better maintenance of DW. These include gauze, films, foams or, hydrocolloid-based dressings as well as polysaccharide-and polymer-based dressings. In recent years, scaffolds have played major role as biomaterial for wound dressing due to its tissue regeneration properties as well as fluid absorption capacity. These are three-dimensional polymeric structures formed from polymers that help in tissue rejuvenation. These offer a large surface area to volume ratio to allow cell adhesion and exudate absorbing capacity and antibacterial properties. They also offer a better retention as well as sustained release of drugs that are directly impregnated to the scaffolds or the ones that are loaded in nanocarriers that are impregnated onto scaffolds. The present review comprehensively describes the pathogenesis of DW, various dressings that are used so far for DW, the limitation of currently used wound dressings, role of scaffolds in topical delivery of drugs, materials used for scaffold fabrication, and application of various polymer-based scaffolds for treating DW

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study

Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat