A clinical study of the effect of Glycyrrhiza glabra plant and exercise on the quality of life of menopausal women

BACKGROUND: Most women experience significant changes during and after menopause which causes various complications of menopause and the changes in quality of their life. The aim of this study was to evaluate the effect of Glycyrrhiza glabra plant and exercise on quality of life (QOL) of menopausal women. METHODS: This clinical experiment was performed in Arak, Iran. The study subjects consisted of 120 menopausal women. The participants were selected through convenience method and randomly divided into 4 groups of 30 subjects. Group 1 participants were administered 3 Glycyrrhiza glabra tablets daily. Group 2 participants had a regular exercise program. Group 3 participants were simultaneously administered Glycyrrhiza glabr tablets like group 1 and had an exercise program like group 2. Group 4 received no intervention. The participants’ QOL was investigated before and 1 month after the intervention using the Menopause-Specific Quality of Life (MENQOL) Questionnaire. Data analysis was performed in SPSS software using Mann-Whitney, Wilcoxon, Kruskal-Wallis, and chi-square tests, and variance analysis. RESULTS: No significant difference between the four groups in terms of vasomotor, psychosocial, physical, and sexual health, and QOL based on the Kruskal-Wallis test before the intervention. However, a significant difference was observed between the groups in terms of vasomotor, psychosocial, physical, and sexual health and QOL after the intervention. CONCLUSION: The results of this study showed the efficacy of Glycyrrhiza glabra and exercise programs in controlling the symptoms of menopause. It is recommended that postmenopausal women use exercise programs and Glycyrrhiza glabra to control menopausal symptoms

Family caregivers' perspectives on barriers to caring for patients with schizophrenia: A descriptive qualitative study

Background & Aim: Schizophrenia significantly burdens family members when a member of their family is afflicted with this condition. Family caregivers play a pivotal role in providing care and support to individuals experiencing schizophrenia within the community. Therefore, an in-depth study of family caregivers' experiences is crucial for developing effective care quality improvement programs. This study aimed at exploring family caregivers' experiences of the barriers to caregiving to patients with schizophrenia. Methods & Materials: This study was conducted in 2021–2022 through in-depth semi-structured. The duration of the interviews varied in length from 45 to 90 minutes. Interviews were conducted with sixteen family caregivers of patients with schizophrenia. The conventional content analysis proposed by Graneheim and Lundman was used for data analysis. Results: The findings can be classified into three primary categories. The category "Inefficiency of Support Resources" encompasses the subcategories of "Inadequate Support by Family Members," "Inadequate Support by the Healthcare System," and "Financial Predicament." The category "Limited Public Knowledge about Psychiatric Disorders" includes the subcategories of "Social Stigmatization" and "Being Social Rejection." Lastly, the category "destructive nature of schizophrenia" encompasses the subcategories of "Gradual Loss of Abilities" and "Gradual Patient Passivity." Conclusion: Family caregivers encounter various barriers in providing patient care. Thus, they require support from the treatment team and family members, as well as financial and the development of rehabilitation programs. Additionally, involving caregivers in the patient's treatment plan and planning programs to reduce the stigma associated with caregivers is crucial

A clinical study of the effect of Glycyrrhiza glabra plant and exercise on the quality of life of menopausal women

BACKGROUND: Most women experience significant changes during and after menopause which causes various complications of menopause and the changes in quality of their life. The aim of this study was to evaluate the effect of Glycyrrhiza glabra plant and exercise on quality of life (QOL) of menopausal women. METHODS: This clinical experiment was performed in Arak, Iran. The study subjects consisted of 120 menopausal women. The participants were selected through convenience method and randomly divided into 4 groups of 30 subjects. Group 1 participants were administered 3 Glycyrrhiza glabra tablets daily. Group 2 participants had a regular exercise program. Group 3 participants were simultaneously administered Glycyrrhiza glabr tablets like group 1 and had an exercise program like group 2. Group 4 received no intervention. The participants’ QOL was investigated before and 1 month after the intervention using the Menopause-Specific Quality of Life (MENQOL) Questionnaire. Data analysis was performed in SPSS software using Mann-Whitney, Wilcoxon, Kruskal-Wallis, and chi-square tests, and variance analysis. RESULTS: No significant difference between the four groups in terms of vasomotor, psychosocial, physical, and sexual health, and QOL based on the Kruskal-Wallis test before the intervention. However, a significant difference was observed between the groups in terms of vasomotor, psychosocial, physical, and sexual health and QOL after the intervention. CONCLUSION: The results of this study showed the efficacy of Glycyrrhiza glabra and exercise programs in controlling the symptoms of menopause. It is recommended that postmenopausal women use exercise programs and Glycyrrhiza glabra to control menopausal symptoms

