121 research outputs found
Primate modularity and evolution: first anatomical network analysis of primate head and neck musculoskeletal system
- Author
- A Goswami
- A Porto
- A Porto
- AM Burrows
- B Esteve-Altava
- B Esteve-Altava
- B Esteve-Altava
- B Esteve-Altava
- B Hallgrímsson
- B Hallgrímsson
- B Hallgrímsson
- BM Waller
- C Rolian
- CF Ross
- D Rasskin-Gutman
- DE Lieberman
- E Bullmore
- G Marroig
- G Marroig
- GB Müller
- GP Wagner
- GP Wagner
- J Ahn
- KL Lewton
- KL Schmidt
- L Scheider
- L Scheider
- LA Parr
- LR Monteiro
- M Bastir
- ML Moss
- ML Zelditch
- NM Young
- NM Young
- P Mitteroecker
- R Cornette
- R Diogo
- R Diogo
- R Laffont
- RR Ackermann
- RR Ackermann
- SE Santana
- SE Santana
- SR Jackson
- T Saucède
- WR Atchley
- X Li
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/02/2018
- Field of study
Network theory is increasingly being used to study morphological modularity and integration. Anatomical network analysis (AnNA) is a framework for quantitatively characterizing the topological organization of anatomical structures and providing an operational way to compare structural integration and modularity. Here we apply AnNA for the first time to study the macroevolution of the musculoskeletal system of the head and neck in primates and their closest living relatives, paying special attention to the evolution of structures associated with facial and vocal communication. We show that well-defined left and right facial modules are plesiomorphic for primates, while anthropoids consistently have asymmetrical facial modules that include structures of both sides, a change likely related to the ability to display more complex, asymmetrical facial expressions. However, no clear trends in network organization were found regarding the evolution of structures related to speech. Remarkably, the increase in the number of head and neck muscles – and thus of musculoskeletal structures – in human evolution led to a decrease in network density and complexity in humans
Prevalência de idosos restritos ao domicílio em região metropolitana de Belo Horizonte (Minas Gerais, Brasil)
- Author
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
AmbuFlex: tele-patient-reported outcomes (telePRO) as the basis for follow-up in chronic and malignant diseases
- Author
- Anne Jessen
- Annette de Thurah
- AV Bennett
- B Bruce
- CF Snyder
- CF Snyder
- CF Snyder
- DC Ayers
- DL Patrick
- E Basch
- E Broadbent
- EF Juniper
- G Velikova
- HH Meyhoff
- J Drennan
- JB Bjorner
- JM Valderas
- L Haverman
- L Haverman
- L Warrington
- Liv Dorflinger
- Liv Marit Valen Schougaard
- Louise Pape Larsen
- LR Olsen
- M Herdman
- M Zuidgeest
- MA Johansen
- MA Johansen
- MB Boyce
- MJ Santana
- MJ Santana
- MS Donaldson
- MW Johns
- MW Johns
- NH Hjollund
- Niels Henrik Hjollund
- P Fayers
- Per Sidenius
- PM Fayers
- R Heun
- RC Rosen
- RE Jensen
- RE Jensen
- RP Snaith
- S Hewlett
- S Marshall
- SE Petersen
- SM Kongsved
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
CHYLOTHORAX IN PARACOCCIDIOIDOMYCOSIS
- Author
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- 01/01/2016
- Field of study
In Vitro and In Vivo Activity of a Palladacycle Complex on Leishmania (Leishmania) amazonensis
- Author
- A Dutta
- A Ponte-Sucre
- A Somanna
- ACF Caires
- AG Tempone
- AK Tanaka
- AL Matsuo
- Antonio C. F. Caires
- AO dos Santos
- C Bincoletto
- C Bogdan
- Carolina de Siqueira Paladi
- CD Robertson
- CL Barbiéri
- Clara Lúcia Barbiéri
- CM Barbosa
- CM Mesa-Valle
- CM Mesa-Valle
- CR Oliveira
- DC Miguel
- DP Santana
- DS Zamboni
- EF da Silva
- EG Rodrigues
- G Bart
- GF de Souza
- H Goto
- HC Lima
- Isabella Aparecida Salerno Pimentel
- JC Mottram
- JC Mottram
- JD Higgins
- LR Guimarães
- M Barral-Netto
- M Navarro
- MA Fuertes
- ME Wilson
- PM Selzer
- PV Desai
- PV Desai
- R Etges
- R Lainson
- R Sen
- RO Pinheiro
- Rodrigo L. O. R. Cunha
- Simone Katz
- SL Croft
- SP Fricker
- SS Cotrin
- T Polonio
- Timothy G. Geary
- TS Tiuman
- V Rodrigues
- Wagner Alves de Souza Judice
- Y Maekawa
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2012
- Field of study
Leishmaniasis is an important public health problem with an estimated annual incidence of 1.5 million of new human cases of cutaneous leishmaniasis and 500,000 of visceral leishmaniasis. Treatment of the diseases is limited by toxicity and parasite resistance to the drugs currently in use, validating the need to develop new leishmanicidal compounds. We evaluated the killing by the palladacycle complex DPPE 1.2 of Leishmania (Leishmania) amazonensis, an agent of human cutaneous leishmaniasis in the Amazon region, Brazil. DPPE 1.2 destroyed promastigotes of L. (L.) amazonensis in vitro at nanomolar concentrations, whereas intracellular amastigotes were killed at drug concentrations 10-fold less toxic than those displayed to macrophages. L. (L.) amazonensis-infected BALB/c mice treated by intralesional injection of DPPE 1.2 exhibited a significant decrease of foot lesion sizes and a 97% reduction of parasite burdens when compared to untreated controls. Additional experiments indicated the inhibition of the cathepsin B activity of L. (L.) amazonensis amastigotes by DPPE 1.2. Further studies are needed to explore the potential of DPPE 1.2 as an additional option for the chemotherapy of leishmaniasis
A política antitabagismo e a variação dos gastos das famílias brasileiras com cigarro: resultados das Pesquisas de Orçamentos Familiares, 2002/2003 e 2008/2009
- Author
- Ana Cláudia Sant'Anna
- Barreto SM
- Cavalcante T
- Colman GJ
- Desapriya E
- Everett SA
- Ezzati M
- Farrelly MC
- Garcia LP
- Guindon GE
- Iglesias R
- Jha P
- Kmietowicz Z
- Kroeff LR
- Leila Posenato Garcia
- Levy D
- Lightwood J
- Luís Carlos Garcia de Magalhães
- Lúcia Rolim Santana de Freitas
- Malta DC
- Malta DC
- Menezes T
- Monteiro C
- Morishima T
- Ng M
- Pinto M
- Ross H
- Sanitária Agência Nacional de Vigilância
- Siahpush M
- Silva GA
- Tauras JA
- Teixeira LA
- Vijayaraghavan M
- Vázquez-Segovia LA
- Wakefield MA
- White CM
- Wilson N
- Wünsch Filho V
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Sciatic nerve regeneration in rats by a nerve conduit engineering with a membrane derived from natural latex
- Author
- Alves de Sousa LC
- Ayhan S
- Balabanian CA
- Battiston B
- Benedicto Oscar Colli
- Bian YZ
- Carlos Henrique Rocha Catalão
- Chang JY
- Chen MH
- Chiono V
- Dijkstra JR
- Frade MA
- Gong Y
- Haastert-Talini K
- Hu X
- Jiang X
- Joaquim Coutinho-Netto
- João-José Lachat
- Kleber Tadeu Carraro
- Luiza da Silva Lopes
- Madduri S
- Magnaghi V
- Marcos Roberto Pedron Oltramari
- Marcos Vinícius Muniz Ganga
- Ricardo Torres Santana
- Robinson LR
- Shin RH
- Wilson Marques Junior
- Zhao Z
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
- Abdelmonem SA
- Abdo WF
- Abellan AN
- Abellán AN
- Abellán AN
- Abellán AN
- Abrams ST
- Ackerley C
- Acuña M
- Adda M
- Adhikari NK
- Adriano G
- Adrie C
- Affatato R
- Affatato R
- Afonso-Rivero D
- Agarossi A
- Agarwal LK
- Ageeva T
- Agrawal R
- Aguayo-DeHoyos E
- Aguilar AL
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguirregabyria M
- Ahmadnia E
- Ahn C
- Ahn JY
- Ahn JY
- Ahn MY
- Ahn MY
- Aitken LM
- Akalaev R
- Akbarzadeh A
- Akcan-Arikan A
- Akhlagh SH
- Akhtar N
- AKI Research Group
- Akiduki N
- Akin S
- Akizuki N
- Akkoc T
- Ala-Kokko T
- Alanio A
- Albaiceta GM
- Albaladejo P
- Alberto F
- Albuisson E
- Alcala MA
- Alcázar L
- Aldabo-Pallas T
- Aldana NN
- Aldecoa C
- Alegría L
- Alejandro R
- Alejo GC
- Alejos RM
- Alexandrova E
- Algarte R
- Algarte R
- Algieri I
- Algora-Weber A
- Alhamdi Y
- Aliaga FA
- Aliberti S
- Alkan A
- Almudena PM
- Almudevar PM
- Almudevar PM
- Almudévar PM
- Altıntas ND
- Alvarez J
- Alves SC
- Alzola LM
- Amargianitakis V
- Amaro R
- Amato MB
- Ambler M
- Amerongen MP
- Amininejad T
- Amor LL
- Amorim V
- Anand RK
- Andersen LW
- Andersson S
- Andoh K
- Andrade AH
- Andrade AH
- Andrade AH
- Andrade G
- Andreis DT
- Andreis DT
- Annane D
- Antonelli M
- Antoniadou A
- Antonio C
- Antonucci E
- Antón DG
- Anzueto A
