Using Subsystem MT2 for Complete Mass Determinations in Decay Chains with Missing Energy at Hadron Colliders

We propose to use the MT2 concept to measure the masses of all particles in SUSY-like events with two unobservable, identical particles. To this end we generalize the usual notion of MT2 and define a new MT2(n,p,c) variable, which can be applied to various subsystem topologies, as well as the full event topology. We derive analytic formulas for its endpoint MT2{max}(n,p,c) as a function of the unknown test mass Mc of the final particle in the subchain and the transverse momentum pT due to radiation from the initial state. We show that the endpoint functions MT2{max}(n,p,c)(Mc,pT) may exhibit three different types of kinks and discuss the origin of each type. We prove that the subsystem MT2(n,p,c) variables by themselves already yield a sufficient number of measurements for a complete determination of the mass spectrum (including the overall mass scale). As an illustration, we consider the simple case of a decay chain with up to three heavy particles, X2 -> X1 -> X0, which is rather problematic for all other mass measurement methods. We propose three different MT2-based methods, each of which allows a complete determination of the masses of particles X0, X1 and X2. The first method only uses MT2(n,p,c) endpoint measurements at a single fixed value of the test mass Mc. In the second method the unknown mass spectrum is fitted to one or more endpoint functions MT2{max}(n,p,c)(Mc,pT) exhibiting a kink. The third method is hybrid, combining MT2 endpoints with measurements of kinematic edges in invariant mass distributions. As a practical application of our methods, we show that the dilepton W+W- and tt-bar samples at the Tevatron can be used for an independent determination of the masses of the top quark, the W boson and the neutrino, without any prior assumptions.Comment: 47 pages, 9 figures. revised version, published in JHEP. Major addition: a new appendix with the complete set of formulas for the MT2 endpoints as functions of the upstream transverse momentum pT and test mass M

Using kinematic boundary lines for particle mass measurements and disambiguation in SUSY-like events with missing energy

We revisit the method of kinematical endpoints for particle mass determination, applied to the popular SUSY decay chain squark -> neutralino -> slepton -> LSP. We analyze the uniqueness of the solutions for the mass spectrum in terms of the measured endpoints in the observable invariant mass distributions. We provide simple analytical inversion formulas for the masses in terms of the measured endpoints. We show that in a sizable portion of the SUSY mass parameter space the solutions always suffer from a two-fold ambiguity, due to the fact that the original relations between the masses and the endpoints are piecewise-defined functions. The ambiguity persists even in the ideal case of a perfect detector and infinite statistics. We delineate the corresponding dangerous regions of parameter space and identify the sets of "twin" mass spectra. In order to resolve the ambiguity, we propose a generalization of the endpoint method, from single-variable distributions to two-variable distributions. In particular, we study analytically the boundaries of the (m_{jl(lo)}, m_{jl(hi)}) and (m_{ll}, m_{jll}) distributions and prove that their shapes are in principle sufficient to resolve the ambiguity in the mass determination. We identify several additional independent measurements which can be obtained from the boundary lines of these bivariate distributions. The purely kinematical nature of our method makes it generally applicable to any model that exhibits a SUSY-like cascade decay.Comment: 47 pages, 19 figure

The JNK Inhibitor XG-102 Protects against TNBS-Induced Colitis

The c-Jun N-terminal kinase (JNK)-inhibiting peptide D-JNKI-1, syn. XG-102 was tested for its therapeutic potential in acute inflammatory bowel disease (IBD) in mice. Rectal instillation of the chemical irritant trinitrobenzene sulfonic acid (TNBS) provoked a dramatic acute inflammation in the colon of 7–9 weeks old mice. Coincident subcutaneous application of 100 µg/kg XG-102 significantly reduced the loss of body weight, rectal bleeding and diarrhoea. After 72 h, the end of the study, the colon was removed and immuno-histochemically analysed. XG-102 significantly reduced (i) pathological changes such as ulceration or crypt deformation, (ii) immune cell pathology such as infiltration and presence of CD3- and CD68-positive cells, (iii) the production of tumor necrosis factor (TNF)-α in colon tissue cultures from TNBS-treated mice, (iv) expression of Bim, Bax, FasL, p53, and activation of caspase 3, (v) complexation of JNK2 and Bim, and (vi) expression and activation of the JNK substrate and transcription factor c-Jun. A single application of subcutaneous XG-102 was at least as effective or even better depending on the outcome parameter as the daily oral application of sulfasalazine used for treatment of IBD