From Diagnosis to Cure: Innovations in Disease Diagnosis and Treatment

Chapter1: Advancements in diagnosis and treatment of neurological disorders Chapter2: Advancements in diagnosis and treatment of mental disorders Chapter3: Advancements in diagnosis and treatment of cardiovascular disease Chapter4: Advancements in surgical procedures Chapter5: New developments in surgical procedure

Global, regional, and national burden of stroke and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Background Regularly updated data on stroke and its pathological types, including data on their incidence, prevalence, mortality, disability, risk factors, and epidemiological trends, are important for evidence-based stroke care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) aims to provide a standardised and comprehensive measurement of these metrics at global, regional, and national levels. Methods We applied GBD 2019 analytical tools to calculate stroke incidence, prevalence, mortality, disability-adjusted life-years (DALYs), and the population attributable fraction (PAF) of DALYs (with corresponding 95% uncertainty intervals [UIs]) associated with 19 risk factors, for 204 countries and territories from 1990 to 2019. These estimates were provided for ischaemic stroke, intracerebral haemorrhage, subarachnoid haemorrhage, and all strokes combined, and stratified by sex, age group, and World Bank country income level. Findings In 2019, there were 12·2 million (95% UI 11·0–13·6) incident cases of stroke, 101 million (93·2–111) prevalent cases of stroke, 143 million (133–153) DALYs due to stroke, and 6·55 million (6·00–7·02) deaths from stroke. Globally, stroke remained the second-leading cause of death (11·6% [10·8–12·2] of total deaths) and the third-leading cause of death and disability combined (5·7% [5·1–6·2] of total DALYs) in 2019. From 1990 to 2019, the absolute number of incident strokes increased by 70·0% (67·0–73·0), prevalent strokes increased by 85·0% (83·0–88·0), deaths from stroke increased by 43·0% (31·0–55·0), and DALYs due to stroke increased by 32·0% (22·0–42·0). During the same period, age-standardised rates of stroke incidence decreased by 17·0% (15·0–18·0), mortality decreased by 36·0% (31·0–42·0), prevalence decreased by 6·0% (5·0–7·0), and DALYs decreased by 36·0% (31·0–42·0). However, among people younger than 70 years, prevalence rates increased by 22·0% (21·0–24·0) and incidence rates increased by 15·0% (12·0–18·0). In 2019, the age-standardised stroke-related mortality rate was 3·6 (3·5–3·8) times higher in the World Bank low-income group than in the World Bank high-income group, and the age-standardised stroke-related DALY rate was 3·7 (3·5–3·9) times higher in the low-income group than the high-income group. Ischaemic stroke constituted 62·4% of all incident strokes in 2019 (7·63 million [6·57–8·96]), while intracerebral haemorrhage constituted 27·9% (3·41 million [2·97–3·91]) and subarachnoid haemorrhage constituted 9·7% (1·18 million [1·01–1·39]). In 2019, the five leading risk factors for stroke were high systolic blood pressure (contributing to 79·6 million [67·7–90·8] DALYs or 55·5% [48·2–62·0] of total stroke DALYs), high body-mass index (34·9 million [22·3–48·6] DALYs or 24·3% [15·7–33·2]), high fasting plasma glucose (28·9 million [19·8–41·5] DALYs or 20·2% [13·8–29·1]), ambient particulate matter pollution (28·7 million [23·4–33·4] DALYs or 20·1% [16·6–23·0]), and smoking (25·3 million [22·6–28·2] DALYs or 17·6% [16·4–19·0]). Interpretation The annual number of strokes and deaths due to stroke increased substantially from 1990 to 2019, despite substantial reductions in age-standardised rates, particularly among people older than 70 years. The highest age-standardised stroke-related mortality and DALY rates were in the World Bank low-income group. The fastest-growing risk factor for stroke between 1990 and 2019 was high body-mass index. Without urgent implementation of effective primary prevention strategies, the stroke burden will probably continue to grow across the world, particularly in low-income countries.publishedVersio

Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

A double burden of malnutrition occurs when individuals, household members or communities experience both undernutrition and overweight. Here, we show geospatial estimates of overweight and wasting prevalence among children under 5 years of age in 105 low- and middle-income countries (LMICs) from 2000 to 2017 and aggregate these to policy-relevant administrative units. Wasting decreased overall across LMICs between 2000 and 2017, from 8.4% (62.3 (55.1–70.8) million) to 6.4% (58.3 (47.6–70.7) million), but is predicted to remain above the World Health Organization’s Global Nutrition Target of <5% in over half of LMICs by 2025. Prevalence of overweight increased from 5.2% (30 (22.8–38.5) million) in 2000 to 6.0% (55.5 (44.8–67.9) million) children aged under 5 years in 2017. Areas most affected by double burden of malnutrition were located in Indonesia, Thailand, southeastern China, Botswana, Cameroon and central Nigeria. Our estimates provide a new perspective to researchers, policy makers and public health agencies in their efforts to address this global childhood syndemic

Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Background: In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive and collectively exhaustive list of diseases and injuries. Methods: GBD estimates incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) due to 369 diseases and injuries, for two sexes, and for 204 countries and territories. Input data were extracted from censuses, household surveys, civil registration and vital statistics, disease registries, health service use, air pollution monitors, satellite imaging, disease notifications, and other sources. Cause-specific death rates and cause fractions were calculated using the Cause of Death Ensemble model and spatiotemporal Gaussian process regression. Cause-specific deaths were adjusted to match the total all-cause deaths calculated as part of the GBD population, fertility, and mortality estimates. Deaths were multiplied by standard life expectancy at each age to calculate YLLs. A Bayesian meta-regression modelling tool, DisMod-MR 2.1, was used to ensure consistency between incidence, prevalence, remission, excess mortality, and cause-specific mortality for most causes. Prevalence estimates were multiplied by disability weights for mutually exclusive sequelae of diseases and injuries to calculate YLDs. We considered results in the context of the Socio-demographic Index (SDI), a composite indicator of income per capita, years of schooling, and fertility rate in females younger than 25 years. Uncertainty intervals (UIs) were generated for every metric using the 25th and 975th ordered 1000 draw values of the posterior distribution. Findings: Global health has steadily improved over the past 30 years as measured by age-standardised DALY rates. After taking into account population growth and ageing, the absolute number of DALYs has remained stable. Since 2010, the pace of decline in global age-standardised DALY rates has accelerated in age groups younger than 50 years compared with the 1990–2010 time period, with the greatest annualised rate of decline occurring in the 0–9-year age group. Six infectious diseases were among the top ten causes of DALYs in children younger than 10 years in 2019: lower respiratory infections (ranked second), diarrhoeal diseases (third), malaria (fifth), meningitis (sixth), whooping cough (ninth), and sexually transmitted infections (which, in this age group, is fully accounted for by congenital syphilis; ranked tenth). In adolescents aged 10–24 years, three injury causes were among the top causes of DALYs: road injuries (ranked first), self-harm (third), and interpersonal violence (fifth). Five of the causes that were in the top ten for ages 10–24 years were also in the top ten in the 25–49-year age group: road injuries (ranked first), HIV/AIDS (second), low back pain (fourth), headache disorders (fifth), and depressive disorders (sixth). In 2019, ischaemic heart disease and stroke were the top-ranked causes of DALYs in both the 50–74-year and 75-years-and-older age groups. Since 1990, there has been a marked shift towards a greater proportion of burden due to YLDs from non-communicable diseases and injuries. In 2019, there were 11 countries where non-communicable disease and injury YLDs constituted more than half of all disease burden. Decreases in age-standardised DALY rates have accelerated over the past decade in countries at the lower end of the SDI range, while improvements have started to stagnate or even reverse in countries with higher SDI. Interpretation: As disability becomes an increasingly large component of disease burden and a larger component of health expenditure, greater research and developm nt investment is needed to identify new, more effective intervention strategies. With a rapidly ageing global population, the demands on health services to deal with disabling outcomes, which increase with age, will require policy makers to anticipate these changes. The mix of universal and more geographically specific influences on health reinforces the need for regular reporting on population health in detail and by underlying cause to help decision makers to identify success stories of disease control to emulate, as well as opportunities to improve. Funding: Bill & Melinda Gates Foundation. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licens

Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019

Background Regularly updated data on stroke and its pathological types, including data on their incidence, prevalence, mortality, disability, risk factors, and epidemiological trends, are important for evidence-based stroke care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) aims to provide a standardised and comprehensive measurement of these metrics at global, regional, and national levels. Methods We applied GBD 2019 analytical tools to calculate stroke incidence, prevalence, mortality, disability-adjusted life-years (DALYs), and the population attributable fraction (PAF) of DALYs (with corresponding 95% uncertainty intervals UIs]) associated with 19 risk factors, for 204 countries and territories from 1990 to 2019. These estimates were provided for ischaemic stroke, intracerebral haemorrhage, subarachnoid haemorrhage, and all strokes combined, and stratified by sex, age group, and World Bank country income level. Findings In 2019, there were 12.2 million (95% UI 11.0-13.6) incident cases of stroke, 101 million (93.2-111) prevalent cases of stroke, 143 million (133-153) DALYs due to stroke, and 6.55 million (6.00-7.02) deaths from stroke. Globally, stroke remained the second-leading cause of death (11.6% 10.8-12.2] of total deaths) and the third-leading cause of death and disability combined (5.7% 5.1-6.2] of total DALYs) in 2019. From 1990 to 2019, the absolute number of incident strokes increased by 70.0% (67.0-73.0), prevalent strokes increased by 85.0% (83.0-88.0), deaths from stroke increased by 43.0% (31.0-55.0), and DALYs due to stroke increased by 32.0% (22.0-42.0). During the same period, age-standardised rates of stroke incidence decreased by 17.0% (15.0-18.0), mortality decreased by 36.0% (31.0-42.0), prevalence decreased by 6.0% (5.0-7.0), and DALYs decreased by 36.0% (31.0-42.0). However, among people younger than 70 years, prevalence rates increased by 22.0% (21.0-24.0) and incidence rates increased by 15.0% (12.0-18.0). In 2019, the age-standardised stroke-related mortality rate was 3.6 (3.5-3.8) times higher in the World Bank low-income group than in the World Bank high-income group, and the age-standardised stroke-related DALY rate was 3.7 (3.5-3.9) times higher in the low-income group than the high-income group. Ischaemic stroke constituted 62.4% of all incident strokes in 2019 (7.63 million 6.57-8.96]), while intracerebral haemorrhage constituted 27.9% (3.41 million 2.97-3.91]) and subarachnoid haemorrhage constituted 9.7% (1.18 million 1.01-1.39]). In 2019, the five leading risk factors for stroke were high systolic blood pressure (contributing to 79.6 million 67.7-90.8] DALYs or 55.5% 48.2-62.0] of total stroke DALYs), high body-mass index (34.9 million 22.3-48.6] DALYs or 24.3% 15.7-33.2]), high fasting plasma glucose (28.9 million 19.8-41.5] DALYs or 20.2% 13.8-29.1]), ambient particulate matter pollution (28.7 million 23.4-33.4] DALYs or 20.1% 16.6-23.0]), and smoking (25.3 million 22.6-28.2] DALYs or 17.6% 16.4-19.0]). Interpretation The annual number of strokes and deaths due to stroke increased substantially from 1990 to 2019, despite substantial reductions in age-standardised rates, particularly among people older than 70 years. The highest age-standardised stroke-related mortality and DALY rates were in the World Bank low-income group. The fastest-growing risk factor for stroke between 1990 and 2019 was high body-mass index. Without urgent implementation of effective primary prevention strategies, the stroke burden will probably continue to grow across the world, particularly in low-income countries

The Qualitative Study of the Sharing Model in Counseling with Islamic Approach and its Role in the Stability of the First, Second and Third Types of Changes in Clients

Many models of counseling have been used in the prevention, development and treatment of clients. One of the new consulting approaches is Ismaily (2014) Sahmgozari  model based on Islamic ontology. The purpose of this study is to explain the components and investigate the role of consultants' Sahmgozari style in order to create sustainable changes of the first, second and third types in clients. For this purpose, we used the grounded theory research method. The sample consisted of 5 counselors and 6 clients who used semi-structured interviews to extract experience-based perspectives. The obtained model includes the underlying factors and strategies and the central phenomenon in the realization of the sharing style. The central phenomenon in the realization of balanced Sahmgozari style is composed of attitudinal, functional and communication components. Creating awareness and perception of being centered around the axes of the role of creation, good creativity and purposeful expansion is the underlying factor of a balanced Sahmgozari style. The therapist's focus on the role of clients in existence, ontological evaluation, and preparation for the future constitute strategies for achieving a balanced Sahmgozari style. The present study shows that using the Sahmgozari model to bring about change can be a good predictor for greater stability in a variety of changes. In addition, due to the fact that the client reaches a higher level of self-awareness and self-coordination with the components of existence, they can act as their own consultant