- Appiani F
- Aquevedo A
- Aragon C
- Araujo NJ
- Araujo VF
- ARIAM registry of adult cardiac surgery
- ARIAM-ANDALUCIA
- Arias CC
- Arias N
- Arias-Verdu MD
- Arias-Verdu MD
- Arias-Verdu MD
- Armaganidis A
- Arora MK
- Arora N
- Arrigo M
- Arslantas MK
- Artiguenave M
- Aslanian P
- Aspide R
- Asyralyyeva G
- Ataman S
- Ataman S
- Atchade E
- Atchade E
- Atchasiri S
- Athapattu P
- Atkins G
- Aublanc M
- Aublanc M
- Augustin P
- Augustin P
- Auquier P
- Avilés-Jurado FX
- Avramidis V
- Ayala LY
- Aydin M
- Azevedo JC
- Azevedo JR
- Aznar GP
- Babalis D
- Babini G
- Bachli EB
- Bader A
- Bader A
- Baena J
- Baidya DK
- Baikova VN
- Bakker J
- Balcázar LC
- Balcázar LC
- Baldassarri R
- Baldwin CE
- Balik M
- Ball I
- Ballin A
- Balsera B
- Banderas-Bravo ME
- Banderas-Bravo ME
- Bandert A
- Bangstad IL
- Baptista N
- Baquero JD
- Barbadillo S
- Barberet G
- Barberet G
- Barberet G
- Barbier J
- Barcenilla F
- Barea-Mendoza JA
- Barinas OD
- Baron AV
- Barrachina LG
- Barral M
- Basile-Filho A
- Bassi GL
- Bates D
- Battistini M
- Bauer M
- Bauer PR
- Baumstarck K
- Baumstarck K
- Bawin M
- Bazan N
- Bañeras J
- Beane A
- Beduneau G
- Beduneau G
- Beduneau G
- Beeharry SD
- Beerepoot M
- Begzjav T
- Beishuizen A
- Bell C
- Belletti A
- Bellissimo-Rodrigues F
- Belloli A
- Bellomo R
- Bellver BQ
- Belmonte R
- Ben-Hamouda N
- Bendel S
- Bendel S
- Benyamina M
- Beretta S
- Berg R
- Bergantino B
- Berghmans J
- Bernal FF
- Berric A
- Berrutti D
- Berthelsen RE
- Bertini P
- Bertini P
- Berto MB
- Besevli SG
- Bestle MH
- Bettex D
- Bettex DA
- Beunders R
- Bhasin D
- Bhattal MK
- Bhide S
- Bianchi I
- Bianchi I
- Bianzina S
- Bianzina S
- Bianzina S
- Bishop J
- Bissenova N
- Bisso MC
- Blans MJ
- Blobner M
- Bloomer MJ
- Blot K
- Blot S
- Blot S
- Boa F
- Bobi Q
- Bodingbauer M
- Bodí M
- Boer C
- Bogossian E
- Bonet S
- Bonn M
- Bonnet M
- Borges FK
- Bouadma L
- Boucekine M
- Bougouin W
- Bourenne J
- Boyd JG
- Boyd JG
- Bozbay S
- Bozza F
- Bradac O
- Brandon RA
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- Braschi A
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- Braschi A
- Brasseur A
- Brasseur A
- Brasseur A
- Braune S
- Brazzi L
- Breitkreutz R
- Brianti R
- Brioni M
- Brochard L
- Brochard L
- Brochard L
- Brock N
- Brody DL
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- Brousseau C
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- Brugger SC
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- Bruno F
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- Brusasco C
- Brusasco C
- Brusasco C
- Bruyere O
- Bucknall T
- Buddi S
- Buise M
- Buitinck SH
- Buranavanich P
- Bureau C
- Burle JF
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- Butrov AV
- Caballero CH
- Caballero J
- Cabello JT
- Cabello JT
- Cabrera AR
- Cabrera JL
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- Cabrini L
- Cairus C
- Cakin O
- Caliskan K
- Calpe P
- Calvo CP
- Calvo SA
- Camargo M
- Cambronero JA
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- Campelo FA
- Campelo FA
- Campos LM
- Cannesson M
- CAPCRI Study
- Capellier G
- Carbonara M
- Cardellino S
- Cardenas CL
- Cariou A
- Cariou A
- Carlesso E
- Carmona AF
- Carmona SA
- Carmona SA
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- Carpio D
- Carratalá A
- Carreira MM
- Carrero-Gómez F
- Carreño ER
- Carreño R
- Carvalho JP
- Carvalho KV
- Casals XN
- Casals XN
- Cassina T
- Castañeda DP
- Castellana D
- Castellanos A
- Castellanos A
- Castillo-Lorente E
- Castillo-Lorente E
- Catalan M
- Catalán RM
- Catena E
- Catena E
- Cauwenberghs H
- Cavalcanti D
- Cavalheiro AM
- Cavalier E
- Cavicchi FZ
- Cavicchi FZ
- Cengiz M
- Ceriani R
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- Cerović O
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- Champigneulle B
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- Chao AS
- Chao HC
- Chaouat M
- Charitidou E
- Charpentier C
- Charpentier J
- Charron C
- Chatelon J
- Chaudhari HK
- Chaussard M
- Chavanon O
- Chaves S
