731 research outputs found
Cardiac Arrest Caused by Torsades de Pointes Tachycardia after Successful Atrial Flutter Radiofrequency Catheter Ablation
- Author
- Publication venue
- Bentham Open
- Publication date
- 01/01/2011
- Field of study
A 66-year-old woman underwent successful radiofrequency catheter ablation for long-lasting, drug refractory fast atrial flutter. Two days later she had a cardiac arrest due to torsades de pointes (TdP) tachycardia attributed to relative sinus bradycardia and QT interval prolongation. After successful resuscitation further episodes of TdP occurred, which were treated with temporary pacing. Because of concomitant systolic dysfunction due to ischemic and valvular heart disease she was finally treated with an implantable defibrillator. In conclusion we strongly advise prolonged monitoring for 2 or more days for patients with structural heart disease following successful catheter ablation for long lasting tachyarrhythmias
Clinical outcome of periodontal regenerative therapy using collagen membrane and deproteinized bovine bone mineral: a 2.5-year follow-up study
- Author
- A Saito
- A Sculean
- A Sculean
- A Stavropoulos
- A Stavropoulos
- Atsushi Saito
- BL Pihlstrom
- C Weigel
- CK Rösing
- Daisuke Irokawa
- G Hajishengallis
- G Heden
- GC Armitage
- H Löe
- Hiroaki Goto
- Hiroki Sugito
- J Silness
- K Fujinami
- Katsuya Noda
- M Camelo
- MA Reynolds
- Masahiko Nikaido
- Masahiro Egawa
- ME Aichelmann-Reidy
- ML Nevins
- P Cortellini
- P Cortellini
- P Cortellini
- P Cortellini
- P Cortellini
- P Nygaard-Østby
- PM Camargo
- RT Kao
- Sachiyo Tomita
- SC Miller
- T Scantlebury
- Takahiro Takeuchi
- Y-K Tu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The fish-hook configuration of the distal ureter indicates bladder outlet obstruction due to benign prostatic hyperplasia
- Author
- AG Wilkinson
- Charalampos Mamoulakis
- CJ Girman
- CV Comiter
- HJ Griffiths
- JL Bosch
- KB Lim
- KE el Din
- Klaus Höfner
- M Oelke
- M Oelke
- M Patel
- Matthias Oelke
- ME Mulligan
- MJ Barry
- N Stavropoulos
- NF Wasserman
- OM Abdel Razzak
- P Abrams
- P Doubilet
- PF Rosier
- R Douenias
- S Costas
- S Madersbacher
- SJ Berry
- SJ Chia
- TC Fenter
- Thomas R. W. Herrmann
- W Schäfer
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2010
- Field of study
Tsx Produces a Long Noncoding RNA and Has General Functions in the Germline, Stem Cells, and Brain
- Author
- A Iacoangeli
- A Lira
- A Nagy
- A Wutz
- AR Bellve
- B Payer
- C Chureau
- C Gross
- D Tian
- Danielle Clift
- DB Cunningham
- DW Cooper
- E Lifschytz
- GE Schafe
- Gregory S. Barsh
- I Jonkers
- J Starmer
- J Zhao
- JC Lucchesi
- Jeannie T. Lee
- JJ Kim
- JR McCarrey
- JT Lee
- JT Lee
- JT Lee
- JY Ahn
- JZ Tsien
- KD Huynh
- L Duret
- MC Simmler
- ME Donohoe
- MF Lyon
- Montserrat C. Anguera
- N Stavropoulos
- R Song
- Raymond J. Kelleher
- RG Phillips
- RJ Kelleher 3rd
- S Pellow
- Satoshi Namekawa
- SH Namekawa
- T Abel
- T Miyamoto
- T Sado
- V Sebastiano
- Weiyuan Ma
- X Cao
- Y Ogawa
- Publication venue
- Public Library of Science
- Publication date
- 01/09/2011
- Field of study
The Tsx gene resides at the X-inactivation center and is thought to encode a protein expressed in testis, but its function has remained mysterious. Given its proximity to noncoding genes that regulate X-inactivation, here we characterize Tsx and determine its function in mice. We find that Tsx is actually noncoding and the long transcript is expressed robustly in meiotic germ cells, embryonic stem cells, and brain. Targeted deletion of Tsx generates viable offspring and X-inactivation is only mildly affected in embryonic stem cells. However, mutant embryonic stem cells are severely growth-retarded, differentiate poorly, and show elevated cell death. Furthermore, male mice have smaller testes resulting from pachytene-specific apoptosis and a maternal-specific effect results in slightly smaller litters. Intriguingly, male mice lacking Tsx are less fearful and have measurably enhanced hippocampal short-term memory. Combined, our study indicates that Tsx performs general functions in multiple cell types and links the noncoding locus to stem and germ cell development, learning, and behavior in mammals