Social environment and food and beverage intake in European adolescents: The Helena study

[Background] The family environment influences food consumption and behaviours, which impact adolescent’s eating habits, diet and health. Young individuals who frequently eat family meals are less likely to develop risk- and behaviour-related outcomes as obesity.[Aim] To assess the relationship between the family meal environment and food and macronutrient consumption in European adolescents.[Methods] 1,703 adolescents aged 12.5-17.5 years (46.5% male) from the European HELENA cross-sectional study were selected. Sociodemographic variables and dietary intake using two non-consecutive self-reported 24-hour dietary recalls were collected from all the included participants. The relationship between family meals’ environment and food and macronutrient consumption was analized using analysis of covariance.[Results] Adolescents who used to take their main meals with their family were associated with high consumption of healthy foods and beverages (i.e. vegetables, fruit, milk, water) and low consumption of energy dense food and beverages as chocolate, savoury snacks, sugar or juices compared with those who used to eat alone, with friends or other people (p < 0.05).[Conclusion] The company/people with whom adolescents consume their meal have an important influence on the adolescent’s consumption of different types of food (especially at lunch). Family’s environment during meals has been associated with a high consumption of healthy foods.This work was carried out as part of the HELENA study (www.helenastudy.com/). We gratefully acknowledge the financial support of the European Community sixth RTD Framework Programme (Contract FOOD-CT-2005-007034). Also, we gratefully acknowledge the Ministry of Science and Innovation (MICINN) and the European Region Development Fund (Fondo Europeo de Desarrollo Regional, FEDER) for their financial support.Peer reviewe

Relationship between self-reported dietary intake and physical activity levels among adolescents: The HELENA study

Background Evidence suggests possible synergetic effects of multiple lifestyle behaviors on health risks like obesity and other health outcomes. Therefore it is important to investigate associations between dietary and physical activity behavior, the two most important lifestyle behaviors influencing our energy balance and body composition. The objective of the present study is to describe the relationship between energy, nutrient and food intake and the physical activity level among a large group of European adolescents. Methods The study comprised a total of 2176 adolescents (46.2% male) from ten European cities participating in the HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) study. Dietary intake and physical activity were assessed using validated 24-h dietary recalls and self-reported questionnaires respectively. Analyses of covariance (ANCOVA) were used to compare the energy and nutrient intake and the food consumption between groups of adolescents with different physical activity levels (1st to 3rd tertile). Results In both sexes no differences were found in energy intake between the levels of physical activity. The most active males showed a higher intake of polysaccharides, protein, water and vitamin C and a lower intake of saccharides compared to less active males. Females with the highest physical activity level consumed more polysaccharides compared to their least active peers. Male and female adolescents with the highest physical activity levels, consumed more fruit and milk products and less cheese compared to the least active adolescents. The most active males showed higher intakes of vegetables and meat, fish, eggs, meat substitutes and vegetarian products compared to the least active ones. The least active males reported the highest consumption of grain products and potatoes. Within the female group, significantly lower intakes of bread and cereal products and spreads were found for those reporting to spend most time in moderate to vigorous physical activity. The consumption of foods from the remaining food groups, did not differ between the physical activity levels in both sexes. Conclusion It can be concluded that dietary habits diverge between adolescents with different self-reported physical activity levels. For some food groups a difference in intake could be found, which were reflected in differences in some nutrient intakes. It can also be concluded that physically active adolescents are not always inclined to eat healthier diets than their less active peers.The HELENA study took place with the financial support of the European Community Sixth RTD Framework Programme (Contract FOOD-CT: 2005-007034). This work was also partially supported by the European Union, in the framework of the Public Health Programme (ALPHA project, Ref: 2006120), the Swedish Council for Working Life and Social Research (FAS), the Spanish Ministry of Education (EX-2007-1124, and EX-2008-0641), and the Spanish Ministry of Health, Maternal, Child Health and Development Network (number RD08/0072) (JPRL, LAM)

Google Goes Cancer: Improving Outcome Prediction for Cancer Patients by Network-Based Ranking of Marker Genes