- Chelly J
- Chemam S
- Chen CM
- Chen CM
- Chen CW
- Chen CW
- Chen GQ
- Chen L
- Chen YS
- Chen YS
- Chen YS
- Cheng CC
- Cheng CC
- Cheng CC
- Cheng CC
- Cheng KC
- Cheng YJ
- Chernyshuk S
- Chevret S
- Chhor V
- Chiang CC
- Chiang CH
- Chiang CH
- Chiang CH
- Chiappa C
- Chiou KR
- Chiou KR
- Chiou KR
- Chiu LC
- Chiumello D
- Chiurazzi C
- Chiurazzi C
- Cho Y
- Cho YJ
- Cho YJ
- Choi JY
- Choi JY
- Choi KS
- Choi S
- Choi YJ
- Choi YY
- Chok L
- Cholkraisuwat J
- Cholley B
- Chondropoulos S
- Chou W
- Chouris I
- Chouvarda I
- Christopher KB
- Chrétien JM
- Chrétien JM
- Chrétien JM
- Chumaev A
- Chung CR
- Churchill K
- Chytas A
- Cinel I
- Cinnella G
- Citerio G
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- Colaprico A
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- Combes A
- Concha P
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- Contreras KM
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- Cordeiro CP
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- Cordón J
- Corona A
- Corona A
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- Corte FD
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- Corzo L
- Coss-Bu JA
- Coss-Bu JA
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- Costa RC
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- Costanzo E
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- Cotton H
- Cotton H
- Courant P
- Cowan R
- Creagh-Brown B
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- Creteur J
- Creteur J
- Creteur J
- Creteur J
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- Creteur J
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- Cuellar AI
- Cui N
- Cunha MM
- Curiel-Balsera E
- Curiel-Balsera E
- Curinga M
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- Cuthbertson BH
- Cutuli SL
- Câmara M
- D'Arsigny C
- da Silva SL
- da Silva VZ
- Daga-Ruiz D
- Dalhuisen A
- Dalorzo M
- Damas P
- Dambrosio M
- Damås JK
- Das Neves A
- David H
- Davis C
- Davis P
- Day A
- de Abreu MG
- De Backer A
- De Brito-Ashurst I
- De Cassai A
- De Freitas FF
- De Gasperi A
- de Hoyos EA
- De la Calle-Pedrosa N
- de la Fuente MV
- De La Fuente-Martos C
- De La Fuente-Martos C
- De La Rica AS
- De la Torre MA
- De Maglie M
- De Maglie M
- de Molina FJ
- De Morton N
- de Oca Sandoval MA
- De Pascale G
- De Rosa S
- De Sanctis F
- De Silva AP
- De Sousa I
- de Vera AP
- de Wilde W
- De Zani D
- Deblier I
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- Del Arco A
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- Del Olmo R
- Del Rosario CG
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- Der Kinderen EP
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- Di Gravio V
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- Di Mussi R
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- Dilek M
- Dilly MP
- Dima E
- Dimitroulakis K
- Dimitrov BD
- Dimitrov BD
- Dimopoulou IK
- Dinh A
- Divatia JV
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- Dougall PC
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- Durovray JD
- Durrant J
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- Díaz PV
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- E YY
- Ebeling G
- Echeverri JE
- Echeverría JG
- Ediboglu O
- Ediboglu O
- Egea-Guerero JJ
- Egginton JS
- Egi M
- El Adawy AS
- El Hamid MA
- El Hossainy R
- El Sayed E
- El Sayed F
- El Sayed I
- El-Hamamsy M
- El-Keraie A
- Eladawy S
- Elbers PW
- Elgendy M
- Eliet J
- Emmanuel J
- Emmerich M
- Encina B
- Endacott R
- Endacott R
- Engelberts D
- ENVIN-HELICS Study Group
- Erb J
- Erdogan M
- Eroles AA
- Escalada SH
- Escalada SH
- Escoval A
- Escribá A
- Escórcio S
- Eslami S
- Espinasse F
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- Esteban A
- Estella A
- Estenssoro E
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- Fanzaghi P
- Farias P
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- Feliot E
- Ferez MA
- Fernandes MJ
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- Fernandez NG
- Fernandez R