Measurement of the inclusive and dijet cross-sections of b-jets in pp collisions at sqrt(s) = 7 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
- Abdinov O
- Abi B
- Abolins M
- Abramowicz H
- Abreu H
- Acerbi E
- Acharya BS
- Ackers M
- Adams DL
- Addy TN
- Adelman J
- Aderholz M
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Aharrouche M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
- Akdogan T
- Akesson TPA
- Akimoto G
- Akimov AV
- Alam MA
- Alam MS
- Albrand S
- Aleksa M
- Aleksandrov IN
- Aleppo M
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Aliyev M
- Allport PP
- Allwood-Spiers SE
- Almenar CC
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alonso J
- Alviggi MG
- Amako K
- Amaral P
- Amelung C
- Ammosov VV
- Amorim A
- Amoros G
- Amram N
- Anastopoulos C
- Andari N
- Andeen T
- Anders CF
- Anderson KJ
- Andreazza A
- Andrei V
- Andrieux M-L
- Anduaga XS
- Angerami A
- Anghinolfi F
- Anh TV
- Anjos N
- Annovi A
- Antonaki A
- Antonelli M
- Antonelli S
- Antos J
- Anulli F
- Aoun S
- Apolle R
- Arabidze G
- Aracena I
- Arai Y
- Arce ATH
- Archambault JP
- Arfaoui S
- Arguin J-F
- Arik E
- Arik M
- Armbruster AJ
- Arms KE
- Armstrong SR
- Arnaez O
- Arnault C
- Artamonov A
- Artoni G
- Arutinov D
- Asai S
- Asfandiyarov R
- Ask S
- Asman B
- Asquith L
- Assamagan K
- Astbury A
- Astvatsatourov A
- Atoian G
- Aubert B
- Auerbach B
- Auge E
- Augsten K
- Aurousseau M
- Austin N
- Avramidou R
- Axen D
- Ay C
- Azuelos G
- Azuma Y
- Baak MA
- Baccaglioni G
- Bacci C
- Bach AM
- Bachacou H
- Bachas K
- Bachy G
- Backes M
- Badescu E
- Bagnaia P
- Bahinipati S
- Bai Y
- Bailey DC
- Bain T
- Baines JT
- Baker OK
- Baker S
- Banas E
- Banerjee P
- Banerjee S
- Banfi D
- Bangert A
- Bansal V
- Bansil HS
- Barak L
- Baranov SP
- Barashkou A
- Barber T
- Barberio EL
- Barberis D
- Barbero M
- Bardin DY
- Barillari T
- Barisonzi M
- Barklow T
- Barlow N
- Barnett BM
- Barnett RM
- Baroncelli A
- Barr AJ
- Barreiro F
- Barrera CO
- Barrillon P
- Bartoldus R
- Barton AE
- Bartsch D
- Bates RL
- Batkova L
- Batley JR
- Battaglia A
- Battistin M
- Battistoni G
- Bauer F
- Bawa HS
- Beare B
- Beau T
- Beauchemin PH
- Beccherle R
- Bechtle P
- Beck HP
- Beckingham M
- Becks KH
- Beddall A
- Beddall AJ
- Bednyakov VA
- Bee C
- Begel M
- Behera PK
- Beimforde M
- Belanger-Champagne C
- Belenguer MJ
- Belhorma B
- Bell PJ
- Bell WH
- Bella G
- Bella LA
- Bellagamba L
- Bellina F
- Bellomo G
- Bellomo M
- Belloni A
- Belotskiy K
- Beltramello O
- Ben Ami S
- Benary O
- Benchekroun D
- Benchouk C
- Bendel M
- Benedict BH
- Benekos N
- Benhammou Y
- Benjamin DP
- Benoit M
- Bensinger JR
- Benslama K
- Bentvelsen S
- Berge D
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- Berghaus F
- Berglund E
- Beringer J
- Bernardet K
- Bernat P
- Bernhard R
- Bernius C
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- Bertin A
- Bertinelli F
- Bertolucci F
- Besana MI
- Besson N
- Bethke S
- Bhimji W
- Bianchi RM
- Bianco M
- Biebel O
- Biesiada J
- Biglietti M
- Bilokon H
- Bindi M
- Bingul A
- Bini C
- Biscarat C
- Bischof R
- Bitenc U
- Black KM
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- Blanchard J-B
- Blanchot G
- Blocker C
- Blocki J
- Blondel A
- Blum W
- Blumenschein U
- Boaretto C
- Bobbink GJ
- Bobrovnikov VB
- Bocci A
- Bock R
- Boddy CR
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- Boek J
- Boelaert N
- Boeser S
- Bogaerts JA
- Bogdanchikov A
- Bogouch A
- Bohm C
- Boisvert V
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- Boldea V
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- Boonekamp M
- Boorman G
- Booth CN
- Booth JRA
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- Bordoni S
- Borer C
- Borisov A
- Borissov G
- Borjanovic I
- Borroni S
- Bos K
- Boscherini D
- Bosman M
- Boterenbrood H
- Botterill D
- Bouchami J
- Boudreau J
- Bouhova-Thacker EV
- Boulahouache C
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- Boveia A