Predicting the clinical outcome of cancer patients based on the expression of marker genes in their tumors has received increasing interest in the past decade. Accurate predictors of outcome and response to therapy could be used to personalize and thereby improve therapy. However, state of the art methods used so far often found marker genes with limited prediction accuracy, limited reproducibility, and unclear biological relevance. To address this problem, we developed a novel computational approach to identify genes prognostic for outcome that couples gene expression measurements from primary tumor samples with a network of known relationships between the genes. Our approach ranks genes according to their prognostic relevance using both expression and network information in a manner similar to Google's PageRank. We applied this method to gene expression profiles which we obtained from 30 patients with pancreatic cancer, and identified seven candidate marker genes prognostic for outcome. Compared to genes found with state of the art methods, such as Pearson correlation of gene expression with survival time, we improve the prediction accuracy by up to 7%. Accuracies were assessed using support vector machine classifiers and Monte Carlo cross-validation. We then validated the prognostic value of our seven candidate markers using immunohistochemistry on an independent set of 412 pancreatic cancer samples. Notably, signatures derived from our candidate markers were independently predictive of outcome and superior to established clinical prognostic factors such as grade, tumor size, and nodal status. As the amount of genomic data of individual tumors grows rapidly, our algorithm meets the need for powerful computational approaches that are key to exploit these data for personalized cancer therapies in clinical practice

National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio : a pooled analysis of 458 population-based studies in Asian and Western countries

Background: Although high-density lipoprotein (HDL) and non-HDL cholesterol have opposite associations with coronary heart disease, multi-country reports of lipid trends only use total cholesterol (TC). Our aim was to compare trends in total, HDL and nonHDL cholesterol and the total-to-HDL cholesterol ratio in Asian and Western countries. Methods: We pooled 458 population-based studies with 82.1 million participants in 23 Asian and Western countries. We estimated changes in mean total, HDL and non-HDL cholesterol and mean total-to-HDL cholesterol ratio by country, sex and age group. Results: Since similar to 1980, mean TC increased in Asian countries. In Japan and South Korea, the TC rise was due to rising HDL cholesterol, which increased by up to 0.17 mmol/L per decade in Japanese women; in China, it was due to rising non-HDL cholesterol. TC declined in Western countries, except in Polish men. The decline was largest in Finland and Norway, at similar to 0.4 mmol/L per decade. The decline in TC in most Western countries was the net effect of an increase in HDL cholesterol and a decline in non-HDL cholesterol, with the HDL cholesterol increase largest in New Zealand and Switzerland. Mean total-to-HDL cholesterol ratio declined in Japan, South Korea and most Western countries, by as much as similar to 0.7 per decade in Swiss men (equivalent to similar to 26% decline in coronary heart disease risk per decade). The ratio increased in China. Conclusions: HDL cholesterol has risen and the total-to-HDL cholesterol ratio has declined in many Western countries, Japan and South Korea, with only a weak correlation with changes in TC or non-HDL cholesterol.Peer reviewe

Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: A pooled analysis of 1018 population-based measurement studies with 88.6 million participants

© The Author(s) 2018. Background: Change in the prevalence of raised blood pressure could be due to both shifts in the entire distribution of blood pressure (representing the combined effects of public health interventions and secular trends) and changes in its high-blood-pressure tail (representing successful clinical interventions to control blood pressure in the hypertensive population). Our aim was to quantify the contributions of these two phenomena to the worldwide trends in the prevalence of raised blood pressure. Methods: We pooled 1018 population-based studies with blood pressure measurements on 88.6 million participants from 1985 to 2016. We first calculated mean systolic blood pressure (SBP), mean diastolic blood pressure (DBP) and prevalence of raised blood pressure by sex and 10-year age group from 20-29 years to 70-79 years in each study, taking into account complex survey design and survey sample weights, where relevant. We used a linear mixed effect model to quantify the association between (probittransformed) prevalence of raised blood pressure and age-group- and sex-specific mean blood pressure. We calculated the contributions of change in mean SBP and DBP, and of change in the prevalence-mean association, to the change in prevalence of raised blood pressure. Results: In 2005-16, at the same level of population mean SBP and DBP, men and women in South Asia and in Central Asia, the Middle East and North Africa would have the highest prevalence of raised blood pressure, and men and women in the highincome Asia Pacific and high-income Western regions would have the lowest. In most region-sex-age groups where the prevalence of raised blood pressure declined, one half or more of the decline was due to the decline in mean blood pressure. Where prevalence of raised blood pressure has increased, the change was entirely driven by increasing mean blood pressure, offset partly by the change in the prevalence-mean association. Conclusions: Change in mean blood pressure is the main driver of the worldwide change in the prevalence of raised blood pressure, but change in the high-blood-pressure tail of the distribution has also contributed to the change in prevalence, especially in older age groups