- Fernandez-Zamora MD
- Fernández IF
- Fernández L
- Fernández MV
- Fernández PA
- Fernández-Barat L
- Fernández-Mondéjar E
- Fernández-Ortega JF
- Ferraz AB
- Ferrero-Calleja J
- Ferri F
- Ferry A
- Ferré A
- Ferrón FR
- Ferrón FR
- Fiks T
- Fiks T
- Fileković S
- Filho CA
- Filho CA
- Filho CA
- Filipe E
- FINNRESUSCI Study Group
- Fischer G
- Fleischmann E
- Fless K
- Floccard B
- Flowers E
- Follin A
- Follin A
- Fong KY
- Fontaiña LP
- Fontana V
- Fontenot T
- Forel JM
- Forni L
- Forni L
- Forni LG
- Forni LG
- Forni LG
- Fournel E
- Fox B
- Franchi P
- Francioni JE
- Francioni JE
- Franco JF
- Frantzeskaki F
- Frantzeskaki F
- Frat JP
- Frat JP
- Frat JP
- Freile MT
- Frenzel T
- Frigeni B
- Frithiof R
- Fritz C
- FROG ICU Investigators
- Fromentin M
- Frontera PR
- Fuentes M
- Fumagalli F
- Fumagalli F
- Fumis RR
- Fushimi K
- Gabán-Díez Á
- Gadgil S
- Gaide-Chevronnay L
- Gainnier M
- Gaite FB
- Gaizauskas E
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- Galache JA
- Gallego-Corpa AI
- Gameiro J
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- Gandolfi S
- Ganuza MS
- Garcia IP
- Garcia IP
- Garcia M
- Garcia PK
- Garcia-Alvarez JM
- Garcia-Alvarez JM
- Garcia-Delgado M
- Garcia-Gigorro R
- García MF
- García-Martínez MV
- García-Olivares P
- Garnacho-Montero J
- Garrido BB
- Garrido BB
- Garrido EM
- Garrouste M
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- Gasparovic V
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- Gavrychenko D
- Gayat E
- Geantot MA
- Gemmell L
- Gemmell LK
- Genc D
- Genève C
- Georgopoulos D
- Geri G
- GETGAG Working Group
- GETGAG/SEMICYUC
- Ghabina S
- Ghazal S
- Gherli T
- Gherli T
- Ghosh S
- Giannantonio M
- Giannopoulos A
- Giesinger RE
- Gigorro RG
- Gil EM
- Gimenez J
- Gimillo MR
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- Gioia A
- Girbes AR
- Girotto V
- Gkirkas K
- Glogoski MZ
- Gobert F
- Godinho I
- Godoy K
- Goldsworthy M
- Golovnya E
- Gomes AA
- Gomez C
- Gomez SE
- Gommers D
- Gommers D
- Gonzalez CA
- Gonzalez JA
- Gonzalez V
- Gonzalez-Engroba R
- González AS
- González BS
- González JC
- González-Jiménez AI
- Gonçalves B
- Goodwin S
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- Gordillo-Brenes A
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- Gordon M
- Gordon M
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- Gouveia J
- Gracia RM
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- Granada RM
- Granados PR
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- Grangé S
- Grangé S
- Grangé S
- Granillo JF
- Grassi L
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- Green RS
- Greer M
- Gregory S
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- Grelon F
- Grelon F
- Grevelink M
- Grossestreuer A
- Guanziroli M
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- Guerrero AP
- Guerrero JE
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- Guerrero-López F
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- Guidet B
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- Harm S
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- Hayakawa M
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- Hendra H
- Henschel B
- Heras G
- Hernandis V
- Hernández A
- Hernández AA
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- Hernández G
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- Herpain A
- Herrera AN
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- Heunks LM
- Hewitt H
- Heyne T
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- Hidalgo C
- Hikasa Y
- Hillier SD
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- Himpe D
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- Hirata A
- Hirayama T
- Hirohata S
- Hodgson LE
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- Hollands S
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- Horvat A
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- Howes D
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- Hraiech S
- Hravnak M
- Hu HC