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- Boyko IR
- Bozhko NI
- Bozovic-Jelisavcic I
- Braccini S
- Bracinik J
- Braem A
- Brambilla E
- Branchini P
- Branco MDO
- Brandenburg GW
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- Bratzler U
- Brau B
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- Butterworth JM
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- Caccia M
- Caforio D
- Cakir IT
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- Caprini I
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- Caprio M
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- Casadei D
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- Castanheira MTD
- Castillo Gimenez V
- Castillo LRF
- Castro NF
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- Cataneo F
- Catinaccio A
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- Cattai A
- Cattani G
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- Cavalcanti TP
- Cavallari A
- Cavalleri P
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- Cavasinni V
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- Cetin SA
- Cevenini F
- Chafaq A
- Chakraborty D
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- Chapleau B
- Chapman JD
- Chapman JW
- Chareyre E
- Charlton DG
- Chavda V
- Cheatham S
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- Chekulaev SV
- Chelkov GA
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- Cheong ALF
- Cheplakov A
- Chepurnov VF
- Cherkaoui El Moursli R
- Chernyatin V
- Cheu E
- Cheung SL
- Chevalier L
- Chevallier F
- Chiefari G
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- Childers JT
- Chilingarov A
- Chiodini G
- Chizhov MV
- Choudalakis G
- Chouridou S
- Christidi IA
- Christov A
- Chromek-Burckhart D
- Chu ML
- Chudoba J
- Ciapetti G
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- Comune G
- Conde Muino P
- Coniavitis E
- Conidi MC
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- Correia AMH
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- Crupi R
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- Curatolo M
- Curtis CJ
- Cwetanski P
- Czirr H
- Czyczula Z
- D'Auria S
- D'Onofrio M
- D'Orazio A
- da Costa JBG
- Da Rocha Gesualdi Mello A
- Da Silva PVM
- Da Via C
- Dabrowski W
- Dahlhoff A
- Dai T
- Dallapiccola C
- Dallison SJ
- Dam M
- Damazio DO
- Dameri M
- Damiani DS
- Danielsson HO
- Dankers R
- Dannheim D
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- Daum C
- Dauvergne JP
- Davey W
- Davidek T
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- Davies M
- Davison AR
- Dawe E
- Dawson I
- Dawson JW
- Daya RK
- de Asmundis R
- De Castro S
- De Cecco S
- de Graat J
- De Groot N
- de Jong P
- De La Cruz-Burelo E
- De La Taille C
- de Lima JGR
- De Lotto B
- De Mora L
- De Nooij L
- De Pedis D
- De Regie JBDV
- de Renstrom PAB
- de Saintignon P
- De Salvo A
- De Sanctis U
- De Santo A
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- Dedes G
- Dedovich DV
- Degenhardt J
- Dehchar M
- Deile M
- Del Papa C
- Del Peso J
- Del Prete T
- Dell'Acqua A
- Dell'Asta L
- Della Pietra M
- della Porta GZ
- della Volpe D
- Delmastro M
- Delpierre P
- Delruelle N
- Delsart PA
- Deluca C
- Demers S
- Demichev M
- Demirkoz B
- Deng J
- Denisov SP
- Dennis C
- Derendarz D
- Derkaoui JE
- Derue F
- Dervan P
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- Devetak E
- Deviveiros PO
- Dewhurst A
- DeWilde B
- Dhaliwal S
- Dhullipudi R
- Di Ciaccio A
- Di Ciaccio L
- Di Girolamo A
- Di Girolamo B
- Di Luise S
- Di Mattia A
- Di Nardo R
- Di Simone A
- Di Sipio R
- Diaz MA
- Diblen F
- Diehl EB
- Dietl H
- Dietrich J
- Dietzsch TA
- Diglio S
- Dingfelder J
- Dionisi C
- Dita P
- Dita S
- Dittus F
- Djama F
- Djilkibaev R
- Djobava T
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- Do Valle Wemans A
- Doan TKO
- Dobbs M
- Dobinson R
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- Dobson E
- Dobson M
- Dodd J
- Dogan OB
- Doglioni C
- Doherty T
- Dohmae T
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- Dolenc I
- Dolezal Z
- Dolgoshein BA
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- Donini J
- Donszelmann TC
- Dopke J
- Doria A
- Dos Anjos A
- Dos Santos DR
- Dosil M
- Dotti A
- Dova MT
- Dowell JD
- Doxiadis AD
- Doyle AT
- Drasal Z
- Drees J
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- Drevermann H
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- Drohan JG
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- Dudarev A
- Dudziak F
- Duehrssen M
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- Edmonds K
- Edwards CA
- Efthymiopoulos I
- Ehrenfeld W
- Ehrich T
- Eifert T
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- Eisenhandler E
- Ekelof T
- El Kacimi M
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- Elmsheuser J
- Elsing M
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- Emeliyanov D
- Engelmann R
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- Espinal Curull X
- Esposito B
- Etienne F
- Etienvre AI
- Etzion E
- Evangelakou D
- Evans H
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- Fabre C
- Facius K
- Fajardo LSG
- Fakhrutdinov RM
- Falciano S
- Falou AC
- Fang Y
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- Farbin A
- Farilla A
- Farley J
- Farooque T
- Farrington SM
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- Fasching D
- Fassnacht P
- Fassouliotis D
- Fatholahzadeh B
- Favareto A
- Fayard L
- Fazio S
- Febbraro R
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- Fedin OL
- Fedorko I
- Fedorko W
- Fehling-Kaschek M
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- Felzmann CU
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- Filipcic A
- Filippas A
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- Fiolhais MCN
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- Fleck I
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- Foster JM
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- Gapienko VA
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- Garitaonandia H
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- Garrido MDMC
- Garvey J
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- Gaudio G
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- Gavrilenko IL
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- Gayde J-C
- Gazis EN
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- Gemmell A
- Genest MH
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- Gershon A
- Geweniger C
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- Giacobbe B
- Giagu S
- Giakoumopoulou V
- Giangiobbe V
- Gianotti F
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- Gibson A
- Gibson SM
- Gieraltowski GF
- Gilbert LM
- Gilchriese M
- Gildemeister O
- Gilewsky V
- Gillberg D
- Gillman AR
- Gingrich DM
- Ginzburg J
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- Giordano R
- Giorgi FM
- Giovannini P
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- Giugni D
- Giusti P
- Gjelsten BK
- Gladilin LK
- Glasman C
- Glatzer J
- Glazov A
- Glitza KW
- Glonti GL
- Godfrey J
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- Goeringer C
- Goessling C
- Goettfert T
- Goia JAM
- Goldfarb S
- Goldin D
- Golling T
- Gollub NP
- Golovnia SN
- Gomes A
- Gomez MMD
- Goncalo R
- Gonella L
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- Gonidec A
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- Gonzalez Silva ML
- Gonzalez S
- Gonzalez-Sevilla S
- Goodson JJ
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- Gordon HA
- Gorelov I
- Gorfine G
- Gorini B
- Gorini E
- Gorisek A
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- Gorokhov SA
- Gorski BT
- Goryachev VN
- Gosdzik B
- Gosselink M
- Gostkin MI
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- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 31/12/2010
- Field of study
The inclusive and dijet production cross-sections have been measured for jets
containing b-hadrons (b-jets) in proton-proton collisions at a centre-of-mass
energy of sqrt(s) = 7 TeV, using the ATLAS detector at the LHC. The
measurements use data corresponding to an integrated luminosity of 34 pb^-1.