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- Huber W
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- Hull AM
- Hung CY
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- Huot B
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- Hutchings S
- Hutchison R
- Hwang GS
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- Ibañes PG
- Ibsen M
- Idei M
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- Idone FA
- Iesu E
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- Ignacio ML
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- Itenov TS
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- Jamali S
- Jang BH
- Janotka M
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- Jansen D
- Jansen N
- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
- Jardim JJ
- Jardim M
- Jareño A
- Javadpour S
- Jayasinghe S
- Jean-Baptiste S
- Jean-Baptiste S
- Jensen AE
- Jensen JU
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- Jiménez GJ
- Jo YH
- Joachim J
- Jochmans S
- John G
- Jonas M
- Jonas M
- Jonas M
- Jones C
- Joshi R
- Joshi V
- Jovaisa T
- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
- Juan WC
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- Juez A
- Juliarena A
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- Jung K
- Jung KW
- Junior JM
- Kaczirek K
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- Kalenka A
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- Kamali E
- Kaminsky GE
- Kaneko M
- Kang M
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- Kao KC
- Kappler F
- Kara A
- Karachi F
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- Karbing DS
- Karsten E
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- Kashiya S
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- Kawano S
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- Kayambu G
- Kazutoshi F
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- Kleinpell R
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- Kobayashi A
- Koco E
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- Komuro T
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- Kongpolprom N
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- Kosuk ME
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- Kox M
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- Kristof J
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- Kurth T
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- Lacerda P
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- Okayama Research Investigation Organizing Network (ORION)investigators
- Olaechea P
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- Zabini D
- Zahorec M
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- Zanello M
- Zani D
- Zarantonello F
- Zayas B
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- Álvarez JT
- Álvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Multi-messenger observations of a binary neutron star merger
- Author
- Aab A
- Aartsen MG
- Abbott BP
- Abbott R
- Abbott TD
- Abbott TMC
- Abdalla H
- Abe F
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- Areeda JS
- Aresu G
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- Array LWA Long Wavelength
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- Li X
- Li X
- Li XB
- Li XF
- Li YG
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- Pant BC
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- Parra A
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- Passuello D
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- Pearlstone BL
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- Pekeur NW
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- Piccinni OJ
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- Piergiovanni F
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- Piran T
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- Piranomonte S
- Pirello M
- Piro AL
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- Pirronello V
- Pisanu T
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- Pollmann A Obertacke
- Poolakkil S
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- Popolizio P
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- Prado RR
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- Principe G
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- Prodi GA
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- Prokoph H
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- Rojas-Bravo C
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- Romero M Dominguez
- Romie JH
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- Rumyantsev VV
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- Sahakian V
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- Salamida F
- Salazar H
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- Salvadori I
- Salvaterra R
- Samajdar A
- Sammut L
- Sampedro L
- Sampson LM
- Samtleben DFE
- Sanchez B
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- Sanchez E
- Sanchez EJ
- Sanchez F
- Sanchez LE
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- Sanchez-Lucas P
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- Sand DJ
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- Sanders JR
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- Santangelo A
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- Schneider A
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- Schoenell W
- Schoenen S
- Schofield RMS
- Scholten O
- Schonbeck A
- Schoneberg S
- Schoorlemmer H
- Schovnek P
- Schreiber E
- Schroder FG
- Schroder S
- Schroder SL
- Schssler F
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- Schulz A
- Schulz A
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- Schwalbe SG
- Schwanke U
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- Sciutto SJ
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- Segreto A
- Seidel E
- Seitenzahl IR
- Sekiguchi Y
- Sellers D
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- Sengupta AS
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- Sergeev A
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- Seunarine S
- Sevilla-Noarbe I
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- Shahriar MS
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- Shang Z
- Shannon RM
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- Shimizu Y
- Shimomukai R
- Shingles LJ
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- Shoemaker DH
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- Siegel MH
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- Siemens X
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- Slagmolen BJJ
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- Starling RLC
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- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy
- Author
- Abdallah J
- Abdul Ghani R
- Abdul Kadir K
- Abdullah R
- Abejuela Z
- Abouglila K
- Abraham O
- Abrahamsen I
- Abraira Munoz Ld
- Abramowitz M
- Abusnana S
- Accini Mendoza Jl
- Acosta I
- Agafyina A
- Agarwal R
- Agarwal Rajiv
- Aggarwal N
- Agra J
- Ahmed F
- Ahuad Guerrero Ra
- Aiello J
- Ainsworth P
- Aizenberg D
- Akiyama H
- Akright L
- Akyea-Djamson A
- Al-Karadsheh A
- Alamartine E
- Alappan R
- Albisu Jp
- Ali N
- Ali Z
- Alicic R
- Allison Dc
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- Alves da Costa Fa
- Amerena J
- Amigo A
- Amodeo C
- Andreeva V
- Andreotti Turatti La
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- Anghel V
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- Aquitania G
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- Arcos E
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- Zinman Bernard
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- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2019
- Field of study
BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to 300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m 2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years
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