The b-jets are identified using either a lifetime-based method, where secondary
decay vertices of b-hadrons in jets are reconstructed using information from
the tracking detectors, or a muon-based method where the presence of a muon is
used to identify semileptonic decays of b-hadrons inside jets. The inclusive
b-jet cross-section is measured as a function of transverse momentum in the
range 20 < pT < 400 GeV and rapidity in the range |y| < 2.1. The bbbar-dijet
cross-section is measured as a function of the dijet invariant mass in the
range 110 < m_jj < 760 GeV, the azimuthal angle difference between the two jets
and the angular variable chi in two dijet mass regions. The results are
compared with next-to-leading-order QCD predictions. Good agreement is observed
between the measured cross-sections and the predictions obtained using POWHEG +
Pythia. MC@NLO + Herwig shows good agreement with the measured bbbar-dijet
cross-section. However, it does not reproduce the measured inclusive
cross-section well, particularly for central b-jets with large transverse
momenta.Comment: 10 pages plus author list (21 pages total), 8 figures, 1 table, final
version published in European Physical Journal
Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abud AA
- Abulaiti Y
- Acharya BS
- Achkar B
- Adachi S
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adersberger M
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmadov F
- Ahmed WS
- Ai X
- Aielli G
- Akatsuka S
- Akesson TPA
- Akilli E
- Akimov A
- Al Khoury K
- Alberghi GL
- Albert J
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi A
- Alfonsi F
- Alhroob M
- Ali B
- Aliev M
- Alimonti G
- Allaire C
- Allbrooke BMM
- Allen BW
- Allport PP
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- Alviggi MG
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- Booth CD
- Borecka-Bielska HM
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- Zahreddine J
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- Zakharchuk N
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- Zanzi D
- Zaripovas DR
- Zeissner S
- Zeitnitz C
- Zemaityte G
- Zeng JC
- Zenin O
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- Zerwas D
- Zgubic M
- Zhang B
- Zhang DF
- Zhang G
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- Zhang Y
- Zhang Z
- Zhao P
- Zhao Z
- Zhemchugov A
- Zheng Z
- Zhong D
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- Zhulanov V
- Zieminska D
- Zimine N
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zu Theenhausen HM
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente
Jet energy measurement with the ATLAS detector in proton-proton collisions at root s=7 TeV
- Author
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- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/03/2013
- Field of study
The jet energy scale and its systematic uncertainty are determined for jets measured with the ATLAS detector at the LHC in proton-proton collision data at a centre-of-mass energy of √s = 7TeV corresponding to an integrated luminosity of 38 pb-1. Jets are reconstructed with the anti-kt algorithm with distance parameters R=0. 4 or R=0. 6. Jet energy and angle corrections are determined from Monte Carlo simulations to calibrate jets with transverse momenta pT≥20 GeV and pseudorapidities {pipe}η{pipe}<4. 5. The jet energy systematic uncertainty is estimated using the single isolated hadron response measured in situ and in test-beams, exploiting the transverse momentum balance between central and forward jets in events with dijet topologies and studying systematic variations in Monte Carlo simulations. The jet energy uncertainty is less than 2. 5 % in the central calorimeter region ({pipe}η{pipe}<0. 8) for jets with 60≤pT<800 GeV, and is maximally 14 % for pT<30 GeV in the most forward region 3. 2≤{pipe}η{pipe}<4. 5. The jet energy is validated for jet transverse momenta up to 1 TeV to the level of a few percent using several in situ techniques by comparing a well-known reference such as the recoiling photon pT, the sum of the transverse momenta of tracks associated to the jet, or a system of low-pT jets recoiling against a high-pT jet. More sophisticated jet calibration schemes are presented based on calorimeter cell energy density weighting or hadronic properties of jets, aiming for an improved jet energy resolution and a reduced flavour dependence of the jet response. The systematic uncertainty of the jet energy determined from a combination of in situ techniques is consistent with the one derived from single hadron response measurements over a wide kinematic range. The nominal corrections and uncertainties are derived for isolated jets in an inclusive sample of high-pT jets. Special cases such as event topologies with close-by jets, or selections of samples with an enhanced content of jets originating from light quarks, heavy quarks or gluons are also discussed and the corresponding uncertainties are determined. © 2013 CERN for the benefit of the ATLAS collaboration
Performance of the CMS Cathode Strip Chambers with Cosmic Rays
- Author
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- Zeinali M
- Zeise M
- Zelepoukine S
- Zeuner WD
- Zeyrek M
- Zhang J
- Zhang L
- Zhang Y
- Zhang Z
- Zheng Y
- Zhiltsov V
- Zhokin A
- Zhu B
- Zhu K
- Zhu RY
- Zhukov V
- Zhukova V
- Ziebarth EB
- Zielinski M
- Zilizi G
- Zinonos Z
- Zito G
- Zoeller MH
- Zotto P
- Zub S
- Zumerle G
- Zuranski A
- Zuyeuski R
- Zych P
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2009
- Field of study
The Cathode Strip Chambers (CSCs) constitute the primary muon tracking device
in the CMS endcaps. Their performance has been evaluated using data taken
during a cosmic ray run in fall 2008. Measured noise levels are low, with the
number of noisy channels well below 1%. Coordinate resolution was measured for
all types of chambers, and fall in the range 47 microns to 243 microns. The
efficiencies for local charged track triggers, for hit and for segments
reconstruction were measured, and are above 99%. The timing resolution per
layer is approximately 5 ns
Function of the Active Site Lysine Autoacetylation in Tip60 Catalysis
- Author
- A Kimura
- A Wolffe
- AJ Morrison
- AJ Morrison
- B Karanam
- B Sun
- BN Albaugh
- C Charvet
- C Choudhary
- C Kramps
- C Lin
- Chao Yang
- CJ Ceol
- CL Peterson
- DE Sterner
- G Blander
- G Legube
- I Nordentoft
- J Kadlec
- J Kamine
- J Wang
- Jiang Wu
- K Halkidou
- KK Lee
- KT Smith
- L Wang
- M Creaven
- M Shogren-Knaak
- M Squatrito
- MC Anguera
- ME Brady
- MP Bhadra
- MW Vetting
- N Avvakumov
- N Blanco-Garcia
- P Stavropoulos
- PR Thompson
- Q Wang
- R Dechend
- R Marmorstein
- R Marmorstein
- RT Utley
- S Gregoire
- S McGraw
- S Spange
- S Zhao
- SH Baek
- SM Sykes
- SR Frank
- Sue Cotterill
- SY Roth
- T Ikura
- T Ikura
- T Kusch
- V Sapountzi
- V Sapountzi
- W An
- XJ Yang
- Y Kato
- Y Sun
- Y Sun
- Y Tang
- Y Tang
- Y Yan
- Y. George Zheng
- YG Zheng
- YY Lin
- Publication venue
- Public Library of Science
- Publication date
- 28/03/2012
- Field of study
The 60-kDa HIV-Tat interactive protein (Tip60) is a key member of the MYST family of histone acetyltransferases (HATs) that plays critical roles in multiple cellular processes. We report here that Tip60 undergoes autoacetylation at several lysine residues, including a key lysine residue (i.e. Lys-327) in the active site of the MYST domain. The mutation of K327 to arginine led to loss of both the autoacetylation activity and the cognate HAT activity. Interestingly, deacetylated Tip60 still kept a substantial degree of HAT activity. We also investigated the effect of cysteine 369 and glutamate 403 in Tip60 autoacetylation in order to understand the molecular pathway of the autoacetylation at K327. Together, we conclude that the acetylation of K327 which is located in the active site of Tip60 regulates but is not obligatory for the catalytic activity of Tip60. Since acetylation at this key residue appears to be evolutionarily conserved amongst all MYST proteins, our findings provide an interesting insight into the regulatory mechanism of MYST activities
Differentially methylated CpG island within human XIST mediates alternative P2 transcription and YY1 binding
- Author
- A Kanhere
- A Paliwal
- A Wutz
- AH Horakova
- Allison M Cotton
- AM Cotton
- Andrew G Chapman
- Angela D Kelsey
- AV Tinker
- BD Hendrich
- BD Hendrich
- BR Migeon
- BR Migeon
- C Beard
- C Chureau
- C Chureau
- C Dupont
- Carolyn J Brown
- CJ Brown
- CJ Brown
- CM Clemson
- CM Clemson
- CM Johnston
- D Tian
- E Hacisuleyman
- EP Consortium
- GD Penny
- HF Willard
- I Jonkers
- I Okamoto
- J Ernst
- J Grant
- J Kim
- J Zhao
- JC Chow
- JD Kim
- JT Lee
- JT Lee
- KR Rosenbloom
- LL Hall
- M Weber
- ME Donohoe
- MF Lyon
- N Brockdorff
- N Stavropoulos
- NC Sheffield
- NJ Caron
- R Tam
- S Luikenhuis
- S Rastan
- S Rastan
- S Sun
- SA Sheardown
- SC Chang
- SC Moseley
- SS Silva
- T Dvash
- Y Jeon
- Y Marahrens
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
- …